The constitutive activity of the ghrelin receptor attenuates apoptosis via a protein kinase C-dependent pathway

Molecular and Cellular Endocrinology

Volumn 299, Issue 2, 2009, Pages 232-239

  Lau, Pui Ngan ^a   Chow, Kevin B S ^a   Chan, Chi Bun ^a   Cheng, Christopher H K ^a   Wise, Helen ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

Apoptosis; Constitutive activity; Ghrelin receptors

Indexed keywords

CADMIUM; CASPASE 3; GHRELIN RECEPTOR; INOSITOL PHOSPHATE; PHOSPHOLIPASE C; PROTEIN KINASE C; STAUROSPORINE;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEA BREAM; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; APOPTOSIS; CASPASE 3; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DNA FRAGMENTATION; ENZYME ACTIVATION; HUMANS; OLIGOPEPTIDES; PROTEIN KINASE C; RECEPTORS, GHRELIN; SEA BREAM; STAUROSPORINE; TRANSFECTION; TYPE C PHOSPHOLIPASES;

EID: 58649097003     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.12.006     Document Type: Article

References (46)

1. Ajenjo N., Canon E., Sanchez-Perez I., Matallanas D., Leon J., Perona R., and Crespo P. Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells. J. Biol. Chem. 279 (2004) 32813-32823
2. Andreis P.G., Malendowicz L.K., Trejter M., Neri G., Spinazzi R., Rossi G.P., and Nussdorfer G.G. Ghrelin and growth hormone secretagogue receptor are expressed in the rat adrenal cortex: evidence that ghrelin stimulates the growth, but not the secretory activity of adrenal cells. FEBS Lett. 536 (2003) 173-179
3. Arnaldi G., Mancini T., Kola B., Appolloni G., Freddi S., Concettoni C., Bearzi I., Masini A., Boscaro M., and Mantero F. Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors. J. Clin. Endocrinol. Metab. 88 (2003) 5834-5840
4. Belloni A.S., Macchi C., Rebuffat P., Conconi M.T., Malendowicz L.K., Parnigotto P.P., and Nussdorfer G.G. Effect of ghrelin on the apoptotic deletion rate of different types of cells cultured in vitro. Int. J. Mol. Med. 14 (2004) 165-167
5. Camina J.P., Lodeiro M., Ischenko O., Martini A.C., and Casanueva F.F. Stimulation by ghrelin of p42/p44 nitrogen-activated protein kinase through the GHS-R1a receptor: role of G-proteins and β-arrestins. J. Cell Physiol. 213 (2007) 187-200
6. Cao J.M., Ong H., and Chen C. Effects of ghrelin and synthetic GH secretagogues on the cardiovascular system. Trends Endocrinol. Metabol. 17 (2006) 13-18
7. Carreira M.C., Camiña J.P., Díaz-Rodrìguez E., Alvear-Perez R., Llorens-Cortes C., and Casanueva F.F. Adenosine does not bind to the growth hormone secretagogue receptor type-1a (GHS-R1a). J. Endocrinol. 191 (2006) 147-157
8. Chan C.B., and Cheng C.H.K. Identification and functional characterization of two alternatively spliced growth hormone secretagogue receptor transcripts from the pituitary of black seabream Acanthopagrus schlegeli. Mol. Cell. Endocrinol. 214 (2004) 81-95
9. Chan C.B., Leung P.K., Wise H., and Cheng C.H.K. Signal transduction mechanism of the seabream growth hormone secretagogue receptor. FEBS Lett. 577 (2004) 147-153
10. Chow K.B.S., Wong Y.H., and Wise H. Prostacyclin receptor-independent inhibition of phospholipase C activity by non-prostanoid prostacyclin mimetics. Br. J. Pharmacol. 134 (2001) 1375-1384
11. Chu K.M., Chow K.B.S., Leung P.K., Lau P.N., Chan C.B., Cheng C.H.K., and Wise H. Over-expression of the truncated ghrelin receptor polypeptide attenuates the constitutive activation of phosphatidylinositol-specific phospholipase C by ghrelin receptors but has no effect on ghrelin-stimulated extracellular signal-regulated kinase 1/2 activity. Int. J. Biochem. Cell Biol. 39 (2007) 752-764
