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Volumn 39, Issue 2, 2012, Pages 137-144

Current understanding and management of nasopharyngeal carcinoma

Author keywords

Chemotherapy; Epstein Barr virus; LMP1; Molecular targeting therapy; Nasopharyngeal carcinoma; Radiotherapy

Indexed keywords

BLEOMYCIN; CISPLATIN; EPIRUBICIN; FLUOROURACIL; PROTEIN P16; PROTEIN P53; VIRUS ANTIBODY;

EID: 84856744853     PISSN: 03858146     EISSN: 18791476     Source Type: Journal    
DOI: 10.1016/j.anl.2011.02.012     Document Type: Review
Times cited : (114)

References (89)
  • 1
    • 0003509335 scopus 로고    scopus 로고
    • IARC Scientific Publications No. 155. IARC, D.M. Parkin, S.L. Whelan, J. Ferlay, L. Teppo, D.B. Thomas (Eds.)
    • Cancer incidence in five continents, Vol. VIII 2002, IARC Scientific Publications No. 155. IARC. D.M. Parkin, S.L. Whelan, J. Ferlay, L. Teppo, D.B. Thomas (Eds.).
    • (2002) Cancer incidence in five continents, Vol. VIII
  • 3
    • 0017695014 scopus 로고
    • Nasopharyngeal cancer in Greenland. The incidence in an Arctic Eskimo population
    • Nielsen N.H., Mikkelsen F., Hansen J.P. Nasopharyngeal cancer in Greenland. The incidence in an Arctic Eskimo population. Acta Pathol Microbiol Scand A 1977, 85:850-858.
    • (1977) Acta Pathol Microbiol Scand A , vol.85 , pp. 850-858
    • Nielsen, N.H.1    Mikkelsen, F.2    Hansen, J.P.3
  • 4
    • 0021994192 scopus 로고
    • Nasopharyngeal carcinoma: an evaluation of 134 patients treated between 1971-1980
    • Dickson R.I., Flores A.D. Nasopharyngeal carcinoma: an evaluation of 134 patients treated between 1971-1980. Laryngoscope 1985, 95:276-283.
    • (1985) Laryngoscope , vol.95 , pp. 276-283
    • Dickson, R.I.1    Flores, A.D.2
  • 5
    • 0016189478 scopus 로고
    • The effect of migration on the risk of nasopharyngeal cancer among Chinese
    • Buell P. The effect of migration on the risk of nasopharyngeal cancer among Chinese. Cancer Res 1974, 34:1189-1191.
    • (1974) Cancer Res , vol.34 , pp. 1189-1191
    • Buell, P.1
  • 6
    • 0023126843 scopus 로고
    • The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA
    • Raab-Traub N., Flynn K., Pearson G., Huang A., Levine P., Lanier A., et al. The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA. Int J Cancer 1987, 39:25-29.
    • (1987) Int J Cancer , vol.39 , pp. 25-29
    • Raab-Traub, N.1    Flynn, K.2    Pearson, G.3    Huang, A.4    Levine, P.5    Lanier, A.6
  • 7
    • 0018241546 scopus 로고
    • Histological typing of nasopharyngeal carcinoma
    • Shanmugaratnam K. Histological typing of nasopharyngeal carcinoma. IARC Sci Publ 1978, 3-12.
    • (1978) IARC Sci Publ , pp. 3-12
    • Shanmugaratnam, K.1
  • 8
    • 0018183888 scopus 로고
    • Proposal for a new histopathological classification of the carcinomas of the nasopharynx
    • Micheau C., Rilke F., Pilotti S. Proposal for a new histopathological classification of the carcinomas of the nasopharynx. Tumori 1978, 64:513-518.
    • (1978) Tumori , vol.64 , pp. 513-518
    • Micheau, C.1    Rilke, F.2    Pilotti, S.3
  • 10
    • 0032147260 scopus 로고    scopus 로고
    • The National Cancer Data Base report on the relationship of race and national origin to the histology of nasopharyngeal carcinoma
    • Marks J.E., Phillips J.L., Menck H.R. The National Cancer Data Base report on the relationship of race and national origin to the histology of nasopharyngeal carcinoma. Cancer 1998, 83:582-588.
    • (1998) Cancer , vol.83 , pp. 582-588
    • Marks, J.E.1    Phillips, J.L.2    Menck, H.R.3
  • 11
    • 0002358470 scopus 로고    scopus 로고
    • Nasopharyngeal carcinoma: classification and histological appearances
    • Nicholls J.M. Nasopharyngeal carcinoma: classification and histological appearances. Adv Anat Pathol 1997, 4:71-84.
    • (1997) Adv Anat Pathol , vol.4 , pp. 71-84
    • Nicholls, J.M.1
  • 12
    • 0020701568 scopus 로고
    • Application of Epstein-Barr virus (EBV) serology to the diagnosis of North American nasopharyngeal carcinoma
    • Pearson G.R., Weiland L.H., Neel H.B., Taylor W., Earle J., Mulroney S.E., et al. Application of Epstein-Barr virus (EBV) serology to the diagnosis of North American nasopharyngeal carcinoma. Cancer 1983, 51:260-268.
    • (1983) Cancer , vol.51 , pp. 260-268
    • Pearson, G.R.1    Weiland, L.H.2    Neel, H.B.3    Taylor, W.4    Earle, J.5    Mulroney, S.E.6
  • 13
    • 0029051898 scopus 로고
    • Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma
    • Pathmanathan R., Prasad U., Sadler R., Flynn K., Raab-Traub N. Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma. N Engl J Med 1995, 333:693-698.
    • (1995) N Engl J Med , vol.333 , pp. 693-698
    • Pathmanathan, R.1    Prasad, U.2    Sadler, R.3    Flynn, K.4    Raab-Traub, N.5
  • 14
    • 0034307317 scopus 로고    scopus 로고
    • High frequency of chromosome 3p deletion in histologically normal nasopharyngeal epithelia from southern Chinese
    • Chan A.S., To K.F., Lo K.W., Mak K.F., Pak W., Chiu B., et al. High frequency of chromosome 3p deletion in histologically normal nasopharyngeal epithelia from southern Chinese. Cancer Res 2000, 60:5365-5370.
