Sequence inversion and phenylalanine surrogates at the β-Turn enhance the antibiotic activity of gramicidin S

Journal of Medicinal Chemistry

Volumn 53, Issue 10, 2010, Pages 4119-4129

  Solanas, Concepción ^a   De La Torre, Beatriz G ^b   Fernández Reyes, María ^c   Santiveri, Clara M ^d   Jiménez, M Ángeles ^d   Rivas, Luis ^c   Jiménez, Ana I ^a   Andreu, David ^b   Cativiela, Carlos ^a  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^d INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; GRAMICIDIN S; PHENYLALANINE; PROLINE;

ACINETOBACTER BAUMANNII; AMINO ACID SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BETA SHEET; CHIRALITY; CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; ERYTHROCYTE; HEMOLYSIS; LISTERIA MONOCYTOGENES; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; SHEEP; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; GRAMICIDIN; HEMOLYSIS; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; PHENYLALANINE; PROTEIN STRUCTURE, SECONDARY; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77952727721     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100143f     Document Type: Article

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