Erratum: Matrix metalloproteinase-dependent microsomal prostaglandin E Synthase-1 expression in macrophages: Role of TNF- And the EP4 prostanoid receptor (J. Immunol (2021) 188 (1970-1980) DOI: 10.4049/jimmunol.1102383);Matrix metalloproteinase-dependent microsomal prostaglandin E synthase-1 expression in macrophages: Role of tnf-α and the EP4 prostanoid receptor

Journal of Immunology

Volumn 188, Issue 4, 2012, Pages 1970-1980

  Khan, K M Faisal ^a,b   Kothari, Poonam ^a,b   Du, Baoheng ^a   Dannenberg, Andrew J ^a   Falcone, Domenick J ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Weill Cornell Medical College of Cornell University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 [5 (4 BIPHENYLYLMETHOXY) 2 MORPHOLINO 3 OXOCYCLOPENTYL] 4 HEPTENOIC ACID; CELECOXIB; CYCLOOXYGENASE 2; EARLY GROWTH RESPONSE FACTOR 1; GELATINASE B; INTERSTITIAL COLLAGENASE; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; STROMELYSIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION;

EID: 84856829089     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.2100445     Document Type: Erratum

References (90)

1. Nagase, H., and Y. Okada. 1996. Proteinases and matrix degradation. In The Textbook of Rheumatology, 5th Ed. W. N. Kelly, E. D. Harris, Jr., S. Ruddy, and C. B. Sledge, eds. W.B. Saunders, Philadelphia, p. 323-341.
2. Page-McCaw, A., A. J. Ewald, and Z. Werb. 2007. Matrix metalloproteinases and the regulation of tissue remodelling. Nat. Rev. Mol. Cell Biol. 8: 221-233.
3. Opdenakker, G., P. E. Van den Steen, and J. Van Damme. 2001. Gelatinase B: a tuner and amplifier of immune functions. Trends Immunol. 22: 571-579. (Pubitemid 33016405)
4. Parks, W. C., C. L. Wilson, and Y. S. López-Boado. 2004. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat. Rev. Immunol. 4: 617-629. (Pubitemid 39025047)
5. Vu, T. H., J. M. Shipley, G. Bergers, J. E. Berger, J. A. Helms, D. Hanahan, S. D. Shapiro, R. M. Senior, and Z. Werb. 1998. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93: 411-422. (Pubitemid 28232085)
6. Colnot, C., Z. Thompson, T. Miclau, Z. Werb, and J. A. Helms. 2003. Altered fracture repair in the absence of MMP9. Development 130: 4123-4133. (Pubitemid 37063429)
7. Heissig, B., K. Hattori, S. Dias, M. Friedrich, B. Ferris, N. R. Hackett, R. G. Crystal, P. Besmer, D. Lyden, M. A. S. Moore, et al. 2002. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 109: 625-637. (Pubitemid 34628725)
8. Corry, D. B., A. Kiss, L. Z. Song, L. Song, J. Xu, S. H. Lee, Z. Werb, and F. Kheradmand. 2004. Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines. FASEB J. 18: 995-997. (Pubitemid 39561503)
9. Lelongt, B., S. Bengatta, M. Delauche, L. R. Lund, Z. Werb, and P. M. Ronco. 2001. Matrix metalloproteinase 9 protects mice from anti-glomerular basement membrane nephritis through its fibrinolytic activity. J. Exp. Med. 193: 793-802. (Pubitemid 32524529)
10. Fernández, F. G., L. G. Campbell, W. Liu, J. M. Shipley, S. Itohara, G. A. Patterson, R. M. Senior, T. Mohanakumar, and A. Jaramillo. 2005. Inhibition of obliterative airway disease development in murine tracheal allografts by matrix metalloproteinase-9 deficiency. Am. J. Transplant. 5: 671-683. (Pubitemid 40461276)
11. Liu, Z., X. Y. Zhou, S. D. Shapiro, J. M. Shipley, S. S. Twining, L. A. Diaz, R. M. Senior, and Z. Werb. 2000. The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo. Cell 102: 647-655.
