Multifunctional Cationic Peptide Fractions from Flaxseed Protein Hydrolysates

Plant Foods for Human Nutrition

Volumn 67, Issue 1, 2012, Pages 1-9

  Udenigwe, Chibuike C ^a,c   Aluko, Rotimi E ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c UNIVERSITY OF GUELPH   (Canada)

Author keywords

Angiotensin converting enzyme; Calmodulin dependent phosphodiesterase; Enzyme inhibition kinetics; Renin: Multifunctional peptides: Flaxseed proteins

Indexed keywords

CALMODULIN; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PEPTIDE; PHOSPHODIESTERASE INHIBITOR; PROTEIN HYDROLYSATE; RENIN; SUBTILISIN; VEGETABLE PROTEIN;

ANIMAL; ARTICLE; CATTLE; CHEMISTRY; CHICKEN; DRUG ANTAGONISM; DRUG EFFECT; FLAX; HUMAN; HYDROLYSIS; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; MOLECULAR WEIGHT; RABBIT;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; CALMODULIN; CATTLE; CHICKENS; FLAX; HUMANS; HYDROLYSIS; KINETICS; MOLECULAR WEIGHT; PEPTIDES; PEPTIDYL-DIPEPTIDASE A; PHOSPHODIESTERASE INHIBITORS; PLANT PROTEINS; PROTEIN HYDROLYSATES; RABBITS; RENIN; SUBTILISINS;

EID: 84856784002     PISSN: 09219668     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11130-012-0275-3     Document Type: Article

References (37)

