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Volumn 9, Issue 5, 2009, Pages 401-408

The chitinase and chitinase-like proteins: A review of genetic and functional studies in asthma and immune-mediated diseases

Author keywords

Acid mammalian chitinase; CHI3L1; CHIA; CHIT1; Chitotriosidase; YKL 40

Indexed keywords

CHITINASE; CHITOTRIOSIDASE; PROTEIN; PROTEIN CHI3L1; PROTEIN CHIA; PROTEIN YKL 40; UNCLASSIFIED DRUG;

EID: 69749119778     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0b013e3283306533     Document Type: Review
Times cited : (93)

References (63)
  • 1
    • 56349119852 scopus 로고    scopus 로고
    • Chitin regulation of immune responses: An old molecule with new roles
    • Excellent comprehensive review of chitin effects on immune response. This review focuses on the conflicting studies of the pro-inflammatory or anti-inflammatory properties of chitin
    • Lee CG, Da Silva CA, Lee JY, et al. Chitin regulation of immune responses: an old molecule with new roles. Curr Opin Immunol 2008; 20:684-689. Excellent comprehensive review of chitin effects on immune response. This review focuses on the conflicting studies of the pro-inflammatory or anti-inflammatory properties of chitin.
    • (2008) Curr Opin Immunol , vol.20 , pp. 684-689
    • Lee, C.G.1    Da Silva, C.A.2    Lee, J.Y.3
  • 2
    • 4644286533 scopus 로고    scopus 로고
    • Chitin checking - Novel insights into asthma
    • DOI 10.1056/NEJMcibr041294
    • Wills-Karp M, Karp CL. Chitin checking: novel insights into asthma. N Engl J Med 2004; 351:1455-1457. (Pubitemid 39288173)
    • (2004) New England Journal of Medicine , vol.351 , Issue.14 , pp. 1455-1457
    • Wills-Karp, M.1    Karp, C.L.2
  • 3
    • 0022005105 scopus 로고
    • Chitin synthesis and sheath morphogenesis in Brugia malayi microfilariae
    • DOI 10.1016/0166-6851(85)90130-6
    • Fuhrman JA, Piessens WF. Chitin synthesis and sheath morphogenesis in Brugia malayi microfilariae. Mol Biochem Parasitol 1985; 17:93-104. (Pubitemid 15227842)
    • (1985) Molecular and Biochemical Parasitology , vol.17 , Issue.1 , pp. 93-104
    • Fuhrman, J.A.1    Piessens, W.F.2
  • 5
    • 0036126147 scopus 로고    scopus 로고
    • Shell disease syndrome in the edible crab, Cancer pagurus - Isolation, characterization and pathogenicity of chitinolytic bacteria
    • Vogan CL, Costa-Ramos C, Rowley AF. Shell disease syndrome in the edible crab, Cancer pagurus: isolation, characterization and pathogenicity of chitinolytic bacteria. Microbiology 2002; 148:743-754. (Pubitemid 34232858)
    • (2002) Microbiology , vol.148 , Issue.3 , pp. 743-754
    • Vogan, C.L.1    Costa-Ramos, C.2    Rowley, A.F.3
  • 7
    • 43449109166 scopus 로고    scopus 로고
    • Global impact of Vibrio cholerae interactions with chitin
    • DOI 10.1111/j.1462-2920.2007.01559.x
    • Pruzzo C, Vezzulli L, Colwell RR. Global impact of Vibrio cholerae interactions with chitin. Environ Microbiol 2008; 10:1400-1410. (Pubitemid 351670245)
    • (2008) Environmental Microbiology , vol.10 , Issue.6 , pp. 1400-1410
    • Pruzzo, C.1    Vezzulli, L.2    Colwell, R.R.3
  • 8
    • 0032714186 scopus 로고    scopus 로고
    • Physiological aspects of chitin catabolism in marine bacteria
    • Keyhani NO, Roseman S. Physiological aspects of chitin catabolism in marine bacteria. Biochim Biophys Acta 1999; 1473:108-122.
    • (1999) Biochim Biophys Acta , vol.1473 , pp. 108-122
    • Keyhani, N.O.1    Roseman, S.2
  • 11
    • 0032518453 scopus 로고    scopus 로고
    • Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages
    • Renkema GH, Boot RG, Au FL, et al. Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages. Eur J Biochem 1998; 251:504-509.
