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Volumn 31, Issue 3, 2012, Pages 495-511

Current status and perspectives of plant-based candidate vaccines against the human immunodeficiency virus (HIV)

Author keywords

HIV prevention; HIV vaccines; Oral immunization; Plant based vaccines; Transgenic plants

Indexed keywords

GAG PROTEIN; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEF PROTEIN; TRANSACTIVATOR PROTEIN; VIRUS ANTIGEN; VIRUS ENVELOPE PROTEIN;

EID: 84856954023     PISSN: 07217714     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00299-011-1194-8     Document Type: Review
Times cited : (19)

References (101)
  • 3
    • 0033401040 scopus 로고    scopus 로고
    • Intranasal interleukin-12 is a powerful adjuvant for protective mucosal immunity
    • Arulanandam BP, O'Toole M, Metzger DW (1999) Intranasal interleukin-12 is a powerful adjuvant for protective mucosal immunity. J Infect Dis 180: 940-994.
    • (1999) J Infect Dis , vol.180 , pp. 940-994
    • Arulanandam, B.P.1    O'Toole, M.2    Metzger, D.W.3
  • 4
    • 47249103823 scopus 로고    scopus 로고
    • Anchorage to the cytosolic face of the endoplasmic reticulum membrane: a new strategy to stabilize a cytosolic recombinant antigen in plants
    • Barbante A, Irons S, Hawes C, Frigerio L, Vitale A, Pedrazzini E (2008) Anchorage to the cytosolic face of the endoplasmic reticulum membrane: a new strategy to stabilize a cytosolic recombinant antigen in plants. Plant Biotechnol J 6: 560-575.
    • (2008) Plant Biotechnol J , vol.6 , pp. 560-575
    • Barbante, A.1    Irons, S.2    Hawes, C.3    Frigerio, L.4    Vitale, A.5    Pedrazzini, E.6
  • 5
    • 76749115071 scopus 로고    scopus 로고
    • HIV-1 vaccine development after STEP
    • Barouch DH, Korber B (2010) HIV-1 vaccine development after STEP. Annu Rev Med 61: 153-167.
    • (2010) Annu Rev Med , vol.61 , pp. 153-167
    • Barouch, D.H.1    Korber, B.2
  • 7
    • 38949195024 scopus 로고    scopus 로고
    • Broadening our view of protective antibody responses against HIV
    • Burke B, Barnett SW (2007) Broadening our view of protective antibody responses against HIV. Curr HIV Res 5: 625-641.
    • (2007) Curr HIV Res , vol.5 , pp. 625-641
    • Burke, B.1    Barnett, S.W.2
  • 10
    • 0026016557 scopus 로고
    • Relation between humoral responses to HIV gag and env proteins at seroconversion and clinical outcome of HIV infection
    • Cheingsong-Popov R, Panagiotidi C, Bowcock S, Aronstam A, Wadsworth J, Weber J (1991) Relation between humoral responses to HIV gag and env proteins at seroconversion and clinical outcome of HIV infection. BMJ 302: 23-26.
    • (1991) Bmj , vol.302 , pp. 23-26
    • Cheingsong-Popov, R.1    Panagiotidi, C.2    Bowcock, S.3    Aronstam, A.4    Wadsworth, J.5    Weber, J.6
  • 11
    • 77956464062 scopus 로고    scopus 로고
    • Impaired plant growth and development caused by human immunodeficiency virus type 1 Tat
    • Cueno ME, Hibi Y, Imai K, Laurena AC, Okamoto T (2010a) Impaired plant growth and development caused by human immunodeficiency virus type 1 Tat. Transgenic Res 19: 903-913.
    • (2010) Transgenic Res , vol.19 , pp. 903-913
    • Cueno, M.E.1    Hibi, Y.2    Imai, K.3    Laurena, A.C.4    Okamoto, T.5
  • 13
    • 34147153529 scopus 로고    scopus 로고
    • Production of biopharmaceuticals and vaccines in plants via the chloroplast genome
    • Daniell H (2006) Production of biopharmaceuticals and vaccines in plants via the chloroplast genome. Biotechnol J 1: 1071-1079.
    • (2006) Biotechnol J , vol.1 , pp. 1071-1079
    • Daniell, H.1
  • 14
  • 15
    • 33846847940 scopus 로고    scopus 로고
    • Exposure of the membrane-proximal external region of HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion
    • Dimitrov AS, Jacobs A, Finnegan CM, Stiegler G, Katinger H, Blumenthal R (2007) Exposure of the membrane-proximal external region of HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion. Biochemistry 46: 1398-1401.