    • (2000) Cancer Res , vol.60 , pp. 5365-5370
    • Chan, A.S.1    To, K.F.2    Lo, K.W.3    Mak, K.F.4    Pak, W.5    Chiu, B.6
  • 15
    • 0036433743 scopus 로고    scopus 로고
    • Genetic and epigenetic changes in nasopharyngeal carcinoma
    • Lo K.W., Huang D.P. Genetic and epigenetic changes in nasopharyngeal carcinoma. Semin Cancer Biol 2002, 12:451-462.
    • (2002) Semin Cancer Biol , vol.12 , pp. 451-462
    • Lo, K.W.1    Huang, D.P.2
  • 16
    • 0030938591 scopus 로고    scopus 로고
    • Detection of Epstein-Barr virus in nasopharyngeal carcinoma by in situ hybridization and polymerase chain reaction
    • Murono S., Yoshizaki T., Tanaka S., Takeshita H., Park C.S., Furukawa M. Detection of Epstein-Barr virus in nasopharyngeal carcinoma by in situ hybridization and polymerase chain reaction. Laryngoscope 1997, 107:523-526.
    • (1997) Laryngoscope , vol.107 , pp. 523-526
    • Murono, S.1    Yoshizaki, T.2    Tanaka, S.3    Takeshita, H.4    Park, C.S.5    Furukawa, M.6
  • 17
    • 33846392944 scopus 로고    scopus 로고
    • Oncogenic role of Epstein-Barr virus-encoded small RNAs (EBERs) in nasopharyngeal carcinoma
    • Yoshizaki T., Endo K., Ren Q., Wakisaka N., Murono S., Kondo S., et al. Oncogenic role of Epstein-Barr virus-encoded small RNAs (EBERs) in nasopharyngeal carcinoma. Auris Nasus Larynx 2007, 34:73-78.
    • (2007) Auris Nasus Larynx , vol.34 , pp. 73-78
    • Yoshizaki, T.1    Endo, K.2    Ren, Q.3    Wakisaka, N.4    Murono, S.5    Kondo, S.6
  • 19
    • 0032584221 scopus 로고    scopus 로고
    • The expression of matrix metalloproteinase 9 is enhanced by Epstein-Barr virus latent membrane protein 1
    • Yoshizaki T., Sato H., Furukawa M., Pagano J.S. The expression of matrix metalloproteinase 9 is enhanced by Epstein-Barr virus latent membrane protein 1. Proc Natl Acad Sci U S A 1998, 95:3621-3626.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 3621-3626
    • Yoshizaki, T.1    Sato, H.2    Furukawa, M.3    Pagano, J.S.4
  • 20
    • 0033391997 scopus 로고    scopus 로고
    • Matrix metalloproteinase 9 is induced by the Epstein-Barr virus BZLF1 transactivator
    • Yoshizaki T., Sato H., Murono S., Pagano J.S., Furukawa M. Matrix metalloproteinase 9 is induced by the Epstein-Barr virus BZLF1 transactivator. Clin Exp Metastasis 1999, 17:431-436.
    • (1999) Clin Exp Metastasis , vol.17 , pp. 431-436
    • Yoshizaki, T.1    Sato, H.2    Murono, S.3    Pagano, J.S.4    Furukawa, M.5
  • 21
    • 0034781792 scopus 로고    scopus 로고
    • Induction of interleukin-8 by Epstein-Barr virus latent membrane protein-1 and its correlation to angiogenesis in nasopharyngeal carcinoma
    • Yoshizaki T., Horikawa T., Qing-Chun R., Wakisaka N., Takeshita H., Sheen T.S., et al. Induction of interleukin-8 by Epstein-Barr virus latent membrane protein-1 and its correlation to angiogenesis in nasopharyngeal carcinoma. Clin Cancer Res 2001, 7:1946-1951.
    • (2001) Clin Cancer Res , vol.7 , pp. 1946-1951
    • Yoshizaki, T.1    Horikawa, T.2    Qing-Chun, R.3    Wakisaka, N.4    Takeshita, H.5    Sheen, T.S.6
  • 22
    • 18644368754 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinoma
    • Kondo S., Wakisaka N., Schell M.J., Horikawa T., Sheen T.S., Sato H., et al. Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinoma. Int J Cancer 2005, 115:368-376.
    • (2005) Int J Cancer , vol.115 , pp. 368-376
    • Kondo, S.1    Wakisaka, N.2    Schell, M.J.3    Horikawa, T.4    Sheen, T.S.5    Sato, H.6
  • 23
    • 33750537081 scopus 로고    scopus 로고
    • EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1alpha through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells
    • Kondo S., Seo S.Y., Yoshizaki T., Wakisaka N., Furukawa M., Joab I., et al. EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1alpha through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells. Cancer Res 2006, 66:9870-9877.
    • (2006) Cancer Res , vol.66 , pp. 9870-9877
    • Kondo, S.1    Seo, S.Y.2    Yoshizaki, T.3    Wakisaka, N.4    Furukawa, M.5    Joab, I.6
  • 24
    • 64949141535 scopus 로고    scopus 로고
    • Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration
    • Endo K., Kondo S., Shackleford J., Horikawa T., Kitagawa N., Yoshizaki T., et al. Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration. Oncogene 2009, 28:1725-1735.
    • (2009) Oncogene , vol.28 , pp. 1725-1735
    • Endo, K.1    Kondo, S.2    Shackleford, J.3    Horikawa, T.4    Kitagawa, N.5    Yoshizaki, T.6
  • 25
    • 79151476551 scopus 로고    scopus 로고
    • Epidemiological analysis of nasopharyngeal carcinoma in the central region of Japan during the period from 1996 to 2005
    • Kimura Y., Suzuki D., Tokunaga T., Takabayashi T., Yamada T., Wakisaka N., et al. Epidemiological analysis of nasopharyngeal carcinoma in the central region of Japan during the period from 1996 to 2005. Auris Nasus Larynx 2010.