    • (1998) Eur J Biochem , vol.251 , pp. 504-509
    • Renkema, G.H.1    Boot, R.G.2    Au, F.L.3
  • 12
    • 0034142181 scopus 로고    scopus 로고
    • Oral administration of chitin down-regulates serum IgE levels and lung eosinophilia in the allergic mouse
    • Shibata Y, Foster LA, Bradfield JF, Myrvik QN. Oral administration of chitin down-regulates serum IgE levels and lung eosinophilia in the allergic mouse. J Immunol 2000; 164:1314-1321. (Pubitemid 30067244)
    • (2000) Journal of Immunology , vol.164 , Issue.3 , pp. 1314-1321
    • Shibata, Y.1    Foster, L.A.2    Bradfield, J.F.3    Myrvik, Q.N.4
  • 13
    • 0030901437 scopus 로고    scopus 로고
    • Alveolar macrophage priming by intravenous administration of chitin particles, polymers of N-acetyl-D-glucosamine, in mice
    • Shibata Y, Foster LA, Metzger WJ, Myrvik QN. Alveolar macrophage priming by intravenous administration of chitin particles, polymers of N-acetyl-D-glucosamine, in mice. Infect Immun 1997; 65:1734-1741. (Pubitemid 27193594)
    • (1997) Infection and Immunity , vol.65 , Issue.5 , pp. 1734-1741
    • Shibata, Y.1    Foster, L.A.2    Metzger, W.J.3    Myrvik, Q.N.4
  • 17
    • 2942668626 scopus 로고    scopus 로고
    • Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation
    • DOI 10.1126/science.1095336
    • Zhu Z, Zheng T, Homer RJ, et al. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science 2004; 304:1678-1682. (Pubitemid 38765861)
    • (2004) Science , vol.304 , Issue.5677 , pp. 1678-1682
    • Zhu, Z.1    Zheng, T.2    Homer, R.J.3    Kim, Y.-K.4    Chen, N.Y.5    Cohn, L.6    Hamid, Q.7    Elias, J.A.8
  • 18
    • 34247626970 scopus 로고    scopus 로고
    • Chitin induces accumulation in tissue of innate immune cells associated with allergy
    • Reese TA, Liang HE, Tager AM, et al. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 2007; 447:92-96.
    • (2007) Nature , vol.447 , pp. 92-96
    • Reese, T.A.1    Liang, H.E.2    Tager, A.M.3
  • 19
    • 69749098523 scopus 로고    scopus 로고
    • Chitin stimulates expression of acidic mammalian chitinase and eotaxin-3 by human sinonasal epithelial cells in vitro
    • A recent study that examined the expression of AMCase in epithelial cells cultured from a human disease
    • Lalaker A, Nkrumah L, Lee WK, et al. Chitin stimulates expression of acidic mammalian chitinase and eotaxin-3 by human sinonasal epithelial cells in vitro. Am J Rhinol Allergy 2009; 23:8-14. A recent study that examined the expression of AMCase in epithelial cells cultured from a human disease.
    • (2009) Am J Rhinol Allergy , vol.23 , pp. 8-14
    • Lalaker, A.1    Nkrumah, L.2    Lee, W.K.3
  • 20
    • 33746177512 scopus 로고    scopus 로고
    • Increased expression of acidic mammalian chitinase in chronic rhinosinusitis with nasal polyps
    • Ramanathan M Jr, Lee WK, Lane AP. Increased expression of acidic mammalian chitinase in chronic rhinosinusitis with nasal polyps. Am J Rhinol 2006; 20:330-335.
