Conception to ongoing pregnancy: The 'black box' of early pregnancy loss

Human Reproduction Update

Volumn 8, Issue 4, 2002, Pages 333-343

  Macklon, N S ^a   Geraedts, J P M ^b   Fauser, B C J M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Aneuploidy; Early pregnancy loss; Human chorionic gonadotrophin; Infertility; IVF

Indexed keywords

CHORIONIC GONADOTROPIN;

ADULT; AMENORRHEA; ARTICLE; CONCEPTION; CONTROLLED STUDY; CYTOGENETICS; EMBRYO; FEMALE; FEMALE INFERTILITY; FERTILITY; HUMAN; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; NIDATION; PREGNANCY; PRIORITY JOURNAL; SPONTANEOUS ABORTION; ANEUPLOIDY; ANIMAL; ENDOMETRIUM; FERTILIZATION; FERTILIZATION IN VITRO; GESTATIONAL AGE; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ABORTION, SPONTANEOUS; ANEUPLOIDY; ANIMAL; EMBRYO; ENDOMETRIUM; FEMALE; FERTILIZATION; FERTILIZATION IN VITRO; GESTATIONAL AGE; HUMAN; PREGNANCY; ANIMALS; HUMANS;

EID: 0036629078     PISSN: 13554786     EISSN: None     Source Type: Journal    
DOI: 10.1093/humupd/8.4.333     Document Type: Article

References (135)

