메뉴 건너뛰기




Volumn 30, Issue 9, 1999, Pages 1013-1018

Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: Biological and clinical implications

Author keywords

Cell cycle; Head and neck squamous carcinoma; Immunohistochemistry; Tumor suppressor gene; Western blotting

Indexed keywords

CYCLIN D1; PROTEIN P16;

EID: 0032887604     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(99)90217-4     Document Type: Article
Times cited : (64)

References (38)
  • 1
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 81:323-330, 1995.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 2
    • 0029921317 scopus 로고    scopus 로고
    • Genetic alterations of cyclins, cyclin-dependent kinases and cdk inhibitors in human cancer
    • Hall M, Peters G: Genetic alterations of cyclins, cyclin-dependent kinases and cdk inhibitors in human cancer. Adv Cancer Res 68:67-108, 1996
    • (1996) Adv Cancer Res , vol.68 , pp. 67-108
    • Hall, M.1    Peters, G.2
  • 3
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr CJ: Cancer cell cycles. Science 274:1672-1677, 1996
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 4
    • 0030924438 scopus 로고    scopus 로고
    • Hypophosphorylation of the retinoblastoma protein (pRb) by Cyclin D: Cdk4/6 complexes results in active pRb
    • Ezhevsky SA, Nagahara H, Vocero-Akbani AM, et al: Hypophosphorylation of the retinoblastoma protein (pRb) by Cyclin D: Cdk4/6 complexes results in active pRb. Proc Natl Acad Sci 94:10699-10704, 1997
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 10699-10704
    • Ezhevsky, S.A.1    Nagahara, H.2    Vocero-Akbani, A.M.3
  • 5
    • 0029054399 scopus 로고
    • Retinoblastoma-protein-dependent cell-cycle inhibition by the tumor suppressor p16
    • Lukas J, Parry D, Aagaard L, et al: Retinoblastoma-protein-dependent cell-cycle inhibition by the tumor suppressor p16. Nature (Lond) 375:503-506, 1995
    • (1995) Nature (Lond) , vol.375 , pp. 503-506
    • Lukas, J.1    Parry, D.2    Aagaard, L.3
  • 6
    • 0028172926 scopus 로고
    • Absence of p16 INK4 protein in restricted to the subset of lung cancer lines that retains wild type RB
    • Otterson GA, Kratzke RA, Coxon A, et al: Absence of p16 INK4 protein in restricted to the subset of lung cancer lines that retains wild type RB. Oncogene 9:3375-3378, 1994
    • (1994) Oncogene , vol.9 , pp. 3375-3378
    • Otterson, G.A.1    Kratzke, R.A.2    Coxon, A.3
  • 7
    • 0029971843 scopus 로고    scopus 로고
    • Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: An immunohistochemical study
    • Sakaguchi M, Fujii Y, Hirabayashi H, et al: Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: An immunohistochemical study. Int J Cancer 65:442-445, 1996
    • (1996) Int J Cancer , vol.65 , pp. 442-445
    • Sakaguchi, M.1    Fujii, Y.2    Hirabayashi, H.3
  • 8
    • 0028961521 scopus 로고
    • Reciprocal Rb inactivation and p16 INK4 expression in primary lung cancers and cell lines
    • Shapiro GI, Edwards CD, Kobzik L, et al: Reciprocal Rb inactivation and p16 INK4 expression in primary lung cancers and cell lines. Cancer Res 55:505-509, 1995
    • (1995) Cancer Res , vol.55 , pp. 505-509
    • Shapiro, G.I.1    Edwards, C.D.2    Kobzik, L.3
  • 9
    • 0030070484 scopus 로고    scopus 로고
    • CDKN2/p16 or Rb alterations occur in the majority of glioblastomas and are inversely correlated
    • Ueki K, Ono Y, Henson JW, et al: CDKN2/p16 or Rb alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res 56:150-153, 1996
    • (1996) Cancer Res , vol.56 , pp. 150-153
