Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: Target for reverse-remodeling therapy

Circulation

Volumn 115, Issue 17, 2007, Pages 2331-2339

  Schermuly, Ralph Theo ^a   Pullamsetti, Soni Savai ^a   Kwapiszewska, Grazyna ^a   Dumitrascu, Rio ^a   Tian, Xia ^a   Weissmann, Norbert ^a   Ghofrani, Hossein Ardeschir ^a   Kaulen, Christina ^a   Dunkern, Torsten ^b   Schudt, Christian ^b   Voswinckel, Robert ^a   Zhou, Jiang ^a   Samidurai, Arun ^a   Klepetko, Walter ^c   Paddenberg, Renate ^a   Kummer, Wolfgang ^a   Seeger, Werner ^a   Grimminger, Friedrich ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b Justus Liebig University Giessen ^*  (Germany)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cardiovascular diseases; Hypertension, pulmonary; Muscle, smooth; Pharmacology; Phosphodiesterases

Indexed keywords

3 ISOBUTYL 8 METHOXYMETHYL 1 METHYLXANTHINE; MESSENGER RNA; MONOCROTALINE; PHOSPHODIESTERASE I; PHOSPHODIESTERASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY MUSCLE; ARTICLE; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME INHIBITION; HEART HYPERTROPHY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LASER MICRODISSECTION; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE;

1-METHYL-3-ISOBUTYLXANTHINE; 3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; CELL DIVISION; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; DNA; HUMANS; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; MICE; MUSCLE, SMOOTH, VASCULAR; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PULMONARY ARTERY; RATS; UP-REGULATION;

EID: 34247586182     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.106.676809     Document Type: Article

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