    • (2007) Biochemistry , vol.46 , pp. 1398-1401
    • Dimitrov, A.S.1    Jacobs, A.2    Finnegan, C.M.3    Stiegler, G.4    Katinger, H.5    Blumenthal, R.6
  • 16
    • 16544367061 scopus 로고    scopus 로고
    • Unwelcome guests with master keys: how HIV enters cells and how it can be stopped
    • Doms R (2004) Unwelcome guests with master keys: how HIV enters cells and how it can be stopped. Top HIV Med 12: 100-103.
    • (2004) Top HIV Med , vol.12 , pp. 100-103
    • Doms, R.1
  • 17
    • 0031792544 scopus 로고    scopus 로고
    • Intranasal immunization with a plant virus expressing a peptide from HIV-1 gp41 stimulates better mucosal and systemic HIV-1-specific IgA and IgG than oral immunization
    • Durrani Z, McInerney TL, McLain L, Jones T, Bellaby T, Brennan FR, Dimmock NJ (1998) Intranasal immunization with a plant virus expressing a peptide from HIV-1 gp41 stimulates better mucosal and systemic HIV-1-specific IgA and IgG than oral immunization. J Immunol Methods 220: 93-103.
    • (1998) J Immunol Methods , vol.220 , pp. 93-103
    • Durrani, Z.1    McInerney, T.L.2    McLain, L.3    Jones, T.4    Bellaby, T.5    Brennan, F.R.6    Dimmock, N.J.7
  • 18
    • 0036392037 scopus 로고    scopus 로고
    • Correlates of antiviral immune restoration in acute and chronic HIV type 1 infection: sustained viral suppression and normalization of T cell subsets
    • Dyer WB, Kuipers H, Coolen MW, Geczy AF, Forrester J, Workman C, Sullivan JS (2002) Correlates of antiviral immune restoration in acute and chronic HIV type 1 infection: sustained viral suppression and normalization of T cell subsets. AIDS Res Hum Retroviruses 18: 999-1010.
    • (2002) AIDS Res Hum Retroviruses , vol.18 , pp. 999-1010
    • Dyer, W.B.1    Kuipers, H.2    Coolen, M.W.3    Geczy, A.F.4    Forrester, J.5    Workman, C.6    Sullivan, J.S.7
  • 20
    • 13944254982 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection
    • rgp120 HIV Vaccine Study Group
    • Flynn NM, Forthal DN, Harro CD, Judson FN, Mayer KH, Para MF, rgp120 HIV Vaccine Study Group (2005) Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection. J Infect Dis 191: 654-665.
    • (2005) J Infect Dis , vol.191 , pp. 654-665
    • Flynn, N.M.1    Forthal, D.N.2    Harro, C.D.3    Judson, F.N.4    Mayer, K.H.5    Para, M.F.6
  • 21
    • 41649090223 scopus 로고    scopus 로고
    • A fusion intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies
    • Frey G, Peng H, Rits-Volloch S, Morelli M, Cheng Y, Chen B (2008) A fusion intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies. Proc Natl Acad Sci USA 105: 3739-3744.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3739-3744
    • Frey, G.1    Peng, H.2    Rits-Volloch, S.3    Morelli, M.4    Cheng, Y.5    Chen, B.6
  • 22
    • 79952923201 scopus 로고    scopus 로고
    • Current progress in the development of a prophylactic vaccine for HIV-1
    • Gamble LJ, Matthews QL (2010) Current progress in the development of a prophylactic vaccine for HIV-1. Drug Des Devel Ther 22: 9-26.
    • (2010) Drug Des Devel Ther , vol.22 , pp. 9-26
    • Gamble, L.J.1    Matthews, Q.L.2
  • 23
    • 33646163652 scopus 로고    scopus 로고
    • A review of vaccine research and development: the human immunodeficiency virus (HIV)
    • Girard MP, Osmanov SK, Kieny MP (2006) A review of vaccine research and development: the human immunodeficiency virus (HIV). Vaccine 24: 4062-4081.
