-
2
-
-
77957113600
-
A large-scale, consortium-based genomewide association study of asthma
-
Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, et al. (2010) A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 363: 1211-1221.
-
(2010)
N Engl J Med
, vol.363
, pp. 1211-1221
-
-
Moffatt, M.F.1
Gut, I.G.2
Demenais, F.3
Strachan, D.P.4
Bouzigon, E.5
-
3
-
-
35648929946
-
Asthma cases attributable to atopy: results from the Third National Health and Nutrition Examination Survey
-
Arbes SJ Jr, Gergen PJ, Vaughn B, Zeldin DC, (2007) Asthma cases attributable to atopy: results from the Third National Health and Nutrition Examination Survey. J Allergy Clin Immunol 120: 1139-1145.
-
(2007)
J Allergy Clin Immunol
, vol.120
, pp. 1139-1145
-
-
Arbes Jr., S.J.1
Gergen, P.J.2
Vaughn, B.3
Zeldin, D.C.4
-
4
-
-
0026783670
-
The association of individual allergen reactivity with respiratory disease in a national sample: data from the second National Health and Nutrition Examination Survey, 1976-80 (NHANES II)
-
Gergen PJ, Turkeltaub PC, (1992) The association of individual allergen reactivity with respiratory disease in a national sample: data from the second National Health and Nutrition Examination Survey, 1976-80 (NHANES II). J Allergy Clin Immunol 90: 579-588.
-
(1992)
J Allergy Clin Immunol
, vol.90
, pp. 579-588
-
-
Gergen, P.J.1
Turkeltaub, P.C.2
-
5
-
-
0033508416
-
The relationships among environmental allergen sensitization, allergen exposure, pulmonary function, and bronchial hyperresponsiveness in the Childhood Asthma Management Program
-
Nelson HS, Szefler SJ, Jacobs J, Huss K, Shapiro G, et al. (1999) The relationships among environmental allergen sensitization, allergen exposure, pulmonary function, and bronchial hyperresponsiveness in the Childhood Asthma Management Program. J Allergy Clin Immunol 104: 775-785.
-
(1999)
J Allergy Clin Immunol
, vol.104
, pp. 775-785
-
-
Nelson, H.S.1
Szefler, S.J.2
Jacobs, J.3
Huss, K.4
Shapiro, G.5
-
6
-
-
0030895694
-
Alternaria as a major allergen for asthma in children raised in a desert environment
-
Halonen M, Stern DA, Wright AL, Taussig LM, Martinez FD, (1997) Alternaria as a major allergen for asthma in children raised in a desert environment. Am J Respir Crit Care Med 155: 1356-1361.
-
(1997)
Am J Respir Crit Care Med
, vol.155
, pp. 1356-1361
-
-
Halonen, M.1
Stern, D.A.2
Wright, A.L.3
Taussig, L.M.4
Martinez, F.D.5
-
7
-
-
0028814147
-
Modulation of airway intraepithelial dendritic cells following exposure to steroids
-
Nelson DJ, McWilliam AS, Haining S, Holt PG, (1995) Modulation of airway intraepithelial dendritic cells following exposure to steroids. Am J Respir Crit Care Med 151: 475-481.
-
(1995)
Am J Respir Crit Care Med
, vol.151
, pp. 475-481
-
-
Nelson, D.J.1
McWilliam, A.S.2
Haining, S.3
Holt, P.G.4
-
8
-
-
17144367365
-
In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma
-
van Rijt LS, Jung S, Kleinjan A, Vos N, Willart M, et al. (2005) In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med 201: 981-991.
-
(2005)
J Exp Med
, vol.201
, pp. 981-991
-
-
van Rijt, L.S.1
Jung, S.2
Kleinjan, A.3
Vos, N.4
Willart, M.5
-
9
-
-
0025762391
-
Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways
-
Schon-Hegrad MA, Oliver J, McMenamin PG, Holt PG, (1991) Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways. J Exp Med 173: 1345-1356.
