Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives

Pharmacognosy Reviews

Volumn 5, Issue 10, 2011, Pages 120-137

  Beg, Sarwar ^a   Swain, Suryakanta ^b   Hasan, Hameed ^a   Barkat, M Abul ^a   Hussain, Md Sarfaraz ^c  

^a HAMDARD UNIVERSITY   (India)

^b Roland Institute of Pharmaceutical Sciences   (India)

^c INTEGRAL UNIVERSITY   (India)

Author keywords

Alkaloids; anti inflammatory agents; cannabinoids; clinical trials; glycosides; herbals; inflammation

Indexed keywords

ALKALOID; ANTIINFLAMMATORY AGENT; ARTEMISIN; ARTEMISININ; BERBAMINE; BOLDINE; CACALOL; CURCUMIN; ESSENTIAL OIL; GANODERAL A; GANODERAL B; GANODERIC ALDEHYDE A; GLEDITSIOSIDE Z; GLYCOSIDE; HERBACEOUS AGENT; HYPERFORIN; HYPERICIN; INUVISCOLIDE; NEOLIGNAN GLYCOSIDE; PLANT EXTRACT; POLYPHENOL; STEROID; STYRAXOSIDE A; STYRAXOSIDE B; TERPENOID; TETRANDINE; TSUGARIC ACID A; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASICINE; ZINGIBERENE;

ALGA; ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; CLINICAL TRIAL (TOPIC); DRUG ISOLATION; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; INFLAMMATION; MARINE SPECIES; MEDICINAL PLANT; NONHUMAN; REVIEW; STRUCTURE ACTIVITY RELATION;

ALGAE; FUNGI;

EID: 84856595018     PISSN: 09737847     EISSN: 09762787     Source Type: Journal    
DOI: 10.4103/0973-7847.91102     Document Type: Review

References (155)