    • (2006) Vaccine , vol.24 , pp. 4062-4081
    • Girard, M.P.1    Osmanov, S.K.2    Kieny, M.P.3
  • 24
    • 0029840636 scopus 로고    scopus 로고
    • HIV-1 Tat protein as a potential AIDS vaccine
    • Goldstein G (1996) HIV-1 Tat protein as a potential AIDS vaccine. Nat Med 2: 960-964.
    • (1996) Nat Med , vol.2 , pp. 960-964
    • Goldstein, G.1
  • 25
    • 0034660318 scopus 로고    scopus 로고
    • Minimization of chronic plasmazviremia in rhesus macaques immunized with synthetic HIV-1 Tat peptides and infected with a chimeric simian/human immunodeficiency virus (SHIV33)
    • Goldstein G, Manson K, Tribbick G, Smith R (2000) Minimization of chronic plasmazviremia in rhesus macaques immunized with synthetic HIV-1 Tat peptides and infected with a chimeric simian/human immunodeficiency virus (SHIV33). Vaccine 25: 2789-2795.
    • (2000) Vaccine , vol.25 , pp. 2789-2795
    • Goldstein, G.1    Manson, K.2    Tribbick, G.3    Smith, R.4
  • 26
    • 79955652900 scopus 로고    scopus 로고
    • Immunogenicity of chloroplast-derived HIV-1 p24 and a p24-Nef fusion protein following subcutaneous and oral administration in mice
    • Gonzalez-Rabade N, McGowan EG, Zhou F, McCabe MS, Bock R, Dix PJ, Gray JC, Ma JK (2011) Immunogenicity of chloroplast-derived HIV-1 p24 and a p24-Nef fusion protein following subcutaneous and oral administration in mice. Plant Biotechnol J 9: 629-638.
    • (2011) Plant Biotechnol J , vol.9 , pp. 629-638
    • Gonzalez-Rabade, N.1    McGowan, E.G.2    Zhou, F.3    McCabe, M.S.4    Bock, R.5    Dix, P.J.6    Gray, J.C.7    Ma, J.K.8
  • 29
    • 36049019911 scopus 로고    scopus 로고
    • Production of recombinant HIV-1/HBV virus-like particles in Nicotiana tabacum and Arabidopsis thaliana plants for a bivalent plant-based vaccine
    • Greco R, Michel M, Guetard D, Cervantes-Gonzalez M, Pelucchi N, Wain-Hobson S, Sala F, Sala M (2007) Production of recombinant HIV-1/HBV virus-like particles in Nicotiana tabacum and Arabidopsis thaliana plants for a bivalent plant-based vaccine. Vaccine 25: 8228-8240.
    • (2007) Vaccine , vol.25 , pp. 8228-8240
    • Greco, R.1    Michel, M.2    Guetard, D.3    Cervantes-Gonzalez, M.4    Pelucchi, N.5    Wain-Hobson, S.6    Sala, F.7    Sala, M.8
  • 30
    • 36248939079 scopus 로고    scopus 로고
    • Carrier potential properties of Bacillus thuringiensis Cry1A toxins for a diphtheria toxin epitope
    • Guerrero GG, Moreno-Fierros L (2007) Carrier potential properties of Bacillus thuringiensis Cry1A toxins for a diphtheria toxin epitope. Scand J Immunol 66: 610-618.
    • (2007) Scand J Immunol , vol.66 , pp. 610-618
    • Guerrero, G.G.1    Moreno-Fierros, L.2
  • 31
    • 46949088296 scopus 로고    scopus 로고
    • Interleukin-12 is necessary for the priming of CD4 + T cells required during the elicitation of HIV-1 gp120-specific cytotoxic T-lymphocyte function
    • Gupta S, Boppana R, Mishra GC, Saha B, Mitra D (2008) Interleukin-12 is necessary for the priming of CD4 + T cells required during the elicitation of HIV-1 gp120-specific cytotoxic T-lymphocyte function. Immunology 124: 553-561.
    • (2008) Immunology , vol.124 , pp. 553-561
    • Gupta, S.1    Boppana, R.2    Mishra, G.C.3    Saha, B.4    Mitra, D.5
  • 36
    • 61449159825 scopus 로고    scopus 로고
    • HIV infection of the genital mucosa in women
    • Hladik F, Hope TJ (2009) HIV infection of the genital mucosa in women. Curr HIV/AIDS Rep 6: 20-28.
