The future therapeutic potential of histone demethylases: A critical analysis

Current Opinion in Drug Discovery and Development

Volumn 12, Issue 5, 2009, Pages 607-615

  Natoli, Gioacchino ^a   Testa, Giuseppe ^a   De Santa, Francesca ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

Author keywords

Histone demethylation; Histone methylation; Hydroxylation; JmjC domain; Substrate specificity; Transcription

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; HISTONE; JMJC PROTEIN; LYSINE; MIXED LINEAGE LEUKEMIA PROTEIN; PROTEIN; PROTEIN P19; UNCLASSIFIED DRUG;

CANCER INHIBITION; CELL PROLIFERATION; DEMETHYLATION; ENZYME ACTIVITY; EPIGENETICS; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; METHYLATION; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SPERMATOGENESIS; X LINKED MENTAL RETARDATION;

ANIMALS; DEALKYLATION; DRUG DESIGN; DRUG DISCOVERY; ENZYME INHIBITORS; EPIGENESIS, GENETIC; HISTONE DEMETHYLASES; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; LYSINE; METHYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STABILITY; SUBSTRATE SPECIFICITY; TRANSCRIPTION, GENETIC;

EID: 70149103553     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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