Molecular mechanisms of liver metastasis

International Journal of Clinical Oncology

Volumn 16, Issue 5, 2011, Pages 464-472

  Kawada, Kenji ^a   Hasegawa, Suguru ^a   Murakami, Teppei ^a   Itatani, Yoshiro ^a,b   Hosogi, Hisahiro ^a   Sonoshita, Masahiro ^b   Kitamura, Takanori ^b,c   Fujishita, Teruaki ^b   Iwamoto, Masayoshi ^a   Matsumoto, Takuya ^a   Matsusue, Ryo ^a   Hida, Koya ^a   Akiyama, Gaku ^a   Okoshi, Kae ^a   Yamada, Masahiro ^a   Kawamura, Junichiro ^a   Taketo, Makoto Mark ^b   Sakai, Yoshiharu ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Chemokine; Colorectal cancer; Liver metastasis

Indexed keywords

1 [5 CHLORO 2 [2 [4 (4 FLUOROBENZYL) 2 METHYL 1 PIPERAZINYL] 2 OXOETHOXY]PHENYL]UREA; ALPHA SMOOTH MUSCLE ACTIN; AMG 487; AZD 4818; BEVACIZUMAB; BKT 140; BL 5923; C 4462; C 6448; CARLUMAB; CCX 354; CHEMOKINE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; CP 481715; CTCE 9908; GRANULOCYTE CHEMOTACTIC PROTEIN 2; MDX 1338; MLN 1202; MLN 3897; MOGAMULIZUMAB; NAVARIXIN; OXALIPLATIN; PLERIXAFOR; SCH 479833; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; UNINDEXED DRUG; CHEMOKINE RECEPTOR;

ACUTE GRANULOCYTIC LEUKEMIA; BONE MARROW CELL; BONE METASTASIS; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL INVASION; CELL MIGRATION; CELL SURVIVAL; CHRONIC MYELOID LEUKEMIA; CHRONIC OBSTRUCTIVE LUNG DISEASE; COLORECTAL CANCER; DRUG RESISTANCE; DRUG TARGETING; DRUG TOLERABILITY; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; HUMAN; LIVER METASTASIS; LUNG METASTASIS; LYMPH NODE METASTASIS; LYMPHOMA; METASTASIS INHIBITION; MULTIPLE MYELOMA; MULTIPLE SCLEROSIS; MYELOID DERIVED SUPPRESSOR CELL; NONHUMAN; OSTEOSARCOMA; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PSORIASIS; RECTUM CANCER; REVIEW; RHEUMATOID ARTHRITIS; SOLID TUMOR; STROMA CELL; SUPPRESSOR CELL; T CELL LEUKEMIA; TUMOR VASCULARIZATION; CANCER INVASION; CELL MOTION; COLORECTAL TUMOR; DRUG ANTAGONISM; GENETICS; LIVER TUMOR; METABOLISM; METASTASIS; MOLECULARLY TARGETED THERAPY; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; TUMOR MICROENVIRONMENT;

CELL MOVEMENT; CHEMOKINES; COLORECTAL NEOPLASMS; HUMANS; LIVER NEOPLASMS; MOLECULAR TARGETED THERAPY; MYELOID CELLS; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, CHEMOKINE; TUMOR MICROENVIRONMENT;

EID: 84857075196     PISSN: 13419625     EISSN: 14377772     Source Type: Journal    
DOI: 10.1007/s10147-011-0307-2     Document Type: Review

References (86)