1. Denko CW. A role of neuropeptides in inflammation. In: Whicher JT, Evans SW, editors. Biochemistry of inflammation. London: Kluwer Publisher; 1992. p. 177-81.
2. Singh A, Malhotra S, Subban R. Anti inflammatory and analgesic agents from Indian medicinal plants. Int J Integ Biol 2008;3:57-72.
3. Serhan CN, Savill J. Resolution of inflammation: The beginning programs the end. Nat Immunol 2005;6:1191-7. (Pubitemid 43045627)
4. Collins CK. Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company; 1998.
5. Bottazzi B, Doni A, Garlanda C, Mantovani A. An integrated view of humoral innate immunity: Pentraxins as a paradigm. Ann Rev Immunol 2010;28:157-83.
6. Lanas A. Nonsteroidal antiinflammatory drugs and cyclooxygenase inhibition in the gastrointestinal tract: A trip from peptic ulcer to colon cancer. Am J Med Sci 2009;338:96-106.
7. Rossi S. Australian medicines handbook. Adelaide: Australian Medicines Handbook Pvt Ltd; 2006.
8. Kandulski A, Venerito M, Malfertheiner P. Non steroidal anti-inflammatory drugs (NSAIDs) - balancing gastrointestinal complications and the cardiovascular risk. Deutsche Medizinische Wochenschrift 2009;134:1635-40.
9. Rainsford KD, Whitehouse MW. Antiinflammatory/antipyretic salicylic acid esters with low gastric activity. Agents Action 1980;10:451-5.
10. Fiebich BL, Chrubasik S. Effects of an ethanolic Salix extract on the release of selected inflammatory mediators in vitro. Phytomedicine 2004;11:135-8. (Pubitemid 38314053)
11. MacLennan AH, Wilson DH, Taylor AW. Prevalence and cost of alternative medicine in Australia. Lancet 1996;347:569-72.
12. Ang-Lee MK, Moss J, Yuan CS. Herbal medicines and perioperative care. J Am Med Asso 2001;286:208-16. (Pubitemid 32640852)
13. Drew AK, Myers SP. Safety issues in herbal medicine:implications for the health professions. WHO Report. Available from: https://www.mja.com.au/public/ issues/may19/drew/drew.html. [cited in 1997]. [accessed on 2009 Oct 26].
14. British Medical Association. Complementary medicine. New approaches to good practice. Oxford: Oxford University Press; 1993. p. 9-36.
15. Anonymous. Program profile. International liaison brings global vision to OAM. Complementary and Alternative Medicine at the NIH, 1996. Vol. 3, p. 3-10.
16. Bent S, Ko R. Commonly used herbal medicines in the United States: A review. Am J Med 2004;116:478-85. (Pubitemid 38388618)
17. Boullata JI, Nace AM. Safety issues with herbal medicine. Pharmacother 2000;20:257-69.
18. Ferrante A, Seow WK, Rowan-Kelly B, Thong YH. Tetrandrine, a plant alkaloid, inhibits the production of tumour necrosis factor-alpha (cachectin) by human monocytes. Clin Exp Immunol 1990;80:232-5. (Pubitemid 20147721)
19. Teh BS, Seow WK, Li SY, Thong YH. Inhibition of prostaglandin and leukotriene generation by the plant alkaloids tetrandrine and berbamine. J Immunopharmacol 1990;12:321-6. (Pubitemid 20111666)
20. Rahman A, Ahmad D, Asif E, Ahmad S, Sener B, Turkoz S. Chemical constituents of Buxus sempervirens. J Nat Prod 1991;54:79-82.
21. Rahman A, Asif E, Ali SS, Nasir H, Jamal SA, Ata A, et al. New steroidal alkaloids from the roots of Buxus papillosa. J Nat Prod 1992;55:1063-70.
22. Chakraborty A, Brantner AH. Study of alkaloids from Adhatoda vasica nees on their antiinflammatory activity. Phytother Res 2001;15:532-4. (Pubitemid 32906440)
23. Rajput N, Srivastava DN, Sahni YP, Nigam JM. Role of mediators in anti-inflammatory activity of Adhatoda vasica on carragenan induced paw oedema in rats. J Vet Pharmacol Toxicol 2006;5:32-6.
24. Sutradhar RK, Rahman AM, Ahmad M, Bachar SC, Saha A, Roy TG. Antiinflammatory and analgesic alkaloid from Sidacordifolia Linn. Pak J Pharm Sci 2007;20:185-8.
25. Gomes A, Sharma RM, Ghatak BJ. Pharmacological investigation of a glycosidal fraction isolated from Maesa chisia D. Don var. angustifolia Hook f and Th. Indian J Exp Biol 1987;25:826-31. (Pubitemid 18264307)
26. Lanhers MC, Fleurentin J, Mortier F, Vinche A, Younos C. Anti-inflammatory and analgesic effects of an aqueous extract of Harpagophytum procumbens. Planta Med 1992;58:117-23.
