A mixture of Trachelospermi caulis and Moutan cortex radicis extracts suppresses collagen-induced arthritis in mice by inhibiting NF-κB and AP-1

Journal of Pharmacy and Pharmacology

Volumn 64, Issue 3, 2012, Pages 420-429

  Kim, Hyuk Soon ^a   Kim, A Ram ^a   Lee, Jeong Min ^b   Kim, Se Na ^b   Choi, Jung Ho ^b   Kim, Do Kyun ^a   Kim, Ji Hyung ^a   Kim, Bokyung ^a   Her, Erk ^a   Yang, Young Mok ^a   Kim, Hyung Sik ^c   Kim, Young Mi ^d   Choi, Wahn Soo ^a  

^a Konkuk University School of Medicine   (South Korea)

^b Sinil Pharmaceutical Co Ltd   (South Korea)

^c Pusan National University   (South Korea)

^d Duksung Women's University   (South Korea)

Author keywords

collagen induced arthritis; Moutan cortex radicis; osteoclasts; rheumatoid arthritis; Trachelospermi caulis

Indexed keywords

ALCOHOL; ANTIRHEUMATIC AGENT; BUCILLAMINE; CARTILAGE OLIGOMERIC MATRIX PROTEIN; COLLAGEN TYPE 2; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1; MATRIX METALLOPROTEINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MOUTAN CORTEX RADICIS EXTRACT PLUS TRACHELOSSPERMI CAULIS EXTRACT; PLANT EXTRACT; RANTES; SERUM AMYLOID P; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; DRUG MIXTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; HISTOPATHOLOGY; MALE; MEDICINAL PLANT; MOUSE; MOUTAN CORTEX RADICIS; NONHUMAN; OSTEOCLAST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SPLEEN CELL; TH1 CELL; TRACHELOSSPERMI CAULIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOCYNACEAE; ARTHRITIS, EXPERIMENTAL; BIOLOGICAL MARKERS; CYTOKINES; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; DRUGS, CHINESE HERBAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; MALE; MICE; NF-KAPPA B; OSTEOCLASTS; PAEONIA; PLANT EXTRACTS; PLANT ROOTS; PLANT STEMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNOVIAL MEMBRANE; TRANSCRIPTION FACTOR AP-1;

EID: 84857049163     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01415.x     Document Type: Article

References (38)