    • (2010) Auris Nasus Larynx
    • Kimura, Y.1    Suzuki, D.2    Tokunaga, T.3    Takabayashi, T.4    Yamada, T.5    Wakisaka, N.6
  • 26
    • 0037399623 scopus 로고    scopus 로고
    • The p53 network in head and neck cancer
    • Gasco M., Crook T. The p53 network in head and neck cancer. Oral Oncol 2003, 39:222-231.
    • (2003) Oral Oncol , vol.39 , pp. 222-231
    • Gasco, M.1    Crook, T.2
  • 27
    • 16244408015 scopus 로고    scopus 로고
    • Expression of p53 protein and primary tumour volume in patients with nasopharyngeal carcinoma
    • Chen M.K., Lee H.S., Chang J.H., Chang C.C. Expression of p53 protein and primary tumour volume in patients with nasopharyngeal carcinoma. J Otolaryngol 2004, 33:304-307.
    • (2004) J Otolaryngol , vol.33 , pp. 304-307
    • Chen, M.K.1    Lee, H.S.2    Chang, J.H.3    Chang, C.C.4
  • 28
    • 10044262203 scopus 로고    scopus 로고
    • MDM2 expression in EBV-infected nasopharyngeal carcinoma cells
    • Wu H.C., Lu T.Y., Lee J.J., Hwang J.K., Lin Y.J., Wang C.K., et al. MDM2 expression in EBV-infected nasopharyngeal carcinoma cells. Lab Invest 2004, 84:1547-1556.
    • (2004) Lab Invest , vol.84 , pp. 1547-1556
    • Wu, H.C.1    Lu, T.Y.2    Lee, J.J.3    Hwang, J.K.4    Lin, Y.J.5    Wang, C.K.6
  • 29
    • 22344443201 scopus 로고    scopus 로고
    • Involvement of the Epstein-Barr virus in the nasopharyngeal carcinoma pathogenesis
    • Burgos J.S. Involvement of the Epstein-Barr virus in the nasopharyngeal carcinoma pathogenesis. Med Oncol 2005, 22:113-121.
    • (2005) Med Oncol , vol.22 , pp. 113-121
    • Burgos, J.S.1
  • 30
    • 0033029244 scopus 로고    scopus 로고
    • Association of Epstein-Barr virus infection with p53 protein accumulation but not bcl-2 protein in nasopharyngeal carcinoma
    • Murono S., Yoshizaki T., Park C.S., Furukawa M. Association of Epstein-Barr virus infection with p53 protein accumulation but not bcl-2 protein in nasopharyngeal carcinoma. Histopathology 1999, 34:432-438.
    • (1999) Histopathology , vol.34 , pp. 432-438
    • Murono, S.1    Yoshizaki, T.2    Park, C.S.3    Furukawa, M.4
  • 31
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang Y., Xiong Y., Yarbrough W.G. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998, 92:725-734.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 32
    • 0032161624 scopus 로고    scopus 로고
    • P63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    • Yang A., Kaghad M., Wang Y., Gillett E., Fleming M.D., Dotsch V., et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 1998, 2:305-316.
    • (1998) Mol Cell , vol.2 , pp. 305-316
    • Yang, A.1    Kaghad, M.2    Wang, Y.3    Gillett, E.4    Fleming, M.D.5    Dotsch, V.6
  • 33
    • 0034644195 scopus 로고    scopus 로고
    • High level expression of deltaN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?
    • Crook T., Nicholls J.M., Brooks L., O'Nions J., Allday M.J. High level expression of deltaN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?. Oncogene 2000, 19:3439-3444.
    • (2000) Oncogene , vol.19 , pp. 3439-3444
    • Crook, T.1    Nicholls, J.M.2    Brooks, L.3    O'Nions, J.4    Allday, M.J.5
  • 34
    • 0033969883 scopus 로고    scopus 로고
    • Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner
    • Potapova O., Gorospe M., Dougherty R.H., Dean N.M., Gaarde W.A., Holbrook N.J. Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner. Mol Cell Biol 2000, 20:1713-1722.
    • (2000) Mol Cell Biol , vol.20 , pp. 1713-1722
    • Potapova, O.1    Gorospe, M.2    Dougherty, R.H.3    Dean, N.M.4    Gaarde, W.A.5    Holbrook, N.J.6
  • 35
    • 3242703867 scopus 로고    scopus 로고
    • Cooperative interactions among p53, bcl-2 and Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma cells
    • Sheu L.F., Chen A., Lee H.S., Hsu H.Y., Yu D.S. Cooperative interactions among p53, bcl-2 and Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma cells. Pathol Int 2004, 54:475-485.
    • (2004) Pathol Int , vol.54 , pp. 475-485
    • Sheu, L.F.1    Chen, A.2    Lee, H.S.3    Hsu, H.Y.4    Yu, D.S.5
  • 36
    • 0033955571 scopus 로고    scopus 로고
    • Absence of nuclear p16 from Epstein-Barr virus-associated undifferentiated nasopharyngeal carcinomas
    • Shibosawa E., Tsutsumi K., Koizuka I., Hoshikawa M., Takakuwa T. Absence of nuclear p16 from Epstein-Barr virus-associated undifferentiated nasopharyngeal carcinomas. Laryngoscope 2000, 110:93-97.
    • (2000) Laryngoscope , vol.110 , pp. 93-97
    • Shibosawa, E.1    Tsutsumi, K.2    Koizuka, I.3    Hoshikawa, M.4    Takakuwa, T.5
  • 37
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg R.A. The retinoblastoma protein and cell cycle control. Cell 1995, 81:323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 38
    • 0032887604 scopus 로고    scopus 로고
    • Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implications
    • El-Naggar A.K., Lai S., Clayman G.L., Zhou J.H., Tucker S.A., Myers J., et al. Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implications. Hum Pathol 1999, 30:1013-1018.