1. Rapid detection of aneuploidies by microsatellite and the quantitative fluorescent polymerase chain reaction
2. Predivision in human oocytes at meiosis 1: A mechanism for trisomy formation in man
3. Cytogenetic analysis of unfertilized human oocytes
4. First-meiotic division nondisjunction in human oocytes
5. Use of time to pregnancy to study environmental exposures
6. The relationship between reduced fecundability and subsequent fetal loss
7. Assessment of polyploidy in human morulae and blastocysts using co-culture and fluorescent in-situ hybridization
8. The impact of embryonic development and endometrial maturity on the timing of implantation
9. Significance of mosaicism in the human preimplantation embryo
10. Human chorionic gonadotrophin concentrations in early pregnancy after in-vitro fertilization
11. Occult pregnancy: A pilot study
12. Chorionic gonadotrophin-beta mRNA, a trophoblast marker, is expressed in human 8-cell embryos derived from tripronucleate zygotes
13. Preimplantation genetics: Chromosomes of fragmented human embryos
14. Human embryo associated immunosuppressor factor(s) from pre- and post-implantation stages share some similarities
15. The partially purified pre-implantation suppressor factor may be one of several factors to play a role in successful pregnancy
16. Purified human early pregnancy factor from preimplantation embryo possesses immunosuppressive properties
17. Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions
18. Biologic and morphologic development of donated human ova recovered by nonsurgical uterine lavage
19. Development of an assay for a biomarker of pregnancy and early fetal loss
20. Chromosome studies in abortuses and stillborn infants
21. Identification of early pregnancy factor as chaperonin 10: Implications for understanding its role
22. Measuring human chorionic gonadotropin in the absence of implantation with use of highly sensitive urinary assays for intact betacore and free beta epitopes
23. Frequency of implantation and early pregnancy loss in natural cycles
24. Measurement of plasma chorionic gonadotropin (hCG) and β-hCG activities in the late luteal phase: Evidence of the occurrence of spontaneous menstrual abortions in infertile women
25. Presence of chromosomal mosaicism in abnormal preimplantation embryos detected by fluorescence in situ hybridisation
26. Association between nondisjunction and maternal age in meiosis-II human oocytes
27. Production of immunosuppressor factor(s) by preimplantation embryos
28. Identification of two species of suppressive factor of different weight released by in vitro fertilized human oocytes
29. Multicolour FISH detects frequent chromosomal mosaicism and chaotic division in normal preimplantation embryos from fertile patients
30. Chromosome studies in first polar bodies from hamster and human oocytes
31. Early embryonic mortality in women
32. A cytogenetic study directly from chorionic villi of 140 spontaneous abortions
33. Implantation in the marmoset monkey: Expansion of the early implantation site
34. Mosaicism in the inner cell mass of human blastocycts
35. A study of early pregnancy factor activity in preimplantation
36. Rapid trisomy diagnosis (21, 18 and 13) using fluorescent PCR and short tandem repeats: Applications for prenatal diagnosis and preimplantation genetic diagnosis
37. Human chorionic gonadotropin secreted by preimplantation embryos cultured in vitro
38. Donation of fertilized uterine ova to infertile women
39. Cytogenetic analyses of culture failures by comparative genomic hybridisation (CGH)-Re-evaluation of chromosome aberration rates in early spontaneous abortions
40. Spectral imaging in preconception/preimplantation genetic diagnosis of aneuploidy: Multicolor, multichrome screening of single cells
41. Noninvasive assessment of human embryo nutrient consumption as a measure of developmental potential
42. Gonadal activity and chromosomal constitution of in vitro generated embryos
43. Prevalence and distribution of chromosome abnormalities in a sample of first trimester internal abortions
44. Infertility and early pregnancy loss
45. Isolation, purification and partial characterization of early pregnancy factor (EPF) from sera of pregnant women
46. To err (meiotically) is human: The genesis of human aneuploidy
47. A cytogenetic study of 1000 spontaneous abortions
48. Monitoring early detection of human chorionic gonadotropin (hCG) following in vitro fertilization and embryo transfer
49. Chorionic gonadotropin and embryo-maternal recognition during the periimplantation period in primates
50. Searching for early fertilized human ova
51. Thirty four fertilized human ova, good bad and indifferent, recovered from 210 women of known fertility. A study of biologic wastage in early human pregnancy
52. Rates of chromosome abnormalities at different maternal ages
53. A prediction model for selecting IVF patients for single embryo transfer
54. Developmental changes in the incidence of chromosome anomalies of bovine embryos fertilized in vitro
55. The chromosome constitution of human preimplantation embryos fertilized in vitro
56. Inverse maternal age effect in monosomy X
57. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors
58. Chorionic gonadotropin secretion by human embryos in vitro
59. Detection of human chorionic gonadotropin in blood of regularly bleeding women using copper intrauterine contraceptive devices
60. Triple colour fluorescent in-situ hybridization for chromosomes X,Y and 1 on spare human embryos
61. The endocrinology of conception cycles and implantation in women
62. Plasma concentrations of human chorionic gonadotrophin from the time of implantation until the second week of pregnancy
63. Premenstrual pregnancy loss
64. Normal and abnormal implantation in spontaneous in-vivo and in-vitro human pregnancies
65. The role of the endometrium during embryo implantation
66. Multicolor FISHing: What's the catch?
67. Early pregnancy wastage in IVF (in vitro fertilization) patients
68. Beta-human chorionic gonadotropin as a monitor of pregnancy outcome in in vitro fertilization-embryo transfer patients
