Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 trial by the Hong Kong Nasopharyngeal Cancer Study Group

Journal of Clinical Oncology

Volumn 23, Issue 28, 2005, Pages 6966-6975

  Lee, Anne W M ^a   Lau, W H ^a   Tung, Stewart Y ^a   Chua, Daniel T T ^a   Chappell, Rick ^a   Xu, L ^a   Siu, Lillian ^a   Sze, W M ^a   Leung, T W ^a   Sham, Jonathan S T ^a   Ngan, Roger K C ^a   Law, Stephen C K ^a   Yau, T K ^a   Au, Joseph S K ^a   O'Sullivan, Brian ^a   Pang, Ellie S Y ^a   O, S K ^a   Au, Gordon K H ^a   Lau, Joseph T ^a  

^a TUEN MUN HOSPITAL   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; FLUOROURACIL; ANTINEOPLASTIC AGENT;

ADJUVANT THERAPY; ADULT; ADVANCED CANCER; ANEMIA; ANGINA PECTORIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER RELAPSE; CANCER STAGING; CAUSE OF DEATH; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRANIAL NERVE PARALYSIS; CRANIAL NEUROPATHY; DEATH; DISEASE FREE SURVIVAL; DISEASE SEVERITY; DRUG DOSE REGIMEN; DRUG DOSE SEQUENCE; ENDOCRINE DISEASE; FEMALE; FOLLOW UP; GASTROINTESTINAL TOXICITY; HAZARD RATIO; HEARING LOSS; HEPATITIS; HONG KONG; HUMAN; INCIDENCE; KIDNEY FAILURE; LEUKOPENIA; LUNG TUBERCULOSIS; MALE; MUCOSA INFLAMMATION; MULTIMODALITY CANCER THERAPY; MULTIPLE CYCLE TREATMENT; NASOPHARYNX CARCINOMA; NEPHROTOXICITY; NEUTROPENIA; OTITIS; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PATIENT COMPLIANCE; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROGNOSIS; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RANDOMIZED CONTROLLED TRIAL; SEPSIS; SIDE EFFECT; SKIN MANIFESTATION; STATISTICAL ANALYSIS; STOMATITIS; THERAPY EFFECT; THROMBOCYTOPENIA; TISSUE INJURY; TREATMENT OUTCOME; VOMITING; CARCINOMA; MIDDLE AGED; MULTICENTER STUDY; NASOPHARYNX TUMOR; PATHOLOGY; SURVIVAL;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA; CISPLATIN; COMBINED MODALITY THERAPY; FEMALE; FLUOROURACIL; HUMANS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 27344447760     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2004.00.7542     Document Type: Article

References (26)

1. Parkin DM, Whelan SL, Ferlay J, et al: Cancer Incidence in Five Continents. IARC Scientific Publications Number 155, Vol. 8. Lyon, France, IARC Press, 2002, pp 534-536
2. Marks JE, Phillips JL, Menck HR: The National Cancer Data Base Report on the relationship of race and national origin to the histology of nasopharyngeal carcinoma. Cancer 83:582-588, 1998
3. Al-Sarraf M, LeBlanc M, Giri PG, et al: Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: Phase III randomized lntergroup study 0099. J Clin Oncol 16(4):1310-1317, 1998
4. Al-Sarraf M, LeBlanc M, Giri PGS, et al: Chemo-radiotherapy (CT-RT) vs radiotherapy (RT) in patients (PTS) with advanced nasopharyngeal cancer (NPC). Intergroup (0099) (SWOG 8892, RTOG 8817, ECOG 2388) Phase III Study: Progress report. J Clin Oncol 17:385a, 1998 (abstr 1483)
5. Beahrs O, Henson DE, Hutter RVP, et al: American Joint Committee on Cancer: Manual for Staging of Cancer, Fourth Edition. Philadelphia, PA, Lippincott, 1992, pp 33-38
6. Chow E, Payne D, O'Sullivan B, et al: Radiotherapy alone in patients with advanced nasopharyngeal cancer: Comparison with an intergroup study - Is combined modality treatment really necessary? Radiother Oncol 63:269-274, 2002
7. Lin JC, Jan JS, Hsu CY, et al: Concurrent Chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma: Positive effect on overall and progression-free survival. J Clin Oncol 21:631-637, 2003
8. Wolden SL, Zelefsky MJ, Kraus DH, et al: Accelerated concomitant boost radiotherapy and chemotherapy for advanced nasopharyngeal carcinoma. J Clin Oncol 19:1105-1110, 2001
9. Chua DTT, Sham J, Au G, et al: Concomitant chemoirradiation for Stage III-IV nasopharyngeal carcinoma in Chinese patients: Results of a matched cohort analysis. Int J Radiat Oncol Biol Phys 53:334-343, 2002
10. Le QT, Tate D, Koong A, et al: Improved local control with stereotactic radiosurgical boost in patients with nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 56:1046-1054, 2003
11. Lee N, Xia P, Quivey JM, et al: Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: An update of the UCSF experience. Int J Radiat Oncol Biol Phys 53:12-22, 2002
12. Shanmugarantnam K, Sobin LH. Histological Typing of Tumors of the Upper Respiratory Tract and Ear, Second Edition. New York, NY, Springer-Verlag, 1991, pp 32-33
13. Fleming ID, Cooper JS, Henson DE, et al: American Joint Committee on Cancer: AJCC Cancer Staging Manual, Fifth Edition. Philadelphia, PA, Lippincott-Raven, 1997, pp 31-39
14. Sobin LH, Wittekind Ch. International Union Against Cancer (UICC): TNM Classification of Malignant Tumors, Fifth Edition. New York, NY, Wiley-Liss, 1997, pp 25-32
15. Freedman J, Furberg C, DeMets D. Fundamentals of Clinical Trials. New York, NY, Springer-Verlag, 1998
16. Cox JD, Stetz J, Pajak TF: Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 31:1341-1346, 1995
17. Miller AB, Hoogstraten B, Staquet M, et al: Reporting results of cancer treatment. Cancer 47:207-214, 1981
18. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481, 1958
19. Peto R, Pike MC, Armitage P, et al: Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Br J Cancer 35:1-39, 1977
20. Cox DR: Regression models and life tables. J Roy Stat Soc B 34:187-220, 1972
21. Schiffer CA, Dodge R, Larson RA: Long-term follow-up of Cancer and Leukemia Group B studies in acute myeloid leukemia. Cancer 80:2210-2214, 1997
22. Kwong DLW, Sham JST, Au GKH, et al: Concurrent and adjuvant chemotherapy for nasopharyngeal carcinoma: A factorial study. J Clin Oncol 22:2643-2653, 2004
23. Wee J, Tan EH, Tai BC, et al: Phase III randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with AJCC/UICC (1997) stage 3 and 4 nasopharyngeal cancer of the endemic variety. J Clin Oncol 23:487, 2004 (abstr 5500)
24. Chan ATC, Teo PML, Ngan RK, et al: Concurrent chemotherapy-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: Progression-free survival analysis of a phase III randomized trial. J Clin Oncol 20:2038-2044, 2002
25. Chan AT, Leung SF, Ngan RK, et al: Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma. J Natl Cancer Inst 97(7):536-539, 2005
26. Lee AW, Sze WM, Au JS, et al: Treatment results for nasopharyngeal carcinoma in the modern era: The Hong Kong experience. Int J Radiat Oncol Biol Phys 61(4):1107-1116, 2005