Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children

Lancet

Volumn 360, Issue 9331, 2002, Pages 455-459

  Morahan, Grant ^a   Huang, Dexing ^a   Wu, Mark ^a   Holt, Barbara J ^b   White, Gregory P ^b   Kendall, Garth E ^b   Sly, Peter D ^b   Holt, Patrick G ^b  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; PROTEIN P40;

ALLERGIC ASTHMA; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE PREDISPOSITION; DISEASE SEVERITY; FEMALE; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENOTYPE; HETEROZYGOSITY; HUMAN; IMMUNE RESPONSE; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROMOTER REGION; TH2 CELL;

EID: 0037055708     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(02)09676-9     Document Type: Article

References (39)

1. The inflammation-repair cycle in asthma: The pivotal role of the airway epithelium
2. Asthma and wheezing in the first six years of life
3. Paediatric origins of adult lung disease
4. The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: More similarities than differences
5. Pathophysiology of severe asthma
6. Relevance of atopy in the pathogenesis of bronchial asthma
7. Recent advances in the genetics of allergy and asthma
8. Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy
9. Significant evidence for linkage of mite-sensitive childhood asthma to chromosome 5q31-q33 near the interleukin 12 B locus by a genome-wide search in Japanese families
10. The role of interleukin 12 in the immune response, disease and therapy
11. Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit
12. Linkage disequilibrium of a Type 1 diabetes susceptibility locus with a regulatory IL12B allele
13. IL-12 is required for the maintenance of IFN-γ production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii
14. Association between breast feeding and asthma in 6 year old children: Findings from a prospective birth cohort study
15. Treatment of asthma in children and adolescents: The need for a different approach
16. Management of acute asthma
17. IL-12p40 is associated with type 1 diabetes in caucasian-American families
18. Identification of missense mutation in the IL12B gene: Lack of association between IL12B polymorphisms and asthma and allergic rhinitis in the Japanese population
19. Reduced interferon-gamma expression in peripheral blood mononuclear cells of infants with severe respiratory syncytial virus disease
20. Reduced interferon-gamma production in infants with bronchiolitis and asthma
21. Decreased interleukin-12 levels in umbilical cord blood in children who developed acute bronchiolitis
22. Nonatopic wheezy children have reduced interferon-gamma
23. Heterogeneity in diphtheria-tetanus-acellular pertussis vaccine-specific cellular immunity during infancy: Relationship to variations in the kinetics of postnatal maturation of systemic Th1 function
24. Interactions between respiratory tract infections and atopy in aetiology of asthma
25. Socioeconomic status, number of siblings, and respiratory infections in early life as determinants of atopy in children
26. Frequency of infections and risk of asthma, atopy and airway hyper-responsiveness in children
27. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years
28. Eosinophilia at the time of respiratory syncytial virus bronchiolitis predicts childhood reactive airway disease
29. Eosinophils are a feature of upper and lower airway pathology in non-atopic asthma, irrespective of the presence of rhinitis
30. The development of respiratory syncytial virus-specific IgE and the release of histamine in nasopharyngeal secretions after infection
31. The relationship between upper respiratory infections and hospital admissions for asthma: A time-trend analysis
32. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice
33. Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyper-responsiveness, eosinophilia, and serum IgE levels
34. Resistance to antigen-induced airway hyper-responsiveness requires endogenous production of IL-12
35. IL-12/IL-13 axis in allergic asthma
36. Beta2-Andrenergic receptor halotypes in mild, moderate and fatal/near fatal asthma
37. Effects of group B streptococci on cord and adult mononuclear cell interleukin-12 and interferon-gamma mRNA accumulation and protein secretion
38. Decreased interleukin-12 (IL-12) from activated cord versus adult peripheral blood mononuclear cells and upregulation of interferon-gamma, natural killer, and lymphokine-activated killer activity by IL-12 in cord blood mononuclear cells