Mesenchymal to embryonic incomplete transition of human cells by chimeric OCT4/3 (POU5F1) with physiological co-activator EWS

Experimental Cell Research

Volumn 315, Issue 16, 2009, Pages 2727-2740

  Makino, Hatsune ^a   Toyoda, Masashi ^a   Matsumoto, Kenji ^a   Saito, Hirohisa ^a   Nishino, Koichiro ^a   Fukawatase, Yoshihiro ^a   Machida, Masakazu ^a   Akutsu, Hidenori ^a   Uyama, Taro ^a   Miyagawa, Yoshitaka ^a   Okita, Hajime ^a   Kiyokawa, Nobutaka ^a   Fujino, Takashi ^b,c   Ishikawa, Yuichi ^b   Nakamura, Takuro ^b   Umezawa, Akihiro ^a  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b CANCER INSTITUTE   (Japan)

^c KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Dedifferentiation; Embryonic carcinoma; iPS cell; Mesoderm; OCT4 3; Stem cell

Indexed keywords

5' NUCLEOTIDASE; ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; BETA1 INTEGRIN; CIS ACTING ELEMENT; DEVELOPMENTAL PLURIPOTENCY ASSOCIATED 4; GENE PRODUCT; HERMES ANTIGEN; KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; RNA BINDING PROTEIN EWS; STAGE SPECIFIC EMBRYO ANTIGEN 3; STEM CELL FACTOR RECEPTOR; TERATOCARCINOMA DERIVED GROWTH FACTOR 1; THY 1 ANTIGEN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; UNDIFFERENTIATED EMBRYONIC CELL TRANSCRIPTION FACTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL; CELL STRUCTURE; CELL SURFACE; CHROMOSOME G BAND; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; EMBRYONAL CARCINOMA; EMBRYONIC STEM CELL; FLOW CYTOMETRY; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; KARYOTYPING; MESENCHYME CELL; MICROCHIP ANALYSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBCUTANEOUS TISSUE;

IPS; MUS;

EID: 68949097507     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2009.06.016     Document Type: Article

References (51)

