Acute Manipulation of Phosphoinositide Levels in Cells

Methods in Cell Biology

Volumn 108, Issue , 2012, Pages 187-207

  Chang Ileto, Belle ^a   Frere, Samuel G ^a   Di Paolo, Gilbert ^a  

^a Department of Medicine   (United States)

Author keywords

Cellular process; Chemically induced dimerization; Cytoskeletal dynamics; Membrane trafficking; Membrane bound signaling; Phosphoinositide

Indexed keywords

EID: 84856753161     PISSN: 0091679X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-386487-1.00010-9     Document Type: Chapter

References (85)

1. Abe N., et al. Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor. J. Cell Sci. 2008, 121:1488-1494.
2. Balla T., et al. Phosphoinositide signaling: new tools and insights. Physiology (Bethesda) 2009, 24:231-244.
3. Banaszynski L.A., et al. A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell 2006, 126:995-1004.
4. Bayle J.H., et al. Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity. Chem. Biol. 2006, 13:99-107.
5. Behnia R., Munro S. Organelle identity and the signposts for membrane traffic. Nature 2005, 438:597-604.
6. Belshaw P.J., et al. Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:4604-4607.
7. Chang-Ileto B., et al. Synaptojanin 1-mediated PI(4,5)P2 hydrolysis is modulated by membrane curvature and facilitates membrane fission. Dev. Cell 2011, 20:206-218.
8. Chen J., et al. Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:4947-4951.
9. Choi J.W., et al. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science 1996, 273:239-242.
10. Chong H., et al. A system for small-molecule control of conditionally replication-competent adenoviral vectors. Mol. Ther. 2002, 5:195-203.
11. Choudhury R., et al. Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network. Mol. Biol. Cell 2005, 16:3467-3479.
12. Clackson T. Dissecting the functions of proteins and pathways using chemically induced dimerization. Chem. Biol. Drug Des. 2006, 67:440-442.
13. Clackson T., et al. Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:10437-10442.
14. Cremona O., et al. Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cell 1999, 99:179-188.
15. Csordas G., et al. Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface. Mol. Cell 2010, 39:121-132.
16. Day R.N., Davidson M.W. The fluorescent protein palette: tools for cellular imaging. Chem. Soc. Rev. 2009, 38:2887-2921.
17. Di Cristofano A., et al. Pten is essential for embryonic development and tumour suppression. Nat. Genet. 1998, 19:348-355.
18. Di Paolo G., De Camilli P. Phosphoinositides in cell regulation and membrane dynamics. Nature 2006, 443:651-657.
19. Di Paolo G., et al. Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking. Nature 2004, 431:415-422.
20. Downing G.J., et al. Characterization of a soluble adrenal phosphatidylinositol 4-kinase reveals wortmannin sensitivity of type III phosphatidylinositol kinases. Biochemistry 1996, 35:3587-3594.
21. Edwards S.R., Wandless T.J. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J. Biol. Chem. 2007, 282:13395-13401.
22. Falkenburger B.H., et al. Phosphoinositides: lipid regulators of membrane proteins. J. Physiol. 2010, 588:3179-3185.
23. Fili N., et al. Compartmental signal modulation: Endosomal phosphatidylinositol 3-phosphate controls endosome morphology and selective cargo sorting. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:15473-15478.
24. Gallop J.L., et al. Mechanism of endophilin N-BAR domain-mediated membrane curvature. EMBO J. 2006, 25:2898-2910.
25. Garcia P., et al. The pleckstrin homology domain of phospholipase C-delta1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes. Biochemistry 1995, 34:16228-16234.
26. Gary J.D., et al. Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. J. Cell Biol. 1998, 143:65-79.
27. Gillooly D.J., et al. Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins. Biochem. J. 2001, 355:249-258.
28. Godi A., et al. FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat. Cell Biol. 2004, 6:393-404.
29. Golebiewska U., et al. Diffusion coefficient of fluorescent phosphatidylinositol 4,5-bisphosphate in the plasma membrane of cells. Mol. Biol. Cell 2008, 19:1663-1669.
30. Guo S., et al. SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases. J. Biol. Chem. 1999, 274:12990-12995.
31. Harris T.W., et al. Mutations in synaptojanin disrupt synaptic vesicle recycling. J. Cell Biol. 2000, 150:589-600.
32. Haucke V. Phosphoinositide regulation of clathrin-mediated endocytosis. Biochem. Soc. Trans. 2005, 33:1285-1289.
33. Heo W.D., et al. PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science 2006, 314:1458-1461.
34. Hilgemann D.W., et al. The complex and intriguing lives of PIP2 with ion channels and transporters. Sci. STKE 2001, 2001:RE19.
35. Huang W., et al. Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling. J. Am. Chem. Soc. 2007, 129:6498-6506.
36. Inoue T., et al. An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways. Nat. Methods 2005, 2:415-418.
37. Itoh T., et al. Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins. Dev. Cell 2005, 9:791-804.
38. Kahlfeldt N., et al. Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2. J. Biol. Chem. 2010, 285:2734-2749.
39. Kim S., et al. Regulation of transferrin recycling kinetics by PtdIns[4,5]P2 availability. Faseb J. 2006, 20:2399-2401.
40. Knight Z.A., et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell 2006, 125:733-747.
41. Komatsu T., et al. Organelle-specific, rapid induction of molecular activities and membrane tethering. Nat. Methods 2010, 7:206-208.
42. Korzeniowski M.K., et al. Activation of STIM1-Orai1 involves an intramolecular switching mechanism. Sci. Signal 2010, 3. ra82.