27. Sanchez-Mateo CC, Bonkanka CX, Hernandez-Perez M, Rabanal RM. Evaluation of the analgesic andtopical anti-inflammatory effects of Hypericum reflexum L. fil. J Ethnopharmacol 2006;107:1-6. (Pubitemid 44038814)
28. Shi HM, Wen J, Jia CQ, Jin W, Zhang XF, Yao ZR, et al. Two new phenolic glycosides from the barks of Hydnocarpus annamensis and their antiinflammatory and antioxidant activities. Planta Med 2006;72:948-50. (Pubitemid 44378963)
29. Kim JS, Kim JC, Shim SH, Lee EJ, Jin WY, Bae K, et al. Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity. Arch Pharmacal Res 2006;29:617-23. (Pubitemid 44338458)
30. Thangavel N, Gupta JK. Anti-inflammatory and anti-snake venom activity of Andrographis stenophylla leaf. Asian J Chem 2007;19:1307-12.
31. Montopoli M, Froldi G, Comelli MC, Prosdocimi M, Caparrotta L. Aescin protection of human vascular endothelial cells exposed to cobalt chloride mimicked hypoxia and inflammatory stimuli. Planta Med 2007;73:285-8. (Pubitemid 46917485)
32. Xu LP, Wang H, Yuan Z. Triterpenoid saponins with anti-inflammatory activity from Codonopsis lanceolata. Planta Med 2008;74:1412-5.
33. Juteaua F, Masotti V, Bessiere JM, Dherbomez M, Vianoa J. Antibacterial and antioxidant activities of Artemisia annua essential oil. Fitoterapia 2002;73:532-5. (Pubitemid 35266814)
34. Kohli K, Ali J. Curcumin: A natural antiinflammatory agent. Indian J Pharmacol 2005;37:141-7. (Pubitemid 40898222)
35. Lindenmeyer MT, Tubaro A, Sosa S, Merfort I. New sesquiterpene lactones from Arnica tincture prepared from fresh flower heads of Arnica montana. Planta Med 2005;71:1044-52. (Pubitemid 41802874)
36. Sosa S, Altinier G, Politi M, Braca A, Morelli I, Della Loggia R. Extracts and constituents of Lavandula multidia with topical anti-inflammatory activity. Phytomedicine 2005;12:271-7. (Pubitemid 40471025)
37. Yun KJ, Min BS, Kim JY, Lee KT. Styraxoside A isolated from the stem bark of Styrax japonica inhibits lipopolysaccharide-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 cells by suppressing nuclear factor-kappa B activation. Biol Pharm Bull 2007;30:139-44.
38. Calou IB, Sousa DI, Cunha GM, De A, Brito GA, De C, et al. Topically applied diterpenoids from Egletes viscosa (Asteraceae) attenuate the dermal inflammation in mouse ear induced by tetradecanoylphorbol 13-acetate- and oxazolone. Biol Pharm Bull 2008;31:1511-6.
39. Chen W, Liu Q, Wang J, Zou J, Meng D, Zuo J, et al. New Guaiane, Megastigmane and Eudesmane type sesquiterpenoids and anti-inflammatory constituents from Youngia japonica. Planta Med 2006;72:143-50. (Pubitemid 43293869)
40. Mack T, Ammon HP, Safayhi H. Abstracts of the International Joint Symposium of Biology and Chemistry of Active Natural Substances. Bonn 1990. p. 177.
41. Ammon HP, Mack T, Singh GB, Safayhi H. Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata. Planta Med 1991;57:203-7.
42. Fan AY, Lao L, Zhang RX, Zhou AN, Wang LB, Moudgil KD, et al. Effects of an acetone extract of Boswellia carterii Birdw: Burseraceae gum resin on adjuvant-induced arthritis in Lewis rats. J Ethnopharmacol 2005;101:104-9. (Pubitemid 41265608)
43. Ammon HP. Boswellic acids in chronic inflammatory diseases. Planta Med 2006;72:1100-16. (Pubitemid 44638909)
44. Orhan I, Kupeli E, Aslan M, Kartal M, Yesilada E. Bioassay-guided evaluation of anti-inflammatory and antinociceptive activities of pistachio Pistacia vera L. J Ethnopharmacol 2006;105:235-40.
45. Choy CS, Hu CM, Chiu WT, Lam CS, Ting Y, Tsai SH, et al. Suppression of lipopolysaccharide-induced of inducible nitric oxide synthase and cyclooxygenase-2 by Sanguis Draconis: A dragons blood resin in RAW 264.7 cells. J Ethnopharmacol 2008;115:455-62. (Pubitemid 350299084)
46. Seo YA, Suk KD. Analgesic and anti-inflammatory activity of Resina Pini. Nat Prod Sci 2007;13:347-54.
47. Dordevic S, Petrovic S, Dobric S, Milenkovic M, Vucicevic D, Zizic S, et al. Antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil. J Ethnopharmacol 2007;109:458-63. (Pubitemid 46070208)
48. Passos GF, Fernandes ES, da Cunha FM, Ferreira J, Pianowski LF, Campos MM, et al. Anti-inflammatory and anti-allergic properties of the essential oil and actie compounds from Cordia verbenacea. J Ethnopharmacol 2007;110:323-33.
