Role of chitotriosidase (Chitinase 1) under normal and disease conditions

Journal of Epithelial Biology and Pharmacology

Volumn 5, Issue , 2012, Pages 1-9

  Kanneganti, Manasa ^a   Kamba, Alan ^a   Mizoguchi, Emiko ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Autoimmunity; Chitinase; Infection; Inflammation; Receptor

Indexed keywords

CHITINASE; CHITINASE LIKE PROTEIN; CHITOTRIOSIDASE; GLUCOSYLCERAMIDE; LYSOSOME ENZYME; MIGLUSTAT; PROTEIN CHI3L1; PROTEIN CHIT1; UNCLASSIFIED DRUG;

ARTICLE; ATHEROSCLEROSIS; BIOLOGICAL ACTIVITY; DISEASE ASSOCIATION; ENTERITIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME LOCALIZATION; ENZYME REPLACEMENT; ENZYME SYNTHESIS; GAUCHER DISEASE; HUMAN; LUNG CANCER; MACROPHAGE ACTIVATION; MALARIA FALCIPARUM; MOLECULAR PATHOLOGY; MUTATOR GENE; NIEMANN PICK DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NPC1 GENE; NPC2 GENE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; SARCOIDOSIS; UPREGULATION;

BACTERIA (MICROORGANISMS); EUKARYOTA; FUNGI; MAMMALIA;

EID: 84856596796     PISSN: None     EISSN: 18750443     Source Type: Journal    
DOI: 10.2174/1875044301205010001     Document Type: Article

References (105)

