Flaxseed protein-derived peptide fractions: Antioxidant properties and inhibition of lipopolysaccharide-induced nitric oxide production in murine macrophages

Food Chemistry

Volumn 116, Issue 1, 2009, Pages 277-284

  Udenigwe, Chibuike C ^a   Lu, Yeh Lin ^b   Han, Chuan Hsiao ^b   Hou, Wen Chi ^b   Aluko, Rotimi E ^a,c  

^a UNIVERSITY OF MANITOBA   (Canada)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Antioxidant; Flaxseed protein hydrolysates; Nitric oxide; RAW 264.7 macrophages; Semicarbazide sensitive amine oxidase

Indexed keywords

1 3 ALCALASE FLAXSEED PROTEIN HYDROLYSATE; 1,1 DIPHENYL 2 PICRYLHYDRAZYL; 3 5 ALCALASE FLAXSEED PROTEIN HYDROLYSATE; AMINE OXIDASE (FLAVIN CONTAINING); ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CELLULASE; FICIN FLAXSEED PROTEIN HYDROLYSATE; GLUTATHIONE; HYDROXYL GROUP; HYDROXYL RADICAL; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PANCREATIN FLAXSEED PROTEIN HYDROXYLYSATE; PAPAIN FLAXSEED PROTEIN HYDROXYLATE; PEPSIN FLAXSEED PROTEIN HYDROLYSATE; PEPTIDE; PEPTIDE FRACTION FI; PEPTIDE FRACTION FII; PROTEIN HYDROLYSATE; PROTEINASE; SEMICARBAZIDE; SUPEROXIDE; THERMOLYSIN FLAXSEED PROTEIN HYDROXYLATE; TRYPSIN FLAXSEED PROTEIN HYDROXYLATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG FORMULATION; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; HYDROLYSIS; IC 50; ION EXCHANGE CHROMATOGRAPHY; ION PAIR CHROMATOGRAPHY; LINSEED; MACROPHAGE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; ULTRAFILTRATION;

MURINAE;

EID: 64549113397     PISSN: 03088146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodchem.2009.02.046     Document Type: Article

References (45)

