The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain

Journal of Biological Chemistry

Volumn 282, Issue 18, 2007, Pages 13395-13401

  Edwards, Sarah R ^a   Wandless, Thomas J ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; FLUORESCENCE; LIGANDS; MASS SPECTROMETRY; YEAST;

FKBP-RAPAMYCIN BINDING (FRB) DOMAIN; IMMUNOSUPPRESSIVE DRUG; MISLOCALIZATION;

DRUG PRODUCTS;

LIGAND; MAMMALIAN TARGET OF RAPAMYCIN; MUTANT PROTEIN; YELLOW FLUORESCENT PROTEIN; DRUG DERIVATIVE; FK 506 BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; PROTEIN KINASE; RAPAMYCIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME SYNTHESIS; FLUORESCENCE; MAMMAL CELL; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STABILITY; QUANTITATIVE ANALYSIS; QUANTITATIVE ASSAY; SACCHAROMYCES CEREVISIAE; SCREENING TEST; WILD TYPE; ANIMAL; CELL STRAIN 3T3; DRUG EFFECT; ENZYME STABILITY; GENETICS; METABOLISM; MOUSE; MUTATION; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN QUATERNARY STRUCTURE; TWO HYBRID SYSTEM;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

AMINO ACID MOTIFS; ANIMALS; ENZYME STABILITY; IMMUNOSUPPRESSIVE AGENTS; LIGANDS; MASS SPECTROMETRY; MICE; MUTATION; NIH 3T3 CELLS; PROTEIN BINDING; PROTEIN KINASES; PROTEIN STRUCTURE, QUATERNARY; SACCHAROMYCES CEREVISIAE; SIROLIMUS; TACROLIMUS BINDING PROTEIN 1A; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 34250316973     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M700498200     Document Type: Article

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