    • (2009) Curr HIV/AIDS Rep , vol.6 , pp. 20-28
    • Hladik, F.1    Hope, T.J.2
  • 37
    • 0030047688 scopus 로고    scopus 로고
    • Optimization of live oral Salmonella-HIV-1 vaccine vectors for the induction of HIV-specific mucosal and systemic immune responses
    • Hone DM, Wu S, Powell RJ, Pascual DW, van Cott J, McGhee J, Fouts TR, Tuskan RG, Lewis GK (1996) Optimization of live oral Salmonella-HIV-1 vaccine vectors for the induction of HIV-specific mucosal and systemic immune responses. J Biotechnol 44: 203-207.
    • (1996) J Biotechnol , vol.44 , pp. 203-207
    • Hone, D.M.1    Wu, S.2    Powell, R.J.3    Pascual, D.W.4    van Cott, J.5    McGhee, J.6    Fouts, T.R.7    Tuskan, R.G.8    Lewis, G.K.9
  • 38
    • 0031905971 scopus 로고    scopus 로고
    • Antibodies and antibody-secreting cells in the female genital tract after vaginal or intranasal immunization with cholera toxin B subunit or conjugates
    • Johansson EL, Rask C, Fredriksson M, Eriksson K, Czerkinsky C, Holmgren J (1998) Antibodies and antibody-secreting cells in the female genital tract after vaginal or intranasal immunization with cholera toxin B subunit or conjugates. Infect Immun 66: 514-520.
    • (1998) Infect Immun , vol.66 , pp. 514-520
    • Johansson, E.L.1    Rask, C.2    Fredriksson, M.3    Eriksson, K.4    Czerkinsky, C.5    Holmgren, J.6
  • 41
    • 0026710616 scopus 로고
    • Premature termination and processing of human immunodeficiency virus type 1-promoted transcripts
    • Kessler M, Mathews MB (1992) Premature termination and processing of human immunodeficiency virus type 1-promoted transcripts. J Virol 66: 4488-4496.
    • (1992) J Virol , vol.66 , pp. 4488-4496
    • Kessler, M.1    Mathews, M.B.2
  • 42
    • 3543096346 scopus 로고    scopus 로고
    • HIV-1 gp120 V3 cholera toxin B subunit fusion gene expression in transgenic potato
    • Kim TG, Gruber A, Langridge WH (2004) HIV-1 gp120 V3 cholera toxin B subunit fusion gene expression in transgenic potato. Protein Expr Purif 37: 196-202.
    • (2004) Protein Expr Purif , vol.37 , pp. 196-202
    • Kim, T.G.1    Gruber, A.2    Langridge, W.H.3
  • 43
    • 84863395948 scopus 로고    scopus 로고
    • How can HIV-Type-1-Env immunogenicity be improved to facilitate antibody-based vaccine development?
    • doi: 10. 1089/aid. 2011. 0053
    • Klasse PJ, Sanders RW, Cerutti A, Moore JP (2011) How can HIV-Type-1-Env immunogenicity be improved to facilitate antibody-based vaccine development? AIDS Res Hum Retroviruses. doi: 10. 1089/aid. 2011. 0053.
    • (2011) AIDS Res Hum Retroviruses
    • Klasse, P.J.1    Sanders, R.W.2    Cerutti, A.3    Moore, J.P.4
  • 44
    • 35549007630 scopus 로고    scopus 로고
    • Intracellular destinies: degradation, targeting assembly, and endocytosis of HIV Gag
    • Klein KC, Reed JC, Lingappa JR (2007) Intracellular destinies: degradation, targeting assembly, and endocytosis of HIV Gag. AIDS Rev 9: 150-161.
    • (2007) AIDS Rev , vol.9 , pp. 150-161
    • Klein, K.C.1    Reed, J.C.2    Lingappa, J.R.3
  • 45
    • 0030861590 scopus 로고    scopus 로고
    • Interactions of antigens and antibodies at mucosal surfaces
    • Lamm ME (1997) Interactions of antigens and antibodies at mucosal surfaces. Annu Rev Microbiol 51: 311-340.
    • (1997) Annu Rev Microbiol , vol.51 , pp. 311-340
    • Lamm, M.E.1
  • 46
    • 0033809199 scopus 로고    scopus 로고
    • Immunization against bacterial diseases of the intestine
    • Levine MM (2000) Immunization against bacterial diseases of the intestine. J Pediatr Gastroenterol Nutr 31: 336-355.