1. Hollak CE, Weely SV, Oers MHV, et al. Marked elevation of plasma chitotriosidase activity. A novel hallmark of Gaucher disease. J Clin Invest 1994; 93: 1288-92.
2. Malaguarnera L. Chitotriosidase: the yin and yang. Cell Mol Life Sci 2006; 63: 3018-29.
3. Aerts JM, Hollak CE. Plasma and metabolic abnormalities in Gaucher's disease. Baillieres Clin Haematol 1997; 10: 691-709.
4. Eiberg H, Den Tandt WR. Assignment of human plasma methylumbelliferyl-tetra-N-acetylchitotetraside hydrolase or chitinase to chromosome 1q by a linkage study. Human Genet 1997; 101: 205-7.
5. Fusetti F, von Moeller H, Huuston D, et al. Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins. J Biol Chem 2002; 277: 25537-44.
6. Boot RG, Renkema GH, Verhock M, et al. The human chitotriosidase gene. Nature of inherited enzyme deficiency. J Biol Chem 1998; 273: 25680-5.
7. Choi EH, Zimmerman PA, Foster CB, Zhu S, et al. Genetic polymorphisms in molecules of innate immunity and susceptibility to infection with Wuchereria bacrofti in South India. Genes Immun 2001; 2: 248-53.
8. Malaguarnera L, Simpore J, Prodi DA, et al. A 24-bp duplication in exon 10 of human chitotriosidase gene from the sub-Sharan to the Mediterranean area: role of parastic diseases and environmental conditions. Genes Immun 2003; 4:570-4.
9. Labadaridis I, Dimitriou E, Theodorakis M, et al. Chitotriosidase in neonates with fungal and bacterial infections. Arch Dis Child Fetal Neonatal Ed 2005; 90: F531-2.
10. Van Eijk M, van Roomen CP, Renkema GH, et al. Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity. Int Immunol 2005; 17: 1505-12.
11. Malaguarnera L, Di Rosa M, Zambito AM, et al. Potential role of chitotriosidase gene in nonalcoholic fatty liver disease evolution. Am J Gastroenterol 2006; 101: 2060-9.
12. Ross R. Atherosclerosis: an inflammatory disease. N Eng J Med 1999; 340: 115-26.
13. Moreno PR, Falk E, Palacios IF, et al. Macrophages infiltration in acute coronary syndromes: implications for plaque rupture. Circulation 1994; 90: 775-8.
14. Tharanathan RN, Kittur FS. Chitin-the undisputed biomolecule of great potential. Crit Rev Food Sci Nutr 2003; 43: 61-87.
15. Goodday GW. The ecology of chitin degratiotic. Advance in microbial ecology. New York: Plenum Press 1990; pp. 387-430.
16. Vandevenne M, Campisi V, Freichels A, et al. Comparative functional analysis of the human macrophage chitotriosidase. Protein Sci 2011; 10.1002/pro.676. [Epub ahead of print].
17. Funkhouser JD, Aronson NN Jr. Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family. BMC Evol Biol 2007; 7: 96-111.
18. Bussink AP, Speijer D, Aerts JM, et al. Evolution of mammalian chitinase(-like) members of family 18 glycosyl hydrolases. Genetics 2007; 177: 959-70.
19. Yan Z, Lambert NC, Guthrie KA, et al. Male microchimerism in women without sons: quantitative assessment and correlation with pregnancy history. Am J Med 2005; 118: 899-906.
20. Elias JA, Homer RJ, Hamid Q, et al. Chitinases and chitinase-like proteins in TH2 inflammation and asthma. J Allergy Clin Immunol 2005; 116: 497-500.
21. Park SK, Cho HW, Heo KW, et al. Role of acidic mammalian chitinase and chitotriosidase in nasal polyps. Otolaryngol Head Neck Surg 2009; 141: 462-6.
22. Kucur M, Isman FK, Balci C, et al. Serum YKL-40 levels and chitotriosidase activity as potential biomarkers in primary prostate cancer and benign prostatic hyperplasia. Urol Oncol 2008; 26: 47-52.
23. Chou YT, Yao S, Czerwinski R, et al. Kinetic characterization of recombinant human acidic mammalian chitinase. Biochemistry 2006; 45: 4444-54.
24. Fusetti F, Pijning T, Kalk KH, et al. Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39. J Biol Chem 2003; 278: 37753-60.
25. Webb Dc, McKenzie AN, Foster PS. Expression of the Ym2 lectinbinding protein is dependent on interleukin (IL)-4 and IL-13 signal transduction: identification of a novel allergy-associated protein. J Biol Chem 2001; 276: 41969-76.
26. Shuhui L, Mok YK, Wong WS. Role of mammalian chitinases in asthma. Int Arch Allergy Immunol 2009; 149: 369-77.