-
(1991)
J Exp Med
, vol.173
, pp. 1345-1356
-
-
Schon-Hegrad, M.A.1
Oliver, J.2
McMenamin, P.G.3
Holt, P.G.4
-
10
-
-
0026551215
-
Intraepithelial airway dendritic cells: a distinct subset of pulmonary dendritic cells obtained by microdissection
-
Gong JL, McCarthy KM, Telford J, Tamatani T, Miyasaka M, et al. (1992) Intraepithelial airway dendritic cells: a distinct subset of pulmonary dendritic cells obtained by microdissection. J Exp Med 175: 797-807.
-
(1992)
J Exp Med
, vol.175
, pp. 797-807
-
-
Gong, J.L.1
McCarthy, K.M.2
Telford, J.3
Tamatani, T.4
Miyasaka, M.5
-
11
-
-
0027461765
-
Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages
-
Holt PG, Oliver J, Bilyk N, McMenamin C, McMenamin PG, et al. (1993) Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J Exp Med 177: 397-407.
-
(1993)
J Exp Med
, vol.177
, pp. 397-407
-
-
Holt, P.G.1
Oliver, J.2
Bilyk, N.3
McMenamin, C.4
McMenamin, P.G.5
-
12
-
-
79251585262
-
Characterisation of bronchus-associated lymphoid tissue and antigen-presenting cells in central airway mucosa of children
-
Heier I, Malmstrom K, Sajantila A, Lohi J, Makela M, et al. (2011) Characterisation of bronchus-associated lymphoid tissue and antigen-presenting cells in central airway mucosa of children. Thorax 66: 151-156.
-
(2011)
Thorax
, vol.66
, pp. 151-156
-
-
Heier, I.1
Malmstrom, K.2
Sajantila, A.3
Lohi, J.4
Makela, M.5
-
13
-
-
70049101757
-
Biology of lung dendritic cells at the origin of asthma
-
Lambrecht BN, Hammad H, (2009) Biology of lung dendritic cells at the origin of asthma. Immunity 31: 412-424.
-
(2009)
Immunity
, vol.31
, pp. 412-424
-
-
Lambrecht, B.N.1
Hammad, H.2
-
14
-
-
77956366626
-
The role of dendritic and epithelial cells as master regulators of allergic airway inflammation
-
Lambrecht BN, Hammad H, (2010) The role of dendritic and epithelial cells as master regulators of allergic airway inflammation. Lancet 376: 835-843.
-
(2010)
Lancet
, vol.376
, pp. 835-843
-
-
Lambrecht, B.N.1
Hammad, H.2
-
15
-
-
53849111567
-
Lung dendritic cells: targets for therapy in allergic disease
-
Lambrecht BN, (2008) Lung dendritic cells: targets for therapy in allergic disease. Curr Mol Med 8: 393-400.
-
(2008)
Curr Mol Med
, vol.8
, pp. 393-400
-
-
Lambrecht, B.N.1
-
16
-
-
77951817855
-
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
-
Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, et al. (2010) Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464: 1367-1370.
-
(2010)
Nature
, vol.464
, pp. 1367-1370
-
-
Neill, D.R.1
Wong, S.H.2
Bellosi, A.3
Flynn, R.J.4
Daly, M.5
-
17
-
-
33846515975
-
Induction of IL-4 expression in CD4(+) T cells by thymic stromal lymphopoietin
-
Omori M, Ziegler S, (2007) Induction of IL-4 expression in CD4(+) T cells by thymic stromal lymphopoietin. J Immunol 178: 1396-1404.
-
(2007)
J Immunol
, vol.178
, pp. 1396-1404
-
-
Omori, M.1
Ziegler, S.2
-
18
-
-
77951817294
-
IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses
-
Saenz SA, Siracusa MC, Perrigoue JG, Spencer SP, Urban JF Jr, et al. (2010) IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses. Nature 464: 1362-1366.
