New guaiane, megastigmane and eudesmane-type sesquiterpenoids and anti-inflammatory constituents from Youngia japonica

Planta Medica

Volumn 72, Issue 2, 2006, Pages 143-150

  Chen, Wenliang ^a,b   Liu, Qunfang ^a   Wang, Jian ^a   Zou, Jian ^a,b   Meng, Dahai ^a,b   Zuo, Jianping ^a   Zhu, Xingzu ^a   Zhao, Weimin ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Anti inflammatory activity; Asteraceae; Immunosuppressive activity; Sesquiterpenoid; Youngia japonica

Indexed keywords

3 OXO 10(14),11(13)GUAIADIEN 12,6 OLIDE; 3 OXO 8ALPHA HYDROXY 10(14),11(13)GUAIADIEN 12,6 OLIDE; 3 OXO 8ALPHA(4 HYDROXYPHENYL)ACETOXY 10(14),11(13)GUAIADIEN 12,6 OLIDE; 3ALPHA HYDROXY 4ALPHA(BETA DEXTRO GLUCOPYRANOSYLOXY) 5,7 MEGASTIGMADIEN 9 ONE; 3ALPHA(BETA DEXTRO GLUCOPYRANOSYLOXY) 4(15),11(13) EUDESMADIEN 12 OIC ACID; 3ALPHA,5BETA,6ALPHA TRIHYDROXY 4ALPHA(BETA DEXTRO GLUCOPYRANOSYLOXY) 7 MEGASTIGMEN 9 ONE; 3BETA HYDROXY 4(15),10(14),11(13)GIAIATRIEN 12,6 OLIDE; 3BETA(BETA DEXTRO GLUCOPYRANOSYLOXY) 4(15),10(14),11(13)GUAIATRIEN 12,6 OLIDE; 3BETA(BETA DEXTRO GLUCOPYRANOSYLOXY) 8ALPHA(4 HYDROXYPHENYL)ACETOXY 4(15),10(14),11(13)GUAIATRIEN 12,6 OLIDE; 3BETA[3 (4 HYDROXYPHENYL)ACETYL BETA DEXTRO GLUCOPYRANOSYLOXY] 4(15),10(14),11(13)GUAIATRIEN 12,6 OLIDE; 3BETA[3 (4 HYDROXYPHENYL)ACETYL BETA DEXTRO GLUCOPYRANOSYLOXY] 8 ALPHA HYDROXY 4(15),10(14),11(13)GUAIATRIEN 12,6 OLIDE; ANTIINFLAMMATORY AGENT; CONCANAVALIN A; INDOMETACIN; PLANT EXTRACT; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG; YOUNGIA JAPONICA EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTERACEAE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; T LYMPHOCYTE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTERACEAE; B-LYMPHOCYTES; CARRAGEENAN; CELL PROLIFERATION; CONCANAVALIN A; EDEMA; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED BALB C; NORISOPRENOIDS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLANT EXTRACTS; SESQUITERPENES; SESQUITERPENES, EUDESMANE; SESQUITERPENES, GUAIANE; T-LYMPHOCYTES;

ANIMALIA; ASTERACEAE; YOUNGIA JAPONICA;

EID: 33644541799     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-916182     Document Type: Article

References (15)

1. Jiangsu New Medical College, Dictionary of Chinese herb medicines. Shanghai: Shanghai Scientific and Technologic Press, 1986: p. 2066
2. Adegawa S, Miyase T, Fukushima S. Sesquiterpene glycosides from Youngia denticulate (Houtt.) kitam. Chem Pharm Bull 1986; 34: 3769-73
3. Samek Z, Holub M, Drozdz B, Iommi G, Corbella A, Gariboldi P. Sesquiterpenic lactones of the Cynara scolymus L. species. Tetrahedron Lett 1971; 50: 4775-8
4. Bohlmann F, Van N. Sesquiterpenlactone und Polyine aus der Gattung Arctotis. Phytochemistry 1977; 16: 487-8
5. Miyase T, Ueno A, Noro T, Kuroyanagi M, Fukushima S. Studies on sesquiterpene glycosides from Crepis japonica Benth. Chem Pharm Bull 1985; 33: 4451-6
6. Miyase T, Fukushima S. Sesquiterpene lactones from Ainsliaea acerifolia Sch. Bip. and A. dissecta Franch. et Sav. Chem Pharm Bull 1984; 32: 3043-6
7. Miyase T, Yamaki K, Fukushima S. Studies on sesquiterpenes from Macroclinidium trilobum makino. 1. Chem Pharm Bull 1984; 32: 3912-7
8. Romo de Vivar A, Cabrera A, Ortega A, Romo J. Constituents of zaluzania species - II structures of zaluzanin C and zaluzanin D. Tetrahedron 1967; 23: 3903-7
9. Shimizu S, Miyase T, Ueno A, Usmanghani K. Sesquiterpene lactone glycosides and ionone derivative glycosides from Sonchus asper. Phytochemistry 1989; 28: 3399-3402
10. Xiang D, Li X. Antitumor activity and immuno-potentiating actions of Achyranthes bidentata polysaccharides. Acta Pharmacol Sin 1993; 14: 556-61
11. Winter C, Risley E, Nuss C. Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med 1962; 111: 544-7
12. Ceccherelli P, Curini M, Marcotullio M, Menghini A. Sesquiterpene acids from Dittrichia viscosa. Phytochemistry 1985; 24: 2987-9
13. Kupchan S, Kelsey J, Maruyama M, Cassady J, Hemingway J, Knox J. Tumor inhibitors. XLI. structural elucidation of tumor-inhibitory sesquiterpene lactones from Eupatorium rotundifolium. J Org Chem 1969; 34: 3876-83
14. Sun C, Syu W, Don M, Lu J, Lee G. Cytotoxic sesquiterpene lactones from the root of Saussurea lappa. J Nat Prod 2003; 66: 1175-80
15. Zidorn C, Ellmerer E, Konwalinka G, Schwaiger N, Stuppner H. 13-Chloro-3-O-β-D-glucopyranosylsolstitialin from Leontodon palisae: the first genuine chlorinated sesquiterpene lactone glucoside. Tetrahedron Lett 2004; 45: 3433-6