27. Dickey BF. Exoskeletons and exhalation. N Engl J Med 2007; 357: 2082-4.
28. Mizoguchi E. Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells. Gastroenterology 2006; 130: 398-411.
29. Kawada M, Chen CC, Arihiro A, et al. Chitinase 3-like-1 enhances bacterial adhesion to colonic epithelial cells through the interaction with bacterial chitin-binding protein. Lab Invest 2008; 88: 883-95.
30. Hall AJ, Morroll S, Tighe P. Human chitotriosidase is expressed in the eye and lacrimal gland and has an antimicrobial spectrum different from lysozyme. Microbes Infect 2008; 10: 69-78.
31. Sutherland TE, Maizels RM, Allen JE. Chitinases and chitinaselike proteins: potential therapeutic targets for the treatment of Thelper type 2 allergies. Clin Exp Allergy 2009; 7: 943-55.
32. Artieda M, Cenarro A, Ganan A, et al. Serum chitotriosidase activity is increased in subjects with atherosclerosis disease. Arterioscler Thromb Vasc Biol 2003; 23: 1645-52.
33. Malaguarnera L, Di Rosa M, Zambito AM, et al. Chitotriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver disease. Gut 2008; 55: 1313-20.
34. Brunner JK, Scholl-Bürgi S, Hössinger D, et al. Chitotriosidase activity in juvenile idiopathic arthritis. Rheumatol Int 2008; 28: 949-50.
35. Johansen JS. Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodeling, fibroses and cancer. Dan Med Bull 2006; 53: 172-209.
36. Kawada M, Hachiya Y, Arihiro A, et al. Role of mammalian chitinases in inflammatory conditions. Keio J Med 2007; 56: 21-7.
37. Sumarac Z, Suvajdžić N, Ignjatović S, et al. Biomarkers in Serbian patients with Gaucher disease. Clin Biochem 2011; 44: 950-4.
38. Di Rosa M, Zambito AM, Marsullo AR, et al. Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways. J Cell Biochem 2009; 107: 881-9.
39. Ober C, Chupp GL. The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune mediated diseases. Curr Opin Allergy Clin Immunol 2009; 9: 401-8.
40. Boot RG, Renkema GH, Strijland A. Cloning of cDNA encoding chitotriosidase, a human chitinase produced by macrophages. J Biol Chem 1995; 270: 26252-6.
41. Boot RG, Blommaart EF, Swart E, et al. Identification of a novel acidic mammalian chitinase distinct from chitotriosidase. J Biol Chem 2001; 276: 6770-8.
42. Fusetti F, von Moeller H, Houston D, et al. Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins. J Biol Chem 2002; 277: 25537-44.
43. Van Aalten DM, Synstad B, Brurberg MB, et al. Structure of a two-domain chitotriosidase from Serratia marcescens at 1.9-A resolution. Proc Natl Acad Sci USA 2000; 97: 5842-7.
44. Beutler E, Grabowsky GA, Scrivner CR, Beaudet AL, Sly WS, Valle D, Eds. The metabolic and molecular basis of inherited disease. New York: McGraw Hill Inc 1995.
45. Cooper DN, Schmidtke J. Molecular genetic approaches to the analysis and diagnosis of human inherited disease: an overview. Ann Med 1992; 24: 29-42.
46. Daniels LB, Glew RH, Diven WF, et al. An improved fluorimetric leukocyte beta-glucosidase assay for Gaucher disease. Clin Chim Acta 1981; 115: 369-75.
47. Wenger DA, Clark C, Sattler M, et al. Synthetic substrate β-glycosidase activity in leukocytes: a reproducible method for the identification of patients and carriers of Gaucher's disease. Clin Genet 1978; 13: 145-53.
48. Staretz-Chacham O, Lang TC, LaMarca ME, et al. Lysosomal storage disorders in the newborn. Pediatrics 2009; 123: 1191-207.
49. Marsden D, Levy H. Newborn screening of lysosomal storage disorders. Clin Chem 2010; 56: 1071-9.
50. Rice EO, Barranger JA. Laboratory diagnosis of and genetic counseling for Gaucher disease. Gaucher Clin Perspect 1996. 4: 1-15.
51. Vellodi A, Foo Y, Cole TJ. Evaluation of three biochemical markers in the monitoring of Gaucher disease. J Inherit Metab Dis 2005; 28: 585-92.
52. Deegan PB, Cox TM. Clinical evaluation of biomarkers in Gaucher disease. Acta Paediatr 2005; 94: 47-50.
53. Aerts JMFG, Hollak CEM, Van Breemen M, et al. Identification and use of biomarkers in Gaucher disease and other lysosomal storage diseases. Acta Paediatr 2005; 94: 43-6.