    • (2006) Am J Rhinol , vol.20 , pp. 330-335
    • Ramanathan Jr., M.1    Lee, W.K.2    Lane, A.P.3
  • 24
    • 36049042862 scopus 로고    scopus 로고
    • Serum chitotriosidase activity, a marker of activated macrophages, predicts new cardiovascular events independently of C-reactive protein
    • DOI 10.1159/000099099
    • Artieda M, Cenarro A, Ganan A, et al. Serum chitotriosidase activity, a marker of activated macrophages, predicts new cardiovascular events independently of C-reactive protein. Cardiology 2007; 108:297-306. (Pubitemid 350126474)
    • (2007) Cardiology , vol.108 , Issue.4 , pp. 297-306
    • Artieda, M.1    Cenarro, A.2    Ganan, A.3    Lukic, A.4    Moreno, E.5    Puzo, J.6    Pocovi, M.7    Civeira, F.8
  • 27
    • 49949112591 scopus 로고    scopus 로고
    • Human chitotriosidase: A potential new marker of sarcoidosis severity
    • Bargagli E, Maggiorelli C, Rottoli P. Human chitotriosidase: a potential new marker of sarcoidosis severity. Respiration 2008; 76:234-238.
    • (2008) Respiration , vol.76 , pp. 234-238
    • Bargagli, E.1    Maggiorelli, C.2    Rottoli, P.3
  • 28
    • 55549111566 scopus 로고    scopus 로고
    • Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit
    • e943. First characterization of true chitinases in the airway epithelial cells from asthmatic patients and smokers
    • Seibold MA, Donnelly S, Solon M, et al. Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit. J Allergy Clin Immunol 2008, 122:944-950 e943. First characterization of true chitinases in the airway epithelial cells from asthmatic patients and smokers.
    • (2008) J Allergy Clin Immunol , vol.122 , pp. 944-950
    • Seibold, M.A.1    Donnelly, S.2    Solon, M.3
  • 29
    • 0027505001 scopus 로고
    • Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family
    • Hakala BE, White C, Recklies AD. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J Biol Chem 1993; 268:25803-25810. (Pubitemid 23358198)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.34 , pp. 25803-25810
    • Hakala, B.E.1    White, C.2    Recklies, A.D.3
  • 30
    • 33646842919 scopus 로고    scopus 로고
    • Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer
    • Johansen JS. Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer. Dan Med Bull 2006; 53:172-209.
    • (2006) Dan Med Bull , vol.53 , pp. 172-209
    • Johansen, J.S.1
  • 31
    • 0027430967 scopus 로고
    • A new biochemical marker for joint injury: Analysis of YKL-40 in serum and synovial fluid
    • Johansen JS, Jensen HS, Price PA. A new biochemical marker for joint injury: analysis of YKL-40 in serum and synovial fluid. Br J Rheumatol 1993; 32:949-955.
    • (1993) Br J Rheumatol , vol.32 , pp. 949-955
    • Johansen, J.S.1    Jensen, H.S.2    Price, P.A.3
  • 32
    • 0026773679 scopus 로고
    • Identification of proteins secreted by human osteoblastic cells in culture
    • Johansen JS, Williamson MK, Rice JS, Price PA. Identification of proteins secreted by human osteoblastic cells in culture. J Bone Miner Res 1992; 7:501-512.
    • (1992) J Bone Miner Res , vol.7 , pp. 501-512
    • Johansen, J.S.1    Williamson, M.K.2    Rice, J.S.3    Price, P.A.4
  • 34
    • 17044374400 scopus 로고    scopus 로고
    • Expression of YKL-40 by peritumoral macrophages in human small cell lung cancer
    • DOI 10.1016/j.lungcan.2004.11.011
    • Junker N, Johansen JS, Andersen CB, Kristjansen PE. Expression of YKL-40 by peritumoral macrophages in human small cell lung cancer. Lung Cancer 2005; 48:223-231. (Pubitemid 40501811)
    • (2005) Lung Cancer , vol.48 , Issue.2 , pp. 223-231
    • Junker, N.1    Johansen, J.S.2    Andersen, C.B.3    Kristjansen, P.E.G.4
  • 35
    • 8444236654 scopus 로고    scopus 로고
    • High serum YKL-40 level in patients with small cell lung cancer is related to early death
    • DOI 10.1016/j.lungcan.2004.05.010, PII S0169500204002260
    • Johansen JS, Drivsholm L, Price PA, Christensen IJ. High serum YKL-40 level in patients with small cell lung cancer is related to early death. Lung Cancer 2004; 46:333-340. (Pubitemid 39487308)
    • (2004) Lung Cancer , vol.46 , Issue.3 , pp. 333-340
    • Johansen, J.S.1    Drivsholm, L.2    Price, P.A.3    Christensen, I.J.4
  • 36
    • 0029094048 scopus 로고
    • Serum YKL-40: A new potential marker of prognosis and location of metastases of patients with recurrent breast cancer
    • Johansen JS, Cintin C, Jorgensen M, et al. Serum YKL-40: a new potential marker of prognosis and location of metastases of patients with recurrent breast cancer. Eur J Cancer 1995; 31A:1437-1442.