1. Agriculture and Agri-Food Canada (2007). Flaxseed: Situation and outlook. Bi-weekly Bulletin, 20(3), AAFC No. 2081/E.
2. Ames B.N. Dietary carcinogens and anticarcinogens: Oxygen radicals and degenerative diseases. Science 221 (1983) 1256-1264
3. Ames B.N., Shigena M.K., and Hegen T.M. Oxidants, antioxidants and the degenerative diseases of aging. Proceedings of the National Academy of Science USA 90 (1993) 7915-7922
4. Boomsma F., De Kam P.J., Tjeerdsma G., Van Den Meiracker A.H., and Van Veldhuisen D.J. Plasma semicarbazide-sensitive amine oxidase (SSAO) is an independent prognostic marker for mortality in chronic heart failure. European Heart Journal 21 (2000) 1859-1863
5. Chen Y.-C., Shen S.-C., Lee W.-R., Hou W.-C., Yang L.-L., and Lee T.J.F. Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin pentaacetate in RAW 264.7 macrophages. Journal of Cellular Biochemistry 82 (2001) 537-548
6. Cumby N., Zhong Y., Naczk M., and Shahidi F. Antioxidant activity and water-holding capacity of canola protein hydrolysates. Food Chemistry 109 (2008) 144-148
7. Dev D.K., and Quensel E. Preparation and functional properties of linseed protein products containing differing levels of mucilage. Journal of Food Science 53 (1988) 1834-1837
8. Dia V.P., Wang W., Oh V.L., de Lumen B.O., and Gonzalez de Mejia E. Isolation, purification and characterization of lunasin from defatted soybean flour and in vitro evaluation of its anti-inflammatory activity. Food Chemistry 114 (2009) 108-115
9. Dodin S., Cunnane S.C., Mâsse B., Lemay A., Jacques H., Asselin G., et al. Flaxseed on cardiovascular disease markers in healthy menopausal women: A randomized, double-blind, placebo-controlled trial. Nutrition 24 (2008) 23-30
10. Fiorentino A., Ricci A., D'Abrosca B., Pacifico S., Golino A., Letizia M., et al. Potential food additives from Carex distacya roots: Identification and in vitro antioxidant properties. Journal of Agricultural and Food Chemistry 56 (2008) 8218-8225
11. Gao R., Yuan Z., Zhao Z., and Gao X. Mechanism of pyrogallol autoxidation and determination of superoxide dismutase enzyme activity. Bioelectrochemistry and Bioenergetics 45 (1998) 41-45
12. Göktürk C., Nilsson J., Nordquist J., Kristensson M., Svensson K., Söderberg C., et al. Overexpression of semicarbazide-sensitive amine oxidase in smooth muscle cells leads to an abnormal structure of the aortic elastic laminas. American Journal of Pathology 163 (2003) 1921-1928
13. Hall III C., Tulbek M.C., and Xu Y. Flaxseed. Advances in Food and Nutrition Research 51 (2006) 1-97
14. Ho S.-C., and Lin C.-C. Investigation of heat treating conditions for enhancing the anti-inflammatory activity of citrus fruits (Citrus reticulate) peels. Journal of Agricultural and Food Chemistry 56 (2008) 7976-7982
15. Hou W.-C., Chen Y.-C., Chen H.-J., Lin Y.-H., Yang L.-L., and Lee M.-H. Antioxidant activities of trypsin inhibitor, a 33 kDa root storage protein of sweet potato (Ipomoea batatas L. Lam cv. Tainong 57). Journal of Agricultural and Food Chemistry 49 (2001) 2978-2981
16. Huang D., Ou B., and Prior R.L. The chemistry behind antioxidant capacity assays. Journal of Agricultural and Food Chemistry 53 (2005) 1841-1856
17. Kris-Etherton P.M., Hecker K.D., Bonanome A., Coval S.M., Binkoski A.E., Hilpert K.F., et al. Bioactive compounds in foods: Their role in the prevention of cardiovascular disease and cancer. American Journal of Medicine 113 (2002) 71S-88S
18. Li L., Abe Y., Kanagawa K., Usui N., Imai K., Mashino T., et al. Distinguishing the 5,5-dimethyl-1-pyrroline N-oxide (DMPO)-OH radical quenching effect from the hydroxyl radical scavenging effect in the ESR spin-trapping method. Analytica Chimica Acta 512 (2004) 121-124
19. Li Y., Jiang B., Zhang T., Mu W., and Liu J. Antioxidant and free radical-scavenging activities of chickpea protein hydrolysate (CPH). Food Chemistry 106 (2008) 444-450
20. Li X.-X., Han L.-J., and Chen L.-J. In vitro antioxidant activity of protein hydrolysates prepared from corn gluten meal. Journal of the Science of Food and Agriculture 88 (2008) 1660-1666
21. Lin S.-Y., Wang C.-C., Lu Y.-L., Wu W.-C., and Hou W.-C. Antioxidant, anti-semicarbazide-sensitive amino oxidase, and anti-hypertensive activities of geraniin isolated from Phyllanthus urinaria. Food and Chemical Toxicology 46 (2008) 2485-2492
22. Liu, B., Gao, H.-M., Wang, J.-Y., Jeohn, G.-H., Cooper, C. L., & Hong, J.-S. (2002). Role of nitric oxide in inflammation-mediated neurodegeneration. Annals of the New York Academy of Sciences, 962, 318-331.
