Treatment results of alternating chemoradiotherapy for nasopharyngeal cancer using cisplatin and 5-fluorouracil - A phase II study

Oral Oncology

Volumn 43, Issue 9, 2007, Pages 948-955

  Fuwa, Nobukazu ^a   Shikama, Naoto ^b   Hayashi, Nobuyuki ^c   Matsuzuka, Takashi ^d   Toita, Takafumi ^e   Yuta, Atsushi ^f   Oonishi, Hiroshi ^g   Kodaira, Takeshi ^a   Tachibana, Hiroyuki ^a   Nakamura, Tatsuya ^a   Daimon, Takashi ^h  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b SHINSHU UNIVERSITY   (Japan)

^c NAGASAKI UNIVERSITY   (Japan)

^d FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^e UNIVERSITY OF THE RYUKYUS   (Japan)

^f MIE UNIVERSITY   (Japan)

^g UNIVERSITY OF YAMANASHI   (Japan)

^h UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

5 Fluorouracil; Alternating chemoradiotherapy; Cisplatin; Nasopharyngeal cancer

Indexed keywords

CISPLATIN; FLUOROURACIL; ONDANSETRON; STEROID;

ADOLESCENT; ADULT; ADVANCED CANCER; AGED; ANEMIA; ARTICLE; BLOOD TOXICITY; BONE MARROW SUPPRESSION; CANCER CHEMOTHERAPY; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER REGRESSION; CANCER SURVIVAL; CLINICAL TRIAL; CONTINUOUS INFUSION; DRUG WITHDRAWAL; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; HYPERAMMONEMIA; KIDNEY DYSFUNCTION; LEUKOPENIA; LIVER DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; NASOPHARYNX CANCER; NEPHROTOXICITY; NEUROLOGIC DISEASE; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION DOSE; SURVIVAL RATE; TREATMENT OUTCOME; VOMITING;

ADOLESCENT; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, SQUAMOUS CELL; CISPLATIN; DISEASE-FREE SURVIVAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; HUMANS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS; RADIOTHERAPY DOSAGE; RADIOTHERAPY, ADJUVANT; REMISSION INDUCTION; SURVIVAL RATE;

EID: 34548384960     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2006.11.003     Document Type: Article

References (43)