1. Takahashi K., and Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126 (2006) 663-676
2. Okita K., Ichisaka T., and Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 448 (2007) 313-317
3. Wernig M., Meissner A., Foreman R., Brambrink T., Ku M., Hochedlinger K., Bernstein B.E., and Jaenisch R. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448 (2007) 318-324
4. Go M.J., Takenaka C., and Ohgushi H. Forced expression of Sox2 or Nanog in human bone marrow derived mesenchymal stem cells maintains their expansion and differentiation capabilities. Exp. Cell Res. 314 (2008) 1147-1154
5. Mori T., Kiyono T., Imabayashi H., Takeda Y., Tsuchiya K., Miyoshi S., Makino H., Matsumoto K., Saito H., Ogawa S., Sakamoto M., Hata J., and Umezawa A. Combination of hTERT and bmi-1, E6, or E7 induces prolongation of the life span of bone marrow stromal cells from an elderly donor without affecting their neurogenic potential. Mol. Cell. Biol. 25 (2005) 5183-5195
6. Lee R.H., Kim B., Choi I., Kim H., Choi H.S., Suh K., Bae Y.C., and Jung J.S. Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue. Cell. Physiol. Biochem. 14 (2004) 311-324
7. Toma J.G., Akhavan M., Fernandes K.J., Barnabe-Heider F., Sadikot A., Kaplan D.R., and Miller F.D. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat. Cell Biol. 3 (2001) 778-784
8. Cui C.H., Uyama T., Miyado K., Terai M., Kyo S., Kiyono T., and Umezawa A. Menstrual blood-derived cells confer human dystrophin expression in the murine model of duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation. Mol. Biol. Cell 18 (2007) 1586-1594
9. Lee O.K., Kuo T.K., Chen W.M., Lee K.D., Hsieh S.L., and Chen T.H. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 103 (2004) 1669-1675
10. Terai M., Uyama T., Sugiki T., Li X.K., Umezawa A., and Kiyono T. Immortalization of human fetal cells: the life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway. Mol. Biol. Cell 16 (2005) 1491-1499
11. Zhang X., Mitsuru A., Igura K., Takahashi K., Ichinose S., Yamaguchi S., and Takahashi T.A. Mesenchymal progenitor cells derived from chorionic villi of human placenta for cartilage tissue engineering. Biochem. Biophys. Res. Commun. 340 (2006) 944-952
12. Allan E.H., Ho P.W., Umezawa A., Hata J., Makishima F., Gillespie M.T., and Martin T.J. Differentiation potential of a mouse bone marrow stromal cell line. J. Cell. Biochem. 90 (2003) 158-169
13. Imabayashi H., Mori T., Gojo S., Kiyono T., Sugiyama T., Irie R., Isogai T., Hata J., Toyama Y., and Umezawa A. Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. Exp. Cell Res. 288 (2003) 35-50
14. Makino S., Fukuda K., Miyoshi S., Konishi F., Kodama H., Pan J., Sano M., Takahashi T., Hori S., Abe H., Hata J., Umezawa A., and Ogawa S. Cardiomyocytes can be generated from marrow stromal cells in vitro. J. Clin. Invest. 103 (1999) 697-705
15. Nishiyama N., Miyoshi S., Hida N.M., Uyama T., Okamoto K., Ikegami Y., Miyado K., Segawa K., Terai M., Sakamoto M., Ogawa S., and Umezawa A. The significant cardiomyogenic potential of human umbilical cord blood-derived mesenchymal stem cells in vitro. Stem Cells 25 (2007) 2017-2024
16. Deng J., Petersen B.E., Steindler D.A., Jorgensen M.L., and Laywell E.D. Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation. Stem Cells 24 (2006) 1054-1064
17. Scholer H.R., Dressler G.R., Balling R., Rohdewohld H., and Gruss P. Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J. 9 (1990) 2185-2195
18. Okamoto K., Okazawa H., Okuda A., Sakai M., Muramatsu M., and Hamada H. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 60 (1990) 461-472
19. Rosner M.H., Vigano M.A., Ozato K., Timmons P.M., Poirier F., Rigby P.W., and Staudt L.M. A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 345 (1990) 686-692
20. Pera M.F., and Herszfeld D. Differentiation of human pluripotent teratocarcinoma stem cells induced by bone morphogenetic protein-2. Reprod. Fertil. Dev. 10 (1998) 551-555
21. Goto T., Adjaye J., Rodeck C.H., and Monk M. Identification of genes expressed in human primordial germ cells at the time of entry of the female germ line into meiosis. Mol. Hum. Reprod. 5 (1999) 851-860
22. Pesce M., Wang X., Wolgemuth D.J., and Scholer H. Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech. Dev. 71 (1998) 89-98
23. Nichols J., Zevnik B., Anastassiadis K., Niwa H., Klewe-Nebenius D., Chambers I., Scholer H., and Smith A. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95 (1998) 379-391
24. Niwa H., Miyazaki J., and Smith A.G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24 (2000) 372-376
25. Abdel-Rahman B., Fiddler M., Rappolee D., and Pergament E. Expression of transcription regulating genes in human preimplantation embryos. Hum. Reprod. 10 (1995) 2787-2792
26. Chew J.L., Loh Y.H., Zhang W., Chen X., Tam W.L., Yeap L.S., Li P., Ang Y.S., Lim B., Robson P., and Ng H.H. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol. Cell. Biol. 25 (2005) 6031-6046
27. Delattre O., Zucman J., Plougastel B., Desmaze C., Melot T., Peter M., Kovar H., Joubert I., de Jong P., Rouleau G., Aurias A., and Thomas G. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 359 (1992) 162-165