    • (1999) Hum Pathol , vol.30 , pp. 1013-1018
    • El-Naggar, A.K.1    Lai, S.2    Clayman, G.L.3    Zhou, J.H.4    Tucker, S.A.5    Myers, J.6
  • 39
    • 0031919421 scopus 로고    scopus 로고
    • Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product
    • Gulley M.L., Nicholls J.M., Schneider B.G., Amin M.B., Ro J.Y., Geradts J. Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product. Am J Pathol 1998, 152:865-869.
    • (1998) Am J Pathol , vol.152 , pp. 865-869
    • Gulley, M.L.1    Nicholls, J.M.2    Schneider, B.G.3    Amin, M.B.4    Ro, J.Y.5    Geradts, J.6
  • 40
    • 9444255067 scopus 로고    scopus 로고
    • High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma
    • Reed A.L., Califano J., Cairns P., Westra W.H., Jones R.M., Koch W., et al. High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res 1996, 56:3630-3633.
    • (1996) Cancer Res , vol.56 , pp. 3630-3633
    • Reed, A.L.1    Califano, J.2    Cairns, P.3    Westra, W.H.4    Jones, R.M.5    Koch, W.6
  • 41
    • 3142618391 scopus 로고    scopus 로고
    • Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein-Barr virus encoded latent membrane protein 1
    • Song X., Tao Y.G., Deng X.Y., Jin X., Tan Y.N., Tang M., et al. Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein-Barr virus encoded latent membrane protein 1. Cell Signal 2004, 16:1153-1162.
    • (2004) Cell Signal , vol.16 , pp. 1153-1162
    • Song, X.1    Tao, Y.G.2    Deng, X.Y.3    Jin, X.4    Tan, Y.N.5    Tang, M.6
  • 42
    • 0043174021 scopus 로고    scopus 로고
    • Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5
    • Ohtani N., Brennan P., Gaubatz S., Sanij E., Hertzog P., Wolvetang E., et al. Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5. J Cell Biol 2003, 162:173-183.
    • (2003) J Cell Biol , vol.162 , pp. 173-183
    • Ohtani, N.1    Brennan, P.2    Gaubatz, S.3    Sanij, E.4    Hertzog, P.5    Wolvetang, E.6
  • 43
    • 0037089689 scopus 로고    scopus 로고
    • E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex
    • Rayman J.B., Takahashi Y., Indjeian V.B., Dannenberg J.H., Catchpole S., Watson R.J., et al. E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex. Genes Dev 2002, 16:933-947.
    • (2002) Genes Dev , vol.16 , pp. 933-947
    • Rayman, J.B.1    Takahashi, Y.2    Indjeian, V.B.3    Dannenberg, J.H.4    Catchpole, S.5    Watson, R.J.6
  • 44
    • 0036668666 scopus 로고    scopus 로고
    • Loss of cyclin D1 and p16 expression correlates with local recurrence in nasopharyngeal carcinoma following radiotherapy
    • Hwang C.F., Cho C.L., Huang C.C., Wang J.S., Shih Y.L., Su C.Y., et al. Loss of cyclin D1 and p16 expression correlates with local recurrence in nasopharyngeal carcinoma following radiotherapy. Ann Oncol 2002, 13:1246-1251.
    • (2002) Ann Oncol , vol.13 , pp. 1246-1251
    • Hwang, C.F.1    Cho, C.L.2    Huang, C.C.3    Wang, J.S.4    Shih, Y.L.5    Su, C.Y.6
  • 45
    • 0037838642 scopus 로고    scopus 로고
    • Loss of p16 expression has prognostic significance in human nasopharyngeal carcinoma
    • Makitie A.A., MacMillan C., Ho J., Shi W., Lee A., O'Sullivan B., et al. Loss of p16 expression has prognostic significance in human nasopharyngeal carcinoma. Clin Cancer Res 2003, 9:2177-2184.
    • (2003) Clin Cancer Res , vol.9 , pp. 2177-2184
    • Makitie, A.A.1    MacMillan, C.2    Ho, J.3    Shi, W.4    Lee, A.5    O'Sullivan, B.6
  • 46
    • 0032759897 scopus 로고    scopus 로고
    • Inhibiting tumorigenic potential by restoration of p16 in nasopharyngeal carcinoma
    • Wang G.L., Lo K.W., Tsang K.S., Chung N.Y., Tsang Y.S., Cheung S.T., et al. Inhibiting tumorigenic potential by restoration of p16 in nasopharyngeal carcinoma. Br J Cancer 1999, 81:1122-1126.
    • (1999) Br J Cancer , vol.81 , pp. 1122-1126
    • Wang, G.L.1    Lo, K.W.2    Tsang, K.S.3    Chung, N.Y.4    Tsang, Y.S.5    Cheung, S.T.6
  • 47
    • 0033638303 scopus 로고    scopus 로고
    • Clinical evaluation of staging system for nasopharyngeal carcinoma: comparison of fourth and fifth editions of UICC TNM classification
    • Tatsumi-Tamori A., Yoshizaki T., Miwa T., Furukawa M. Clinical evaluation of staging system for nasopharyngeal carcinoma: comparison of fourth and fifth editions of UICC TNM classification. Ann Otol Rhinol Laryngol 2000, 109:1125-1129.
    • (2000) Ann Otol Rhinol Laryngol , vol.109 , pp. 1125-1129
    • Tatsumi-Tamori, A.1    Yoshizaki, T.2    Miwa, T.3    Furukawa, M.4
  • 49
    • 0036786846 scopus 로고    scopus 로고
    • The effect of primary tumor volumes in advanced T-staged nasopharyngeal tumors
    • Chang C.C., Chen M.K., Liu M.T., Wu H.K. The effect of primary tumor volumes in advanced T-staged nasopharyngeal tumors. Head Neck 2002, 24:940-946.
    • (2002) Head Neck , vol.24 , pp. 940-946
    • Chang, C.C.1    Chen, M.K.2    Liu, M.T.3    Wu, H.K.4
  • 50
    • 2542583455 scopus 로고    scopus 로고
    • Primary tumor volume of nasopharyngeal carcinoma: prognostic significance for local control
    • Sze W.M., Lee A.W., Yau T.K., Yeung R.M., Lau K.Y., Leung S.K., et al. Primary tumor volume of nasopharyngeal carcinoma: prognostic significance for local control. Int J Radiat Oncol Biol Phys 2004, 59:21-27.
