Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Bachmaier, Kurt ^a   Guzman, Edgar ^a   Kawamura, Takeshi ^a   Gao, Xiaopei ^a   Malik, Asrar B ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENT COMPONENT C5L2 RECEPTOR; ENDOTOXIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; SPHINGOSINE KINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANAPHYLATOXIN; CHEMOKINE RECEPTOR; CYTOKINE; DRUG DERIVATIVE; GPR77 PROTEIN, MOUSE; LIPOPOLYSACCHARIDE; LYSOPHOSPHOLIPID; PHOSPHOTRANSFERASE; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE; LUNG INJURY; LUNG PARENCHYMA; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTE; PNEUMONIA; PROTEIN EXPRESSION; SEPSIS; SIGNAL TRANSDUCTION; SPHK1 GENE; UPREGULATION; WILD TYPE; ANIMAL; BONE MARROW; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

MUS;

ANAPHYLATOXINS; ANIMALS; BONE MARROW; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; LIPOPOLYSACCHARIDES; LYSOPHOSPHOLIPIDS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PNEUMONIA; RECEPTOR, ANAPHYLATOXIN C5A; RECEPTORS, CHEMOKINE; SEPSIS; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 84857089757     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030742     Document Type: Article

References (47)

1. Puneet P, Yap CT, Wong LK, Yulin L, Koh DR, et al. (2010) Sphk1 Regulates Proinflammatory Responses Associated with Endotoxin and Polymicrobial Sepsis. Science 328: 1290-1294.
2. Lee MJ, Van Brocklyn JR, Thangada S, Liu CH, Hand AR, et al. (1998) Sphingosine-1-phosphate as a ligand for the G protein coupled receptor EDG-1. Science 279: 1552-1555.
3. Oskouian B, Saba J, (2007) Sphingosine-1-phosphate metabolism and intestinal tumorigenesis- Lipid signaling strikes again. Cell Cycle 6: 522-527.
4. Brinkmann V, (2007) Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol Ther 115: 84-105.
5. Hla T, Venkataraman K, Michaud J, (2008) The vascular S1P gradient- Cellular sources and biological significance. Biochim Biophys Acta 1781: 477-482.
6. Peng XQ, Hassoun PM, Sammani S, McVerry BJ, Burne MJ, et al. (2004) Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. Am J Respir Crit Care Med 169: 1245-1251.
7. Zhao YT, Kalari SK, Usatyuk PV, Gorshkova I, He DH, et al. (2007) Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells- Role of lipid phosphate phosphatase-1 and sphingosine kinase 1. J Biol Chem 282: 14165-14177.
8. McVerry BJ, Peng XQ, Hassoun PM, Sammani S, Simon BA, et al. (2004) Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. Am J Respir Crit Care Med 170: 987-993.
9. Jacobson JR, Garcia JGN, (2007) Novel therapies for microvascular permeability in sepsis. Curr Drug Targets 8: 509-514.
10. Liu HB, Cui NQ, Wang Q, Li DH, Xue XP, (2008) Sphingosine-1-phosphate and its analogue FTY720 diminish acute pulmonary injury in rats with acute necrotizing pancreatitis. Pancreas 36: E10-E15.
11. Pappu R, Schwab SR, Cornelissen I, Pereira JP, Regard JB, (2007) Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 316: 295-298.
12. Hanel P, Andreani P, Graler MH, (2007) Erythrocytes store and release sphingosine 1-phosphate in blood. FASEB J 21: 1202-1209.
13. Allende ML, Sasaki T, Kawai H, Olivera A, Mi YD, et al. (2004) Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J Biol Chem 279: 52487-52492.
14. Mizugishi K, Yamashita T, Olivera A, Miller GF, Spiegel S, et al. (2005) Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol 25: 11113-11121.
15. Rosen H, Goetzl EJ, (2005) Sphingosine 1-phosphate and its receptors: An autocrine and paracrine network. Nat Rev Immunol 5: 560-570.
16. Spiegel S, Milstien S, (2007) Functions of the multifaceted family of sphingosine kinases and some close relatives. J Biol Chem 282: 2125-2129.
17. Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, et al. (2005) Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309: 1735-1739.
18. Dorsam G, Graeler MH, Seroogy C, Kong Y, Voice JK, et al. (2003) Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P(1) G protein-coupled receptor. J Immunol 171: 3500-3507.
19. Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, et al. (2004) Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427: 355-360.
20. Ibrahim FBM, Pang SJ, Melendez AJ, (2004) Anaphylatoxin signaling in human neutrophils- A key role for sphingosine kinase. J Biol Chem 279: 44802-44811.