23. Liu D.-Z., Wu W.-C., Liang H.-J., and Hou W.-C. Antioxidant and semicarbazide-sensitive amine oxidase inhibitory activities of alginic acid hydroxamates. Journal of the Science of Food and Agriculture 87 (2007) 138-146
24. Liu Y.-W., Shang H.-F., Wang C.-K., Hsu F.-L., and Hou W.-C. Immunomodulatory activity of dioscorin, the storage protein of yam (Dioscorea alata cv. Tainong No. 1) tuber. Food and Chemical Toxicology 45 (2007) 2312-2318
25. Magyar K., Mészáros Z., and Mátyus P. Semicarbazide-sensitive amine oxidase. Its physiological significance. Pure and Applied Chemistry 73 (2001) 1393-1400
26. 14C] glutamate in islets and Peyer's patches, reduces abnormally high mitotic activity in mesenteric lymph nodes, enhances islet insulin and tends to normalize NO production. International Journal of Experimental Diabetes Research 1 (2000) 121-130
27. Marambe P.W.M.L.H.K., Shand P.J., and Wanasundara J.P.D. An in vitro investigation of selected biological activities of hydrolyzed flaxseed (Linum usitatissimum L) proteins. Journal of the American Oil Chemists' Society 85 (2008) 1155-1164
28. Marklund S., and Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. European Journal of Biochemistry 47 (1974) 469-474
29. Markwell M.A.C., Haas S.M., Biebar L.L., and Tolbert N.E. A modification of the Lowry procedure to simplify protein determination in membrane and in protein samples. Analytical Biochemistry 87 (1978) 206-211
30. Omoni A.O., and Aluko R.E. Mechanism of the inhibition of calmodulin-dependent neuronal nitric oxide synthase by flaxseed protein hydrolysates. Journal of the American Oil Chemists' Society 83 (2006) 335-340
31. Omoni A.O., and Aluko R.E. Effect of cationic flaxseed protein hydrolysate fractions on the in vitro structure and activity of calmodulin-dependent endothelial nitric oxide synthase. Molecular Nutrition and Food Research 50 (2006) 958-966
32. Oomah B.D., and Mazza G. Flaxseed proteins - a review. Food Chemistry 48 (1993) 109-114
33. Pacher P., Beckman J.S., and Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiological Reviews 87 (2007) 315-424
34. Pan M.-H., Chang Y.-H., Tsai M.-L., Lai C.-S., Ho S.-Y., Badmaev V., et al. Pterostilbene suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages. Journal of Agricultural and Food Chemistry 56 (2008) 7502-7509
35. Peng X., Xiong Y.L., and Kong B. Antioxidant activity of peptide fractions from whey protein hydrolysates as measured by electron spin resonance. Food Chemistry 113 (2009) 196-201
36. Prior R.L., Wu X., and Schaich K. Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. Journal of Agricultural and Food Chemistry 53 (2005) 4290-4302
37. Sakanaka S., and Tachibana Y. Active oxygen scavenging activity of egg-yolk protein hydrolysates and their effects on lipid oxidation in beef and tuna homogenates. Food Chemistry 95 (2006) 243-249
38. Stolen C.M., Madanat R., Marti L., Kari S., Yegutkin G.G., Sariola H., et al. Semicarbazide-sensitive amine oxidase overexpression has dual consequences: Insulin mimicry and diabetes-like complications. FASEB Journal 18 (2004) 702-704
39. Stolen C.M., Yegutkin G.G., Kurkijarvi R., Bono P., Alitalo K., and Jalkanen S. Origins of serum semicarbazide-sensitive amine oxidase. Circulation Research 95 (2004) 50-57
40. Szutowicz A., Kobes R.D., and Orsulak P.J. Colorimetric assay for monoamine oxidase in tissues using peroxidase and 2′,2-azinodi(3-ethylbenzthiazoline-6-sulfonic acid) as chromogen. Analytical Biochemistry 138 (1984) 86-94
41. Torre D., Pugliese A., and Speranza F. Role of nitric oxide in HIV-1 infection: Friend or foe?. Lancet Infectious Diseases 2 (2002) 273-280
42. Udenigwe C.C., Lin Y.-S., Hou W.-C., and Aluko R.E. Kinetics of the inhibition of renin and angiotensin I-converting enzyme by flaxseed protein hydrolysate fractions. Journal of Functional Foods (2009) 10.1016/j.jff.2009.01.009
43. Wang J.-S., Zhao M.-M., Zhao Q.-Z., and Jiang Y.-M. Antioxidant properties of papain hydrolysates of wheat gluten in different oxidation systems. Food Chemistry 101 (2007) 1658-1663
44. Wu H.-C., Chen H.-M., and Shiau C.-.Y. Free amino acids and peptides as related to antioxidant properties in protein hydrolysates of mackreal (Scomber austriasicus). Food Research International 36 (2003) 949-957
45. Xie Z., Huang J., Xu X., and Jin Z. Antioxidant activity of peptides isolated from alfalfa leaf protein hydrolysate. Food Chemistry 111 (2008) 370-376