Promiscuity in protein-RNA interactions: Conformational ensembles facilitate molecular recognition in the spliceosome: Conformational diversity in U2AF 65 facilitates binding to diverse RNA sequences

BioEssays

Volumn 34, Issue 3, 2012, Pages 174-180

  Boehr, David D ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Conformational dynamics; Conformational selection; Energy landscape; Molecular recognition; Spliceosome

Indexed keywords

POLYPYRIMIDINE TRACT BINDING PROTEIN; RNA; SMALL NUCLEAR RIBONUCLEOPROTEIN; TROPONIN T;

ARTICLE; CATALYSIS; ENZYME REGULATION; HUMAN; KINETICS; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE; PLASTICITY; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN RNA BINDING; PROTEIN STRUCTURE; RNA SEQUENCE; RNA STRUCTURE; SPLICEOSOME; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

AMINO ACID MOTIFS; BASE SEQUENCE; BIOCATALYSIS; EVOLUTION, MOLECULAR; GENETIC VARIATION; MACROMOLECULAR SUBSTANCES; NUCLEAR PROTEINS; NUCLEIC ACID CONFORMATION; POLYMORPHISM, GENETIC; PROTEIN BINDING; PROTEIN CONFORMATION; RIBONUCLEOPROTEINS; RNA SPLICE SITES; RNA SPLICING; RNA, MESSENGER; RNA-BINDING PROTEINS; SPLICEOSOMES;

EID: 84857061013     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201100152     Document Type: Article

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