    • (1995) Eur J Cancer , vol.31 A , pp. 1437-1442
    • Johansen, J.S.1    Cintin, C.2    Jorgensen, M.3
  • 37
    • 31344473090 scopus 로고    scopus 로고
    • Genetics of the Lp(a)/apo(a) system in an autochthonous Black African population from the Gabon
    • DOI 10.1038/sj.ejhg.5201512, PII 5201512
    • Schmidt K, Kraft HG, Parson W, Utermann G. Genetics of the Lp(a)/apo(a) system in an autochthonous Black African population from the Gabon. Eur J Hum Genet 2006; 14:190-201. (Pubitemid 43135862)
    • (2006) European Journal of Human Genetics , vol.14 , Issue.2 , pp. 190-201
    • Schmidt, K.1    Kraft, H.G.2    Parson, W.3    Utermann, G.4
  • 40
    • 0032704645 scopus 로고    scopus 로고
    • YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization
    • DOI 10.1086/315050
    • Nordenbaek C, Johansen JS, Junker P, et al. YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization. J Infect Dis 1999; 180:1722-1726. (Pubitemid 29506483)
    • (1999) Journal of Infectious Diseases , vol.180 , Issue.5 , pp. 1722-1726
    • Nordenbaek, C.1    Johansen, J.S.2    Junker, P.3    Borregaard, N.4    Sorensen, O.5    Price, P.A.6
  • 41
    • 0025744474 scopus 로고
    • Prediction of human mRNA donor and acceptor sites from the DNA sequence
    • Brunak S, Engelbrecht J, Knudsen S. Prediction of human mRNA donor and acceptor sites from the DNA sequence. J Mol Biol 1991; 220:49-65. (Pubitemid 121004542)
    • (1991) Journal of Molecular Biology , vol.220 , Issue.1 , pp. 49-65
    • Brunak, S.1    Engelbrecht, J.2    Knudsen, S.3
  • 42
    • 0035028329 scopus 로고    scopus 로고
    • Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathology
    • Volck B, Johansen JS, Stoltenberg M, et al. Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathology. Osteoarthritis Cartilage 2001; 9:203-214.
    • (2001) Osteoarthritis Cartilage , vol.9 , pp. 203-214
    • Volck, B.1    Johansen, J.S.2    Stoltenberg, M.3
  • 43
    • 0035661247 scopus 로고    scopus 로고
    • Serum YKL-40 levels in rheumatoid arthritis: Correlations between clinical and laboratory parameters
    • Matsumoto T, Tsurumoto T. Serum YKL-40 levels in rheumatoid arthritis: correlations between clinical and laboratory parameters. Clin Exp Rheumatol 2001; 19:655-660. (Pubitemid 34026828)
    • (2001) Clinical and Experimental Rheumatology , vol.19 , Issue.6 , pp. 655-660
    • Matsumoto, T.1    Tsurumoto, T.2
  • 44
    • 40949145677 scopus 로고    scopus 로고
    • Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C
    • Fontana RJ, Goodman ZD, Dienstag JL, et al. Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C. Hepatology 2008; 47:789-798.
    • (2008) Hepatology , vol.47 , pp. 789-798
    • Fontana, R.J.1    Goodman, Z.D.2    Dienstag, J.L.3
  • 45
    • 66049139534 scopus 로고    scopus 로고
    • Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis
    • The first study characterizing the phenotype of the YKL-40/BRP-30- knockout and airway-specific overexpression transgenic mice, showing that YKL-40 is a key regulator of apoptosis in Th2 inflammatory responses
    • Lee CG, Hartl D, Lee GR, et al. Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med 2009; 206:1149-1166. The first study characterizing the phenotype of the YKL-40/BRP-30-knockout and airway-specific overexpression transgenic mice, showing that YKL-40 is a key regulator of apoptosis in Th2 inflammatory responses.