1. Matsuda T, Marugame T, Kamo K et al (2008) Cancer incidence and incidence rates in Japan in 2002: based on data from 11 population-based cancer registries. Jpn J Clin Oncol 38:641-648
2. Weinberg RA (2007) Multi-step tumorigenesis. Biol Cancer (Garland Science) 11:399-462
3. Millikan KW, Staren ED, Doolas A (1997) Invasive therapy of metastatic colorectal cancer to the liver. Surg Clin North Am 77:27-28
4. Jemal A, Murray T, Ward E et al (2005) Cancer statistics, 2005. CA Cancer J Clin 55:10-30 (Pubitemid 40310185)
5. Rees M, Tekkis PP, Welsh FK et al (2008) Evaluation of longterm survival after hepatic resection for metastatic colorectal cancer: a multifactorial model of 929 patients. Ann Surg 247:125-135
6. Nordlinger B, Guiguet M, Vaillant J-C et al (1996) Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Cancer 77:1254-1262 (Pubitemid 26102322)
7. Chambers AF, Groom AC, MacDonald IC (2002) Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2:563-572 (Pubitemid 37328923)
8. Wang JM, Deng X, Gong W et al (1998) Chemokines and their role in tumor growth and metastasis. J Immunol Methods 220:1-17 (Pubitemid 28527062)
9. Müller A, Homey B, Soto H et al (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410:50-56 (Pubitemid 32225831)
10. Kang Y, Siegel PM, Shu W et al (2003) A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3:537-549 (Pubitemid 36808649)
11. Nagasawa T, Hirota S, Tachibana K et al (1996) Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382:635-638 (Pubitemid 26268957)
12. Tachibana K, Hirota S, Iizasa H et al (1998) The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393:591-594 (Pubitemid 28319250)
13. Zeelenberg IS, Ruuls-Van Stalle L, Roos E (2003) The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastasis. Cancer Res 62:3833-3839 (Pubitemid 36793074)
14. Kim J, Takeuchi H, Lam ST et al (2005) Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival. J Clin Oncol 23:2744-2753 (Pubitemid 46179464)
15. Gassmann P, Haier J, Schlüter K et al (2009) CXCR4 regulates the early extravasation of metastatic tumor cells in vivo. Neoplasia 11:651-661
16. Matsusue R, Kubo H, Hisamori S et al (2009) Hepatic stellate cells promote liver metastasis of colon cancer cells by the action of SDF-1/CXCR4 axis. Ann Surg Oncol 16:2645-2653
17. Xu L, Duda DG, di Tomaso E et al (2009) Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1a, CXCR4, CXCL6, and Neuropilin 1 in tumors from patients with rectal cancer. Cancer Res 69:7905-7910
18. Willett CG, Duda DG, di Tomaso E et al (2009) Efficacy, safety and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol 27:3020-3026
19. Cella M, Jarrossay D, Facchetti F et al (1999) Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med 5:919-923 (Pubitemid 29372419)
20. Janatpour MJ, Hudak S, Sathe M et al (2001) Tumor necrosis factor-dependent segmental control of MIG expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment. J Exp Med 193:1375-1384 (Pubitemid 33055054)
21. Martin-Fontecha A, Thomsen LL, Brett S et al (2004) Induced recruitment of NK cells to lymph nodes provides IFN-c for TH1 priming. Nat Immunol 5:1260-1265 (Pubitemid 41057741)
22. Yoneyama H, Narumi S, Zhang Y et al (2002) Pivotal role of dendritic cell-derived CXCL10 in the retention of T helper cell lymphocytes in secondary lymph nodes. J Exp Med 195:1257-1266 (Pubitemid 34564328)
23. Kawada K, Sonoshita M, Sakashita H et al (2004) Pivotal role of CXCR3 in melanoma cell metastasis to lymph nodes. Cancer Res 64:4010-4017 (Pubitemid 38697317)
24. Kawada K, Hosogi H, Sonoshita M et al (2007) Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes. Ongocene 26:4679-4688 (Pubitemid 47067410)
25. Kawada K, Taketo MM (2011) Significance and mechanism of lymph node metastasis in cancer progression. Cancer Res 71:1214-1218
26. Zipin-Roitman A, Meshel T, Sagi-Assif O et al (2007) CXCL10 promotes invasion-related properties in human colorectal carcinoma cells. Cancer Res 67:3396-3405 (Pubitemid 46724880)
27. Rubie C, Kollmar O, Frick VO et al (2008) Differential CXC receptor expression in colorectal carcinomas. Scand J Immunol 68:635-644
28. Cambien B, Karimdjee BF, Richard-Fiardo P et al (2009) Organspecific inhibition of metastatic colon carcinoma by CXCR3 antagonism. Br J Cancer 100:1755-1764
29. Walser TC, Rifat S, Ma X et al (2006) Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer. Cancer Res 66:7701-7707 (Pubitemid 44289229)
