COX-1 and COX-2 contribute differentially to the LPS-induced release of PGE2 and TxA2 in liver macrophages

Prostaglandins and Other Lipid Mediators

Volumn 79, Issue 1-2, 2006, Pages 93-100

  Bezugla, Yevgeniya ^a   Kolada, Angelika ^a   Kamionka, Sabine ^a   Bernard, Brigitte ^a   Scheibe, Roland ^a   Dieter, Peter ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Cyclooxygenase; Dexamethasone; Kupffer cell; Lipopolysaccharide; Macrophage; Prostaglandin; Prostaglandin synthase; Thromboxane

Indexed keywords

4 [5 (4 CHLOROPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DEXAMETHASONE; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; PROSTAGLANDIN E2 SYNTHASE; SYNTHETASE; THROMBOXANE A2; THROMBOXANE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG MECHANISM; FATTY ACID SYNTHESIS; KUPFFER CELL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DEXAMETHASONE; DINOPROSTONE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; KUPFFER CELLS; LIPOPOLYSACCHARIDES; LIVER; MALE; MEMBRANE PROTEINS; RATS; THROMBOXANE A2;

EID: 33644523393     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2005.11.001     Document Type: Article

References (18)

1. K. Decker Biologically active products of stimulated liver macrophages (Kupffer cells) Eur J Biochem 192 1990 245 261
2. P. Dieter, and E. Fitzke Formation of diacylglycerol, inositol phosphates, arachidonic acid and its metabolites in macrophages Eur J Biochem 218 1993 753 758
3. 2+ and phosphorylation Biochem J 311 Pt. 1 1995 189 195
4. 2 affects differently the release of inflammatory mediators from resident macrophages by LPS and muramyl tripeptides Mediators Inflamm 8 1999 295 303
5. 2+ requirement of prostanoid but not of superoxide production by rat Kupffer cells Eur J Biochem 177 1988 61 67
6. P. Dieter, A. Schulze-Specking, and K. Decker Differential inhibition of prostaglandin and superoxide production by dexamethasone in primary cultures of rat Kupffer cells Eur J Biochem 159 1986 451 457
7. W.L. Smith, D.L. Dewitt, and R.M. Garavito Cyclooxygenases: structural, cellular, and molecular biology Annu Rev Biochem 69 2000 145 182
8. 2 in eicosanoid generation Am J Respir Crit Care Med 161 2000 S32 S35
9. 2 Cell Signal 14 2002 199 204
10. M. Murakami, Y. Nakatani, T. Tanioka, and I. Kudo Prostaglandin E synthase Prostaglandins Other Lipid Mediators 68-69 2002 383 399
11. 2-biosynthetic pathway Prog Lipid Res 43 2004 3 35
12. P.J. Jakobsson, S. Thoren, R. Morgenstern, and B. Samuelsson Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target Proc Natl Acad Sci USA 96 1999 7220 7225
13. 2 synthase that acts in concert with cyclooxygenase-2 J Biol Chem 275 2000 32783 32792
14. 2 biosynthesis J Biol Chem 275 2000 32775 32782
15. N. Tanikawa, Y. Ohmiya, and H. Ohkubo Identification and characterization of a novel type of membrane-associated prostaglandin E synthase Biochem Biophys Res Commun 291 2002 884 889
16. S. Eyhorn, H.J. Schlayer, and H.P. Henninger Rat hepatic sinusoidal endothelial cells in monolayer culture. Biochemical and ultrastructural characteristics J Hepatol 6 1988 23 35
17. P. Dieter, R. Scheibe, P.J. Jakobsson, K. Watanabe, A. Kolada, and S. Kamionka Functional coupling of cyclooxygenase 1 and 2 to discrete prostanoid synthases in liver macrophages Biochem Biophys Res Commun 276 2000 488 492
18. S. Schade, Y. Bezugla, A. Kolada, S. Kamionka, R. Scheibe, and P. Dieter Diverse functional coupling of cyclooxygenase 1 and 2 with final prostanoid synthases in liver macrophages Biochem Pharmacol 64 2002 1227 1232