Constitutively signaling G-proteincoupled receptors and human disease

Trends in Endocrinology and Metabolism

Volumn 9, Issue 1, 1998, Pages 27-31

  Arvanitakis, Leandros ^a   Geras Raaka, Elizabeth ^b   Gershengorn, Marvin C ^b  

^a HELLENIC PASTEUR INSTITUTE   (Greece)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN;

CANCER; GENE MUTATION; GENOME; HERPES SIMPLEX VIRUS; HUMAN; PRIORITY JOURNAL; REVIEW; TUMOR; VIRUS CARCINOGENESIS;

EID: 0031897256     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(98)00007-1     Document Type: Article

References (43)

1. Ahuja SK, Murphy PM Molecular piracy of mammalian interleukin-8 receptor type B by Herpesvirus saimiri. J Biol Chem. 268:1993;20691-20694.
2. Arvanitakis L, Geras-Raaka E, Varma Aet al. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature. 385:1997;347-350.
3. Bais C, Santomasso B, Coso Oet al. Kaposi's sarcoma associated G protein-coupled receptor is a viral oncogene and angiogenesis activator. Nature. 391:1998;86-89.
4. 2C receptors reveal novel inverse agonist activity of receptor ligands. J Biol Chem. 269:1994;11687-11690.
5. 2-adrenoceptor. Nature. 374:1995;272-276.
6. Bouaboula M, Perrachon S, Milligan Let al. A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1 - evidence for a new model of receptor/ligand interactions. J Biol Chem. 272:1997;22330-22339.
7. Cesarman E, Nador RG, Bai Fet al. Kaposi's sarcoma associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma. J Virol. 70:1996;8218-8223.
8. Chang Y, Cesarman E, Pessin MSet al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 266:1994;1865-1869.
9. Chattopadhyay N, Mithal A, Brown EM The calcium-sensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism. Endocr Rev. 17:1996;289-307.
10. Chee MS, Satchwell SC, Preddie Eet al. Human cytomegalovirus encodes three G protein-coupled receptor homologues. Nature. 344:1990;774-777.
11. Chidiac P, Hebert TE, Valiquette Met al. Inverse agonist activity of β-adrenergic antagonists. Mol Pharmacol. 45:1994;490-499.
12. Cohen DP, Thaw CN, Varma Aet al. Human calcitonin receptors exhibit agonist-independent (constitutive) signaling activity. Endocrinology. 138:1997;1400-1405.
13. Costa T, Ogino Y, Munson PJet al. Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand. Mol Pharmacol. 41:1992;549-560.
14. Gao J-L, Murphy PM Human cytomegalovirus open reading frame US28 encodes a functional β chemokine receptor. J Biol Chem. 269:1994;28539-28542.
15. Gardella TJ, Luck MD, Jensen GSet al. Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively ac-tive mutant PTH/PTHrP receptors. Endocrinology. 137:1996;3936-3941.
16. Hasegawa H, Negishi M, Ichikawa A Two isoforms of the prostaglandin E receptor EP3 subtype different in agonist-independent constitutive activity. J Biol Chem. 271:1996;1857-1860.
17. Heinflink M, Nussenzveig DR, Grimberg Het al. A constitutively active mutant thyrotropin-releasing hormone receptor is chronically down-regulated in pituitary cells: evidence using chlordiazepoxide as a negative antagonist. Mol Endocrinol. 9:1995;1455-1460.
18. Jinsi-Parimoo A, Gershengorn MC Constitutive activity of native thyrotropin-releasing hormone receptors revealed using a protein kinase C-responsive reporter gene. Endocrinology. 138:1997;1471-1475.
19. Kosugi S, Van Dop C, Geffner MEet al. Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty. Hum Mol Genet. 4:1995;183-188.
20. Labrecque J, Fargin A, Bouvier Met al. Serotonergic antagonists differentially inhibit spontaneous activity and decrease ligand binding capacity of the rat 5-hydoxytryptamine type 2C receptor in Sf9 cells. Mol Pharmacol. 48:1995;150-159.
21. Leeb-Lundberg LMF, Mathis SA, Herzig MCS Antagonists of bradykinin that stabilize a G-protein-uncoupled state of the B2 receptor act as inverse agonists in rat myometrial cells. J Biol Chem. 269:1994;25970-25973.
22. Lefkowitz RJ, Cotecchia S, Samama Pet al. Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends Pharmacol Sci. 14:1993;303-307.
23. 2-adrenergic receptor. Science. 264:1994;582-586.
24. Nicholas J, Cameron KR, Honess RW Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins. Nature. 355:1992;362-365.
25. Nussenzveig DR, Thaw CN, Gershengorn MC Inhibition of inositol phosphate second messenger formation by intracellular loop one of a human calcitonin receptor. Expression and mutational analysis of synthetic receptor genes. J Biol Chem. 269:1994;28123-28129.
26. Post GR, Brown JH G protein-coupled receptors and signaling pathways regulating growth responses. FASEB. J 10:1996;741-749.
27. Prézeau L, Gomeza J, Ahern Set al. Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity. Mol Pharmacol. 49:1996;422-429.
28. Rao VR, Cohen GB, Oprian DD Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness. Nature. 367:1994;639-642.
29. Rettig MB, Ma HJ, Vescio RAet al. Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients. Science. 276:1997;1851-1854.
30. Robbins LS, Nadeau JH, Johnson KRet al. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell. 72:1993;827-834.
31. Robinson PR, Cohen GB, Zhukovsky EAet al. Constitutively active mutants of rhodopsin. Neuron. 9:1992;719-725.
32. Russo JJ, Bohenzky RA, Chien MCet al. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci USA. 93:1996;14862-14867.
33. 2-adrenergic receptor. Extending the ternary complex model. J Biol Chem. 268:1993;4625-4636.
34. Scheer A, Cotecchia S Constitutively active G protein-coupled receptors: potential mechanisms of receptor activation. J Recept Signal Transduct Res. 17:1997;57-73.
35. Schipani E, Kruse K, Jüppner H A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science. 268:1995;98-100.
36. Schutz W, Freissmuth M Reverse intrinsic activity of antagonists on G protein-coupled receptors. Trends Pharmacol Sci. 13:1992;376-380.
37. Shenker A, Laue L, Kosugi Set al. A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature. 365:1993;652-654.
38. 2 receptors. Proc Natl Acad Sci USA. 93:1996;6802-6807.
39. Spiegel AM Defects in G protein-coupled signal transduction in human disease. Annu Rev Physiol. 58:1995;143-170.
40. Strader CD, Fong TM, Tota MRet al. Structure and function of G protein-coupled receptors. Annu Rev Biochem. 63:1994;101-132.
41. Themmen APN, Martens JWM, Brunner HG Gonadotropin receptor mutations. J Endocrinol. 153:1997;179-183.
42. Tiberi M, Caron MG High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype. J Biol Chem. 269:1994;27925-27931.
43. Van Sande J, Parma J, Tonacchera Met al. Somatic and germline mutations of the TSH receptor gene in thyroid diseases. J Clin Endocrinol Metab. 80:1995;2577-2585.