    • (2000) J Pediatr Gastroenterol Nutr , vol.31 , pp. 336-355
    • Levine, M.M.1
  • 47
    • 29244450157 scopus 로고    scopus 로고
    • Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions
    • Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2005) Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. Cell Res 15: 923-934.
    • (2005) Cell Res , vol.15 , pp. 923-934
    • Li, L.1    Li, H.S.2    Pauza, C.D.3    Bukrinsky, M.4    Zhao, R.Y.5
  • 48
    • 79952103981 scopus 로고    scopus 로고
    • Plant-derived medicines: a novel class of immunological adjuvants
    • Licciardi PV, Underwood JR (2011) Plant-derived medicines: a novel class of immunological adjuvants. Int Immunopharmacol 11: 390-398.
    • (2011) Int Immunopharmacol , vol.11 , pp. 390-398
    • Licciardi, P.V.1    Underwood, J.R.2
  • 49
    • 58149142623 scopus 로고    scopus 로고
    • Feeding of mice with Arabidopsis thaliana expressing the HIV-1 subtype C p24 antigen gives rise to systemic immune responses
    • Lindh I, Kalbina I, Thulin S, Scherbak N, Sävenstrand H, Bråve A, Hinkula J, Strid A, Andersson S (2008) Feeding of mice with Arabidopsis thaliana expressing the HIV-1 subtype C p24 antigen gives rise to systemic immune responses. APMIS 116: 985-994.
    • (2008) Apmis , vol.116 , pp. 985-994
    • Lindh, I.1    Kalbina, I.2    Thulin, S.3    Scherbak, N.4    Sävenstrand, H.5    Bråve, A.6    Hinkula, J.7    Strid, A.8    Andersson, S.9
  • 50
    • 60549114157 scopus 로고    scopus 로고
    • Production of mouse interleukin-12 is greater in tobacco hairy roots grown in a mist reactor than in an airlift reactor
    • Liu C, Towler MJ, Medrano G, Cramer CL, Weathers PJ (2009) Production of mouse interleukin-12 is greater in tobacco hairy roots grown in a mist reactor than in an airlift reactor. Biotechnol Bioeng 102: 1074-1086.
    • (2009) Biotechnol Bioeng , vol.102 , pp. 1074-1086
    • Liu, C.1    Towler, M.J.2    Medrano, G.3    Cramer, C.L.4    Weathers, P.J.5
  • 52
    • 0036231461 scopus 로고    scopus 로고
    • Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes
    • Lundquist CA, Tobiume M, Zhou J, Unutmaz D, Aiken C (2002) Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. J Virol 76: 4625-4633.
    • (2002) J Virol , vol.76 , pp. 4625-4633
    • Lundquist, C.A.1    Tobiume, M.2    Zhou, J.3    Unutmaz, D.4    Aiken, C.5
  • 54
    • 34248357883 scopus 로고    scopus 로고
    • Pathogenesis of lipodystrophy and lipid abnormalities in patients taking antiretroviral therapy
    • Mallon PW (2007) Pathogenesis of lipodystrophy and lipid abnormalities in patients taking antiretroviral therapy. AIDS Rev 9: 3-15.
    • (2007) AIDS Rev , vol.9 , pp. 3-15
    • Mallon, P.W.1
  • 55
    • 0034881226 scopus 로고    scopus 로고
    • Chimeric plant virus particles as immunogens for inducing murine and human immune responses against human immunodeficiency virus type 1
    • Marusic C, Rizza P, Lattanzi L, Mancini C, Spada M, Belardelli F, Benvenuto E, Capone I (2001) Chimeric plant virus particles as immunogens for inducing murine and human immune responses against human immunodeficiency virus type 1. J Virol 75: 8434-8439.
    • (2001) J Virol , vol.75 , pp. 8434-8439
    • Marusic, C.1    Rizza, P.2    Lattanzi, L.3    Mancini, C.4    Spada, M.5    Belardelli, F.6    Benvenuto, E.7    Capone, I.8
  • 57
    • 0032947286 scopus 로고    scopus 로고
    • Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies
    • Mascola JR, Lewis MG, Stiegler G, Harris D, VanCott TC, Hayes D (1999) Protection of Macaques against pathogenic simian/human immunodeficiency virus 89. 6PD by passive transfer of neutralizing antibodies. J Virol 73: 4009-4018.