43. Krauss M., et al. ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma. J. Cell Biol. 2003, 162:113-124.
44. Lemmon M.A. Membrane recognition by phospholipid-binding domains. Nat. Rev. Mol. Cell Biol. 2008, 9:99-111.
45. Lemmon M.A., et al. Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:10472-10476.
46. Liberles S.D., et al. Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:7825-7830.
47. Liu J., et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 1991, 66:807-815.
48. Logan M.R., Mandato C.A. Regulation of the actin cytoskeleton by PIP2 in cytokinesis. Biol. Cell 2006, 98:377-388.
49. Mao Y.S., Yin H.L. Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases. Pflugers Arch. 2007, 455:5-18.
50. Nakanishi S., et al. A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:5317-5321.
51. Nakatsu F., et al. The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics. J. Cell Biol. 2010, 190:307-315.
52. Ozaki S., et al. Intracellular delivery of phosphoinositides and inositol phosphates using polyamine carriers. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:11286-11291.
53. Peter B.J., et al. BAR domains as sensors of membrane curvature: the amphiphysin BAR structure. Science 2004, 303:495-499.
54. Pollard T.D., Borisy G.G. Cellular motility driven by assembly and disassembly of actin filaments. Cell 2003, 112:453-465.
55. Prasad N.K., Decker S.J. SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor. J. Biol. Chem. 2005, 280:13129-13136.
56. Rohatgi R., et al. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. J. Cell Biol. 2000, 150:1299-1310.
57. Rollins C.T., et al. A ligand-reversible dimerization system for controlling protein-protein interactions. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:7096-7101.
58. Rusk N., et al. Synaptojanin 2 functions at an early step of clathrin-mediated endocytosis. Curr. Biol. 2003, 13:659-663.
59. Schu P.V., et al. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 1993, 260:88-91.
60. Sigal Y.J., et al. Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions. Biochem. J. 2005, 387:281-293.
61. Sorensen S.D., et al. A role for a wortmannin-sensitive phosphatidylinositol-4-kinase in the endocytosis of muscarinic cholinergic receptors. Mol. Pharmacol. 1998, 53:827-836.
62. Spencer D.M., et al. Controlling signal transduction with synthetic ligands. Science 1993, 262:1019-1024.
63. Stambolic V., et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 1998, 95:29-39.
64. Stankunas K., et al. Conditional protein alleles using knockin mice and a chemical inducer of dimerization. Mol. Cell 2003, 12:1615-1624.
65. Stankunas K., et al. Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands. Chembiochem 2007, 8:1162-1169.
66. Subramanian D., et al. Activation of membrane-permeant caged PtdIns(3)P induces endosomal fusion in cells. Nat. Chem. Biol. 2010, 6:324-326.
67. Suh B.C., Hille B. Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate. Curr. Opin. Neurobiol. 2005, 15:370-378.
68. Suh B.C., Hille B. PIP2 is a necessary cofactor for ion channel function: how and why?. Annu. Rev. Biophys. 2008, 37:175-195.
69. Suh B.C., et al. Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science 2006, 314:1454-1457.
70. Szentpetery Z., et al. Acute manipulation of Golgi phosphoinositides to assess their importance in cellular trafficking and signaling. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:8225-8230.
71. Terebiznik M.R., et al. Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella. Nat. Cell Biol. 2002, 4:766-773.
72. Varnai P., Balla T. Visualization of phosphoinositides that bind pleckstrin homology domains: calcium- and agonist-induced dynamic changes and relationship to myo-[3H]inositol-labeled phosphoinositide pools. J. Cell Biol. 1998, 143:501-510.
73. Varnai P., Balla T. Visualization and manipulation of phosphoinositide dynamics in live cells using engineered protein domains. Pflugers Arch. 2007, 455:69-82.
74. Varnai P., et al. Selective cellular effects of overexpressed pleckstrin-homology domains that recognize PtdIns(3,4,5)P3 suggest their interaction with protein binding partners. J. Cell Sci. 2005, 118:4879-4888.
75. Varnai P., et al. Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells. J. Cell Biol. 2006, 175:377-382.
76. Varnai P., et al. Visualization and manipulation of plasma membrane-endoplasmic reticulum contact sites indicates the presence of additional molecular components within the STIM1-Orai1 Complex. J. Biol. Chem. 2007, 282:29678-29690.
77. Verstreken P., et al. Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating. Neuron 2003, 40:733-748.
78. Wang Y.J., et al. Critical role of PIP5KI{gamma}87 in InsP3-mediated Ca(2+) signaling. J. Cell Biol. 2004, 167:1005-1010.
79. Wiedemann C., et al. Chromaffin granule-associated phosphatidylinositol 4-kinase activity is required for stimulated secretion. EMBO J. 1996, 15:2094-2101.
80. Xu Y., et al. Chemical synthesis and molecular recognition of phosphatase-resistant analogues of phosphatidylinositol-3-phosphate. J. Am. Chem. Soc. 2006, 128:885-897.
81. Yin H.L., Janmey P.A. Phosphoinositide regulation of the actin cytoskeleton. Annu. Rev. Physiol. 2003, 65:761-789.
82. Zhang H., et al. Synthesis and biological activity of PTEN-resistant analogues of phosphatidylinositol 3,4,5-trisphosphate. J. Am. Chem. Soc. 2006, 128:16464-16465.
83. Zhang H., et al. Synthesis and biological activity of phospholipase C-resistant analogues of phosphatidylinositol 4,5-bisphosphate. J. Am. Chem. Soc. 2006, 128:5642-5643.
84. Zhou X., et al. Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:9424-9429.
85. Zoncu R., et al. Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:3793-3798.