Anti-inflammatory activity of a flavonol glycoside from Tephrosia Spinosa

Natural Product Sciences

Volumn 11, Issue 2, 2005, Pages 63-66

  Chakradhar, V ^a   Babu, Y Hari ^b   Ganapaty, S ^a   Prasad, Y Rajendra ^a   Rao, N Koteswara ^c  

^a ANDHRA UNIVERSITY   (India)

^b RVS College of Pharmacy   (India)

^c GITAM UNIVERSITY   (India)

Author keywords

Anti inflammatory activity; Eupalitin 3 O D glucoside; Flavonol glycoside; Leguminosae; Tephrosia spinosa

Indexed keywords

ANTIINFLAMMATORY AGENT; EUPALITIN 3 O BETA DEXTRO GLUCOSIDE; FLAVONOID GLYCOSIDE; INDOMETACIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; DRUG ISOLATION; FEMALE; INDIA; INFRARED SPECTROSCOPY; LEGUME; MALE; NONHUMAN; PAW EDEMA; PLANT; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TEPHROSIA SPINOSA;

EID: 22144435547     PISSN: 12263907     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Agarwal, R.B. and Rangari, V.D., Anti-inflammatory and Antiarthritic activities of Lupeol and 19a-H Lupeol isolated from Strobilanthus callosus and Strobilanthus ixiocephala roots. Ind. J. Pharmacol. 35, 384-387 (2003).
2. Al-Haboubi, H.A. and Zeitlin, I.J., Re-appraisal of the role of histamine in carrageenan-induced paw oedema. Eur. J. Pharmacol. 88, 169-176 (1983).
3. Jang, D.S., Park, E.J., Kang, Y.H., Hawthrone, M.E., Vigo, J.S., Graham, J.G, Cabieses, F., Fong, H.H.S., Mehta, R., John M. Pezzuto, J.M., and Kinghorn, D.A., Potential cancer chemopreventive flavonoids from the stems of Tephrosia toxicaria, J. Nat. Prod. 66, 1166-1170 (2003).
4. Deshpande, S.S., Shah, G.B., and Parmar, N.S., Antiulcer activity of Tephrosia purpurea in rats. Indian J. Pharmacol 35, 168-172 (2003).
5. Duwiejua, M., Zeitlin, I.A., Waterman, P.G., and Gray A.I., Anti-Inflammatory activity of Polygonum bistorta, Guaiacum officinale and Hamamelis virginiana in rats. J. Pharm. Pharmacol. 46, 286-290 (1994).
6. Gokhale, A.B. and Saraf, M.N., Influence of Ethanolic extract of Tephrosia purpurea Linn, on the late-phase of allergic reaction. Indian J. Pharm. Sci., Sep-Oct. 356-359 (2000).
7. Gokhale, A.B. and Saraf, M.N., Studies on antiallergic activity of ethanolic extract of Tephrosia purpurea Linn. Indian Drugs 37, 228-232 (2000).
8. Jagat, P.S. Sarin, Satyawan Singh, Garg, H.S., Khanna, N.H., and Dhar, M.M., A Flavonol glycoside with Anticancer activity from Tephrosia candida. Phytochem. 15, 232-234 (1976).
9. Kapil, A., and Sharma S., Effect of oleanolic acid on complement in adjuvant and carrageenan-induced inflammation in rats. J. Pharm. Pharmacol. 47, 585-587 (1995).
10. Chang, L.C., Gerhauser, C., Song, K., Fransworth, N.R., Pezzuto, J.M., and Kinghorn, D.A., Activity guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase-II Enzyme, Quinone Reductase. J. Nat. Prod. 60, 869-873 (1997a).
11. Cheng, L.C., Chavez, D.L., Song, L.L., Fransworth, N.R., Pezzuto, J.M., and Kinghorn, D.A., Absolute configuration of Novel bioactive flavonoids from Tephrosia purpurea. Org. Lett. 2, 515-518 (2000b).
12. Rongzhi, L., Nianbai, F., and Mabry, T.J., Flavonoids from Brickellia scoparia. J. Nat. Prod. 19, 732-733 (1986).
13. Pirrung, M.C. and Lee, Y.R., Total Synthesis and absolute configuration of Pseudosemiglabrin, a Platelet aggregation antagonist and its Diastereomer Semiglabrin. J. Chem. Soc. 117, 4814-4821 (1995).
14. Mitra, S.K., Venkataranganna, M.V., Sundaram, R., and Gopumadhavan, S., Protective Effect of HD-03, A herbal formulation against various hepatotoxic agents in rats. J. Ethanopharmacol. 63, 181-186 (1998).
15. Saleem, M., Ahmed, S.U., Alam, A., and Sultana, S., Tephrosia purpurea alleviates Phorbol Ester induced Tumor promotion response in murine skin. Pharmacol. Res. 43, 135-144 (2001).
16. Ravi, K.K., Krishan, A.S., Suri, O.P., and Chand K.A., 3,5,4′-trihydroxy-6,7-dimethoxyflavone 3-glucoside from Sesuvium portulacastrum. Phytochem. 21, 1179-1180 (1982).
17. Sanchez, I., Gomez-Garibay, Taboada, J., and Ruiz, B.H., Antiviral effects of flavonoids on the Dengue virus. Phytother. Res. 14, 89-92 (2000).
18. Murthy, M.S.R., Rao, E.V., Dhawan, B.N., and Panaik, G.K., Antispasmodic activity of certain Maxima isoflavones. Indian J. Pharm. Sci., Sep-Oct. 140-141 (1986).
19. Thangam, C. and Dhananjayan, R., Anti-inflammatory potential of the seeds of Carum copticum Linn., Ind. J. Pharmacol. 35, 388-391 (2003).
20. Rao, E.V. and Prasad, Y.R., Two chalcones from Tephrosia spinosa. Phytochem. 31, 2121-2122 (1992a).
21. Rao, E.V. and Prasad, Y.R., Prenylated Flavonoids from Tephrosia spinosa. Phytochem. 32, 183-185 (1993b).
22. Vinegar, R., Schreiber, W., and Hugs, R., Biphasic development of carrageenan oedema in rats. J. Pharmac. Exp. Ter. 166, 95-98 (1969).
23. Winter, C.A., Risley, E.A., and Nuss, G.W., Carrageenan induced oedema in hind paw of the rat as an assay for antiinflammatory drugs. Proc. Soc. Exp. Biol. Med. 111, 544-547 (1962).