12. Chantrain, C. F., H. Shimada, S. Jodele, S. Groshen, W. Ye, D. R. Shalinsky, Z. Werb, L. M. Coussens, and Y. A. DeClerck. 2004. Stromal matrix metalloproteinase-9 regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment. Cancer Res. 64: 1675-1686. (Pubitemid 38428689)
13. Masson, V., L. R. de la Ballina, C. Munaut, B. Wielockx, M. Jost, C. Maillard, S. Blacher, K. Bajou, T. Itoh, S. Itohara, et al. 2005. Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes. FASEB J. 19: 234-236. (Pubitemid 40189266)
14. Lessner, S. M., D. E. Martinson, and Z. S. Galis. 2004. Compensatory vascular remodeling during atherosclerotic lesion growth depends on matrix metalloproteinase-9 activity. Arterioscler. Thromb. Vasc. Biol. 24: 2123-2129. (Pubitemid 39482440)
15. Choi, E. T., E. T. Collins, L. A. Marine, M. G. Uberti, H. Uchida, J. E. Leidenfrost, M. F. Khan, K. P. Boc, D. R. Abendschein, and W. C. Parks. 2005. Matrix metalloproteinase-9 modulation by resident arterial cells is responsible for injury-induced accelerated atherosclerotic plaque development in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 25: 1020-1025. (Pubitemid 40627849)
16. Ikonomidis, J. S., J. R. Barbour, Z. Amani, R. E. Stroud, A. R. Herron, D. M. McClister, Jr., S. E. Camens,M. L. Lindsey, R. Mukherjee, and F. G. Spinale. 2005. Effects of deletion of the matrix metalloproteinase 9 gene on development of murine thoracic aortic aneurysms. Circulation 112(9, Suppl): I242-I248. (Pubitemid 41266681)
17. Steenport, M., K. M. Khan, B. Du, S. E. Barnhard, A. J. Dannenberg, and D. J. Falcone. 2009. Matrix metalloproteinase (MMP)-1 and MMP-3 induce macrophage MMP-9: evidence for the role of TNF-alpha and cyclooxygenase-2. J. Immunol. 183: 8119-8127.
18. Fahmi, H. 2004. mPGES-1 as a novel target for arthritis. Curr. Opin. Rheumatol. 16: 623-627. (Pubitemid 39128335)
19. Park, J. Y., M. H. Pillinger, and S. B. Abramson. 2006. Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases. Clin. Immunol. 119: 229-240. (Pubitemid 44269070)
20. Jania, L. A., S. Chandrasekharan, M. G. Backlund, N. A. Foley, J. Snouwaert, I. M. Wang, P. Clark, L. P. Audoly, and B. H. Koller. 2009. Microsomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E2 biosynthesis. Prostaglandins Other Lipid Mediat. 88: 73-81.
21. Lovgren, A. K., M. Kovarova, and B. H. Koller. 2007. cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis. Mol. Cell. Biol. 27: 4416-4430. (Pubitemid 46906565)
22. Uematsu, S., M. Matsumoto, K. Takeda, and S. Akira. 2002. Lipopolysaccharide- dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway. J. Immunol. 168: 5811-5816. (Pubitemid 34556168)
23. Bezugla, Y., A. Kolada, S. Kamionka, B. Bernard, R. Scheibe, and P. Dieter. 2006. COX-1 and COX-2 contribute differentially to the LPS-induced release of PGE2 and TxA2 in liver macrophages. Prostaglandins Other Lipid Mediat. 79: 93-100.
24. Trebino, C. E., J. L. Stock, C. P. Gibbons, B. M. Naiman, T. S. Wachtmann, J. P. Umland, K. Pandher, J. M. Lapointe, S. Saha, M. L. Roach, et al. 2003. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc. Natl. Acad. Sci. USA 100: 9044-9049. (Pubitemid 36899220)
25. Westman, M., M. Korotkova, E. af Klint, A. Stark, L. P. Audoly, L. Klareskog, A. K. Ulfgren, and P. J. Jakobsson. 2004. Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium. Arthritis Rheum. 50: 1774-1780. (Pubitemid 38725089)
26. Edelson, P. J., and Z. A. Cohn. 1976. Purification and cultivation of monocytes and macrophages. In In Vitro Methods in Cell Mediated Tumor Immunity. B. R. Bloom, and J. R. David, eds. Academic Press, New York, p. 333-340.