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , pp. 21-27
    • Sze, W.M.1    Lee, A.W.2    Yau, T.K.3    Yeung, R.M.4    Lau, K.Y.5    Leung, S.K.6
  • 51
    • 0034750027 scopus 로고    scopus 로고
    • Quantitative analysis of Epstein-Barr virus DNA in plasma and serum: applications to tumor detection and monitoring
    • Lo Y.M. Quantitative analysis of Epstein-Barr virus DNA in plasma and serum: applications to tumor detection and monitoring. Ann N Y Acad Sci 2001, 945:68-72.
    • (2001) Ann N Y Acad Sci , vol.945 , pp. 68-72
    • Lo, Y.M.1
  • 52
    • 0026720425 scopus 로고
    • Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976-1985: overall survival and patterns of failure
    • Lee A.W., Poon Y.F., Foo W., Law S.C., Cheung F.K., Chan D.K., et al. Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976-1985: overall survival and patterns of failure. Int J Radiat Oncol Biol Phys 1992, 23:261-270.
    • (1992) Int J Radiat Oncol Biol Phys , vol.23 , pp. 261-270
    • Lee, A.W.1    Poon, Y.F.2    Foo, W.3    Law, S.C.4    Cheung, F.K.5    Chan, D.K.6
  • 53
    • 0026101465 scopus 로고
    • Improved local control of nasopharyngeal carcinoma after intracavitary brachytherapy boost
    • Wang C.C. Improved local control of nasopharyngeal carcinoma after intracavitary brachytherapy boost. Am J Clin Oncol 1991, 14:5-8.
    • (1991) Am J Clin Oncol , vol.14 , pp. 5-8
    • Wang, C.C.1
  • 54
    • 0030929185 scopus 로고    scopus 로고
    • The effect of interruptions and prolonged treatment time in radiotherapy for nasopharyngeal carcinoma
    • Kwong D.L., Sham J.S., Chua D.T., Choy D.T., Au G.K., Wu P.M. The effect of interruptions and prolonged treatment time in radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 1997, 39:703-710.
    • (1997) Int J Radiat Oncol Biol Phys , vol.39 , pp. 703-710
    • Kwong, D.L.1    Sham, J.S.2    Chua, D.T.3    Choy, D.T.4    Au, G.K.5    Wu, P.M.6
  • 55
    • 0024816501 scopus 로고
    • Treatment of stage I nasopharyngeal carcinoma: analysis of the patterns of relapse and the results of withholding elective neck irradiation
    • Lee A.W., Sham J.S., Poon Y.F., Ho J.H. Treatment of stage I nasopharyngeal carcinoma: analysis of the patterns of relapse and the results of withholding elective neck irradiation. Int J Radiat Oncol Biol Phys 1989, 17:1183-1190.
    • (1989) Int J Radiat Oncol Biol Phys , vol.17 , pp. 1183-1190
    • Lee, A.W.1    Sham, J.S.2    Poon, Y.F.3    Ho, J.H.4
  • 56
    • 0027939102 scopus 로고
    • The effect of loco-regional control on distant metastatic dissemination in carcinoma of the nasopharynx: an analysis of 1301 patients
    • Kwong D., Sham J., Choy D. The effect of loco-regional control on distant metastatic dissemination in carcinoma of the nasopharynx: an analysis of 1301 patients. Int J Radiat Oncol Biol Phys 1994, 30:1029-1036.
    • (1994) Int J Radiat Oncol Biol Phys , vol.30 , pp. 1029-1036
    • Kwong, D.1    Sham, J.2    Choy, D.3
  • 58
    • 0038724758 scopus 로고    scopus 로고
    • Improved local control with stereotactic radiosurgical boost in patients with nasopharyngeal carcinoma
    • Le Q.T., Tate D., Koong A., Gibbs I.C., Chang S.D., Adler J.R., et al. Improved local control with stereotactic radiosurgical boost in patients with nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2003, 56:1046-1054.
    • (2003) Int J Radiat Oncol Biol Phys , vol.56 , pp. 1046-1054
    • Le, Q.T.1    Tate, D.2    Koong, A.3    Gibbs, I.C.4    Chang, S.D.5    Adler, J.R.6
  • 59
    • 0037403120 scopus 로고    scopus 로고
    • Linear accelerator-based stereotactic radiosurgery for limited, locally persistent, and recurrent nasopharyngeal carcinoma: efficacy and complications
    • Chua D.T., Sham J.S., Kwong P.W., Hung K.N., Leung L.H. Linear accelerator-based stereotactic radiosurgery for limited, locally persistent, and recurrent nasopharyngeal carcinoma: efficacy and complications. Int J Radiat Oncol Biol Phys 2003, 56:177-183.
    • (2003) Int J Radiat Oncol Biol Phys , vol.56 , pp. 177-183
    • Chua, D.T.1    Sham, J.S.2    Kwong, P.W.3    Hung, K.N.4    Leung, L.H.5
  • 60
    • 0347388016 scopus 로고    scopus 로고
    • Limitation of conventional two dimensional radiation therapy planning in nasopharyngeal carcinoma
    • Waldron J., Tin M.M., Keller A., Lum C., Japp B., Sellmann S., et al. Limitation of conventional two dimensional radiation therapy planning in nasopharyngeal carcinoma. Radiother Oncol 2003, 68:153-161.
    • (2003) Radiother Oncol , vol.68 , pp. 153-161
    • Waldron, J.1    Tin, M.M.2    Keller, A.3    Lum, C.4    Japp, B.5    Sellmann, S.6
  • 61
    • 0035917934 scopus 로고    scopus 로고
    • Comparison of intensity modulated radiation therapy (IMRT) treatment techniques for nasopharyngeal carcinoma
    • Cheng J.C., Chao K.S., Low D. Comparison of intensity modulated radiation therapy (IMRT) treatment techniques for nasopharyngeal carcinoma. Int J Cancer 2001, 96:126-131.