1. Sanchez D, Quinones M, Moulay L, Muguerza B, Miguel M, Aleixandre A (2010) Changes in arterial blood pressure of a soluble cocoa fiber product on spontaneously hypertensive rats. J Agric Food Chem 58: 417-422.
2. Gradman AH, Kad R (2008) Renin inhibition in hypertension. J Am Coll Cardiol 51: 519-528.
3. Jiang X, Li J, Paskind M, Epstein PM (1996) Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells. Proc Natl Acad Sci USA 93: 11236-11241.
4. Kass DA, Takimoto E, Nagayama T, Champion HC (2007) Phosphodiesterase regulation of nitric oxide signalling. Cardiovasc Res 75: 303-314.
5. Fouad-Tarazi F, Bumpus M, Khosla M, Healy B (1988) The renin-angiotensin system and treatment of heart failure. Am J Med 84(suppl 3A): 83-86.
6. Peach MJ (1997) Renin-angiotensin system: Biochemistry and mechanisms of action. Physiol Rev 57: 313-370.
7. Yang HYT, Erdös EG, Levin Y (1970) A dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin. Biochim Biophys Acta 214: 374-376.
8. Bender AT, Beavo JA (2006) Nucleotide phosphodiesterase: Molecular regulation to clinical use. Pharmacol Rev 58: 488-520.
9. Cho MJ, Vaghy PL, Kondo R, Lee SH, Davis JP, Rehl R, Heo WD, Johnson JD (1998) Reciprocal regulation of mammalian nitric oxide synthase and calcineurin by plant calmodulin isoforms. Biochemistry 37: 15593-15597.
10. Rybalkin SD, Yan C, Bornfeldt KE, Beavo JA (2003) Cyclic GMP phosphodiesterases and regulation of smooth muscle function. Circ Res 93: 280-291.
11. 2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival. Circ Res 98: 777-784.
12. Kim D, Rybalkin SD, Pi X, Wang Y, Zhang C, Munzel T, Beavo JA, Berk BC, Yan C (2001) Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance. Circulation 104: 2338-2343.
13. Schermuly RT, Pullamsetti SS, Kwapiszewska G, Dumitrascu R, Tian X, Weissmann N, Ghofrani HA, Kaulen C, Dunkern T, Schudt C, Voswinckel R, Zhou J, Samidurai A, Klepetko W, Paddenberg R, Kummer W, Seeger W, Grimminger F (2007) Phosphodiesterase 1 upregulation in pulmonary arterial hypertension. Target for reverse-remodeling therapy. Circulation 115: 2331-2339.
14. Bender AT, Ostenson CL, Wang EH, Beavo JA (2005) Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation. Proc Natl Acad Sci USA 102: 497-502.
15. O'Neil KT, DeGrado WF (1990) How calmodulin binds its targets: Sequence independent recognition of amphiphilic α-helices. Trends Biochem Sci 15: 59-64.
16. Udenigwe CC, Aluko RE (2011) Food protein-derived bioactive peptides: Production, processing and potential health benefits. J Food Sci 77: R11-R24.
17. Bremmer AD (2003) Antihypertensive medication and quality of life- silent treatment of a silent killer?Cardiovasc Drugs Ther 16: 353-364.
18. Fujita H, Yamagani T, Ohshima K (2001) Effects of an ace-inhibitory agent, katsuobushi oligopeptide, in spontaneously hypertensive rat and in borderline and mildly hypertensive subjects. Nutr Res 21: 1149-1158.
19. Germino FW, Neutel J, Nonaka M, Hendler SS (2010) The impact of lactotripeptides on blood pressure response in stage 1 and stage 2 hypertensives. J Clin Hypertens 12: 153-159.
20. Boelsma E, Kloek J (2010) IPP-rich milk protein hydrolysate lowers blood pressure in subjects with stage 1 hypertension, a randomized controlled trial. Nutr J 9: 52.
21. Marambe PWMLHK, Shand PJ, Wanasundara JPD (2008) An in vitro investigation of selected biological activities of hydrolyzed flaxseed (Linum usitatissimum L.) proteins. J Am Oil Chem Soc 85: 1155-1164.
22. Marambe HK, Shand PJ, Wanasundara JPD (2011) Release of angiotensin I-converting enzyme inhibitory peptides from flaxseed (Linum usitatissimum L.) protein under simulated gastrointestinal digestion. J Agric Food Chem 59: 9596-9604.
23. Udenigwe CC, Lin Y-S, Hou W-C, Aluko RE (2009) Kinetics of the inhibition of renin and angiotensin I-converting enzyme by flaxseed protein hydrolysate fractions. J Funct Foods 1: 199-207.
24. Udenigwe CC, Lu Y-L, Han C-H, Hou W-C, Aluko RE (2009) Flaxseed protein-derived peptide fractions: Antioxidant properties and inhibition of lipopolysaccharide-induced nitric oxide production in murine macrophages. Food Chem 116: 277-284.
25. Udenigwe CC, Aluko RE (2010) Antioxidant and angiotensin converting enzyme-inhibitory properties of a flaxseed protein-derived high Fischer ratio peptide mixture. J Agric Food Chem 58: 4762-4768.
26. Okamoto A, Hanagata H, Kawamura Y, Yanagida F (1995) Anti-hypertensive substances in fermented soybean, natto. Plant Foods Hum Nutr 47: 39-47.
27. Ajibola CF, Eleyinmi AF, Aluko RE (2011) Kinetics of the inhibition of renin and angiotensin-I converting enzyme by polar and non-polar polyphenolic extracts of Vernonia amygdalina and Gongronema latifolium leaves. Plant Foods Hum Nutr 66: 320-327.
28. Omoni AO, Aluko RE (2006) Effect of cationic flaxseed protein hydrolysate fractions on the in vitro structure and activity of calmodulin-dependent endothelial nitric oxide synthase. Mol Nutr Food Res 50: 958-966.
29. Omoni AO, Aluko RE (2006) Mechanism of the inhibition of calmodulin-dependent neuronal nitric oxide synthase by flaxseed protein hydrolysates. J Am Oil Chem Soc 83: 335-340.
30. Firdaous L, Dhulster P, Amiot J, Gaudreau A, Lecouturier D, Kapel R, Lutin F, Vézina L-P, Bazinet L (2009) Concentration and selective separation of bioactive peptides from alfalfa white protein hydrolysate by electrodialysis with ultrafiltration membranes. J Membr Sci 329: 60-67.
31. You SJ, Udenigwe CC, Aluko RE, Wu J (2010) Multifunctional peptides from egg white lysozyme. Food Res Int 43: 848-855.
32. Pripp AH, Isaksson T, Stepaniak L, Sørhaug T, Ardö Y (2004) Quantitative structure-activity relationship modelling peptides and proteins as a tool in food science. Trends Food Sci Technol 16: 484-494.
33. Kizawa K, Naganuma K, Murakami U (1995) Calmodulin-binding peptides isolated from α-casein peptone. J Dairy Res 62: 587-592.
34. Barnette MS, Daly R, Weiss B (1983) Inhibition of calmodulin activity by insect venom peptides. Biochem Pharmacol 32: 2929-2933.
35. Li H, Aluko RE (2005) Kinetics of the inhibition of calcium/calmodulin-dependent protein kinase II by pea protein-derived peptides. J Nutr Biochem 16: 656-662.
36. Cushman DW, Cheung HS (1971) Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem Pharmacol 20: 1637-1648.
37. Wang GT, Chung CC, Holzman TF, Krafft GA (1993) A continuous fluorescence assay of renin activity. Anal Biochem 210: 351-359.