54. Vedder AC, Cox Brinkman J, Hollak CE, et al. Plasma chitotriosidase in male Fabry patients: a marker for monitoring lipid-laden macrophages and correction by enzyme replacement therapy. Mol Genet Metab 2006; 89: 239-44.
55. Guffon N. Gaucher disease and chitotriosidase. Rev Med Interne 2006; 27: S26-S9.
56. Aerts JMFG, Boot RG, Blammaart EFC, et al. Chitotriosidase: applications and features of the enzyme. Gaucher Clin Perspect 1999; 7: 4-8.
57. Guo Y, He W, Boer AM, et al. Elevated plasma chitotriosidase activity in various lysosomal storage disorders. J Inherit Metab Dis 1995; 18: 717-22.
58. Bouzas L, Guinarte JC, Tutor JC. Chitotriosidase activity in plasma and mononuclear and polymononuclear leukocyte populations. J Clin Lab Anal 2003; 17: 271-5.
59. Baroe R, Sotgiu S, Musumeci S. Plasma chitotriosidase in health and pathology. Clin Lab 2007; 53: 321-33.
60. Wajner A, Michelin K, Burin MG, et al. Comparison between the biochemical properties of plasma chitotriosidase from normal individuals and from patients with Gaucher disease, GM1-gangliosidosis, Krabbe disease and heterozygotes for Gaucher disease. Clin Biochem 2007; 40: 365-9.
61. Novakovic I, Maksimovic N, Cvetkovic S. Gene polymorphisms as marker of disease susceptibility. J Med Biochem 2010; 29: 135-8.
62. Harmanci O, Bayraktar Y. Gaucher disease: new developments in treatment and etiology. World J Gastroenterol 2008; 14: 3968-73.
63. Brady RO, Murray GJ, Barton NW. Modifying exogenous glucocerebrosidase for effective replacement therapy in Gaucher disease. J Inherit Metab Dis 1994; 17: 510-9.
64. Sumarac Z, Suvajdžić N, Iggjatović S, et al. Biomarkers in Serbian patients with Gaucher disease. Clin Biochem 2011; 44: 950-4.
65. Zervas M, Somers KL, Thrall MA, et al. Critical role for glycosphingolipids in Niemann-Pick disease type C. Curr Bio 2001; 11: 1283-7.
66. Lo SM, McNamara J, Seashore MR. Misdiagnosis of Niemann-Pick disease type C as Gaucher disease. J Inherit Metab Dis 2010. [Epub ahead of print].
67. Brinkman J, Wijburg FA, Hollak CE. Plasma chitotriosidase and CCL18: early biochemical surrogate markers in type B Niemann-Pick disease. J Inherit Metab Dis 2005; 28: 13-20.
68. Sheth JJ, Sheth FJ, Oza NJ, et al. Plasma chitotriosidase activity in children with lysosomal storage disorders. Indian J Pediatr 2010; 77: 203-5.
69. Barone R, Simporé J, Malaguarnera L, et al. Plasma chitotriosidase activity in acute Plasmodium falciparum malaria. Clin Chim Acta 2003; 331: 79-85.
70. Weatherall DJ, Abdalla S. The anaemia of Plasmodium falciparum malaria. Br Med Bull 1982; 38: 147-51.
71. Weiss L. The spleen in malaria: the role of barrier cells. Immunol Lett 1990; 25: 165-72.
72. Kwiatkowski D. The molecular genetic approach to malarial pathogenesis and immunity. Parassitologia 1999; 41: 233-40.
73. Haffner SM, Lehto S, Ronnemaa T, et al. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Eng J Med 1998; 339: 229-34.
74. Souza BM, Assmann TS, Kliemann LM, et al. The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications. Arg Bras Endocrinol Metabol 2011; 55: 239-48.
75. Sibal L, Agarwal SC, Home PD, et al. The role of asymmetric dimethylarginine (ADMA) in endothelial dysfunction and cardiovascular disease. Curr Cardiol Rev 2010; 6: 82-90.
76. Sonmez A, Haymana C, Tapan S, et al. Chitotriosidase activity predicts endothelial dysfunction in type-2 diabetes mellitus. Endocrine 2010; 37: 455-9.
77. Baughman RP, Lower EE, du Bois RM. Sarcoidosis. Lancet 2003; 361: 1111-8.
78. Rossman MD, Kreider ME. Lesson learned from ACCESS (A case controlled etiologic study of sarcoidosis). Proc Am Thorac Soc 2007; 4: 453-6.
79. Reich JM. Mortality of intrathoracic sarcoidosis in referral vs population-based settings: influence of stage, ethnicity and corticosteroid therapy. Chest 2002; 121: 32-9.
80. Bargagli E, Bianchi N, Margollicci M, et al. Chitotriosidase and soluble IL-2 receptor: comparison of two markers of sarcoidosis severity. Scand J Clin Invest 2008; 68: 479-83.