    • Ueki, K.1    Ono, Y.2    Henson, J.W.3
  • 10
    • 0028911406 scopus 로고
    • Increased p16 levels correlate with pRb alterations in human urothelial cells
    • Yeager T, Stadler W, Belair C, et al: Increased p16 levels correlate with pRb alterations in human urothelial cells. Cancer Res 55:493-497, 1995
    • (1995) Cancer Res , vol.55 , pp. 493-497
    • Yeager, T.1    Stadler, W.2    Belair, C.3
  • 12
    • 0028869884 scopus 로고
    • ink4//mts1 tumor suppressor gene product
    • ink4//mts1 tumor suppressor gene product. EMBO J 14:503-511, 1995
    • (1995) EMBO J , vol.14 , pp. 503-511
    • Parry, D.1    Bates, S.2    Mann, D.J.3
  • 13
    • 0028261383 scopus 로고
    • Cyclin D1 expression is regulated by the retinoblastoma protein
    • Muller H, Lukas J, Schneider A, et al: Cyclin D1 expression is regulated by the retinoblastoma protein. Proc Natl Acad Sci USA 91:2945-2949, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2945-2949
    • Muller, H.1    Lukas, J.2    Schneider, A.3
  • 14
    • 15144341364 scopus 로고    scopus 로고
    • Expression of p16 induces transcriptional downregulation of the Rb gene
    • Fang X, Jin Z, Xu HJ, et al: Expression of p16 induces transcriptional downregulation of the Rb gene. Oncogene 16:1-8, 1998
    • (1998) Oncogene , vol.16 , pp. 1-8
    • Fang, X.1    Jin, Z.2    Xu, H.J.3
  • 15
    • 0031895370 scopus 로고    scopus 로고
    • Disruption of the Rb pathway and cell-proliferative activity in non-small cell lung cancers
    • Tanaka H, Fuji Y, Hirabayashi H, et al: Disruption of the Rb pathway and cell-proliferative activity in non-small cell lung cancers. IntJ Cancer (Pred Oncol) 79:111-115, 1998
    • (1998) IntJ Cancer (Pred Oncol) , vol.79 , pp. 111-115
    • Tanaka, H.1    Fuji, Y.2    Hirabayashi, H.3
  • 16
    • 0032548965 scopus 로고    scopus 로고
    • Retinoblastoma and p16 proteins in mammary carcinoma: Their relationship to cyclin D1 and pathological parameter
    • Dublin EA, Patel NK, Gillet CE, et al: Retinoblastoma and p16 proteins in mammary carcinoma: Their relationship to cyclin D1 and pathological parameter. Int J Cancer (Pred Oncol) 79:71-75, 1998
    • (1998) Int J Cancer (Pred Oncol) , vol.79 , pp. 71-75
    • Dublin, E.A.1    Patel, N.K.2    Gillet, C.E.3
  • 17
    • 0031920711 scopus 로고    scopus 로고
    • Frequent alterations of cell cycle regulators in early-stage breast lesions as detected by immunohisto-chemistry
    • March KL, Varley JM: Frequent alterations of cell cycle regulators in early-stage breast lesions as detected by immunohisto-chemistry. Br J Cancer 77:1460-1468, 1998
    • (1998) Br J Cancer , vol.77 , pp. 1460-1468
    • March, K.L.1    Varley, J.M.2
  • 18
    • 0029883680 scopus 로고    scopus 로고
    • A clinicopathologic study on overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancer
    • Michalides R, Hageman PH, van Tinteren H, et al: A clinicopathologic study on overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancer. Br J Cancer 73:728-734, 1996
    • (1996) Br J Cancer , vol.73 , pp. 728-734
    • Michalides, R.1    Hageman, P.H.2    Van Tinteren, H.3
  • 19
    • 0031031998 scopus 로고    scopus 로고
    • Cyclin D1 expression in invasive breast cancer: Correlations and prognostic value
    • van Diest PJ, Michalides RJ, Jannink I, et al: Cyclin D1 expression in invasive breast cancer: Correlations and prognostic value. Am J Pathol 150:705-711, 1997
    • (1997) Am J Pathol , vol.150 , pp. 705-711
    • Van Diest, P.J.1    Michalides, R.J.2    Jannink, I.3
  • 20
