Identification of transcriptional targets of Wnt/β-catenin signaling in dermal papilla cells of human scalp hair follicles: EP2 is a novel transcriptional target of Wnt3a

Journal of Dermatological Science

Volumn 58, Issue 2, 2010, Pages 91-96

  Shin, HyeRim ^a   Kwack, Mi Hee ^a   Shin, Seung Hyun ^a   Oh, Ji Won ^a   Kang, Bo Mi ^a   Kim, Ahnsup Andrew ^a   Kim, Jinoh ^a   Kim, Moon Kyu ^a   Kim, Jung Chul ^a   Sung, Young Kwan ^a  

^a Kyungpook National University School of Medicine   (South Korea)

Author keywords

Dermal papilla; EP2; Hair follicle; Microarray; PGE2; Wnt3a

Indexed keywords

BETA CATENIN; CYCLIC AMP; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; WNT PROTEIN; WNT3A PROTEIN;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE IDENTIFICATION; GENE TARGETING; HAIR FOLLICLE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MALE; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCALP HAIR; SKIN CELL; TRANSCRIPTION INITIATION; TRANSIENT TRANSFECTION;

BETA CATENIN; CELL NUCLEUS; CYCLIC AMP; HAIR FOLLICLE; HUMANS; IMMUNOENZYME TECHNIQUES; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, PROSTAGLANDIN E; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCALP; SIGNAL TRANSDUCTION; SKIN; WNT PROTEINS;

EID: 77952239375     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2010.02.011     Document Type: Article

References (25)

1. Hardy M.H. The secret life of the hair follicle. Trends Genet 1992, 8:55-61.
2. Botchkarev V.A., Kishimoto J. Molecular control of epithelial-mesenchymal interactions during hair follicle cycling. J Investig Dermatol Symp Proc 2003, 8:46-55.
3. Stenn K.S., Paus R. Controls of hair follicle cycling. Physiol Rev 2001, 81:449-494.
4. Miler J.K. The Wnts. Genome Biol 2002, 3:1-15.
5. González-Sancho J.M., Aguilera O., García J.M., Pendás-Franco N., Peña C., Cal S., et al. The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. Oncogene 2005, 24(6):1098-1103.
6. Kishimoto J., Burgeson R.E., Morgan B.A. Wnt signaling maintains the hair-inducing activity of the dermal papilla. Genes Dev 2000, 14:1181-1185.
7. Shimizu H., Morgan B.A. Wnt Signaling through the β-catenin pathway is sufficient to maintain, but not restore, anagen-phase characteristics of dermal papilla cells. J Invest Dermatol 2004, 122:239-245.
8. Maretto S., Cordenonsi M., Dupont S., Braghetta P., Broccoli V., Hassan A.B., et al. Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci 2003, 100(6):3299-3304.
9. Ouji Y., Yoshikawa M., Moriya K., Ishizaka S. Effects of Wnt10b on hair shaft growth in hair follicle cultures. BBRC 2007, 359:516-522.
10. Kitagawa T., Matsuda K., Inui S., Takenaka H., Katoh N., Itani S., et al. Keratinocyte growth inhibition through the modification of Wnt signaling by androgen in balding dermal papilla cells. J Clin Endocrinol Metab 2009, 94:1288-1294.
11. Klapholz-Brown Z., Walmsley G., Nusse Y., Nusse R., Brown P. Transcriptional program induced by Wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironment. PLoS One 2007, 2:e945.
12. Coghlan M.P., Culbert A.A., Cross D.A., Corcoran S.L., Yates J.W., Pearce N.J., et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 2000, 7:793-803.
13. Carmichael J., Sugars K.L., Bao Y.P., Rubinsztein D.C. Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation. J Biol Chem 2002, 277:33791-33798.
14. Cross D.A., Culbert A.A., Chalmers K.A., Facci L., Skaper S.D., Reith A.D. Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from death. J Neurochem 2001, 77:94-102.
15. Colombe L., Michelet J.F., Bernard B.A. Prostanoid receptors in anagen human hair follicles. Exp Dermatol 2007, 17:63-72.
16. Ichikawa A., Sugimoto Y., Negishi M. Molecular aspects of the structures and functions of the prostaglandin E receptors. J Lipid Mediat Cell Signal 1996, 14:83-87.
17. Regan J.W. EP2 and EP4 prostanoid receptor signaling. Life Sci 2003, 74:143-153.
18. McElwee K.J., Kissling S., Wenzel E., Huth A., Hoffmann R. Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla. J Invest Dermatol 2003, 121:1267-1275.
19. Rendl M., Polak L., Fuchs E. BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties. Genes Dev 2008, 22:543-557.
20. Lu Z.F., Cai S.Q., Wu J.J., Zheng M. Biological characterization of cultured dermal papilla cells and hair follicle regeneration in vitro and in vivo. Chin Med J (Engl) 2006, 119:275-281.
21. Sasaki S., Hozumi Y., Kondo S. Influence of prostaglandin F2 alpha and its analogues on hair regrowth and follicular melanogenesis in a murine model. Exp Dermatol 2005, 14:323-328.
22. Hanson W.R., Pelka A.E., Nelson A.K., Malkinson F.D. Subcutaneous or topical administration of 16, 16 dimethyl prostaglandin E2 protects form radiation-induced alopecia in mice. Int J Radiat Oncol Biol Phys 1992, 23:333-337.
23. Roenigk H. New topical agents for hair growth. Clin Dermatol 1988, 6:119-121.
24. Colombe L., Vindrios A., Michelet J.F., Bernard B.A. Prostaglandin metabolism in human hair follicle. Exp Dermatol 2007, 16:762-769.
25. Michelet J.F., Commo S., Billoni N., Mahe Y.F., Bernard B.A. Activation of cytoprotective prostaglandin synthase-1 by minoxidil as a possible explanation for its hair growth-stimulating effect. J Invest Dermatol 1997, 108:205-209.