21. Tauseef M, Kini V, Knezevic N, Brannan M, Ramchandaran R, et al. (2008) Activation of Sphingosine Kinase-1 Reverses the Increase in Lung Vascular Permeability Through Sphingosine-1-Phosphate Receptor Signaling in Endothelial Cells. Circ Res 103: 1164-U1214.
22. Czermak BJ, Sarma V, Pierson CL, Warner RL, Huber-Lang M, et al. (1999) Protective effects of C5a blockade in sepsis. Nat Med 5: 788-792.
23. Pushparaj PN, H'ng SC, Melendez AJ, (2008) Refining siRNA in vivo transfection: Silencing SPHK1reveals its key role in C5a-induced inflammation in vivo. Int J Biochem Cell Biol 40: 1817-1825.
24. Ohno M, Hirata T, Enomoto M, Araki T, Ishimaru H, et al. (2000) A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells. Mol Immunol 37: 407-412.
25. Lee H, Whitfeld PL, Mackay CR, (2008) Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2. Immunol Cell Biol 86: 153-160.
26. Gerard NP, Lu B, Liu P, Craig S, Fujiwara Y, et al. (2005) An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2. J Biol Chem 280: 39677-39680.
27. Chen NJ, Mirtsos C, Suh D, Lu YC, Lin WJ, et al. (2007) C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Nature 446: 203-207.
28. Höpken UE, Lu B, Gerard NP, Gerard C, (1997) Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. J Exp Med 186: 749-756.
29. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, et al. (2008) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 36: 296-327.
30. Di AK, Kawamura T, Gao XP, Tang HY, Berdyshev E, et al. (2010) A Novel Function of Sphingosine Kinase 1 Suppression of JNK Activity in Preventing Inflammation and Injury. J Biol Chem 285: 15848-15857.
31. Niessen F, Schaffner F, Furlan-Freguia C, Pawlinski R, Bhattacharjee G, et al. (2008) Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature 452: 654-658.
32. Riedemann NC, Guo RF, Neff TA, Laudes IJ, Keller KA, et al. (2002) Increased C5a receptor expression in sepsis. J Clin Invest 110: 101-108.
33. Wang L, Han G, Wang R, Chen G, Xu R, et al. (2010) Regulation of IL-8 production by complement-activated product, C5a, in vitro and in vivo during sepsis. Clin Immunol 137: 157-165.
34. Rittirsch D, Flierl MA, Nadeau BA, Day DE, Huber-Lang M, et al. (2008) Functional roles for C5a receptors in sepsis. Nat Med 14: 551-557.
35. Riedemann NC, Guo RF, Bernacki KD, Reuben JS, Laudes IJ, et al. (2003) Regulation by C5a of neutrophil activation during sepsis. Immunity 19: 193-202.
36. Hawlisch H, Belkaid Y, Baelder R, Hildeman D, Gerard C, et al. (2005) C5a negatively regulates Toll-like receptor 4-induced immune responses. Immunity 22: 415-426.
37. Riedemann NC, Guo RF, Hollmann TJ, Gao H, Neff TA, et al. (2004) Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. FASEB J 18: 370-372.
38. Perianayagam MC, Balakrishnan VS, King AJ, Pereira BJ, Jaber BL, (2002) C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway. Kidney Int 61: 456-463.
39. Ricklin D, Hajishengallis G, Yang K, Lambris JD, (2010) Complement: a key system for immune surveillance and homeostasis. Nat Immunol 11: 785-797.
40. Huber-Lang M, Sarma JV, Rittirsch D, Schreiber H, Weiss M, et al. (2005) Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans. J Immunol 174: 1104-1110.
41. Ward PA, Sarma V, Rittersch D, Zetoune E, Brueckner U, et al. (2004) Changes in the C5L2 receptor during experimental and clinical sepsis. Mol Immunol 41: 323-324.
42. Gavrilyuk V, Kalinin S, Hilbush BS, Middlecamp A, McGuire S, et al. (2005) Identification of complement 5a-like receptor (C5L2) from astrocytes: characterization of anti-inflammatory properties. J Neurochem 92: 1140-1149.
43. Flierl MA, Rittirsch D, Nadeau BA, Day DE, Zetoune FS, et al. (2008) Functions of the complement components C3 and C5 during sepsis. FASEB J 22: 3483-3490.
44. Camerer E, Cornelissen I, Kataoka H, Duong DN, Zheng YW, et al. (2006) Roles of protease-activated receptors in a mouse model of endotoxemia. Blood 107: 3912-3921.
45. Bachmaier K, Toya S, Gao X, Triantafillou T, Garrean S, et al. (2007) E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury. Nat Med 13: 920-926.
46. Berdyshev EV, Gorshkova IA, Garcia JG, Natarajan V, Hubbard WC, (2005) Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. Anal Biochem 339: 129-136.
47. Park JM, Greten FR, Li ZW, Karin M, (2002) Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science 297: 2048-2051.