1. Ho J.H.C. An epidemiological and clinical study of nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 4 (1978) 183-197
2. Wang D.C., Cai W.M., and Hu V.C. Long term survival of 1035 cases of nasopharyngeal carcinoma. Cancer 61 (1988) 2328-2341
3. Sanada K, Kimura S, Fuhara T. In: Parkin DM, Whelan SL, Ferlay J, Raymond L, Young J, editors. Cancer Incidence in Five Continents, vol. VII. LYON: IARC Scientific Publications No. 143; 1987. p. 382-405.
4. Hoppe R.T., Goffinet D.R., and Bagshaw M.A. Carcinoma of the nasopharynx. Eighteen years experience with megavoltage radiation therapy. Cancer 37 (1976) 2605-2612
5. Marcial V.A., Hanley J.A., Chang C., et al. Spirit-course radiation therapy of carcinoma of the nasopharynx: results of a national collaborative clinical trial of the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 6 (1980) 409-414
6. Mesic J.B., Fletcher G.H., and Goepfert H. Megavoltage irradiation of epithelial tumors of the nasopharynx. Int J Radiat Oncol Biol Phys 7 (1981) 447-453
7. Perez C.A., Ackerman L.V., Mill W.B., Ogura J.H., Powers W.E., Perez C.A., et al. Cancer of the nasopharynx. Factors influencing prognosis. Cancer 24 (1969) 1-17
8. Wang C.C., and Meyer J.E. Radiotherapeutic management of the carcinoma of the nasopharynx. Analysis of 170 patients. Cancer 28 (1971) 566-570
9. Qin D.X., Hu Y.H., Yan J.H., et al. Analysis of 1379 patients with nasopharyngeal carcinoma treated by radiation. Cancer 61 (1988) 1117-1124
10. Al-Sarraf M., Pajak T.F., Cooper J.S., Mohiuddin M., Herskovic A., and Ager P.J. Chemo-radiotherapy in patients with locally advanced nasopharyngeal carcinoma: a Radiation Therapy Oncology Group study. J Clin Oncol 8 (1990) 1342-1351
11. Huang S.C., Lui L.T., and Lynn T.C. Nasopharyngeal cancer study III. A review of 1206 patients treated with combined modalities. Int J Radiat Oncol Biol Phys 11 (1985) 1789-1793
12. Souhami L., and Rabinowits M. Combined treatment in carcinoma of the nasopharynx. Laryngoscope 98 (1988) 881-883
13. Bachouchi M., Cvitkovic E., Azli N., et al. High complete response in advanced nasopharyngeal carcinoma with bleomycin, epirubicin, and cisplatin before radiotherapy. J Natl Cancer Inst 82 (1990) 616-620
14. Chatani M., Teshima T., Inoue T., et al. Radiation therapy for nasopharyngeal carcinoma. Cancer 57 (1986) 2267-2271
15. Dimery I.W., Peters L.J., Goepfert H., et al. Effectiveness of combined induction chemotherapy and radiotherapy in advanced nasopharyngeal carcinoma. J Clin Oncol 11 (1993) 1919-1928
16. Lin J.C., Jan J.S., and Hsu C.Y. Neoadjuvant chemotherapy for advanced nasopharyngeal carcinoma. Am J Clin Oncol 18 (1995) 139-143
17. Teo P.M., Leung T.W., Chan A.T., et al. A retrospective study of the use of cisplatin-5 fluorouracil neoadjuvant chemotherapy in cervical-node-positive nasopharyngeal carcinoma (NPC). Eur J Cancer B Oral Oncol 31B (1995) 373-379
18. Dimery I.W., Legha S.S., Peters L.J., Goepfert H., and Oswald M.J. Adjuvant chemotherapy for advanced nasopharyngeal carcinoma. Cancer 60 (1987) 943-949
19. Rahima M., Rakowsky E., Barzilay J., and Sidi J. Carcinoma of the nasopharynx. An analysis of 91 cases and a comparison of differing treatment approaches. Cancer 58 (1986) 843-849
20. Azli N., Armand J.P., Rahal M., et al. Alternating chemo-radiotherapy with cisplatin and 5-fluorouracil plus bleomycin by continuous infusion for locally advanced undifferentiated carcinoma nasopharyngeal type. Eur J Cancer 28A (1992) 1792-1797
21. Fuwa N., Ito Y., Kodaira T., et al. Therapeuric results of alternating chemoradiotherapy for nasopharyngeal cancer using cisplatin and 5-fluorouracil - its usefulness and controversial points. Jpn J Clin Oncol 31 (2001) 589-595
22. Fuwa N., Kano M., Toita T., et al. Alternating chemoradiotherapy for nasopharyngeal cancer using cisplatin and 5-fluorouracil: a preliminary report of phase II study. Radiother Oncol 61 (2001) 257-260
23. International Union Against Cancer. In: Sobin L.H., and Wittekind C. (Eds). TNM classification of malignant tumours. fifth ed. (1997), Wiley-Liss Inc., New York
24. WHO handbook for reporting results of cancer treatment. Geneva: World Health Organization; 1979. p. 14-27.
25. Kaplan E.L., and Meier P. Nonparametric estimations from incomplete observations. J Am Stat Assoc 53 (1958) 475-481
26. Cox D.R. Regression models and life tables. J R Stat Soc 34 (1972) 187-222
27. Al-Sarraf M., LeBlanc M., Giri P.G., et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup Study 0099. J Clin Oncol 16 (1998) 1310-1317
28. Chan A.T., Teo P.M., Leung T.W., et al. Prospective randomized trial conducted to compare chemo-radiotherapy against radiotherapy alone in the treatment of locoregionally advanced nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 33 (1995) 569-577
29. Chan A.T., Leung S.F., Ngan R.K., et al. Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma. J Natl Cancer Inst 97 (2005) 536-539
30. Chi K.H., Chang Y.C., Guo W.Y., et al. A phase III study of adjuvant chemotherapy in advanced nasopharyngeal carcinoma patients. Int J Radiat Oncol Biol Phys 52 (2002) 1238-1244
31. Chua D.T., Sham J.S., Choy D., et al. Preliminary report of the Asian-Oceanian Clinical Oncology Association randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with local-regionally advanced nasopharyngeal carcinoma. Cancer 83 (1998) 2270-2283
32. Hareyama M., Sakata K., Shirato H., et al. A prospective, randomized trial comparing neoadjuvant chemotherapy with radiotherapy alone in patients with advanced nasopharyngeal carcinoma. Cancer 15 (2002) 2217-2223
33. International Nasopharynx Cancer Study Group. VUMCA I trial. Preliminary results of a randomized trial comparing neoadjuvant chemotherapy (cisplatin, epirubicin, bleomycin) plus radiotherapy vs. radiotherapy alone in stage IV (> or =N2, M0) undifferentiated nasopharyngeal carcinoma: a positive effect on progression-free survival. Int J Radiat Oncol Biol Phys 35 (1996) 463-469
34. Lee A.W., Lau W.H., Tung S.Y., et al. Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group. J Clin Oncol 23 (2005) 6966-6975
35. Lin J.C., Jan J.S., Hsu C.Y., Liang W.M., Jiang R.S., and Wang W.Y. Phase III study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma: positive effect on overall and progression-free survival. J Clin Oncol 15 (2003) 631-637
36. Ma J., Mai H.Q., Hong M.H., et al. Results of a prospective randomized trial comparing neoadjuvant chemotherapy plus radiotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma. J Clin Oncol 19 (2001) 1350-1357
37. Rossi A, Molinari R, Boracchi P, et al. Adjuvant chemotherapy with vincristine, cyclophosphamide, and doxorubicin after radiotherapy in local-regional nasopharyngeal cancer: results of a 4-year multicenter randomized study. J Clin Oncol.
38. Wee J., Tan E.H., Tai B.C., et al. Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety. J Clin Oncol 23 (2005) 6730-6738
39. Langendijk J.A., Leemans C.R., Buter J., Berkhof J., and Slotman B.J. The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta-analysis of the published literature. J Clin Oncol 22 (2004) 4604-4612
40. Kummermehr J., Dorr W., and Trott K.R. Kinetics of accelerated repopulation in normal and malignant squamous epithelia during fractionated therapy. Br J Radiol. 24 (1992) 193-199
41. Peters L.J., and Withers H.R. Applying radiobiological principles to combined modality treatment of head and neck cancer-the time factor. Int J Radiat Oncol Biol Phys 39 (1997) 831-836 1988;6:1401-10
42. Tannock I.F. Combined modality treatment with radiotherapy and chemotherapy. Radiother Oncol 16 (1989) 83-101
43. Merlano M., Benasso M., Corvo R., et al. Five-year update of a randomized trial of alternating radiotherapy and chemotherapy compared with radiotherapy alone in treatment of unresectable squamous cell carcinoma of the head and neck. J Natl Cancer Inst 88 (1996) 583-589