69. Mechanisms and factors of early pregnancy wastage in in vitro fertilization-embryo transfer patients
70. A comparison of the chromosome complement of inner cell mass and trophoblast cells in day-10 pig embryos
71. The potential of early human embryos to form blastocysts, hatch from their zona and secrete hCG in culture
72. Modification of the choriogonadotropin beta-subunit radioimmunoassay for determination of urinary choriogonadotropin
73. Increased incidence of numerical chromosome abnormalities in spermatozoa injected into human oocytes by ICSI
74. The impact of ovarian hyperstimulation on the luteal Phase
75. Chromosome identification in human oocytes and polar bodies by spectral karyotyping
76. The frequency of aneuploidy among individual chromosomes in 6821 human sperm chromosome complements
77. Fetal loss after implantation
78. Daily immunologic pregnancy testing of initially non-pregnant women
79. An early pregnancy factor detected in human serum by the rosette inhibition test
80. Diagnosis of major aneuploidies in human preimplantation embryos
81. Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities
82. Treatment-related chromosome abnormalities in human embryos
83. Polyploid cells in blastocysts and early fetuses from Australian Merino sheep
84. Relationship between blood and urine concentrations of intact human chorionic gonadotropin and its free subunits in early pregnancy
85. Dating the endometrial biopsy
86. A cytogenetic study of spontaneous abortions with direct analysis of chorionic villi
87. Chromosome analysis of epididymal and testicular sperm in azoospermic patients undergoing ICSI
88. Differential distribution of aneuploidy in human gametes according to their sex
89. Direct assessment of the rate of chromosome abnormalities in grade IV human embryos produced by in-vitro fertilization procedure
90. Relationship between morphology and chromosomal constitution in human preimplantation embryo
91. Lower implantation rates in high responders: Evidence for an altered endocrine milieu during the preimplantation period
92. Triploid cell cultures from a macerated foetus
93. Aneuploidy frequencies in semen fractions from ten oligoasthenoteratozoospermic patients donating sperm for intracytoplasmic sperm injection
94. In situ hybridization studies of human gametes, zygotes and pre-embryos
95. Triploidy after in vitro fertilization: Cytogenetic analysis of human zygotes and embryos
96. The human oocyte. Genetic aspects
97. Chromosomal abnormalities in oocytes
98. From oocyte to embryo: A model, deduced from in vitro fertilization, for natural selection against chromosome abnormalities
99. Cytogenetic analysis and developmental capacity of normal and abnormal embryos after IVF
100. Where have all the conceptions gone?
101. Current studies on human implantation: A brief overview
102. Fish analysis on day 5 post-insemination of human arrested and blastocyst stage embryos
103. Survival of chromosome abnormalities to blastocyst stage
104. Assisted reproductive technology in the United States: 1998 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry
105. Pregnancy-specific beta 1-glycoprotein and chorionic gonadotropin-like immunoreactivity during the latter half of the cycle in women using intrauterine contraception
106. Early conceptual loss in subfertile patients
107. The secretion of hormones during the culture of human preimplantation embryos with corona cells
108. Increased uterine receptivity by decreasing estradiol levels during the preimplantation period in high responder patients by using an FSH step-down regimen
109. Early pregnancy losses in vitro fertilization and oocyte donation
110. Placental proteins in the diagnosis and evaluation of the 'elusive' early pregnancy
111. Time to pregnancy and semen parameters: A cross-sectional study among fertile couples from four European cities
112. Assembly of microarrays for genome-wide measurement of DNA copy number
113. The relationship between hCG and relaxin secretion in normal pregnancies vs. peri-implantation spontaneous abortions
114. Serum levels of pregnancy-specific beta 1-glycoprotein (SP1) and human chorionic gonadotropin (beta-hCG) in women using an intrauterine device
115. Factors that affect outcome of in-vitro fertilisation treatment
116. Ovarian stimulation protocol for in-vitro fertilization with gonadotropin-releasing hormone agonist widens the implantation window
117. A radioimmunoassay which specifically measures human chorionic gonadotropin in the presence of luteinizing hormone
118. Delaying childbearing: Effect of age on fecundity and outcome of pregnancy
119. Correlation between semen parameters and sperm aneuploidy rates investigated by fluorescence in-situ hybridization in infertile men
120. Karyotyping of human oocytes by chromosomal analysis of the second polar bodies
121. Is there a place for preimplantation genetic diagnosis screening in recurrent miscarriage patients?
122. Chromosome analysis of blatomeres from human embryos by using comparative genomic hybridization
123. Occult biochemical pregnancy: Fact or fiction?
124. Improved monitoring of gestational trophoblastic neoplasia using a highly sensitive assay for urinary human chorionic gonadotropin
125. Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genome hybridization
126. Histological and histochemical observations on the corpus lutea associated with early normal and abnormal ova
127. Unsuspected pregnancy loss in healthy women
128. Measuring early pregnancy loss: Laboratory and field methods
129. Incidence of early loss of pregnancy
130. Time of implantation of the conceptus and loss of pregnancy
131. Birth of a healthy infant after preimplantation confirmation of euploidy by comparative genomic hybridization
132. The presence of chorionic gonadotrophin β subunit in normal cyclic human endometrium
133. Early pregnancy loss in in vitro fertilization (IVF) is a positive predictor of subsequent IVF success
134. The prognostic value of hCG, PAPP-A, E2 and P in the early human pregnancy
135. Estimates of human fertility and pregnancy loss