    • (2001) Int J Cancer , vol.96 , pp. 126-131
    • Cheng, J.C.1    Chao, K.S.2    Low, D.3
  • 62
    • 1642389377 scopus 로고    scopus 로고
    • Comparison of clinical and molecular surveillance in patients with advanced nasopharyngeal carcinoma after primary therapy: the potential role of quantitative analysis of circulating Epstein-Barr virus DNA
    • Hong R.L., Lin C.Y., Ting L.L., Ko J.Y., Hsu M.M. Comparison of clinical and molecular surveillance in patients with advanced nasopharyngeal carcinoma after primary therapy: the potential role of quantitative analysis of circulating Epstein-Barr virus DNA. Cancer 2004, 100:1429-1437.
    • (2004) Cancer , vol.100 , pp. 1429-1437
    • Hong, R.L.1    Lin, C.Y.2    Ting, L.L.3    Ko, J.Y.4    Hsu, M.M.5
  • 63
    • 4844223514 scopus 로고    scopus 로고
    • Intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: a prospective study on disease control and preservation of salivary function
    • Kwong D.L., Pow E.H., Sham J.S., McMillan A.S., Leung L.H., Leung W.K., et al. Intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: a prospective study on disease control and preservation of salivary function. Cancer 2004, 101:1584-1593.
    • (2004) Cancer , vol.101 , pp. 1584-1593
    • Kwong, D.L.1    Pow, E.H.2    Sham, J.S.3    McMillan, A.S.4    Leung, L.H.5    Leung, W.K.6
  • 64
    • 30544442262 scopus 로고    scopus 로고
    • Preliminary results of radiation dose escalation for locally advanced nasopharyngeal carcinoma
    • Kwong D.L., Sham J.S., Leung L.H., Cheng A.C., Ng W.M., Kwong P.W., et al. Preliminary results of radiation dose escalation for locally advanced nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2006, 64:374-381.
    • (2006) Int J Radiat Oncol Biol Phys , vol.64 , pp. 374-381
    • Kwong, D.L.1    Sham, J.S.2    Leung, L.H.3    Cheng, A.C.4    Ng, W.M.5    Kwong, P.W.6
  • 65
    • 36849010786 scopus 로고    scopus 로고
    • Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients
    • Kam M.K., Leung S.F., Zee B., Chau R.M., Suen J.J., Mo F., et al. Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients. J Clin Oncol 2007, 25:4873-4879.
    • (2007) J Clin Oncol , vol.25 , pp. 4873-4879
    • Kam, M.K.1    Leung, S.F.2    Zee, B.3    Chau, R.M.4    Suen, J.J.5    Mo, F.6
  • 66
    • 33746353435 scopus 로고    scopus 로고
    • Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: results of a prospective longitudinal study
    • McMillan A.S., Pow E.H., Kwong D.L., Wong M.C., Sham J.S., Leung L.H., et al. Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: results of a prospective longitudinal study. Head Neck 2006, 28:712-722.
    • (2006) Head Neck , vol.28 , pp. 712-722
    • McMillan, A.S.1    Pow, E.H.2    Kwong, D.L.3    Wong, M.C.4    Sham, J.S.5    Leung, L.H.6
  • 67
    • 68949083598 scopus 로고    scopus 로고
    • Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225
    • Lee N., Harris J., Garden A.S., Straube W., Glisson B., Xia P., et al. Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225. J Clin Oncol 2009, 27:3684-3690.
    • (2009) J Clin Oncol , vol.27 , pp. 3684-3690
    • Lee, N.1    Harris, J.2    Garden, A.S.3    Straube, W.4    Glisson, B.5    Xia, P.6
  • 68
    • 0029589624 scopus 로고
    • A retrospective study of the use of cisplatinum-5-fluorouracil neoadjuvant chemotherapy in cervical-node-positive nasopharyngeal carcinoma (NPC)
    • Teo P.M., Leung T.W., Chan A.T., Yu P., Lee W.Y., Leung S.F., et al. A retrospective study of the use of cisplatinum-5-fluorouracil neoadjuvant chemotherapy in cervical-node-positive nasopharyngeal carcinoma (NPC). Eur J Cancer B Oral Oncol 1995, 31B:373-379.
    • (1995) Eur J Cancer B Oral Oncol , vol.31 B , pp. 373-379
    • Teo, P.M.1    Leung, T.W.2    Chan, A.T.3    Yu, P.4    Lee, W.Y.5    Leung, S.F.6
  • 69
    • 0344915699 scopus 로고    scopus 로고
    • Preliminary results of a randomized trial comparing neoadjuvant chemotherapy (cisplatin, epirubicin, bleomycin) plus radiotherapy vs
    • radiotherapy alone in stage IV(> or =N2, M0) undifferentiated nasopharyngeal carcinoma: a positive effect on progres sion-free survival. International Nasopharynx Cancer Study Group. VUMCA I trial. Int J Radiat Oncol Biol Phys.
    • Preliminary results of a randomized trial comparing neoadjuvant chemotherapy (cisplatin, epirubicin, bleomycin) plus radiotherapy vs. radiotherapy alone in stage IV(> or =N2, M0) undifferentiated nasopharyngeal carcinoma: a positive effect on progression-free survival. International Nasopharynx Cancer Study Group. VUMCA I trial. Int J Radiat Oncol Biol Phys. 1996;35:463-9.
    • (1996) , vol.35 , pp. 463-9
  • 70
    • 0030471349 scopus 로고    scopus 로고
    • Does induction chemotherapy have a role in the management of nasopharyngeal carcinoma? Results of treatment in the era of computerized tomography
    • Garden A.S., Lippman S.M., Morrison W.H., Glisson B.S., Ang K.K., Geara F., et al. Does induction chemotherapy have a role in the management of nasopharyngeal carcinoma? Results of treatment in the era of computerized tomography. Int J Radiat Oncol Biol Phys 1996, 36:1005-1012.