    • (1999) J Virol , vol.73 , pp. 4009-4018
    • Mascola, J.R.1    Lewis, M.G.2    Stiegler, G.3    Harris, D.4    Vancott, T.C.5    Hayes, D.6
  • 59
    • 58149387540 scopus 로고    scopus 로고
    • Biochemical and immunological characterization of the plant-derived candidate human immunodeficiency virus type 1 mucosal vaccine CTB-MPR
    • Matoba N, Kajiura H, Cherni I, Doran JD, Bomsel M, Fujiyama K, Mor TS (2009) Biochemical and immunological characterization of the plant-derived candidate human immunodeficiency virus type 1 mucosal vaccine CTB-MPR. Plant Biotechnol J 7: 129-145.
    • (2009) Plant Biotechnol J , vol.7 , pp. 129-145
    • Matoba, N.1    Kajiura, H.2    Cherni, I.3    Doran, J.D.4    Bomsel, M.5    Fujiyama, K.6    Mor, T.S.7
  • 60
    • 0030175998 scopus 로고    scopus 로고
    • Stimulation of neutralizing antibodies to human immunodeficiency virus type 1 in three strains of mice immunized with a 22 amino acid peptide of gp41 expressed on the surface of a plant virus
    • McLain L, Durrani Z, Wisniewski LA, Porta C, Lomonossoff GP, Dimmock NJ (1996) Stimulation of neutralizing antibodies to human immunodeficiency virus type 1 in three strains of mice immunized with a 22 amino acid peptide of gp41 expressed on the surface of a plant virus. Vaccine 14: 799-810.
    • (1996) Vaccine , vol.14 , pp. 799-810
    • McLain, L.1    Durrani, Z.2    Wisniewski, L.A.3    Porta, C.4    Lomonossoff, G.P.5    Dimmock, N.J.6
  • 62
    • 0026575692 scopus 로고
    • p24 antigenaemia as a predictor of good immunological responsiveness to zidovudine therapy in asymptomatic HIV infection
    • Montroni M, Silvestri G, Butini L, Bartocci C, Regnery C, Danieli G (1992) p24 antigenaemia as a predictor of good immunological responsiveness to zidovudine therapy in asymptomatic HIV infection. AIDS 6: 338-339.
    • (1992) Aids , vol.6 , pp. 338-339
    • Montroni, M.1    Silvestri, G.2    Butini, L.3    Bartocci, C.4    Regnery, C.5    Danieli, G.6
  • 66
    • 33646146379 scopus 로고    scopus 로고
    • GP120: target for neutralizing HIV-1 antibodies
    • Pantophlet R, Burton DR (2006) GP120: target for neutralizing HIV-1 antibodies. Annu Rev Immunol 24: 739-769.
    • (2006) Annu Rev Immunol , vol.24 , pp. 739-769
    • Pantophlet, R.1    Burton, D.R.2
  • 67
    • 79955702711 scopus 로고    scopus 로고
    • Structure-based vaccine design in HIV: blind men and the elephant?
    • Pejchal R, Wilson IA (2010) Structure-based vaccine design in HIV: blind men and the elephant? Curr Pharm Des 16: 3744-3753.
    • (2010) Curr Pharm Des , vol.16 , pp. 3744-3753
    • Pejchal, R.1    Wilson, I.A.2
  • 68
    • 33845433434 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand
    • Pitisuttithum P, Gilbert P, Gurwith M, Heyward W, Martin M, van Griensven F, Hu D, Tappero JW, Choopanya K (2006) Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand. J Infect Dis 194: 1661-1671.
    • (2006) J Infect Dis , vol.194 , pp. 1661-1671
    • Pitisuttithum, P.1    Gilbert, P.2    Gurwith, M.3    Heyward, W.4    Martin, M.5    van Griensven, F.6    Hu, D.7    Tappero, J.W.8    Choopanya, K.9
  • 70
    • 0026509758 scopus 로고
    • An improved method for monitoring efficacy of anti-retroviral therapy in HIV-infected individuals: a highly sensitive HIV p24 antigen assay
    • Reddy MM, Winger EE, Hargrove D, McHugh T, McKinley GF, Grieco MH (1992) An improved method for monitoring efficacy of anti-retroviral therapy in HIV-infected individuals: a highly sensitive HIV p24 antigen assay. J Clin Lab Anal 6: 125-129.