-
(2010)
Nature
, vol.464
, pp. 1362-1366
-
-
Saenz, S.A.1
Siracusa, M.C.2
Perrigoue, J.G.3
Spencer, S.P.4
Urban Jr., J.F.5
-
19
-
-
33845460525
-
Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity
-
Sharkhuu T, Matthaei KI, Forbes E, Mahalingam S, Hogan SP, et al. (2006) Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity. Clin Exp Allergy 36: 1575-1583.
-
(2006)
Clin Exp Allergy
, vol.36
, pp. 1575-1583
-
-
Sharkhuu, T.1
Matthaei, K.I.2
Forbes, E.3
Mahalingam, S.4
Hogan, S.P.5
-
20
-
-
58749115782
-
Reversal of thymic stromal lymphopoietin-induced airway inflammation through inhibition of Th2 responses
-
Zhou B, Headley MB, Aye T, Tocker J, Comeau MR, et al. (2008) Reversal of thymic stromal lymphopoietin-induced airway inflammation through inhibition of Th2 responses. J Immunol 181: 6557-6562.
-
(2008)
J Immunol
, vol.181
, pp. 6557-6562
-
-
Zhou, B.1
Headley, M.B.2
Aye, T.3
Tocker, J.4
Comeau, M.R.5
-
21
-
-
0019505760
-
Inhibition of specific IgE responses in mice by pre-exposure to inhaled antigen
-
Holt PG, Batty JE, Turner KJ, (1981) Inhibition of specific IgE responses in mice by pre-exposure to inhaled antigen. Immunology 42: 409-417.
-
(1981)
Immunology
, vol.42
, pp. 409-417
-
-
Holt, P.G.1
Batty, J.E.2
Turner, K.J.3
-
22
-
-
0021054152
-
Induction of IgE-isotype specific tolerance by passive antigenic stimulation of the respiratory mucosa
-
Sedgwick JD, Holt PG, (1983) Induction of IgE-isotype specific tolerance by passive antigenic stimulation of the respiratory mucosa. Immunology 50: 625-630.
-
(1983)
Immunology
, vol.50
, pp. 625-630
-
-
Sedgwick, J.D.1
Holt, P.G.2
-
23
-
-
0032473551
-
Aerosol-induced immunoglobulin (Ig)-E unresponsiveness to ovalbumin does not require CD8+ or T cell receptor (TCR)-gamma/delta+ T cells or interferon (IFN)-gamma in a murine model of allergen sensitization
-
Seymour BW, Gershwin LJ, Coffman RL, (1998) Aerosol-induced immunoglobulin (Ig)-E unresponsiveness to ovalbumin does not require CD8+ or T cell receptor (TCR)-gamma/delta+ T cells or interferon (IFN)-gamma in a murine model of allergen sensitization. J Exp Med 187: 721-731.
-
(1998)
J Exp Med
, vol.187
, pp. 721-731
-
-
Seymour, B.W.1
Gershwin, L.J.2
Coffman, R.L.3
-
24
-
-
73949118676
-
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
-
Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, et al. (2009) Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci U S A 106: 20388-20393.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 20388-20393
-
-
Iyer, S.S.1
Pulskens, W.P.2
Sadler, J.J.3
Butter, L.M.4
Teske, G.J.5
-
25
-
-
70249093313
-
Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2
-
Kouzaki H, O'Grady SM, Lawrence CB, Kita H, (2009) Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2. J Immunol 183: 1427-1434.
-
(2009)
J Immunol
, vol.183
, pp. 1427-1434
-
-
Kouzaki, H.1
O'Grady, S.M.2
Lawrence, C.B.3
Kita, H.4
-
26
-
-
70350341667
-
Link between allergic asthma and airway mucosal infection suggested by proteinase-secreting household fungi
-
Porter P, Susarla SC, Polikepahad S, Qian Y, Hampton J, et al. (2009) Link between allergic asthma and airway mucosal infection suggested by proteinase-secreting household fungi. Mucosal Immunol.