49. Zhang B, Li JB, Zhang DM, Ding Y, Du GH. Analgesic and anti-inflammatory activities of a fraction rich in gaultherin isolated from Gaultheria yunnanensis (Franch.) Rehder Biol Pharm Bull 2007;30:465-9. (Pubitemid 46355926)
50. Esteves I, Souza IR, Rodrigues M, Cardoso LG, Santos LS, Sertie JA, et al. Gastric antiulcer and anti-inflammatory activities of the essential oil from Casearia sylvestris Sw. J Ethnopharmacol 2005;101:191-6. (Pubitemid 41265621)
51. Altinier G, Sosa S, Aquino RP, Mencherini T, Loggia RD, Tubaro A. Characterization of topical antiinflammatory compounds in Rosmarinus officinalis L. J Agricul Food Chem 2007;55:1718-23. (Pubitemid 46479575)
52. Popov SV, Popova GY, Ovodova RG, Ovodov YS. Antiinflammatory activity of the pectic polysacharide from Comarum palustre. Fitoterapia 2005;76:281-7. (Pubitemid 40745201)
53. Tragni E, Galli CL, Tubaro A, Del Negro P, Della Loggia R. Anti-inflammatory activity of Echinacea angustifolia fractions separated on the basis of molecular weight. Pharmacol Res Commun 1988;20:87-90. (Pubitemid 19058382)
54. Xie G, Schepetkin IA, Siemsen DW, Kirpotina LN, Wiley JA, Quinn MT. Fractionation and characterization of biologically-active polysaccharides from Artemisia tripartita. Phytochem 2008;69:1359-71.
55. Tubaro A, Del Negro P, Bianchi P, Romussi G, Della Loggia R. Topical anti-inflammatory activity of a new acylated flavonoid. Agents Act 1989;26:229-30. (Pubitemid 19034666)
56. El-Ghazaly M, Khayyal MT, Okpanyi SN, Arens-Corell M. Study of the anti-inflammatory activity of Populus tremula, Solidago virgaurea and Fraxinus excelsior. Arzneimforsch 1992;42:333-6.
57. Yang JW, Pokharel YR, Kim MR, Woo ER, Choi HK, Kang KW. Inhibition of inducible nitric oxide synthase by sumaflavone isolated from Selaginella tamariscina. J Ethnopharmacol 2006;105:107-13.
58. Rao YK, Fang SH, Tzeng YM. Antiinflammatory activities of flavonoids isolated from Caesalpinia pulcherrima. J Ethnopharmacol 2005;100:249-53. (Pubitemid 41206619)
59. Chakradhar V, Babu YH, Ganapaty S, Prasad YR, Rao NK. Anti-inflammatory activity of a flavonol glycoside from Tephrosia spinosa. Nat Prod Sci 2005;11:63-6. (Pubitemid 40976415)
60. Kwon HM, Choi YJ, Jeong YJ, Kang SW, Kang IJ, Lim SS, et al. Anti-inflammatory inhibition of endothelial cell adhesion molecule expression by flavone derivatives. J Agr Food Chem 2005;53:5150-7.
61. Lim H, Son KH, Chang HW, Sang SS, Kim HP. Effects of antiinflammatory biflavonoid, ginkgetin on chronic skin inflammation. Biol Pharm Bull 2006;29:1046-9.
62. Park YM, Won JH, Yun KJ, Ryu JH, Han YN, Choi SK, et al. Preventive effect of Ginkgo biloba extract (GBB) on the lipopolysaccharide-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 via suppression of nuclearfactor-keppaB in raw 264-7 cells. Biol Pharm Bull 2006;29:985-90.
63. Bas E, Recio MC, Giner RM, Manez S, Nicholas MC, Rios JL. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideretis tragoriganum. Planta Med 2006;72:136-42. (Pubitemid 43293868)
64. Moscatelli V, Hnatyszyn O, Acevedo C, Javier M, Alcaraz MJ, Ferraro G. Flavonoids from Artemesia copa with antiinflammatory activity. Planta Med 2006;72:72-4. (Pubitemid 43241597)
65. Benedek B, Kopp B, Melzig MF. Achillea millefolium L. s.l.: Is the anti-inflammatory activity mediated by protease inhibition. J Ethnopharmacol 2007;113:312-7. (Pubitemid 47239258)
66. Breu T, Ustunes L, Lermioglu F, Ozer A. Antiinflammatory, analgesic, and antipyretic effects of an aqueous extract of Erythraea centaurium. Planta Med 1991;57:34-7.
67. de Almeida ER, da Silva Filho AA, dos Santos ER, Lopes CA. Antiinflammatory action of lapachol. J Ethnopharmacol 1990;29:239-41. (Pubitemid 20162727)
68. Sezik E, Tabata M, Yeşilada E, Honda G, Goto K, Ikeshiro Y. Traditional medicine in Turkey: I, Folk medicine in northeast Anatolia. J Ethnopharmacol 1991;35:191-6.
69. Wu Y, Zhou C, Song L, Li X, Shi S, Mo J, et al. Effect of total phenolics from Laggeraalata on acute and chronic inflammatory models. J Ethnopharmacol 2006;108:243-50. (Pubitemid 44635036)