    • (1992) J Clin Lab Anal , vol.6 , pp. 125-129
    • Reddy, M.M.1    Winger, E.E.2    Hargrove, D.3    McHugh, T.4    McKinley, G.F.5    Grieco, M.H.6
  • 71
    • 71949127747 scopus 로고    scopus 로고
    • High level protein expression in plants through the use of a novel autonomously replicating geminivirus shuttle vector
    • Regnard GL, Halley-Stott RP, Tanzer FL, Hitzeroth II, Rybicki EP (2010) High level protein expression in plants through the use of a novel autonomously replicating geminivirus shuttle vector. Plant Biotechnol J 8: 38-46.
    • (2010) Plant Biotechnol J , vol.8 , pp. 38-46
    • Regnard, G.L.1    Halley-Stott, R.P.2    Tanzer, F.L.3    Hitzeroth, I.I.4    Rybicki, E.P.5
  • 74
    • 0034914208 scopus 로고    scopus 로고
    • A defined conformational epitope from the C4 domain of HIV type 1 glycoprotein 120: anti-cyclic C4 antibodies from HIV-positive donors magnify glycoprotein 120 suppression of interleukin 2 produced by T cells
    • Robey FA, Robert-Guroff M (2001) A defined conformational epitope from the C4 domain of HIV type 1 glycoprotein 120: anti-cyclic C4 antibodies from HIV-positive donors magnify glycoprotein 120 suppression of interleukin 2 produced by T cells. AIDS Res Hum Retroviruses 17: 533-541.
    • (2001) AIDS Res Hum Retroviruses , vol.17 , pp. 533-541
    • Robey, F.A.1    Robert-Guroff, M.2
  • 77
    • 58149138864 scopus 로고    scopus 로고
    • Expression of an Escherichia coli antigenic fusion protein comprising the heat labile toxin B subunit and the heat stable toxin, and its assembly as a functional oligomer in transplastomic tobacco plants
    • Rosales-Mendoza S, Alpuche-Solís AG, Soria-Guerra RE, Moreno-Fierros L, Martínez-González L, Herrera-Díaz A, Korban SS (2009) Expression of an Escherichia coli antigenic fusion protein comprising the heat labile toxin B subunit and the heat stable toxin, and its assembly as a functional oligomer in transplastomic tobacco plants. Plant J 57: 45-54.
    • (2009) Plant J , vol.57 , pp. 45-54
    • Rosales-Mendoza, S.1    Alpuche-Solís, A.G.2    Soria-Guerra, R.E.3    Moreno-Fierros, L.4    Martínez-González, L.5    Herrera-Díaz, A.6    Korban, S.S.7
  • 81
    • 79957551445 scopus 로고    scopus 로고
    • A novel candidate HIV vaccine vector based on the replication deficient Capripoxvirus, Lumpy skin disease virus (LSDV)
    • Shen YJ, Shephard E, Douglass N, Johnston N, Adams C, Williamson C, Williamson AL (2011) A novel candidate HIV vaccine vector based on the replication deficient Capripoxvirus, Lumpy skin disease virus (LSDV). Virol J 8: 265.
    • (2011) Virol J , vol.8 , pp. 265
    • Shen, Y.J.1    Shephard, E.2    Douglass, N.3    Johnston, N.4    Adams, C.5    Williamson, C.6    Williamson, A.L.7
  • 83
    • 85027952290 scopus 로고    scopus 로고
    • Two decades of plant-based candidate vaccines: a review of the chimeric protein approaches
    • Soria-Guerra RE, Moreno-Fierros L, Rosales-Mendoza S (2011) Two decades of plant-based candidate vaccines: a review of the chimeric protein approaches. Plant Cell Rep 30: 1367-1382.
    • (2011) Plant Cell Rep , vol.30 , pp. 1367-1382
    • Soria-Guerra, R.E.1    Moreno-Fierros, L.2    Rosales-Mendoza, S.3
  • 84
    • 69149083668 scopus 로고    scopus 로고
    • Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?
    • Stamatatos L, Morris L, Burton DR, Mascola JR (2009) Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine? Nat Med 15: 866-870.
    • (2009) Nat Med , vol.15 , pp. 866-870
    • Stamatatos, L.1    Morris, L.2    Burton, D.R.3    Mascola, J.R.4
  • 85
    • 3242692296 scopus 로고    scopus 로고
    • Oral immunization with recombinant listeria monocytogenes controls virus load after vaginal challenge with feline immunodeficiency virus
    • Stevens R, Howard KE, Nordone S, Burkhard M, Dean GA (2004) Oral immunization with recombinant listeria monocytogenes controls virus load after vaginal challenge with feline immunodeficiency virus. J Virol 78: 8210-8218.