-
(2009)
Mucosal Immunol
-
-
Porter, P.1
Susarla, S.C.2
Polikepahad, S.3
Qian, Y.4
Hampton, J.5
-
27
-
-
79955040263
-
The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses
-
Kouzaki H, Iijima K, Kobayashi T, O'Grady SM, Kita H, (2011) The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J Immunol 186: 4375-4387.
-
(2011)
J Immunol
, vol.186
, pp. 4375-4387
-
-
Kouzaki, H.1
Iijima, K.2
Kobayashi, T.3
O'Grady, S.M.4
Kita, H.5
-
28
-
-
0029876629
-
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
-
Kaplan MH, Schindler U, Smiley ST, Grusby MJ, (1996) Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4: 313-319.
-
(1996)
Immunity
, vol.4
, pp. 313-319
-
-
Kaplan, M.H.1
Schindler, U.2
Smiley, S.T.3
Grusby, M.J.4
-
29
-
-
15844404509
-
Essential role of Stat6 in IL-4 signalling
-
Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, et al. (1996) Essential role of Stat6 in IL-4 signalling. Nature 380: 627-630.
-
(1996)
Nature
, vol.380
, pp. 627-630
-
-
Takeda, K.1
Tanaka, T.2
Shi, W.3
Matsumoto, M.4
Minami, M.5
-
30
-
-
0032127279
-
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
-
Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, et al. (1998) Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9: 143-150.
-
(1998)
Immunity
, vol.9
, pp. 143-150
-
-
Adachi, O.1
Kawai, T.2
Takeda, K.3
Matsumoto, M.4
Tsutsui, H.5
-
31
-
-
0031578229
-
Interleukin-18 activates NF-kappaB in murine T helper type 1 cells
-
Matsumoto S, Tsuji-Takayama K, Aizawa Y, Koide K, Takeuchi M, et al. (1997) Interleukin-18 activates NF-kappaB in murine T helper type 1 cells. Biochem Biophys Res Commun 234: 454-457.
-
(1997)
Biochem Biophys Res Commun
, vol.234
, pp. 454-457
-
-
Matsumoto, S.1
Tsuji-Takayama, K.2
Aizawa, Y.3
Koide, K.4
Takeuchi, M.5
-
32
-
-
0035222187
-
A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation
-
Das J, Chen CH, Yang L, Cohn L, Ray P, et al. (2001) A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol 2: 45-50.
-
(2001)
Nat Immunol
, vol.2
, pp. 45-50
-
-
Das, J.1
Chen, C.H.2
Yang, L.3
Cohn, L.4
Ray, P.5
-
33
-
-
7944224566
-
The role of protease activation of inflammation in allergic respiratory diseases
-
Reed CE, Kita H, (2004) The role of protease activation of inflammation in allergic respiratory diseases. J Allergy Clin Immunol 114: 997-1008; quiz 1009.
-
(2004)
J Allergy Clin Immunol
, vol.114
, pp. 997-1008
-
-
Reed, C.E.1
Kita, H.2
-
34
-
-
5844310778
-
IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6
-
Yoshimoto T, Mizutani H, Tsutsui H, Noben-Trauth N, Yamanaka K, et al. (2000) IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6. Nat Immunol 1: 132-137.
-
(2000)
Nat Immunol
, vol.1
, pp. 132-137
-
-
Yoshimoto, T.1
Mizutani, H.2
Tsutsui, H.3
Noben-Trauth, N.4
Yamanaka, K.5
-
35
-
-
0035898446
-
Regulation of interleukin (IL)-18 receptor alpha chain expression on CD4(+) T cells during T helper (Th)1/Th2 differentiation. Critical downregulatory role of IL-4
-
Smeltz RB, Chen J, Hu-Li J, Shevach EM, (2001) Regulation of interleukin (IL)-18 receptor alpha chain expression on CD4(+) T cells during T helper (Th)1/Th2 differentiation. Critical downregulatory role of IL-4. J Exp Med 194: 143-153.