70. Formukong EA, Evans AT, Evans FJ. Analgesic and antiinflammatory activity of constituents of Cannabis sativa L. Inflammation 1988;12:361-71.
71. Zurier RB. Prospects for cannabinoids as anti-inflammatory agents. J Cell Biochem 2003;88:462-6. (Pubitemid 36158268)
72. Yesilada E, Ezer N. The antiinflammatory activity of some Sideritis species growing in Turkey. Int J Crude Drug Res 1989;27:38-40. (Pubitemid 19114750)
73. Yunes RA, Pizzolatti MG, Calixto JB, Goulart S, Ana AE, Hawkes GE. Abstracts of the phytochemical potential of tropical plants: An International Symposium. 2nd Joint Meeting of the Phytochemical Societies of Europe and North America, Miami Beach 1992. p. 8-12.
74. Ko HH, Hung CF, Wang JP, Lin CN. Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G.tsugae. Phytochemistry 2008;69:234-9.
75. Miller C, Yamaguchi RY, Ziboh VA. Guinea pig epidermis generates putative anti-inflammatory metabolites from fish oil polyunsaturated fatty acids. Lipids 1989;24:998-1003. (Pubitemid 20027372)
76. Singh S, Nair V, Jain S, Gupta YK. Evaluation of anti-inflammatory activity of plant lipids containing alpha-linolenic acid. Indian J Exp Biol 2008;46:453-6.
77. Oh PS, Lee SJ, Lim KT. Glycoprotein isolated from Rhus verniciflua Stokes inhibits inflammation-related protein and nitric oxide production in LPS-stimulated RAW 264.7 cells. Biol Pharm Bull 2007;30:111-6.
78. Joy J, Nair CK. Nephro protective and anti-inflammatory activities of Rubia cordifolia. Amala Res Bull 2007;27:118-27.
79. Kassuya CA, Leite DF, de Melo LV, Rohder VL, Calixto JB. Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus. Planta Med 2005;71:721-6. (Pubitemid 41306191)
80. Lin LC, Shen CC, Shen YC, Tsai TH. Antiinflammatory neolignans from Piper kadsura. J Nat Prod 2006;69:842-4.
81. Sosa S, Tubaro A, Kastner U, Glasl S, Jurenitsch J, Della Loggia R. Topical anti-inflammatory activity of a new germacrane derivative from Achillea pannonica. Planta Med 2001;67:654-8. (Pubitemid 32929578)
82. Picerno P, Autore G, Marzocco S, Meloni M, Sanogo R, Aquino RP. Anti-inflammatory activity of verminoside from Kigelia africana and evaluation of cutaneous irritation in cell cultures and reconstituted human epidermis. J Nat Prod 2005;68:1610-4. (Pubitemid 41789566)
83. Das S, Samal D, Basu SP. Anti-inflammatory and antinociceptive activity of arbortristoside-A. J Ethnopharmacol 2008;116:198-203.
84. Matsui T, Ito C, Itoigawa M, Okada T, Furukawa H. Anti-inflammatory activity of Phenylpropanoids and phytoquinoids from Illicium species in RBL-2H3 cells. Planta Med 2007;73:662-5. (Pubitemid 47066159)
85. Han AR, Min HY, Nam JW, Lee NY, Wiryawan A, Suprapto W, et al. Identification of a new naphthalene and its derivatives from the bulb of Eleutherine Americana with inhibitory activity on lipopolysaccharide induced nitric oxide production. Chem Pharm Bull 2008;56:1314-6.
86. Seelinger G, Merfort I, Schempp CM. Antioxidant, antiinflammatory and antiallergic activities of luteolin. Planta Med 2008;74:1667-7.
87. Chen J, Cho JY, Hwang TL, Chen IS. Benzoic acid derivatives, acetophenones, and antiinflammatory constituents from Melicope semecarpifolia. J Nat Prod 2008;71:71-5. (Pubitemid 351236399)
88. Buyukokuroglu ME, Berashvili D, Gepdiremen A, Altinkeser M. Antiinflammatory and antinociceptive properties of luteolin diglucuronide and apigenin diglucuronide obtained from Perillan ankinensis. Asian J Chem 2008;20:1900-6.
89. Ziyan L, Yongmei Z, Nan Z, Ning T, Baolin L. Evaluation of the anti-inflammatory activity of luteolin in experimental animal models. Planta Med 2007;73:221-6. (Pubitemid 46917473)
90. Sindhu ER, Kuttan R. Antioxidant and anti-inflammatory activity of lutein and its ester. Amala Res Bull 2007;27:261-70.
91. Byeon SE, Lee YG, Kim JC, Han JG, Lee HY, Cho JY. Hinokitiol: A natural tropolone derivative, inhibits TNF-alpha production in LPS-activated macrophages via suppression of NF-KB. Planta Med 2008;74:828-33. (Pubitemid 351991117)