    • 0024309158 scopus 로고
    • The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours
    • Varley JM, Armour J, Swallow JE, et al: The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours. Oncogene 4:725-729, 1989
    • (1989) Oncogene , vol.4 , pp. 725-729
    • Varley, J.M.1    Armour, J.2    Swallow, J.E.3
  • 21
    • 0028894280 scopus 로고
    • Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer
    • Stauss M, Gusterson B, Bartek J: Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer. Cancer Res 55:949-956, 1995
    • (1995) Cancer Res , vol.55 , pp. 949-956
    • Stauss, M.1    Gusterson, B.2    Bartek, J.3
  • 22
    • 0029963811 scopus 로고    scopus 로고
    • Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas
    • Maelandsmo GM, Florenes VA, Hovig E, et al: Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas. Br J Cancer 73:909-916, 1996
    • (1996) Br J Cancer , vol.73 , pp. 909-916
    • Maelandsmo, G.M.1    Florenes, V.A.2    Hovig, E.3
  • 23
    • 0031023425 scopus 로고    scopus 로고
    • Deregulation of cyclin E and D1 in breast cancer is associated with inactivation of the retinoblastoma protein
    • Nielsen NH, Emdin SO, Cajander J, et al: Deregulation of cyclin E and D1 in breast cancer is associated with inactivation of the retinoblastoma protein. Oncogene 14:295-304, 1997
    • (1997) Oncogene , vol.14 , pp. 295-304
    • Nielsen, N.H.1    Emdin, S.O.2    Cajander, J.3
  • 24
    • 9444255067 scopus 로고    scopus 로고
    • High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation of head and neck squamous cell carcinoma
    • Reed AL, Califano J, Cairns P, et al: High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation of head and neck squamous cell carcinoma. Cancer Res 56:3630-3633, 1996
    • (1996) Cancer Res , vol.56 , pp. 3630-3633
    • Reed, A.L.1    Califano, J.2    Cairns, P.3
  • 25
    • 0030708545 scopus 로고    scopus 로고
    • Methylation: A dominant mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma
    • El-Naggar AK, Lai S, Clayman G, et al: Methylation: A dominant mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma. Am J Pathol 151:1767-1774, 1997
    • (1997) Am J Pathol , vol.151 , pp. 1767-1774
    • El-Naggar, A.K.1    Lai, S.2    Clayman, G.3
  • 26
    • 0031038935 scopus 로고    scopus 로고
    • Alterations of the p16 gene in head and neck cancer: Frequency and association with p53, PRAD-1 and HPV
    • Olshan AF, Weissler MC, Pei H, et al: Alterations of the p16 gene in head and neck cancer: Frequency and association with p53, PRAD-1 and HPV. Oncogene 14:811-818, 1997
    • (1997) Oncogene , vol.14 , pp. 811-818
    • Olshan, A.F.1    Weissler, M.C.2    Pei, H.3
  • 27
    • 0028865984 scopus 로고
    • ink4 in archival human solid tumors: Correlation with retinoblastoma protein expression
    • ink4 in archival human solid tumors: Correlation with retinoblastoma protein expression. Cancer Res 54:6006-6011, 1995
    • (1995) Cancer Res , vol.54 , pp. 6006-6011
    • Geradts, J.1    Kratzke, R.A.2    Niehanx, G.A.3
  • 28
    • 0029992389 scopus 로고    scopus 로고
    • Altered retinoblastoma and p53 protein status in non-small cell carcinoma of the lung: Potential synergistic effects on prognosis
    • Xu HJ, Cagle PT, Hu SX, et al: Altered retinoblastoma and p53 protein status in non-small cell carcinoma of the lung: Potential synergistic effects on prognosis. Clin Cancer Res 2:1169-1176, 1996
    • (1996) Clin Cancer Res , vol.2 , pp. 1169-1176
    • Xu, H.J.1    Cagle, P.T.2    Hu, S.X.3
  • 29
    • 0024334870 scopus 로고