28. Urano F., Umezawa A., Hong W., Kikuchi H., and Hata J. A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma. Biochem. Biophys. Res. Commun. 219 (1996) 608-612
29. Mitelman F., Johansson B., and Mertens F. The impact of translocations and gene fusions on cancer causation. Nat. Rev. Cancer 7 (2007) 233-245
30. Kuroda M., Ishida T., Takanashi M., Satoh M., Machinami R., and Watanabe T. Oncogenic transformation and inhibition of adipocytic conversion of preadipocytes by TLS/FUS-CHOP type II chimeric protein. Am. J. Pathol. 151 (1997) 735-744
31. Yamaguchi S., Yamazaki Y., Ishikawa Y., Kawaguchi N., Mukai H., and Nakamura T. EWSR1 is fused to POU5F1 in a bone tumor with translocation t(6;22)(p21;q12). Genes Chromosomes Cancer 43 (2005) 217-222
32. Hata J., Fujimoto J., Ishii E., Umezawa A., Kokai Y., Matsubayashi Y., Abe H., Kusakari S., Kikuchi H., Yamada T., and Maruyama T. Differentiation of human germ cell tumor cells in vivo and in vitro. Acta Histochem. Cytochem. 25 (1992) 563-576
33. Schrock E., Veldman T., Padilla-Nash H., Ning Y., Spurbeck J., Jalal S., Shaffer L.G., Papenhausen P., Kozma C., Phelan M.C., Kjeldsen E., Schonberg S.A., O'Brien P., Biesecker L., du Manoir S., and Ried T. Spectral karyotyping refines cytogenetic diagnostics of constitutional chromosomal abnormalities. Hum. Genet. 101 (1997) 255-262
34. Sano M., Umezawa A., Abe H., Akatsuka A., Nonaka S., Shimizu H., Fukuma M., and Hata J. EAT/mcl-1 expression in the human embryonal carcinoma cells undergoing differentiation or apoptosis. Exp. Cell Res. 266 (2001) 114-125
35. Gojo S., Gojo N., Takeda Y., Mori T., Abe H., Kyo S., Hata J., and Umezawa A. In vivo cardiovasculogenesis by direct injection of isolated adult mesenchymal stem cells. Exp. Cell Res. 288 (2003) 51-59
36. Sugimoto T., Umezawa A., and Hata J. Neurogenic potential of Ewing's sarcoma cells. Virchows Arch. 430 (1997) 41-46
37. Miyagawa Y., Okita H., Nakaijima H., Horiuchi Y., Sato B., Taguchi T., Toyoda M., Katagiri Y.U., Fujimoto J., Hata J., Umezawa A., and Kiyokawa N. Inducible expression of chimeric EWS/ETS proteins confers Ewing's family tumor-like phenotypes to human mesenchymal progenitor cells. Mol. Cell. Biol. 28 (2008) 2125-2137
38. Yen B.L., Huang H.I., Chien C.C., Jui H.Y., Ko B.S., Yao M., Shun C.T., Yen M.L., Lee M.C., and Chen Y.C. Isolation of multipotent cells from human term placenta. Stem Cells 23 (2005) 3-9
39. Waller E.K., Olweus J., Lund-Johansen F., Huang S., Nguyen M., Guo G.R., and Terstappen L. The "common stem cell" hypothesis reevaluated: human fetal bone marrow contains separate populations of hematopoietic and stromal progenitors. Blood 85 (1995) 2422-2435
40. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., and Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131 (2007) 861-872
41. Lee J., Rhee B.K., Bae G.Y., Han Y.M., and Kim J. Stimulation of Oct-4 activity by Ewing's sarcoma protein. Stem Cells 23 (2005) 738-751
42. Zhang D., Paley A.J., and Childs G. The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription. J. Biol. Chem. 273 (1998) 18086-18091
43. Palmieri S.L., Peter W., Hess H., and Scholer H.R. Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev. Biol. 166 (1994) 259-267
44. Barberi T., Willis L.M., Socci N.D., and Studer L. Derivation of multipotent mesenchymal precursors from human embryonic stem cells. PLoS Med. 2 (2005) e161
45. Kimura H., Tada M., Nakatsuji N., and Tada T. Histone code modifications on pluripotential nuclei of reprogrammed somatic cells. Mol. Cell. Biol. 24 (2004) 5710-5720
46. Kraft H.J., Mosselman S., Smits H.A., Hohenstein P., Piek E., Chen Q., Artzt K., and van Zoelen E.J. Oct-4 regulates alternative platelet-derived growth factor alpha receptor gene promoter in human embryonal carcinoma cells. J. Biol. Chem. 271 (1996) 12873-12878
47. Kalluri R., and Neilson E.G. Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 112 (2003) 1776-1784
48. Martinez-Alvarez C., Blanco M.J., Perez R., Rabadan M.A., Aparicio M., Resel E., Martinez T., and Nieto M.A. Snail family members and cell survival in physiological and pathological cleft palates. Dev. Biol. 265 (2004) 207-218
49. Peinado H., Portillo F., and Cano A. Transcriptional regulation of cadherins during development and carcinogenesis. Int. J. Dev. Biol. 48 (2004) 365-375
50. de Laplanche E., Gouget K., Cleris G., Dragounoff F., Demont J., Morales A., Bezin L., Godinot C., Perriere G., Mouchiroud D., and Simonnet H. Physiological oxygenation status is required for fully differentiated phenotype in kidney cortex proximal tubules. Am. J. Physiol. Renal Physiol. 291 (2006) F750-760
51. Looijenga L.H., Stoop H., de Leeuw H.P., de Gouveia Brazao C.A., Gillis A.J., van Roozendaal K.E., van Zoelen E.J., Weber R.F., Wolffenbuttel K.P., van Dekken H., Honecker F., Bokemeyer C., Perlman E.J., Schneider D.T., Kononen J., Sauter G., and Oosterhuis J.W. POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. Cancer Res. 63 (2003) 2244-2250