92. Hong SS, Lee SA, Han XH, Lee MH, Hwang S, Park JS, et al. Melampolides from the leaves of Smallanthus sonchifolius and their inhibitory activity of LPS-induced nitric oxide production. Chem Pharm Bull 2008;56:199-202. (Pubitemid 351206647)
93. Choi YH, Shin EM, Kim YS, Cai XF, Lee JJ, Kim HP. Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms. Arch Pharmacal Res 2006;29:293-7.
94. Yao C, Lin M, Wang L. Isolation and biomimetic synthesis of anti-inflammatory stilbenolignans from Gnetum cleistostachyum. Chem Pharm Bull 2006;54:1053-7.
95. Fan CQ, Zhu XZ, Zhan ZJ, Ji XQ, Li H, Yue JM. Lignans from Saussurea conica and their NO production suppressing activity. Planta Med 2006;72:590-5.
96. Jin XY, Lee SH, Kim JY, Zhao YZ, Park EJ, Lee BS, et al. Polyozellin inhibits nitric oxide production by down-regulating LPS-induced activity of NF-kB and SAPK/JNK in RAW 264.7 cells. Planta Med 2006;72:857-9. (Pubitemid 44204654)
97. Lee J, Jung E, Lim J, Lee J, Hur S, Kim SS, et al. Involvement of nuclear factor-kB in the inhibition of pro-inflammatory mediators by pinosylvin. Planta Med 2006;72:801-6. (Pubitemid 44204642)
98. Ko HC, Kuo YH, Wei BL, Chiou WF. Laxifolone A suppresses LPS/IFN-gamma-induced NO synthesis by attenuating NF-Kb translocation: Role of NF-kB p 105 level. Planta Med 2005;71:514-9.
99. Koo HJ, Lim KH, Jung HJ, Park EH. Anti-inflammatory evaluation of gardenia extract, geniposide and genipin. J Ethnopharmacol 2006;103:496-500.
100. Patel B, Patel S, Hoffman R. Inhibition of cyclo-oxygenase-2 expression in mouse macrophages by 4-(3-methyl-but-1-enyl)-3,5,3′,4′- tetrahydroxystilbene: A resveratrol derivative from peanuts. Phytother Res 2005;19:552-5. (Pubitemid 41345537)
101. Han AR, Kim MS, Jeong YH, Lee SK, Seo EK. Cyclooxygenase-2 inhibitory phenylbutenoids from the rhizomes of Zingiber cassumunar. Chem Pharm Bull 2005;53:1466-8. (Pubitemid 41634219)
102. Marsik P, Kokoska L, Landa P, Nepovim A, Soudek P, Vanek T. In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1-and-2-catalyzed prostaglandin E2 biosyntheses. Planta Med 2005;71:739-42. (Pubitemid 41306194)
103. Stulzer HK, Tagliari MP, Zampirolo JA, Cechinel-Filho V, Schlemper V. Antioedematogenic effect of marrubiin obtained from Marrubium vulgare. J Ethnopharmacol 2006;108:379-84. (Pubitemid 44693104)
104. Won JH, Kim JY, Yun KJ, Lee JH, Back NI, Chung HG, et al. Gigantol isolated from the whole plants of Cymbidium goeringii inhibits the LPS-induced INOS and COX-2 Expression via NF-kB inactivation in RAW 264.7 macrophages cells. Planta Med 2006;72:1181-7.
105. Rasool M, Sabina EP, Lavanya B. Anti-inflammatory effect of Spirulina fusiformis on adjuvant-induced arthritis in mice. Biol Pharm Bull 2006;29:2483-7. (Pubitemid 44885873)
106. Yonathan M, Asres K, Assefa A, Bucar F. In vivo anti-inflammatory and anti-nociceptive activities of Cheilanthes farinosa. J Ethnopharmacol 2006;108:462-70. (Pubitemid 44693113)
107. Lim CS, Jin DQ, Sung JY, Lee JH, Choi HG, Ha I, et al. Antioxidant and anti-inflammatory activities of the methanolic extract of Neorhodomela aculeate in hippocampal and microglial cells. Biol Pharm Bull 2006;29:1212-6. (Pubitemid 43845485)
108. Bingol F, Sener B. A review of terrestrial plants and marine organisms having antiinflammatory activity. Pharm Biol 1995;33:81-97.
109. Konig GM, Wright AD, Sticher O, Jurcic K, Offer-mann F, Redl K, et al. Abstracts of the International Research Congress on Natural Products, and 32nd Annual Meeting of American Society of Pharmacognosy. Chicago, Illinois: 1991. p. 129-52.
110. Kang JY, Khan MN, Park NH, Cho JY, Lee MC, Fujii H, et al. Antipyretic, analgesic, and anti-inflammatory activities of the sea weed Sargassum fulvellum and Sargassum thunbergii in mice. J Ethnopharmacol 2008;116:187-90.
111. Hua KF, Hsu HY, Su YC, Lin IF, Yang SS, Chen YM, et al. Study on the antiinflammatory activity of methanol extract from sea grass Zostera japonica. J Agr Food Chem 2006;54:306-11.
112. Shu XS, Gao ZH, Yang XL. Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract. J Ethnopharmacol 2006;103:327-32.
113. Park EK, Ryu MH, Kim YH, Lee YA, Lee SH, Woo DH, et al. Antiinflammatory effects of an ethanolic extract from Clematis mandshurica Rupr. J Ethnopharmacol 2006;108:142-7. (Pubitemid 44498994)
