Discovery of a novel series of CXCR3 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 12, 2010, Pages 3614-3617

  Crosignani, Stefano ^a   Missotten, Marc ^a   Cleva, Christophe ^a   Dondi, Ruggero ^a   Ratinaud, Yann ^a   Humbert, Yves ^a   Mandal, Ashis Baran ^b   Bombrun, Agns ^a   Power, Christine ^a   Chollet, André ^a   Proudfoot, Amanda ^a  

^a MERCK SERONO S A   (Switzerland)

^b SYNGENE INTERNATIONAL LTD   (India)

Author keywords

Chemokines; CXCR3; GPCR antagonists; Multiple sclerosis; Rheumatoid arthritis

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; PROTEIN INHIBITOR;

ANIMAL CELL; ARTICLE; ASSAY; CHEMOTAXIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; IC 50; METABOLISM; MOUSE; NONHUMAN; RAT;

ANIMALS; CELL LINE; CHEMOTAXIS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICROSOMES; RATS; RECEPTORS, CXCR3; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 77954213547     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.113     Document Type: Article

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