Exploring relationships between mimic configuration, peptide conformation and biological activity in indolizidin-2-one amino acid analogs of gramicidin S

Journal of Peptide Research

Volumn 60, Issue 4, 2002, Pages 198-214

  Roy, S ^a,b   Lombart, H G ^a,c   Lubell, W D ^a   Hancock, R E W ^d   Farmer, S W ^d  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b METHYLGENE INC   (Canada)

^c PFIZER INC   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

turn; Antibiotic peptides; Antimicrobial peptide; Circular dichroism spectroscopy; Gramicidin S; Indolizidin 2 one amino acid; Solid phase synthesis

Indexed keywords

AMINO ACID DERIVATIVE; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; CYCLO(VALYLLYSYLLEUCINE INDOLIZIDIN 2 ONE AMINO ACID); CYCLO(VALYLORNITHYLLEUCINE INDOLIZIDIN 2 ONE AMINO ACID); GRAMICIDIN S; LEUCINE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; VALINE; AMINO ACID; DRUG DERIVATIVE; GRAMICIDIN;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; BETA SHEET; CIRCULAR DICHROISM; DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; HEMOLYSIS; MOLECULAR MIMICRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN CONFORMATION; SOLID; STEREOCHEMISTRY; STEREOISOMERISM; BACTERIUM; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; MICROBIOLOGICAL EXAMINATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TEMPERATURE;

AMINO ACID SEQUENCE; AMINO ACIDS; ANTI-BACTERIAL AGENTS; BACTERIA; CIRCULAR DICHROISM; GRAMICIDIN; HEMOLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 0036795520     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2002.21026.x     Document Type: Article

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