81. Boot RG, Hollak CEM, Verhoek M, et al. Plasma chitotriosidase and CCL18 as surrogate markers for granulomatous macrophages in sarcoidosis. Clin Chim Acta 2010; 411: 31-6.
82. Teřcelj M, Rott T, Rylander R. Antifungal treatment in sarcoidosis-a pilot intervention trial. Resp Med 2007; 101: 774-8.
83. Teřcelj M, Salobir B, Rylander R. Microbial antigen treatment in sarcoidosis-a new paradigm? Medical Hypotheses 2008; 70: 831-4.
84. Tercelj M, Salobir B, Simcic S, et al. Chitotriosidase activity in sarcoidosis and some other pulmonary diseases. Scand J Clin Lab Invest 2009; 69: 575-8.
85. Lusis AJ, Mar R, Pajukanta P. Genetics of Atherosclerosis. Annu Rev Genomics Hum Genet 2004; 5: 189-218.
86. Stary HC. Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis 1989; 9: 19-32.
87. Febbraio M, Podrez EA, Smith JD, et al. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. J Clin Invest 2000; 105: 1049-56.
88. Karadag B, Kucur M, Isman FK, et al. Serum chitotriosidase activity in patients with coronary artery disease. Circ J 2008; 72: 71-5.
89. Artieda M, Cenarro A, Ganan A, et al. Serum chitotriosidase activity is increased in subjects with atherosclerosis disease. Arterioscler Thromb Vasc Biol 2003; 23: 1645-52.
90. Canudas J, Cenarro A, Civeira F, et al. Chitotriosidase genotype and serum activity in subjects with combined hyperlipidemia: effect of the lipid-lowering agents, atorvastatin and bezafibrate. Metabolism 2001; 50: 447-50.
91. Boot RG, van Achterberg TA, van Aken BE, et al. Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages. Arterioscler Thromb Vasc Biol 1999; 19: 687-94.
92. Moreno PR, Falk E, Palacios IF, et al. Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture. Circulation 1994; 90: 775-8.
93. Iqbal N, Oliver JR, Wagner FH, Lazenby AS, Elson CO, Weaver CT. T helper 1 and T helper 2 cells are pathogenic in an antigenspecific model of colitis. J Exp Med 2002; 195: 71-84.
94. Maggio-Price L, Shows D, Waggie K, et al. Helicobacter billis infection accelerates and H. hepaticus infection delays the development of colitis in multi drug resistance-deficient (mdr1a-/-) mice. Am J Pathol 2002; 160:739-51.
95. Mizoguchi A, Mizoguchi E, Bhan AK. Immune networks in animal models of inflammatory bowel disease. Inflamm Bowel Dis 2003; 9: 246-59.
96. Sartor SB. Role of commensal enteric bacteria in the pathogenesis of immune-mediated intestinal inflammation: lessons from animal models and implications for translational research. J Pediatr Gastroenterol Nutr 2005; 40:S30-S1.
97. Darfeuille-Michaud A, Boudeau J, Bulois P, et al. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 2004; 127: 412-21.
98. Swidsinski A, Ladhoff A, Pernthaler A, et al. Mucosal flora in inflammatory bowel disease. Gastroenterology 2002; 22:44-54.
99. Recklies AD, White C, Ling H. The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase-and protein kinase B-mediated signaling pathways. J Biochem 2002; 365:119-26.
100. Boot RG, Bussink AP, Verhoek M, de Boer PAJ, Moorman AFM, Aerts JFMG. Marked differences in tissue-specific expression of chitinases in mouse and man. J Histochem Cytochem 2005; 53:1283-92.
101. Zhu Z, Zheng T, Homer RJ, et al. Acidic mammalian chhitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science 2003; 304: 1678-82.
102. Golab K, Passowicz-Muszynska E, Jankowska R. Serum activity of chitotriosidase, lysozyme and cathepsin H in patients with lung cancer and patients with inflammatory exudate (preliminary report). Pol Merkur Lekarski 2009; 26:194-7.
103. Tercelj M, Salobir B, Simcic S, Wraber B, Zupancic M, Rylander R. Chitotriosidase activity in sarcoidosis and some other pulmonary diseases. Scand J Clin Lab Invest 2009; 69: 575-8.
104. Kucur M, Isman FK, Balci C, et al. Serum YKL-40 levels and chitotriosidase activity as potential biomarkers in primary prostate cancer and benign prostatic hyperplasia. Urol Oncol 2008; 26: 47-52.
105. Qureshi AM, Hannigan A, Campbell D, Nixon C, Wilson JB. Chitinase-like proteins are autoantigens in a model of inflammationpromoted incipient neoplasia. Genes Cancer 2011; 2: 74-87.