-
(2001)
J Exp Med
, vol.194
, pp. 143-153
-
-
Smeltz, R.B.1
Chen, J.2
Hu-Li, J.3
Shevach, E.M.4
-
36
-
-
0033973582
-
Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
-
Ouyang W, Lohning M, Gao Z, Assenmacher M, Ranganath S, et al. (2000) Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 12: 27-37.
-
(2000)
Immunity
, vol.12
, pp. 27-37
-
-
Ouyang, W.1
Lohning, M.2
Gao, Z.3
Assenmacher, M.4
Ranganath, S.5
-
37
-
-
0032476742
-
Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation
-
Yang L, Cohn L, Zhang DH, Homer R, Ray A, et al. (1998) Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation. J Exp Med 188: 1739-1750.
-
(1998)
J Exp Med
, vol.188
, pp. 1739-1750
-
-
Yang, L.1
Cohn, L.2
Zhang, D.H.3
Homer, R.4
Ray, A.5
-
38
-
-
0034162514
-
IFN-gamma-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma
-
Wild JS, Sigounas A, Sur N, Siddiqui MS, Alam R, et al. (2000) IFN-gamma-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma. J Immunol 164: 2701-2710.
-
(2000)
J Immunol
, vol.164
, pp. 2701-2710
-
-
Wild, J.S.1
Sigounas, A.2
Sur, N.3
Siddiqui, M.S.4
Alam, R.5
-
39
-
-
61449199387
-
Asthma-related enviromental fungus, Alternaria, activates dendritic cells and produces potent Th2 adjuvant activity
-
Kobayashi T, Iijima K, Radhakrishnan S, Mehta V, Vassallo R, et al. (2009) Asthma-related enviromental fungus, Alternaria, activates dendritic cells and produces potent Th2 adjuvant activity. J Immunol 182: 2502-2510.
-
(2009)
J Immunol
, vol.182
, pp. 2502-2510
-
-
Kobayashi, T.1
Iijima, K.2
Radhakrishnan, S.3
Mehta, V.4
Vassallo, R.5
-
40
-
-
70249093313
-
Proteases induce production of thymic stromal lympho protein by airway epithelial cells through protease-activated receptor-2
-
Kouzaki H, O'Grady SM, Lawrence CB, Kita H, (2009) Proteases induce production of thymic stromal lympho protein by airway epithelial cells through protease-activated receptor-2. J Immunol 183: 1427-1434.
-
(2009)
J Immunol
, vol.183
, pp. 1427-1434
-
-
Kouzaki, H.1
O'Grady, S.M.2
Lawrence, C.B.3
Kita, H.4
-
41
-
-
23644456321
-
ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation
-
Boldogh I, Bacsi A, Choudhury BK, Dharajiya N, Alam R, et al. (2005) ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation. J Clin Invest 115: 2169-2179.
-
(2005)
J Clin Invest
, vol.115
, pp. 2169-2179
-
-
Boldogh, I.1
Bacsi, A.2
Choudhury, B.K.3
Dharajiya, N.4
Alam, R.5
-
42
-
-
0030293642
-
Immunomodulatory effects of IL-12 on allergic lung inflammation depend on timing of doses
-
Sur S, Lam J, Bouchard P, Sigounas A, Holbert D, et al. (1996) Immunomodulatory effects of IL-12 on allergic lung inflammation depend on timing of doses. J Immunol 157: 4173-4180.
-
(1996)
J Immunol
, vol.157
, pp. 4173-4180
-
-
Sur, S.1
Lam, J.2
Bouchard, P.3
Sigounas, A.4
Holbert, D.5
-
43
-
-
0033563211
-
Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides
-
Sur S, Wild JS, Choudhury BK, Sur N, Alam R, et al. (1999) Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. J Immunol 162: 6284-6293.
-
(1999)
J Immunol
, vol.162
, pp. 6284-6293
-
-
Sur, S.1
Wild, J.S.2
Choudhury, B.K.3
Sur, N.4
Alam, R.5
|