27. Falcone, D. J., and M. J. Ferenc. 1988. Acetyl-LDL stimulates macrophage-dependent plasminogen activation and degradation of extracellular matrix. J. Cell. Physiol. 135: 387-396.
28. Raschke, W. C., S. Baird, P. Ralph, and I. Nakoinz. 1978. Functional macrophage cell lines transformed by Abelson leukemia virus. Cell 15: 261-267. (Pubitemid 9027529)
29. Pavlovic, S., B. Du, K. Sakamoto, K. M. F. Khan, C. Natarajan, R. M. Breyer, A. J. Dannenberg, and D. J. Falcone. 2006. Targeting prostaglandin E2 receptors as an alternative strategy to block cyclooxygenase-2-dependent extracellular matrix-induced matrix metalloproteinase-9 expression by macrophages. J. Biol. Chem. 281: 3321-3328. (Pubitemid 43852881)
30. Hou, Z., D. J. Falcone, K. Subbaramaiah, and A. J. Dannenberg. 2011. Macrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification. Carcinogenesis 32: 695-702.
31. Zar, J. H. 1984. Biostatistical Analysis, 2nd Ed. Prentice Hall, Englewood Cliffs, NJ.
32. Ikeda-Matsuo, Y., Y. Ikegaya, N. Matsuki, S. Uematsu, S. Akira, and Y. Sasaki. 2005. Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production. J. Neurochem. 94: 1546-1558. (Pubitemid 41324637)
33. Subbaramaiah, K., K. Yoshimatsu, E. Scherl, K. M. Das, K. D. Glazier, D. Golijanin, R. A. Soslow, T. Tanabe, H. Naraba, and A. J. Dannenberg. 2004. Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1. J. Biol. Chem. 279: 12647-12658. (Pubitemid 38445836)
34. Ogata, Y., Y. Itoh, and H. Nagase. 1995. Steps involved in activation of the promatrix metalloproteinase 9 (progelatinase B)-tissue inhibitor of metalloproteinases-1 complex by 4-aminophenylmercuric acetate and proteinases. J. Biol. Chem. 270: 18506-18511.
35. Goldberg, G. I., A. Strongin, I. E. Collier, L. T. Genrich, and B. L. Marmer. 1992. Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin. J. Biol. Chem. 267: 4583-4591.
36. Dreier, R., S. Wallace, S. Fuchs, P. Bruckner, and S. Grässel. 2001. Paracrine interactions of chondrocytes and macrophages in cartilage degradation: articular chondrocytes provide factors that activate macrophage-derived pro-gelatinase B (pro-MMP-9). J. Cell Sci. 114: 3813-3822. (Pubitemid 33094696)
37. Ramos-DeSimone, N., E. Hahn-Dantona, J. Sipley, H. Nagase, D. L. French, and J. P. Quigley. 1999. Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion. J. Biol. Chem. 274: 13066-13076.
38. Coughlin, S. R. 2005. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J. Thromb. Haemost. 3: 1800-1814. (Pubitemid 41716567)
39. Boire, A., L. Covic, A. Agarwal, S. Jacques, S. Sherifi, and A. Kuliopulos. 2005. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 120: 303-313. (Pubitemid 40222426)
40. Saksela, O., and D. B. Rifkin. 1990. Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity. J. Cell Biol. 110: 767-775.
