Design, synthesis and structural analysis of mixed α/β-peptides that adopt stable cyclic hairpin-like conformations

Tetrahedron

Volumn 68, Issue 10, 2012, Pages 2391-2400

  Van Der Knaap, Matthijs ^a   Otero, José M ^b   Llamas Saiz, Antonio ^b   Van Raaij, Mark J ^c   Lageveen, Lianne I ^d   Busscher, Henk J ^d   Grotenbreg, Gijsbert M ^e   Van Der Marel, Gijsbert A ^a   Overkleeft, Herman S ^a   Overhand, Mark ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cyclic mixed peptides; H bonding pattern; Hairpin like structure; Nano channels

Indexed keywords

ALPHA AMINO ACID; ALPHA PEPTIDE; BETA AMINO ACID; BETA PEPTIDE; FUNCTIONAL GROUP; GRAMICIDIN S; PEPTIDE; PEPTIDE DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HYDROGEN BOND; ISOMER; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; STAPHYLOCOCCUS AUREUS; STEREOCHEMISTRY; STREPTOCOCCUS MITIS; STRUCTURE ANALYSIS; X RAY ANALYSIS;

EID: 84857045430     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2012.01.015     Document Type: Article

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