114. Liu BG, Jia XM, Cao YY, Chen SH, Gao PH, Wang Y, et al. Changtai granule: A traditional Chinese drug, protects hapten-induced colitis by attenuating inflammatory and immune dysfunctions. J Ethnopharmacol 2008;115:1-8. (Pubitemid 350166797)
115. Jung HW, Yoon CH, Kim YH, Boo YC, Park KM, Park YK. Wen-Pi-Tang-Hab-Wu- Ling-San extract inhibits the release of inflammatory mediators from LPS-stimulated mouse macrophages. J Ethnopharmacol 2007;114:439-45. (Pubitemid 350026228)
116. Kaileh M, Berghe WV, Boone E, Essawi T, Haegeman G. Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. J Ethnopharmacol 2007;113:510-6. (Pubitemid 47371050)
117. Lyu SA, Lee SY, Lee SJ, Son SW, Kim MO, Kim GY, et al. Seungma-galgeun-tang attenuates proinflammatory activities through the inhibition of NF- kB signal pathway in the BV- microglial cells. J Ethnopharmacol 2006;107:59-66. (Pubitemid 44038811)
118. Tseng SH, Lee HH, Chen LG, Wu CH, Wang CC. Effects for three purgative decoctions on inflammatory mediators. J Ethnopharmacol 2006;105:118-24.
119. Lo YC, Lin YL, Yu KL, Lai YH, Wu YC, Ann LM, et al. San-Huang-Xie-Xin- Tang attenuates inflammatory responses in lipopolysaccharide-exposed rat lungs. J Ethnopharmacol 2005;101:68-74. (Pubitemid 41265603)
120. Rhule A, Navarro S, Smith JR, Shepherd DM. Panax notoginseng attenuates LPS-induced pro-inflammatory mediators in RAW264.7 cells. J Ethnopharmacol 2006;106:121-8.
121. Bae EA, Kim EJ, Park JS, Kim HS, Ryu JH, Kim DH. Ginsenosides Rg3 and Rh2inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferon-gamma-stimulated by BV-2 microglial cells. Planta Med 2006;72:627-33.
122. Liu L, Ning ZQ, Shan S, Zhang K, Deng T, Ping Lu X, et al. Phathalide lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNF-alpha-medicated NF-kB activation. Planta Med 2005;71:808-13. (Pubitemid 41501175)
123. Fang QM, Zhang H, Cao Y, Wang C. Antiinflammatory and free radical scavenging activities of ethanol extract of three seeds used as "Bolengguazi". J Ethnopharmacol 2007;114:61-5. (Pubitemid 47454555)
124. Shreedhara CS and Vaidya VP. Screening of Momordica dioica for hepatoprotective, antioxidant, and antiinflammatory activities. Nat Prod Sci 2006;12:157-61. (Pubitemid 44606114)
125. Goulart S, Moritz MI, Lang KL, Liz R, Schenkel EP, Frode TS. Anti-inflammatory evaluation of Solidago chilensis Meyen in a murinemodel of pleurisy. J Ethnopharmacol 2007;113:346-53. (Pubitemid 47239263)
126. Enk R, Ehehalt R, Graham JE, Bierhaus A, Remppis A, Greten HJ. Differential effect of Rhizoma coptidis and its main alkaloid compound berberine on TNF-alpha induced NFkB translocation in human keratinocytes. J Ethnopharmacol 2007;109:170-5. (Pubitemid 44821677)
127. Orhan I, Kupeli E, Sener B, Yesilada E. Appraisal of anti-inflammatory potential of the clubmoss, Lycopodium clavatum L. J Ethnopharmacol 2007;109:146-50. (Pubitemid 44821680)
128. Barros IM, Lopes LD, Borges MO, Borges AC, Ribeiro MN, Freire SM. Anti-inflammatory and anti-nociceptive activities of Pluchea quitoc (DC.) ethanolic extract. J Ethnopharmacol 2006;106:317-20. (Pubitemid 44202257)
129. Costa SS, de Souza M, de L, Ibrahim T, de Melo GO, de Almeida AP, et al. Kalanchosine dimalate, an anti-inflammatory salt from Kalanchoe brasiliensis. J Nat Prod 2006;69:815-8. (Pubitemid 44021412)
130. Ara T, Maeda Y, Fujinami Y, Imamura Y, Hattori T, Wang PL. Preventive effects of a Kampo medicine, Shosaikoto, on inflammatory responses in LPS-treated human gingival fibroblasts. Biol Pharm Bull 2008;31:1141-4. (Pubitemid 351871165)
131. Herbal Medicine. National Center for Complementary and Alternative Medicine. Available from: http://www.nlm.nih.gov/medlineplus/herbalmedicine. html. [accessed on 2009 Sep 1].
132. Herbal Medicine Safety. Herbal medications are very popular, but are they safe? From Marian Anne Eure, former About.com Guide. Available from: http://seniorhealth.about.com/cs/altmedicine1/a/herb-safety.htm. [accessed on 2009 Sep 24].