30. Ma X, Norsworthy K, Kundu N et al (2009) CXCR3 expression is associated with poor survival in breast cancer and promotes metastasis in a murine model. Mol Cancer Ther 8:490-498 (Pubitemid 46988082)
31. Shimizu Y, Murata H, Kashii Y et al (2001) CC-chemokine receptor 6 and its ligand macrophage inflammatory protein 3alpha might be involved in the amplification of local necroinflammatory response in the liver. Hepatology 34:311-319 (Pubitemid 32702344)
32. Dwinell MB, Eckmann L, Leopard JD et al (1999) Chemokine receptor expression by human intestinal epithelial cells. Gastroenterology 117:359-367 (Pubitemid 29352944)
33. Ghadjar P, Coupland SE, Na I-K et al (2006) Chemokine receptor CCR6 expression level and liver metastases in colorectal cancer. J Clin Oncol 24:1910-1916 (Pubitemid 46646227)
34. Rubie C, Oliveira V, Kempf K et al (2006) Involvement of chemokine receptor CCR6 in colorectal cancer metastasis. Tumor Biol 27:166-174
35. Kagaya T, Nakamoto Y, Sakai Y et al (2006) Monocyte chemoattractant protein-1 gene delivery enhances antitumor effects of herpes simplex virus thymidine kinase/ganciclovir system in a model of colon cancer. Cancer Gene Ther 13:357-366
36. Bailey C, Negus R, Morris A et al (2007) Chemokine expression is associated with the accumulation of tumour associated macrophages (TAMs) and progression in human colorectal cancer. Clin Exp Metastasis 24:121-130 (Pubitemid 46669245)
37. Hu H, Sun L, Guo C et al (2009) Tumor cell-microenvironment interaction models coupled with clinical validation reveal CCL2 and SNCG as two predictors of colorectal cancer hepatic metastasis. Clin Cancer Res 15:5485-5493
38. Folkman J (2002) Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29:15-18
39. Strieter RM, Kunkel SL, Elner VM et al (1992) Interleukin-8, a corneal factor that induces neovascularization. Am J Pathol 141:1279-1284 (Pubitemid 23002612)
40. Brew R, Southern SA, Flanagan BF et al (1996) Detection of interleukin-8 mRNA and protein in human colorectal carcinoma cells. Eur J Cancer 32A:2142-2147 (Pubitemid 26419466)
41. Yang S-K, Eckmann L, Panja A et al (1997) Differential and regulated expression of C-X-C. C-C, and C-chemokines by human colon epithelial cells. Gastroenterology 113:1214-1223 (Pubitemid 27418975)
42. Brew R, Southern SA, Flanagan BF et al (2000) Interleukin-8 as an autocrine growth factor for human colon carcinoma cells in vitro. Cytokine 12:78-85 (Pubitemid 30042685)
43. Li A, Varney ML, Singh RK (2001) Expression of interleukin 8 and its receptors in human colon carcinoma cells with different metastatic potentials. Clin Cancer Res 7:3298-3304 (Pubitemid 32963857)
44. Mizukami Y, Jo W-S, Duerr E-M et al (2005) Induction of interleukin-8 preserves the angiogenic response in HIF-1-α-deficient colon cancer cells. Nat Med 11:992-997 (Pubitemid 41294446)
45. Ning Y, Manegold PC, Hong YK et al (2010) Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models. Int J Cancer 128:2038-2049
46. Varney ML, Singh S, Li A et al (2011) Small molecule antagonists for CXCR2 and CXCR1 inhibit human colon cancer liver metastases. Cancer Lett 300:180-188
47. Ueda T, Shimada E, Urakawa T et al (1994) Serum levels of cytokines in patients with colorectal cancer: possible involvement of interleukin-6 and interleukin-8 in hematogenous metastasis. J Gastroenterol 29:423-429 (Pubitemid 24262709)
48. Richmond A, Thomas HG (1988) Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution. J Cell Biochem 36:185-198 (Pubitemid 18034925)
49. Li A, Varney ML, Singh RK (2004) Constitutive expression of growth regulated oncogene (gro) in human colon carcinoma cells with different metastatic potential and its role in regulating their metastatic phenotype. Clin Exp Metast 21:571-579 (Pubitemid 40298656)
50. Wen Y, Giardina SF, Hamming D et al (2006) GROα is highly expressed in adenocarcinoma of the colon and down-regulates Fibulin-1. Clin Cancer Res 12:5951-5959 (Pubitemid 44703754)
51. Minn AJ, Gupta GP, Siegel PM et al (2005) Genes that mediate breast cancer metastasis to lung. Nature 436:518-524 (Pubitemid 41112921)
52. Doll D, Keller L, Maak M et al (2010) Differential expression of the chemokines GRO-2, GRO-3 and interleukin-8 in colon cancer and their impact on metastatic disease and survival. Ing J Colorectal Dis 25:573-581
53. Rubie C, Frick VO, Pfeil S et al (2007) Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer. World J Gastroenterol 11:125-131
54. Smith SC, Theodorescu D (2009) Learning therapeutic lessons from metastasis suppressor proteins. Nat Rev Cancer 9:253-264