    • (1996) Int J Radiat Oncol Biol Phys , vol.36 , pp. 1005-1012
    • Garden, A.S.1    Lippman, S.M.2    Morrison, W.H.3    Glisson, B.S.4    Ang, K.K.5    Geara, F.6
  • 71
    • 0024274529 scopus 로고
    • Adjuvant chemotherapy with vincristine, cyclophosphamide, and doxorubicin after radiotherapy in local-regional nasopharyngeal cancer: results of a 4-year multicenter randomized study
    • Rossi A., Molinari R., Boracchi P., Del Vecchio M., Marubini E., Nava M., et al. Adjuvant chemotherapy with vincristine, cyclophosphamide, and doxorubicin after radiotherapy in local-regional nasopharyngeal cancer: results of a 4-year multicenter randomized study. J Clin Oncol 1988, 6:1401-1410.
    • (1988) J Clin Oncol , vol.6 , pp. 1401-1410
    • Rossi, A.1    Molinari, R.2    Boracchi, P.3    Del Vecchio, M.4    Marubini, E.5    Nava, M.6
  • 72
    • 0028840284 scopus 로고
    • A prospective randomized study of chemotherapy adjunctive to definitive radiotherapy in advanced nasopharyngeal carcinoma
    • Chan A.T., Teo P.M., Leung T.W., Leung S.F., Lee W.Y., Yeo W., et al. A prospective randomized study of chemotherapy adjunctive to definitive radiotherapy in advanced nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 1995, 33:569-577.
    • (1995) Int J Radiat Oncol Biol Phys , vol.33 , pp. 569-577
    • Chan, A.T.1    Teo, P.M.2    Leung, T.W.3    Leung, S.F.4    Lee, W.Y.5    Yeo, W.6
  • 73
    • 0031947875 scopus 로고    scopus 로고
    • Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099
    • Al-Sarraf M., LeBlanc M., Giri P.G., Fu K.K., Cooper J., Vuong T., et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol 1998, 16:1310-1317.
    • (1998) J Clin Oncol , vol.16 , pp. 1310-1317
    • Al-Sarraf, M.1    LeBlanc, M.2    Giri, P.G.3    Fu, K.K.4    Cooper, J.5    Vuong, T.6
  • 74
    • 15444347863 scopus 로고    scopus 로고
    • Preliminary report of the Asian-Oceanian Clinical Oncology Association randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with locoregionally advanced nasopharyngeal carcinoma. Asian-Oceanian Clinical Oncology Association Nasopharynx Cancer Study Group
    • Chua D.T., Sham J.S., Choy D., Lorvidhaya V., Sumitsawan Y., Thongprasert S., et al. Preliminary report of the Asian-Oceanian Clinical Oncology Association randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with locoregionally advanced nasopharyngeal carcinoma. Asian-Oceanian Clinical Oncology Association Nasopharynx Cancer Study Group. Cancer 1998, 83:2270-2283.
    • (1998) Cancer , vol.83 , pp. 2270-2283
    • Chua, D.T.1    Sham, J.S.2    Choy, D.3    Lorvidhaya, V.4    Sumitsawan, Y.5    Thongprasert, S.6
  • 75
    • 27344447760 scopus 로고    scopus 로고
    • Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group
    • Lee A.W., Lau W.H., Tung S.Y., Chua D.T., Chappell R., Xu L., et al. Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group. J Clin Oncol 2005, 23:6966-6975.
    • (2005) J Clin Oncol , vol.23 , pp. 6966-6975
    • Lee, A.W.1    Lau, W.H.2    Tung, S.Y.3    Chua, D.T.4    Chappell, R.5    Xu, L.6
  • 76
    • 27244452301 scopus 로고    scopus 로고
    • Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety
    • Wee J., Tan E.H., Tai B.C., Wong H.B., Leong S.S., Tan T., et al. Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety. J Clin Oncol 2005, 23:6730-6738.
    • (2005) J Clin Oncol , vol.23 , pp. 6730-6738
    • Wee, J.1    Tan, E.H.2    Tai, B.C.3    Wong, H.B.4    Leong, S.S.5    Tan, T.6
  • 77
    • 47149084927 scopus 로고    scopus 로고
    • Preliminary results of a prospective randomized trial comparing concurrent chemoradiotherapy plus adjuvant chemotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma in endemic regions of china
    • Chen Y., Liu M.Z., Liang S.B., Zong J.F., Mao Y.P., Tang L.L., et al. Preliminary results of a prospective randomized trial comparing concurrent chemoradiotherapy plus adjuvant chemotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma in endemic regions of china. Int J Radiat Oncol Biol Phys 2008, 71:1356-1364.
    • (2008) Int J Radiat Oncol Biol Phys , vol.71 , pp. 1356-1364
    • Chen, Y.1    Liu, M.Z.2    Liang, S.B.3    Zong, J.F.4    Mao, Y.P.5    Tang, L.L.6
  • 78
    • 4344709667 scopus 로고    scopus 로고
    • Concurrent and adjuvant chemotherapy for nasopharyngeal carcinoma: a factorial study
    • Kwong D.L., Sham J.S., Au G.K., Chua D.T., Kwong P.W., Cheng A.C., et al. Concurrent and adjuvant chemotherapy for nasopharyngeal carcinoma: a factorial study. J Clin Oncol 2004, 22:2643-2653.
    • (2004) J Clin Oncol , vol.22 , pp. 2643-2653
    • Kwong, D.L.1    Sham, J.S.2    Au, G.K.3    Chua, D.T.4    Kwong, P.W.5    Cheng, A.C.6
  • 80
    • 34548384960 scopus 로고    scopus 로고
    • Treatment results of alternating chemoradiotherapy for nasopharyngeal cancer using cisplatin and 5-fluorouracil--a phase II study
    • Fuwa N., Shikama N., Hayashi N., Matsuzuka T., Toita T., Yuta A., et al. Treatment results of alternating chemoradiotherapy for nasopharyngeal cancer using cisplatin and 5-fluorouracil--a phase II study. Oral Oncol 2007, 43:948-955.