1. Smolen JS, Aletaha D,. Developments in the clinical understanding of rheumatoid arthritis. Arthritis Res Ther 2009; 11: 204.
2. Cunnane G, et al,. Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis. Arthritis Rheum 2001; 44: 2263-2274. (Pubitemid 32977494)
3. Mclnnes IB, Schett G,. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 2007; 7: 429-442. (Pubitemid 46834849)
4. Feldmann M, et al,. Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 1996; 14: 397-440. (Pubitemid 26130190)
5. Konttinen YT, et al,. Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis. Ann Rheum Dis 1999; 58: 691-697. (Pubitemid 29517255)
6. Ogata Y, et al,. Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9. J Biol Chem 1992; 267: 3581-3584.
7. Knauper V, et al,. Biochemical characterization of human collagenase-3. J Biol Chem 1996; 271: 1544-1550. (Pubitemid 26028643)
8. Jackson C, et al,. Selective matrix metalloproteinase (MMP) inhibition in rheumatoid arthritis targeting gelatinase A activation. Inflamm Res 2001; 50: 183-186. (Pubitemid 32382244)
9. Begley CG, Nicola NA,. Resolving conflicting signals: cross inhibition of cytokine signaling pathways. Blood 1999; 93: 1443-1447. (Pubitemid 29102468)
10. Tran CN, et al,. Synovial biology and T cells in rheumatoid arthritis. Pathophysiology 2005; 12: 183-189. (Pubitemid 41375641)
11. Takayanagi H, et al,. Osteoimmunology and the effects of the immune system on bone. Nat Rev Rheumatol 2009; 5: 667-676.
12. Kyriakis JM, Avruch J,. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001; 81: 807-869. (Pubitemid 32267078)
13. Feng X, et al,. Regulatory roles and molecular signaling of TNF family members in osteoclasts. Gene 2005; 350: 1-13.
14. Li Y, et al,. Pharmacological of cortex moutan and core. Zhongguo Zhong Yao Za Zhi 1997; 22: 214-216.
15. Sheehan MP, Atherton DJ,. One-year follow up of children treated with Chinese medicinal herbs for atopic eczema. Br J Dermatol 1994; 130: 488-493. (Pubitemid 24204669)
16. Lee MH, et al,. In-vitro and in-vivo anti-inflammatory action of the ethanol extract of Trachelospermi caulis. J Pharm Pharmacol 2007; 59: 123-130. (Pubitemid 46133051)
17. Kim HS, et al,. Morus bombycis Koidzumi extract suppresses collagen-induced arthritis by inhibiting the activation of nuclear factor-κB and activator protein-1 in mice. J Ethnopharmacol 2011; 136: 392-398.
18. Brahn E, et al,. Collagen induced arthritis: reversal by mercaptoethylguanidine, a novel anti-inflammatory agent with a combined mechanism of action. J Rheumatol 1998; 25: 1785-1793. (Pubitemid 28439274)
19. Ono Y, et al,. Suppressive effect of Kanzo-bushi-to, a Kampo medicine, on collagen-induced arthritis. Biol Pharm Bull 2004; 27: 1406-1413. (Pubitemid 41701684)
20. Schulze-Koops H, et al,. Elevated Th1- or Th0-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis. Modulation by treatment with anti-ICAM-1 correlates with clinical benefit. J Immunol 1995; 155: 5029-5037. (Pubitemid 3010845)
21. Liacini A, et al,. Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa b (NF-kB) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes. Matrix Biol 2002; 21: 251-262. (Pubitemid 34497016)
22. Han Z, et al,. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest 2001; 108: 73-81. (Pubitemid 32634924)
23. Okamoto H, et al,. Molecular aspects of rheumatoid arthritis: role of transcription factors. FEBS J 2008; 275: 4463-4470.
24. Simmonds RE, Foxwell BM,. Signalling, inflammation and arthritis NF-kappaB and its relevance to arthritis and inflammation. Rheumatology (Oxford) 2008; 47: 584-590. (Pubitemid 351619194)
25. Park JH, et al,. Treatment with SI000413, a new herbal formula, ameliorates murine collagen-induced arthritis. Biol Pharm Bull 2008; 31: 1337-1342.
26. Brand DD, et al,. Immunopathogenesis of collagen arthritis. Springer Semin Immunopathol 2003; 25: 3-18. (Pubitemid 37000035)
27. Woessner JF, et al,. Matrix metalloproteinase and their inhibitors in connective tissue remodeling. FASEB J 1991; 5: 2145-2154.
28. Andreakos ET, et al,. Cytokines and anti-cytokine biologicals in autoimmunity: present and future. Cytokine Growth Factor Rev 2003; 13: 299-313.
29. Green MJ, et al,. Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis. Rheumatology 2003; 42: 83-88. (Pubitemid 36131572)
30. Borzi RM, et al,. Human chondrocytes express functional chemokines receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokines. Arthritis Rheum 2000; 43: 1734-1741.
31. Kanbe K, et al,. Stimulation of matrix metalloprotease 3 release from human chondrocytes by the interaction of stromal cell-derived factor 1 and CXC chemokines receptor 4. Arthritis Rheum 2002; 46: 130-137. (Pubitemid 34121659)
32. Garcia-Vicuna R, et al,. CC and CXC chemokines receptors mediate migration, proliferation, and matrix metalloproteinase production by fibroblast-like synoviocytes from rheumatoid arthritis patients. Arthritis Rheum 2004; 50: 3866-3877. (Pubitemid 39643933)
33. Williams RO, et al,. Cytokine inhibitors in rheumatoid arthritis and other autoimmune disease. Curr Opin Pharmacol 2007; 7: 412-417. (Pubitemid 47289266)
34. Myers LK, et al,. Collagen induced arthritis, an animal model of autoimmunity. Life Sci 1997; 61: 1861-1878. (Pubitemid 27461519)
35. Shiozawa S, et al,. Studies on the contribution of c-fos/AP-1 to arthritic joint destruction. J Clin Invest 1997; 99: 1210-1216. (Pubitemid 27142756)
36. Han Z, et al,. AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity 1998; 28: 197-208. (Pubitemid 29027651)
37. Morel J, Berenbaum F,. Signal transduction pathways: new targets for treating rheumatoid arthritis. Joint Bone Spine 2004; 71: 503-510. (Pubitemid 39626717)
38. Rannou F, et al,. Cartilage breakdown in rheumatoid arthritis. Joint Bone Spine 2006; 73: 29-36. (Pubitemid 43197702)