    • (2009) J Exp Med , vol.206 , pp. 1149-1166
    • Lee, C.G.1    Hartl, D.2    Lee, G.R.3
  • 47
    • 36148984547 scopus 로고    scopus 로고
    • Exoskeletons and exhalation
    • Dickey BF. Exoskeletons and exhalation. N Engl J Med 2007; 357:2082-2084.
    • (2007) N Engl J Med , vol.357 , pp. 2082-2084
    • Dickey, B.F.1
  • 49
    • 34748905249 scopus 로고    scopus 로고
    • Human chitotriosidase polymorphisms G354R and A442V associated with reduced enzyme activity
    • DOI 10.1016/j.bcmd.2007.06.013, PII S1079979607001209
    • Lee P, Waalen J, Crain K, et al. Human chitotriosidase polymorphisms G354R and A442V associated with reduced enzyme activity. Blood Cells Mol Dis 2007; 39:353-360. (Pubitemid 47484470)
    • (2007) Blood Cells, Molecules, and Diseases , vol.39 , Issue.3 , pp. 353-360
    • Lee, P.1    Waalen, J.2    Crain, K.3    Smargon, A.4    Beutler, E.5
  • 50
    • 3242733034 scopus 로고    scopus 로고
    • A 24-bp duplication in exon 10 of human chitotriosidase gene from the sub-Saharan to the Mediterranean area: Role of parasitic diseases and environmental conditions
    • DOI 10.1038/sj.gene.6364025
    • Malaguarnera L, Simpore J, Prodi DA, et al. A 24-bp duplication in exon 10 of human chitotriosidase gene from the sub-Saharan to the Mediterranean area: role of parasitic diseases and environmental conditions. Genes Immun 2003; 4:570-574. (Pubitemid 38961153)
    • (2003) Genes and Immunity , vol.4 , Issue.8 , pp. 570-574
    • Malaguarnera, L.1    Simpore, J.2    Prodi, D.A.3    Angius, A.4    Sassu, A.5    Persico, I.6    Barone, R.7    Musumeci, S.8
  • 51
    • 0032707163 scopus 로고    scopus 로고
    • Population choices in mapping for complex diseases
    • Wright AF, Carothers AD, Pirastu M. Population choices in mapping for complex diseases. Nat Genet 1999; 23:397-404.
    • (1999) Nat Genet , vol.23 , pp. 397-404
    • Wright, A.F.1    Carothers, A.D.2    Pirastu, M.3
  • 52
    • 33646860542 scopus 로고    scopus 로고
    • Genetic polymorphisms of chitotriosidase in Caucasian children with bronchial asthma
    • DOI 10.1111/j.1744-313X.2006.00597.x
    • Bierbaum S, Superti-Furga A, Heinzmann A. Genetic polymorphisms of chitotriosidase in Caucasian children with bronchial asthma. Int J Immunogenet 2006; 33:201-204. (Pubitemid 43781723)
    • (2006) International Journal of Immunogenetics , vol.33 , Issue.3 , pp. 201-204
    • Bierbaum, S.1    Superti-Furga, A.2    Heinzmann, A.3
  • 53
    • 27144455830 scopus 로고    scopus 로고
    • Common genetic variants in the interleukin-6 and chitotriosidase genes are associated with the risk for serious infection in children undergoing therapy for acute myeloid leukemia
    • DOI 10.1038/sj.leu.2403922, PII 2403922
    • Lehrnbecher T, Bernig T, Hanisch M, et al. Common genetic variants in the interleukin-6 and chitotriosidase genes are associated with the risk for serious infection in children undergoing therapy for acute myeloid leukemia. Leukemia 2005; 19:1745-1750. (Pubitemid 41486151)
    • (2005) Leukemia , vol.19 , Issue.10 , pp. 1745-1750
    • Lehrnbecher, T.1    Bernig, T.2    Hanisch, M.3    Koehl, U.4    Behl, M.5    Reinhardt, D.6    Creutzig, U.7    Klingebiel, T.8    Chanock, S.J.9    Schwabe, D.10
  • 55
    • 2442585696 scopus 로고    scopus 로고
    • The effects of human population structure on large genetic association studies
    • DOI 10.1038/ng1337
    • Marchini J, Cardon LR, Phillips MS, Donnelly P. The effects of human population structure on large genetic association studies. Nat Genet 2004; 36:512-517. (Pubitemid 38620038)
    • (2004) Nature Genetics , vol.36 , Issue.5 , pp. 512-517
    • Marchini, J.1    Cardon, L.R.2    Phillips, M.S.3    Donnelly, P.4
  • 57
    • 58149316013 scopus 로고    scopus 로고
    • A functional variation in CHI3L1 is associated with severity of liver fibrosis and YKL-40 serum levels in chronic hepatitis C infection
    • Interesting study supporting a role for a promoter variant in CHI3L1 and YKL-40 levels in the severity of liver fibrosis in chronic hepatitis C patients
    • Berres ML, Papen S, Pauels K, et al. A functional variation in CHI3L1 is associated with severity of liver fibrosis and YKL-40 serum levels in chronic hepatitis C infection. J Hepatol 2009; 50:370-376. Interesting study supporting a role for a promoter variant in CHI3L1 and YKL-40 levels in the severity of liver fibrosis in chronic hepatitis C patients.