41. Sahin, U., G. Weskamp, K. Kelly, H. M. Zhou, S. Higashiyama, J. Peschon, D. Hartmann, P. Saftig, and C. P. Blobel. 2004. Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J. Cell Biol. 164: 769-779. (Pubitemid 38282960)
42. Falcone, D. J., T. A. McCaffrey, A. Haimovitz-Friedman, J.-A. Vergilio, and A. C. Nicholson. 1993. Macrophage and foam cell release of matrix-bound growth factors. Role of plasminogen activation. J. Biol. Chem. 268: 11951-11958. (Pubitemid 23168155)
43. Gearing, A. J., P. Beckett, M. Christodoulou, M. Churchill, J. Clements, A. H. Davidson, A. H. Drummond, W. A. Galloway, R. Gilbert, J. L. Gordon, et al. 1994. Processing of tumour necrosis factor-alpha precursor by metalloproteinases. Nature 370: 555-557. (Pubitemid 24264920)
44. Mohan, M. J., T. Seaton, J. Mitchell, A. Howe, K. Blackburn, W. Burkhart, M. Moyer, I. Patel, G. M. Waitt, J. D. Becherer, et al. 2002. The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity. Biochemistry 41: 9462-9469. (Pubitemid 34810022)
45. Giannelli, G., J. Falk-Marzillier, O. Schiraldi, W. G. Stetler-Stevenson, and V. Quaranta. 1997. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Science 277: 225-228. (Pubitemid 27446075)
46. Faisal Khan, K. M., G. W. Laurie, T. A. McCaffrey, and D. J. Falcone. 2002. Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression. J. Biol. Chem. 277: 13778-13786. (Pubitemid 34967981)
47. Adair-Kirk, T. L., J. J. Atkinson, D. G. Kelley, R. H. Arch, J. H. Miner, and R. M. Senior. 2005. A chemotactic peptide from laminin alpha 5 functions as a regulator of inflammatory immune responses via TNF alpha-mediated signaling. J. Immunol. 174: 1621-1629.
48. Naraba, H., C. Yokoyama, N. Tago, M. Murakami, I. Kudo, M. Fueki, S. Oh-Ishi, and T. Tanabe. 2002. Transcriptional regulation of the membrane-associated prostaglandin E2 synthase gene. Essential role of the transcription factor Egr-1. J. Biol. Chem. 277: 28601-28608. (Pubitemid 41079288)
49. Guha, M., M. A. O'Connell, R. Pawlinski, A. Hollis, P. McGovern, S. F. Yan, D. Stern, and N. Mackman. 2001. Lipopolysaccharide activation of the MEK-ERK1/ 2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression. Blood 98: 1429-1439.
50. Cherukuri, D. P., X. B. Chen, A. C. Goulet, R. N. Young, Y. Han, R. L. Heimark, J. W. Regan, E. Meuillet, and M. A. Nelson. 2007. The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. Exp. Cell Res. 313: 2969-2979. (Pubitemid 47125887)
51. Fujino, H., W. Xu, and J. W. Regan. 2003. Prostaglandin E2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinases. J. Biol. Chem. 278: 12151-12156. (Pubitemid 36800194)
52. Breyer, R. M., C. K. Bagdassarian, S. A. Myers, and M. D. Breyer. 2001. Prostanoid receptors: subtypes and signaling. Annu. Rev. Pharmacol. Toxicol. 41: 661-690. (Pubitemid 32385902)
53. Hata, A. N., and R. M. Breyer. 2004. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharmacol. Ther. 103: 147-166. (Pubitemid 39209041)
54. Hubbard, N. E., S. Lee, D. Lim, and K. L. Erickson. 2001. Differential mRNA expression of prostaglandin receptor subtypes in macrophage activation. Prostaglandins Leukot. Essent. Fatty Acids 65: 287-294. (Pubitemid 34258927)
55. Ikegami, R., Y. Sugimoto, E. Segi, M. Katsuyama, H. Karahashi, F. Amano, T. Maruyama, H. Yamane, S. Tsuchiya, and A. Ichikawa. 2001. The expression of prostaglandin E receptors EP2 and EP4 and their different regulation by lipopolysaccharide in C3H/HeN peritoneal macrophages. J. Immunol. 166: 4689-4696. (Pubitemid 32233756)
56. Tani, K., A. Naganawa, A. Ishida, H. Egashira, K. Sagawa, H. Harada, M. Ogawa, T. Maruyama, S. Ohuchida, H. Nakai, et al. 2001. Design and synthesis of a highly selective EP2-receptor agonist. Bioorg. Med. Chem. Lett. 11: 2025-2028. (Pubitemid 32709716)
