The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells

Experimental Cell Research

Volumn 313, Issue 14, 2007, Pages 2969-2979

  Cherukuri, Durga Prasad ^a   Chen, Xiao B O ^b   Goulet, Anne Christine ^a   Young, Robert N ^c   Han, Yongxin ^c   Heimark, Ronald L ^a   Regan, John W ^b   Meuillet, Emmanuelle ^b   Nelson, Mark A ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Colon cancer; egr 1; ERK1 2; L 161,982; PGE2

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; ALPHA TUBULIN; COMPLEMENTARY DNA; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIMETHYL SULFOXIDE; G PROTEIN COUPLED RECEPTOR; GEFITINIB; L 161982; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; ONO AE2 227; ONO AE3 208; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E1 RECEPTOR; PROSTAGLANDIN E2; PROSTAGLANDIN E3 RECEPTOR; PROSTAGLANDIN E4 RECEPTOR; PROSTAGLANDIN RECEPTOR AFFECTING AGENT; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROSTAGLANDING E4 RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; EARLY GROWTH RESPONSE GENE 1; ENZYME PHOSPHORYLATION; GENE TARGETING; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROSTAGLANDIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION;

EID: 34547194891     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2007.06.004     Document Type: Article

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