    • The retinoblastoma susceptibility gene product: A characteristic pattern in normal cells and abnormal expression in malignant
    • Xu HJ, Hu SX, Hashimoto T, et al: The retinoblastoma susceptibility gene product: A characteristic pattern in normal cells and abnormal expression in malignant. Oncogene 4:807-812, 1989
    • (1989) Oncogene , vol.4 , pp. 807-812
    • Xu, H.J.1    Hu, S.X.2    Hashimoto, T.3
  • 30
    • 0033521887 scopus 로고    scopus 로고
    • Level of retinoblastoma protein expression correlates with p16 (MTS-1/INK4A/ CDKN2) status in bladder cancer
    • Benedict WF, Lerner SP, Zhou J, et al: Level of retinoblastoma protein expression correlates with p16 (MTS-1/INK4A/ CDKN2) status in bladder cancer. Oncogene 18:1197-1203, 1999
    • (1999) Oncogene , vol.18 , pp. 1197-1203
    • Benedict, W.F.1    Lerner, S.P.2    Zhou, J.3
  • 31
    • 0027516618 scopus 로고
    • Loss of Rb protein expression in primary bladder cancer correlates with loss of heterozygosity at the Rb locus and tumor progression
    • Xu HJ, Cairns P, Hu SX, et al: Loss of Rb protein expression in primary bladder cancer correlates with loss of heterozygosity at the Rb locus and tumor progression. Int J Cancer 53:781-784, 1993
    • (1993) Int J Cancer , vol.53 , pp. 781-784
    • Xu, H.J.1    Cairns, P.2    Hu, S.X.3
  • 32
    • 0028971961 scopus 로고
    • INK4a inactivation in non-small cell lung cancer cell lines
    • INK4a inactivation in non-small cell lung cancer cell lines. Cancer Res 55:6200-6209, 1995
    • (1995) Cancer Res , vol.55 , pp. 6200-6209
    • Shapiro, G.I.1    Park, J.E.2    Edwards, C.D.3
  • 33
    • 0031660965 scopus 로고    scopus 로고
    • Cell cycle-related gene abnormalities and product expression in esophageal carcinoma
    • Roncalli M, Bosari S, Marchetti A, et al: Cell cycle-related gene abnormalities and product expression in esophageal carcinoma. Lab Invest 78:1049-1057, 1998
    • (1998) Lab Invest , vol.78 , pp. 1049-1057
    • Roncalli, M.1    Bosari, S.2    Marchetti, A.3
  • 34
    • 0029893319 scopus 로고    scopus 로고
    • Cyclin D1 and prognosis in human breast cancer
    • Gillett C, Smith P, Gregory W, et al: Cyclin D1 and prognosis in human breast cancer. Int J Cancer 69:92-99, 1996
    • (1996) Int J Cancer , vol.69 , pp. 92-99
    • Gillett, C.1    Smith, P.2    Gregory, W.3
  • 36
    • 0026744608 scopus 로고
    • Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer
    • Schuuring E, Verhoeven E, Tinteren H van, et al: Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer. Cancer Res 52:5229-5234, 1991
    • (1991) Cancer Res , vol.52 , pp. 5229-5234
    • Schuuring, E.1    Verhoeven, E.2    Van Tinteren, H.3
  • 37
    • 0025970229 scopus 로고
    • D112287, a putative oncogene on chromosome 11q13 is amplified and expressed in squamous cell and mammary carcinomas and linked to bc1-1
    • Lammie G, Fantl V, Smith R, et al: D112287, a putative oncogene on chromosome 11q13 is amplified and expressed in squamous cell and mammary carcinomas and linked to bc1-1. Oncogene 6:439-444, 1991
    • (1991) Oncogene , vol.6 , pp. 439-444
    • Lammie, G.1    Fantl, V.2    Smith, R.3
  • 38
    • 0028953560 scopus 로고
    • Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck
    • Michalides R, van Veelee N, Hart A, et al: Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck. Cancer Res 55:975-978, 1995
    • (1995) Cancer Res , vol.55 , pp. 975-978
    • Michalides, R.1    Van Veelee, N.2    Hart, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.