57. Kiriyama, M., F. Ushikubi, T. Kobayashi, M. Hirata, Y. Sugimoto, and S. Narumiya. 1997. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br. J. Pharmacol. 122: 217-224. (Pubitemid 27397191)
58. Matsumoto, H., H. Naraba, M. Murakami, I. Kudo, K. Yamaki, A. Ueno, and S. Oh-ishi. 1997. Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages. Biochem. Biophys. Res. Commun. 230: 110-114. (Pubitemid 27210253)
59. Yoshimatsu, K., D. Golijanin, P. B. Paty, R. A. Soslow, P. J. Jakobsson, R. A. DeLellis, K. Subbaramaiah, and A. J. Dannenberg. 2001. Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer. Clin. Cancer Res. 7: 3971-3976. (Pubitemid 34044615)
60. Yoshimatsu, K., N. K. Altorki, D. Golijanin, F. Zhang, P. J. Jakobsson, A. J. Dannenberg, and K. Subbaramaiah. 2001. Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer. Clin. Cancer Res. 7: 2669-2674. (Pubitemid 32911370)
61. Golijanin, D., J. Y. Tan, A. Kazior, E. G. Cohen, P. Russo, G. Dalbagni, K. J. Auborn, K. Subbaramaiah, and A. J. Dannenberg. 2004. Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis. Clin. Cancer Res. 10: 1024-1031. (Pubitemid 38198904)
62. Boulet, L., M. Ouellet, K. P. Bateman, D. Ethier, M. D. Percival, D. Riendeau, J. A. Mancini, and N. Méthot. 2004. Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile. J. Biol. Chem. 279: 23229-23237. (Pubitemid 38685630)
63. Inada, M., C. Matsumoto, S. Uematsu, S. Akira, and C. Miyaura. 2006. Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation. J. Immunol. 177: 1879-1885. (Pubitemid 44092527)
64. Cipollone, F., M. L. Fazia, A. Iezzi, C. Cuccurullo, D. De Cesare, S. Ucchino, F. Spigonardo, A. Marchetti, F. Buttitta, L. Paloscia, et al. 2005. Association between prostaglandin E receptor subtype EP4 overexpression and unstable phenotype in atherosclerotic plaques in human. Arterioscler. Thromb. Vasc. Biol. 25: 1925-1931. (Pubitemid 41243464)
65. Faour, W. H., Y. L. He, Q. W. He, M. de Ladurantaye, M. Quintero, A. Mancini, and J. A. Di Battista. 2001. Prostaglandin E(2) regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1 beta-treated human synovial fibroblasts. J. Biol. Chem. 276: 31720-31731.
66. Wang, D., F. G. Buchanan, H. Wang, S. K. Dey, and R. N. DuBois. 2005. Prostaglandin E2 enhances intestinal adenoma growth via activation of the Rasmitogen- activated protein kinase cascade. Cancer Res. 65: 1822-1829. (Pubitemid 40478610)
67. 2 and pro-inflammatory cytokine production in human airway epithelial cells. Pulm. Pharmacol. Ther. 24: 42-48.
68. Harris, S. G., J. Padilla, L. Koumas, D. Ray, and R. P. Phipps. 2002. Prostaglandins as modulators of immunity. Trends Immunol. 23: 144-150. (Pubitemid 34178297)
69. Sakata, D., C. Yao, and S. Narumiya. 2010. Prostaglandin E2, an immunoactivator. J. Pharmacol. Sci. 112: 1-5.
70. Betz, M., and B. S. Fox. 1991. Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146: 108-113.
71. Hilkens, C. M., H. Vermeulen, R. J. van Neerven, F. G. Snijdewint, E. A. Wierenga, and M. L. Kapsenberg. 1995. Differential modulation of T helper type 1 (Th1) and T helper type 2 (Th2) cytokine secretion by prostaglandin E2 critically depends on interleukin-2. Eur. J. Immunol. 25: 59-63.
72. Shinomiya, S., H. Naraba, A. Ueno, I. Utsunomiya, T. Maruyama, S. Ohuchida, F. Ushikubi, K. Yuki, S. Narumiya, Y. Sugimoto, et al. 2001. Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists. Biochem. Pharmacol. 61: 1153-1160. (Pubitemid 32285482)
73. Takayama, K., G. García-Cardena, G. K. Sukhova, J. Comander, M. A. Gimbrone, Jr., and P. Libby. 2002. Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor. J. Biol. Chem. 277: 44147-44154. (Pubitemid 36157844)
74. Wall, E. A., J. R. Zavzavadjian, M. S. Chang, B. Randhawa, X. Zhu, R. C. Hsueh, J. Liu, A. Driver, X. R. Bao, P. C. Sternweis, et al. 2009. Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105. Sci. Signal. 2: ra28.