    • (2004) J Virol , vol.78 , pp. 8210-8218
    • Stevens, R.1    Howard, K.E.2    Nordone, S.3    Burkhard, M.4    Dean, G.A.5
  • 86
    • 69249086612 scopus 로고    scopus 로고
    • HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysis
    • Tudor D, Derrien M, Diomede L, Drillet AS, Houimel M, Moog C, Reynes JM, Lopalco L, Bomsel M (2009) HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysis. Mucosal Immunol 2: 412-426.
    • (2009) Mucosal Immunol , vol.2 , pp. 412-426
    • Tudor, D.1    Derrien, M.2    Diomede, L.3    Drillet, A.S.4    Houimel, M.5    Moog, C.6    Reynes, J.M.7    Lopalco, L.8    Bomsel, M.9
  • 87
    • 33745875334 scopus 로고    scopus 로고
    • Production of a short recombinant C4V3 HIV-1 immunogen that induces strong anti-HIV responses by systemic and mucosal routes without the need of adjuvants
    • Varona-Santos JT, Vazquez-Padrón RI, Moreno-Fierros L (2006) Production of a short recombinant C4V3 HIV-1 immunogen that induces strong anti-HIV responses by systemic and mucosal routes without the need of adjuvants. Viral Immunol 19: 237-249.
    • (2006) Viral Immunol , vol.19 , pp. 237-249
    • Varona-Santos, J.T.1    Vazquez-Padrón, R.I.2    Moreno-Fierros, L.3
  • 89
    • 77957334358 scopus 로고    scopus 로고
    • Role of IL-12 in HIV infection and vaccine
    • Villinger F, Ansari AA (2010) Role of IL-12 in HIV infection and vaccine. Eur Cytokine Netw 21: 215-218.
    • (2010) Eur Cytokine Netw , vol.21 , pp. 215-218
    • Villinger, F.1    Ansari, A.A.2
  • 96
    • 79953697416 scopus 로고    scopus 로고
    • Clinical development of plant-produced recombinant pharmaceuticals: Vaccines, antibodies, and beyond
    • Yusibov V, Streatfield SJ, Kushnir N (2011) Clinical development of plant-produced recombinant pharmaceuticals: Vaccines, antibodies, and beyond. Hum Vaccin 7: 313-321.
    • (2011) Hum Vaccin , vol.7 , pp. 313-321
    • Yusibov, V.1    Streatfield, S.J.2    Kushnir, N.3
  • 97
    • 0002665922 scopus 로고    scopus 로고
    • In planta expression of HIV-1 p24 protein using an RNA plant virus-based expression vector
    • Zhang G, Leung C, Murdin L, Rovinski B, White KA (2000) In planta expression of HIV-1 p24 protein using an RNA plant virus-based expression vector. Mol Biotechnol 14: 99-107.
    • (2000) Mol Biotechnol , vol.14 , pp. 99-107
    • Zhang, G.1    Leung, C.2    Murdin, L.3    Rovinski, B.4    White, K.A.5
  • 98
    • 0036180955 scopus 로고    scopus 로고
    • Production of HIV-1 p24 protein in transgenic tobacco plants
    • Zhang GG, Rodrigues L, Rovinski B, White KA (2002) Production of HIV-1 p24 protein in transgenic tobacco plants. Mol Biotechnol 20: 131-136.
    • (2002) Mol Biotechnol , vol.20 , pp. 131-136
    • Zhang, G.G.1    Rodrigues, L.2    Rovinski, B.3    White, K.A.4
  • 99
    • 0028859150 scopus 로고
    • Novel mechanism and factor for regulation by HIV-1 Tat
    • Zhou Q, Sharp PA (1995) Novel mechanism and factor for regulation by HIV-1 Tat. EMBO J 14: 321-328.
    • (1995) EMBO J , vol.14 , pp. 321-328
    • Zhou, Q.1    Sharp, P.A.2
  • 101
    • 1542615646 scopus 로고    scopus 로고
    • Identifying epitopes of HIV-1 that induce protective antibodies
    • Zolla-Pazner S (2004) Identifying epitopes of HIV-1 that induce protective antibodies. Nat Rev 4: 199-210.
    • (2004) Nat Rev , vol.4 , pp. 199-210
    • Zolla-Pazner, S.1


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