55. Kalluri R, Zeisberg M (2006) Fibroblasts in cancer. Nat Rev Cancer 6:392-401
56. Coussens LM, Tinkle CL, Hanahan D et al (2000) MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103:481-490
57. Orimo A, Gupta PB, Sgroi DC et al (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121:335-348 (Pubitemid 40692295)
58. Lin EY, Nguyen AV, Russel RG et al (2001) Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 193:727-739 (Pubitemid 32524466)
59. Karnoub AE, Dash AB, Vo AP et al (2007) Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 446:557-563 (Pubitemid 47525152)
60. Joyce JA, Pollard JW (2009) Microenvironmental regulation of metastasis. Nat Rev Cancer 9:239-252
61. Kaplan RN, Riba RD, Zacharoulis S et al (2005) VEGFR1-positive haematopoietic bone marrow progenitors initiate the premetastatic niche. Nature 438:820-827 (Pubitemid 41753060)
62. Hiratsuka S, Watanabe A, Aburatani H et al (2006) Tumourmediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol 8:1369-1375 (Pubitemid 44835111)
63. Erler JT, Bennewith KL, Cox TR et al (2009) Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell 15:35-44
64. Murdoch C, Muthana M, Coffelt SB et al (2008) The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer 8:618-631
65. Hiratsuka S, Duda DG, Huang Y et al (2011) C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells. Proc Natl Acad Sci USA 108:302-307
66. Yamamoto M, Kikuchi H, Ohta M et al (2008) TSU68 prevents liver metastasis of colon cancer xenografts by modulating the premetastatic niche. Cancer Res 68:9754-9762
67. Taketo MM, Edelmann W (2009) Mouse models of colon cancer. Gastroenterology 136:780-798
68. Takaku K, Oshima M, Miyoshi H et al (1998) Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 92:645-656 (Pubitemid 28141513)
69. Kitamura T, Kometani K, Hashida H et al (2007) SMAD4-deficient intestinal tumors recruit CCR1 + myeloid cells that promote invasion. Nat Genet 39:467-475 (Pubitemid 46514777)
70. Kitamura T, Taketo MM (2007) Keeping out the bad guys: gateway to cellular target therapy. Cancer Res 67:10099-10102 (Pubitemid 350070778)
71. Yang L, Huang J, Ren X et al (2008) Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1 + CD11b + myeloid cells that promote metastasis. Cancer Cell 13:23-35 (Pubitemid 350309741)
72. Kitamura T, Fujishita T, Loetscher P et al (2010) Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model. Proc Natl Acad Sci USA 107:13063-13068
73. Kusmartsev S, Gabrilovich DI (2006) Role of immature myeloid cells in mechanisms of immune evasion in cancer. Cancer Immunol Immunother 55:237-245 (Pubitemid 41683212)
74. Yang L, Debusk LM, Fukuda K et al (2004) Expansion of myeloid immune suppressor Gr+ CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell 6:409-421 (Pubitemid 39361441)
75. Wells TN, Power CA, Shaw JP et al (2006) Chemokine blockers-therapeutics in the making? Trends Pharmacol Sci 27:41-47
76. Pradelli E, Karimdjee-Soilihi B, Michiels JF et al (2009) Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs. Int J Cancer 125:2586-2594
77. Wijtmans M, Verzijl D, Leurs R et al (2008) Towards smallmolecule CXCR3 ligands with clinical potential. Chem Med Chem. 3:861-872
78. McGuinness BF, Carroll CD, Zawacki LG et al (2009) Novel CXCR3 antagonists with a piperazinyl-piperidine core. Bioorg Med Chem Lett 19:5205-5208
79. Crosignani S, Missotten M, Cleva C et al (2010) Discovery of a novel series of CXCR3 antagonists. Bioorg Med Chem Lett 20:3614-3617
80. Wijtmans M, Verzijl D, Bergmans S et al (2011) CXCR3 antagonists: quaternary ammonium salts equipped with biphenyland polycycloaliphatic-anchors. Bioorg Med Chem 19:3384-3393
81. Gladue RP, Brown MF, Zwillich SH (2010) CCR1 antagonists: what have we learned from clinical trials. Curr Top Med Chem 10:1268-1277
82. Sonoshita M, Aoki M, Fuwa H et al (2011) Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling. Cancer Cell 19:125-137
83. Taketo MM (2011) Reflections on the spread of metastasis to cancer prevention. Cancer Prev Res 4:324-328
84. Garber K (2009) First results for agents targeting cancer-related inflammation. J Natl Cancer Inst 101:1110-1112
85. Sun X, Cheng G, Hao M et al (2010) CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression. Cancer Metastasis Rev 29:709-722
86. Burger JA, Stewart DJ (2009) CXCR4 chemokine receptor antagonists: perspectives in SCLC. Expert Opin Investig Drugs 18:481-490