75. Shi, J., J. Johansson, N. S. Woodling, Q. Wang, T. J. Montine, and K. Andreasson. 2010. The prostaglandin E2 E-prostanoid 4 receptor exerts antiinflammatory effects in brain innate immunity. J. Immunol. 184: 7207-7218.
76. Tang, E. H., K. Shimizu, T. Christen, V. Z. Rocha, E. Shvartz, Y. Tesmenitsky, G. Sukhova, G. P. Shi, and P. Libby. 2011. Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions. Cardiovasc. Res. 89: 234-243.
77. Tang, E. H., E. Shvartz, K. Shimizu, V. Z. Rocha, C. Zheng, D. Fukuda, G. P. Shi, G. Sukhova, and P. Libby. 2011. Deletion of EP4 on bone marrow-derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler. Thromb. Vasc. Biol. 31: 261-269.
78. Ogawa, M., J. Suzuki, H. Kosuge, K. Takayama, R. Nagai, and M. Isobe. 2009. The mechanism of anti-inflammatory effects of prostaglandin E2 receptor 4 activation in murine cardiac transplantation. Transplantation 87: 1645-1653.
79. Kamei, D., K. Yamakawa, Y. Takegoshi, M. Mikami-Nakanishi, Y. Nakatani, S. Oh-Ishi, H. Yasui, Y. Azuma, N. Hirasawa, K. Ohuchi, et al. 2004. Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1. J. Biol. Chem. 279: 33684-33695. (Pubitemid 39063018)
80. Shankavaram, U. T., D. L. DeWitt, S. E. Funk, E. H. Sage, and L. M. Wahl. 1997. Regulation of human monocyte matrix metalloproteinases by SPARC. J. Cell. Physiol. 173: 327-334. (Pubitemid 27481089)
81. 2 and matrix metalloproteinases. J. Biol. Chem. 270: 10365-10368.
82. Ottino, P., and H. E. P. Bazan. 2001. Corneal stimulation of MMP-1, -9 and uPA by platelet-activating factor is mediated by cyclooxygenase-2 metabolites. Curr. Eye Res. 23: 77-85. (Pubitemid 34499628)
83. Khan, K. M. F., L. R. Howe, and D. J. Falcone. 2004. Extracellular matrix-induced cyclooxygenase-2 regulates macrophage proteinase expression. J. Biol. Chem. 279: 22039-22046.
84. Hara, S., D. Kamei, Y. Sasaki, A. Tanemoto, Y. Nakatani, and M. Murakami. 2010. Prostaglandin E synthases: understanding their pathophysiological roles through mouse genetic models. Biochimie 92: 651-659.
85. Wang, M., A. M. Zukas, Y. Q. Hui, E. Ricciotti, E. Puré, and G. A. FitzGerald. 2006. Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis. Proc. Natl. Acad. Sci. USA 103: 14507-14512. (Pubitemid 44484780)
86. Wang, M., E. Lee, W. Song, E. Ricciotti, D. J. Rader, J. A. Lawson, E. Puré, and G. A. FitzGerald. 2008. Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation. Circulation 117: 1302-1309. (Pubitemid 351365673)
87. Yao, C., D. Sakata, Y. Esaki, Y. Li, T. Matsuoka, K. Kuroiwa, Y. Sugimoto, and S. Narumiya. 2009. Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. Nat. Med. 15: 633-640.
88. Murase, A., T. Okumura, A. Sakakibara, H. Tonai-Kachi, K. Nakao, and J. Takada. 2008. Effect of prostanoid EP4 receptor antagonist, CJ-042,794, in rat models of pain and inflammation. Eur. J. Pharmacol. 580: 116-121.
89. Clark, P., S. E. Rowland, D. Denis, M. C. Mathieu, R. Stocco, H. Poirier, J. Burch, Y. Han, L. Audoly, A. G. Therien, and D. Xu. 2008. MF498 [N-[4-(5,9- Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl] sulfonyl-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis. J. Pharmacol. Exp. Ther. 325: 425-434. (Pubitemid 351574801)
90. McCoy, J. M., J. R. Wicks, and L. P. Audoly. 2002. The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis. J. Clin. Invest. 110: 651-658. (Pubitemid 34988789)