133. Miller LG. Herbal medicinals: Selected clinical considerations focusing on known or potential drug-herb interactions. Arch Int Med 1998;158:2200-11. (Pubitemid 28512494)
134. Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs:a systematic review. Drugs 2001;61:2163-75. (Pubitemid 34074799)
135. Cupp MJ. Herbal remedies: Adverse effects and drug interactions. Am Fam Phys 1999;59:1239-45.
136. Ernst E. The risk-benefit profile of commonly used herbal therapies: Ginkgo, St Johns Wort, Ginseng, Echinacea, Saw Palmetto, and Kava. Ann Intern Med 2002;136;42-53. (Pubitemid 34038696)
137. Abebe W. Herbal medication: Potential for adverse interactions with analgesic drugs. J Clin Pharm Ther 2002;27:391-401. (Pubitemid 35469171)
138. Hukkeri VI, Savadi RV, Tippimath CD, Karadi RV, Jaiprakash B. Antiinflammatory activity of leaves of Acacia farnesiana Willd. Ind Drugs 2002;39:664-6. (Pubitemid 36958080)
139. Kumar V, Singh PN, Bhattacharya SK. Antiinflammatory and analgesic activity of Indian Hypericum perforatum L. Ind J Exp Biol 2001;39:339-43. (Pubitemid 32663156)
140. Gao ZZ, Xia YF, Yao XJ, Dai Y, Wang Q. A new triterpenoids saponin from Gleditisia sinensis and structure-activity relationships of inhibitory effects on lipopolysaccharide-induced nitric oxide production. Nat Prod Res 2008;22:320-32. (Pubitemid 351356687)
141. Manez S, Hernandez V, Giner RM, Rios JL, del Carmen Recio M. Inhibition of pro-inflammatory enzymes by inuviscolide: A sesquiterpene lactone from Inula viscosa. Fitoterapia 2007;78:329-31. (Pubitemid 46777210)
142. Tang WZ, Liu YB, Yu SS, Qu J, Su DM. New sesquiterpene lactone and neolignan glycosides with antioxidant and anti-inflammatory activities from the fruits of Illicium oligandrum. Planta Med 2007;73:484-90. (Pubitemid 46917465)
143. Jimenez-Estrada M, Chilpa RR, Apan TR, Lledias F, Hansberg W, Arrieta D, et al. Antiinflammatory activity of cacalol and cacalone sesquiterpenes isolated from Psacalium decompositum. J Ethnopharmacol 2006;105:34-8.
144. Shinde UA, Phadke AM, Nair AM, Mungantiwar AA, Dikshit VJ, Saraf MN. Studies on the antiinflammatory and analgesic activity of Cedrus deodraa (Roxb.) Loud. Wood oil. J Ethnopharmacol 1999;65:21-7. (Pubitemid 29193061)
145. Madav SS, Tadan K, Lal J, Tripathi HC. Anti-inflammatory activity of andrographolide. Fitoterapia 1996;67:452-8. (Pubitemid 26405254)
146. Herbal monograph. Himalaya herbal health care. Available from: http://www.himalayahealthcare.com/herbfinder/h-commip.html. [accessed on 2010 Apr 2].
147. Deodhar SD, Sethi R, Srimal RC. Preliminary study on antirheumatic activity of curcumin (diferuloyl methane). Indian J Med Res 1980;71:632-4. (Pubitemid 10058826)
148. Satoskar RR, Shah SJ, Shenoy SG. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int J Clin Pharmacol Ther Toxicol 1986;24:651-4. (Pubitemid 17205963)
149. Simmet T, Ammon HP. Use of boswellic acid for treating brain tumors. US6174876, 2001.
150. Gupta I, Gupta V, Parihar A, Gupta S, Ludtke R, Safayhi H, Ammon HP. Effects of Boswellia serrata gum resin in patients with bronchial asthma: Results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998;3:511-4.
151. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee: A randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7. (Pubitemid 36262200)
152. Chrubasik S, Eisenberg E, Balan E, Weinberger T, Luzzati R, Conradt C. Treatment of low back pain exacerbations with willow bark extract: A randomized double-blind study. Am J Med 2000;109:9-14. (Pubitemid 30608731)
153. Biegert C, Wagner I, Ludtke R, Kotter I, Lohmuller C, Gunaydin I, et al. Efficacy and safety of willow bark extract in the treatment of osteoarthritis and rheumatoid arthritis:results of 2 randomized double-blind controlled trials. J Rheumatol 2004;31:2121-30. (Pubitemid 39453229)
154. Chrubasik S, Thanner J, Kunzel O, Conradt C, Black A, Pollak S. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine 2002;9:181-94. (Pubitemid 34475549)
155. Chrubasik S, Kunzel O, Thanner J, Conradt C, Black A. A 1-year follow-up after a pilot study with Doloteffin for low back pain. Phytomedicine 2005;12:1-9. (Pubitemid 40174322)