    • (2009) J Hepatol , vol.50 , pp. 370-376
    • Berres, M.L.1    Papen, S.2    Pauels, K.3
  • 59
    • 63249099414 scopus 로고    scopus 로고
    • Genetic variation in the promoter region of chitinase 3-like 1 is associated with atopy
    • Identified a second functional promoter variant that was associated with atopic phenotypes in Koreans
    • Sohn MH, Lee JH, Kim KW, et al. Genetic variation in the promoter region of chitinase 3-like 1 is associated with atopy. Am J Respir Crit Care Med 2009; 179:449-456. Identified a second functional promoter variant that was associated with atopic phenotypes in Koreans.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 449-456
    • Sohn, M.H.1    Lee, J.H.2    Kim, K.W.3
  • 60
    • 34249684451 scopus 로고    scopus 로고
    • A CHI3L1 gene polymorphism is associated with serum levels of YKL-40, a novel sarcoidosis marker
    • DOI 10.1016/j.rmed.2006.12.006, PII S0954611106006160
    • Kruit A, Grutters JC, Ruven HJ, et al. A CHI3L1 gene polymorphism is associated with serum levels of YKL-40, a novel sarcoidosis marker. Respir Med 2007; 101:1563-1571. (Pubitemid 46832220)
    • (2007) Respiratory Medicine , vol.101 , Issue.7 , pp. 1563-1571
    • Kruit, A.1    Grutters, J.C.2    Ruven, H.J.T.3    Van Moorsel, C.C.M.4    Van Den Bosch, J.M.M.5
  • 61
    • 65549123032 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene
    • Himes BE, Hunninghake GM, Baurley JW, et al. Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet 2009; 84:581-593.
    • (2009) Am J Hum Genet , vol.84 , pp. 581-593
    • Himes, B.E.1    Hunninghake, G.M.2    Baurley, J.W.3
  • 62
    • 3042653185 scopus 로고    scopus 로고
    • Maximum-likelihood estimation of haplotype frequencies in nuclear families
    • DOI 10.1002/gepi.10323
    • Becker T, Knapp M. Maximum-likelihood estimation of haplotype frequencies in nuclear families. Genet Epidemiol 2004; 27:21-32. (Pubitemid 38808342)
    • (2004) Genetic Epidemiology , vol.27 , Issue.1 , pp. 21-32
    • Becker, T.1    Knapp, M.2
  • 63
    • 67749096192 scopus 로고    scopus 로고
    • Differential enzymatic activity of common haplotypic versions of the human acidic mammalian chitinase protein
    • [Epub ahead of print]. Comprehensive survey of genetic variation in the CHIA gene in ethnically diverse populations. First study to demonstrate genotype effects on AMCase activity
    • Seibold MA, Reese TA, Choudhry S, et al. Differential enzymatic activity of common haplotypic versions of the human acidic mammalian chitinase protein. J Biol Chem 2009 [Epub ahead of print]. Comprehensive survey of genetic variation in the CHIA gene in ethnically diverse populations. First study to demonstrate genotype effects on AMCase activity.
    • (2009) J Biol Chem
    • Seibold, M.A.1    Reese, T.A.2    Choudhry, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.