    • (2007) Oral Oncol , vol.43 , pp. 948-955
    • Fuwa, N.1    Shikama, N.2    Hayashi, N.3    Matsuzuka, T.4    Toita, T.5    Yuta, A.6
  • 81
    • 0037100036 scopus 로고    scopus 로고
    • Health-related quality of life for nasopharyngeal carcinoma patients with cancer-free survival after treatment
    • Fang F.M., Chiu H.C., Kuo W.R., Wang C.J., Leung S.W., Chen H.C., et al. Health-related quality of life for nasopharyngeal carcinoma patients with cancer-free survival after treatment. Int J Radiat Oncol Biol Phys 2002, 53:959-968.
    • (2002) Int J Radiat Oncol Biol Phys , vol.53 , pp. 959-968
    • Fang, F.M.1    Chiu, H.C.2    Kuo, W.R.3    Wang, C.J.4    Leung, S.W.5    Chen, H.C.6
  • 82
    • 3042561388 scopus 로고    scopus 로고
    • Oral health-related quality of life in southern Chinese following radiotherapy for nasopharyngeal carcinoma
    • McMillan A.S., Pow E.H., Leung W.K., Wong M.C., Kwong D.L. Oral health-related quality of life in southern Chinese following radiotherapy for nasopharyngeal carcinoma. J Oral Rehabil 2004, 31:600-608.
    • (2004) J Oral Rehabil , vol.31 , pp. 600-608
    • McMillan, A.S.1    Pow, E.H.2    Leung, W.K.3    Wong, M.C.4    Kwong, D.L.5
  • 83
    • 0026746288 scopus 로고
    • Pathological basis of surgery in the management of postradiotherapy cervical metastasis in nasopharyngeal carcinoma
    • discussion 30
    • Wei W.I., Ho C.M., Wong M.P., Ng W.F., Lau S.K., Lam K.H. Pathological basis of surgery in the management of postradiotherapy cervical metastasis in nasopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg 1992, 118:923-929. discussion 30.
    • (1992) Arch Otolaryngol Head Neck Surg , vol.118 , pp. 923-929
    • Wei, W.I.1    Ho, C.M.2    Wong, M.P.3    Ng, W.F.4    Lau, S.K.5    Lam, K.H.6
  • 84
    • 77955097287 scopus 로고    scopus 로고
    • Is it necessary to perform radical neck dissection as a salvage procedure for persistent or recurrent neck disease after chemoradiotherapy in patients with nasopharyngeal cancer?
    • Khafif A., Ferlito A., Takes R.P., Robbins K.T. Is it necessary to perform radical neck dissection as a salvage procedure for persistent or recurrent neck disease after chemoradiotherapy in patients with nasopharyngeal cancer?. Eur Arch Otorhinolaryngol 2010, 267:997-999.
    • (2010) Eur Arch Otorhinolaryngol , vol.267 , pp. 997-999
    • Khafif, A.1    Ferlito, A.2    Takes, R.P.3    Robbins, K.T.4
  • 85
    • 23344449981 scopus 로고    scopus 로고
    • Endoscopic nasopharyngectomy for patients with recurrent nasopharyngeal carcinoma at the primary site
    • Yoshizaki T., Wakisaka N., Murono S., Shimizu Y., Furukawa M. Endoscopic nasopharyngectomy for patients with recurrent nasopharyngeal carcinoma at the primary site. Laryngoscope 2005, 115:1517-1519.
    • (2005) Laryngoscope , vol.115 , pp. 1517-1519
    • Yoshizaki, T.1    Wakisaka, N.2    Murono, S.3    Shimizu, Y.4    Furukawa, M.5
  • 86
    • 0038647681 scopus 로고    scopus 로고
    • Treatment outcome for synchronous locoregional failures of nasopharyngeal carcinoma
    • Chua D.T., Wei W.I., Sham J.S., Cheng A.C., Au G. Treatment outcome for synchronous locoregional failures of nasopharyngeal carcinoma. Head Neck 2003, 25:585-594.
    • (2003) Head Neck , vol.25 , pp. 585-594
    • Chua, D.T.1    Wei, W.I.2    Sham, J.S.3    Cheng, A.C.4    Au, G.5
  • 87
    • 41849131014 scopus 로고    scopus 로고
    • Treatment of locally recurrent Epstein-Barr virus-associated nasopharyngeal carcinoma using the anti-viral agent cidofovir
    • Yoshizaki T., Wakisaka N., Kondo S., Murono S., Shimizu Y., Nakashima M., et al. Treatment of locally recurrent Epstein-Barr virus-associated nasopharyngeal carcinoma using the anti-viral agent cidofovir. J Med Virol 2008, 80:879-882.
    • (2008) J Med Virol , vol.80 , pp. 879-882
    • Yoshizaki, T.1    Wakisaka, N.2    Kondo, S.3    Murono, S.4    Shimizu, Y.5    Nakashima, M.6
  • 88
    • 67650394808 scopus 로고    scopus 로고
    • Discerning regulation of cis- and trans-presentation of CD8+ T-cell epitopes by EBV-encoded oncogene LMP-1 through self-aggregation
    • Smith C., Wakisaka N., Crough T., Peet J., Yoshizaki T., Beagley L., et al. Discerning regulation of cis- and trans-presentation of CD8+ T-cell epitopes by EBV-encoded oncogene LMP-1 through self-aggregation. Blood 2009, 113:6148-6152.
    • (2009) Blood , vol.113 , pp. 6148-6152
    • Smith, C.1    Wakisaka, N.2    Crough, T.3    Peet, J.4    Yoshizaki, T.5    Beagley, L.6
  • 89
    • 20444463584 scopus 로고    scopus 로고
    • Technology insight: Applications of emerging immunotherapeutic strategies for Epstein-Barr virus-associated malignancies
    • Khanna R., Moss D., Gandhi M. Technology insight: Applications of emerging immunotherapeutic strategies for Epstein-Barr virus-associated malignancies. Nat Clin Pract Oncol 2005, 2:138-149.
    • (2005) Nat Clin Pract Oncol , vol.2 , pp. 138-149
    • Khanna, R.1    Moss, D.2    Gandhi, M.3


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