12. Chung H., Kim E., Lee D.H., Seo S., Ju S., Lee D., Kim H., and Park S. Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation. Endocrinology 148 (2007) 148-159
13. Davenport A.P., Bonner T.I., Foord S.M., Harmar A.J., Neubig R.R., Pin J.P., Spedding M., Kojima M., and Kangawa K. International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function. Pharmacol. Rev. 57 (2005) 541-546
14. Delgado-Rubín de Célix A., Chowen J.A., Argente J., and Frago L.M. Growth hormone releasing peptide-6 acts as a survival factor in glutamate-induced excitotoxicity. J. Neurochem. 99 (2006) 839-849
15. Duxbury M.S., Waseem T., Ito H., Robinson M.K., Zinner M.J., Ashley S.W., and Whang E.E. Ghrelin promotes pancreatic and adenocarcinoma cellular proliferation and invasiveness. Biochem. Biophys. Res. Commun. 309 (2003) 464-468
16. Frago L.M., Pañeda C., Dickson S.L., Hewson A.K., Argente J., and Chowen J.A. Growth hormone (GH) and GH-releasing peptide-6 increase brain insulin-like growth factor-1 expression and activate intracellular signaling pathways involved in neuroprotection. Endocrinology 143 (2002) 4113-4122
17. Gaytan F., Barreiro M.L., Caminos J.E., Chopin L.K., Herington A., Morales C., Pinilla L., Paniagua R., Nistal M., Casanueva F.F., Aguilar E., Dieguez C., and Tena-Sempere M. Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors. J. Clin. Endocrinol. Metab. 89 (2004) 400-409
18. Glavaski-Joksimovic A., Jeftinija K., Scanes C.G., Anderson L.L., and Jeftinija S. Stimulatory effect of ghrelin on isolated procine somatotropes. Neuroendocrinology 77 (2003) 367-379
19. Hamada T., Sasaguri T., Tanimoto A., Arima N., Shimajiri S., Abe T., and Sasaguri Y. Apoptosis of human kidney 293 cells is promoted by polymerized cadmium-metallothionein. Biochem. Biophys. Res. Commun. 219 (1996) 829-834
20. Holst B., Brandt E., Bach A., Heding A., and Schwartz T.W. Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling. Mol. Endocrinol. 19 (2005) 2400-2411
21. Holst B., Cygankiewicz A., Jensen T.H., Ankersen M., and Schwartz T.W. High constitutive signaling of the ghrelin receptor-identification of a potent inverse agonist. Mol. Endocrinol. 17 (2003) 2201-2210
22. Holst B., and Schwartz T.W. Ghrelin receptor mutations-too little height and too much hunger. J. Clin. Invest. 116 (2006) 637-641
23. Howard A.D., Feighner S.D., Cully D.F., Arena J.P., Liberator P.A., Rosenblum C.I., Hamelin M., Hreniuk D.L., Palyha O.C., Anderson J., Paress P.S., Diaz C., Chou M., Liu L.-Y., McKee K.K., Pong S.-S., Chaung L.-Y., Elbrecht A., Dashkevicz M., Heavens R., Rigby M., Sirinathsinghji D.J.S., Dean D.C., Melillo D.G., Patchett A.A., Nargund R., Griffin P.R., DeMartino J.A., Gupta S.K., Schaeffer J.M., Smith R.G., and Van der Ploeg L.H.T. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273 (1996) 974-977
24. Jeffery P.L., Herington A.C., and Chopin L.K. The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer. Cytokine Growth Factor Rev. 14 (2003) 113-122
25. Jeffery P.L., Herington A.C., and Chopin L.K. Expression and action of the growth hormone releasing peptide ghrelin and its receptor in prostate cancer cell lines. J. Endocrinol. 172 (2002) R7-R11
26. Kim M.S., Yoon C.Y., Jang P.G., Park Y.J., Shin C.S., Park H.S., Ryu J.W., Pak Y.K., Park J.Y., Lee K.U., Kim S.Y., Lee H.K., Kim Y.B., and Park K.S. The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes. Mol. Endocrinol. 18 (2004) 2291-2301
27. Kim S.W., Her S.J., Park S.J., Kim D., Park K.S., Lee H.Y., Han B.H., Kim M.S., Shin C.S., and Kim S.Y. Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells. Bone 37 (2005) 359-369
28. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
29. Korbonits M., Bustin S.A., Kojima M., Jordan S., Adams E.F., Lowe D.G., Kangawa K., and Grossman A.B. The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. J. Clin. Endocrinol. Metab. 86 (2001) 881-887
30. Leung P.K., Chow K.B.S., Lau P.N., Chu K.M., Chan C.B., Cheng C.H.K., and Wise H. The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor. Cell. Signal. 19 (2007) 1011-1022
31. Li A., Cheng G., Zhu G.H., and Tarnawski A.S. Ghrelin stimulates angiogenesis in human microvascular endothelial cells: implications beyond GH release. Biochem. Biophys. Res. Commun. 353 (2007) 238-243
32. López E., Figueroa S., Oset-Gasque M.J., and Gonzàlez M.P. Apoptosis and necrosis: two distinct events induced by cadmium in cortical neurons in culture. Br. J. Pharmacol. 138 (2003) 901-911
33. Mousseaux D., Le Gallic L., Ryan J., Oiry C., Gagne D., Fehrentz J.-A., Galleyrand J.-C., and Martinez J. Regulation of ERK1/2 activity by ghrelin-activated growth hormone secretagogue receptor 1A involves a PLC/PKCε pathway. Br. J. Pharmacol. 148 (2006) 350-365
34. Nanzer A.M., Khalaf S., Mozid A.M., Fowkes R.C., Patel M.V., Burrin J.M., Grossman A.B., and Korbonits M. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur. J. Endocrinol. 151 (2004) 233-240
35. New D.C., Wu K., Kwok A.W.S., and Wong Y.H. G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis. FEBS J. 274 (2007) 6025-6036
36. Nicholson D.W. Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ. 6 (1999) 1028-1042
37. Ozawa K., Kuwabara K., Tamatani M., Takatsuji K., Tsukamoto Y., Kaneda S., Yanagi H., Stern D.M., Eguchi Y., Tsujimoto Y., Ogawa S., and Tohyama M. 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death. J. Biol. Chem. 274 (1999) 6397-6404
38. Sato M., Nakahara K., Goto S., Kaiya H., Miyazato M., Date Y., Nakazato M., Kangawa K., and Murakami N. Effects of ghrelin and des-acyl ghrelin on neurogenesis of the rat fetal spinal cord. Biochem. Biophys. Res. Commun. 350 (2006) 598-603
39. Smith R.G., Cheng K., Schoen W.R., Pong S.-S., Hickey G., Jacks T., Butler B., Chan W.W.S., Chaung L.-Y.P., Judith F., Taylor J., Wyvratt M.J., and Fisher M.H. A nonpeptidyl growth hormone secretagogue. Science 260 (1993) 1640-1643
40. Takahashi K., Furukawa C., Takano A., Ishikawa N., Kato T., Hayama S., Suzuki C., Yasui W., Inai K., Sone S., Ito T., Nishimura F., Tsuchiya E., Nakamura Y., and Daigo Y. The neuromedin U-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer. Cancer Res. 66 (2006) 9408-9419
41. van der Lely A.J., Tschop M., Heiman M.L., and Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr. Rev. 25 (2004) 426-457
42. Volante M., Allia E., Gugliotta P., Funaro A., Broglio F., Deghenghi R., Muccioli G., Ghigo E., and Papotti M. Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. J. Clin. Endocrinol. Metab. 87 (2002) 1300-1308
43. Whelan J.A., Russell N.B., and Whelan M.A. A method for the absolute quantification of cDNA using real-time PCR. J. Immunol. Methods 278 (2003) 261-269
44. Wyllie A.H. Glucocorticoid-induced thymocyte apoptosis is associated with endoenous endonuclease activation. Nature 284 (1980) 555-556
45. Yeung C.M., Chan C.B., Woo N.Y.S., and Cheng C.H.K. Seabream ghrelin: cDNA cloning, genomic organization and promoter studies. J. Endocrinol. 189 (2006) 365-379
46. Zhang W.Z., Hu Y.X., Lin T.R., Fan Y.Y., and Mulholland M.W. Stimulation of neurogenesis in rat nucleus of the solitary tract by ghrelin. Peptides 26 (2005) 2280-2288