Immunosuppression-free transplantation reconsidered from a regenerative medicine perspective

Expert Review of Clinical Immunology

Volumn 8, Issue 2, 2012, Pages 179-187

  Orlando, Giuseppe ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

cells; immunosuppression; organ bioengineering; regenerative medicine; scaffolds; tolerance; transplantation

Indexed keywords

METHOXYPOLYETHYLENE GLYCOL; NANOFILM; POLYMER; UNCLASSIFIED DRUG;

AUTOIMMUNITY; BIOENGINEERING; BLADDER; BLOOD VESSEL GRAFT; CELL ADHESION; CELL DIFFERENTIATION; CELL ENCAPSULATION; CELL MIGRATION; CHIMERA; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; FIBROBLAST; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; IMMUNE DEFICIENCY; IMMUNE SYSTEM; IMMUNOCLOAKING; IMMUNOLOGICAL PROCEDURES; IMMUNOSUPPRESSION FREE STATE; ISOLATION PROCEDURE; NONHUMAN; ORGAN TRANSPLANTATION; PANCREAS ISLET BETA CELL; REGENERATIVE MEDICINE; REVIEW; SMOOTH MUSCLE FIBER; STEM CELL; THYMUS; TISSUE ENGINEERING; UPPER RESPIRATORY TRACT; URETHRA; VASCULARIZATION;

ANIMALS; BIOENGINEERING; HUMANS; IMMUNOSUPPRESSION; ORGAN TRANSPLANTATION; REGENERATIVE MEDICINE; TRANSPLANTATION, HOMOLOGOUS;

EID: 84856591645     PISSN: 1744666X     EISSN: 17448409     Source Type: Journal    
DOI: 10.1586/eci.11.101     Document Type: Review

References (65)

1. Orlando G, Hematti P, Stratta RJ, et al. Clinical operational tolerance after renal transplantation: current status and future challenges. Ann. Surg. 252(6), 915-928 (2010).
2. Orlando G, Soker S, Wood KJ. Clinical operational tolerance after liver Transplantation J. Hepatol. 50(6), 1247-1257 (2009).
3. Orlando G. Finding the right time for weaning off immunosuppression in solid organ transplant recipients. Expert Rev. Clin. Immunol. 6(6), 879-892 (2010).
4. Kirk AD. Clinical tolerance 2008. Transplantation 87(7), 953-955 (2009).
5. Orlando G, Wood KJ, Soker S, et al. How regenerative medicine may contribute to the achievement of an immunosuppression-free state. Transplantation 92(8), e36-e38 (2011).
6. Orlando G. Transplantation as a subfield of regenerative medicine. Expert Rev. Clin. Immunol. 7(2), 137-141 (2011).
7. Brasile L, Glowacki P, Stubenitsky BM. Bioengineered skin allografts: a new method to prevent humoral response. ASAIO J. 57(3), 239-243 (2011).
8. Brasile L, Glowacki P, Castracane J, et al. Pretransplant kidney-specific treatment to eliminate the need for systemic immunosuppression. Transplantation 90(12), 1294-1298 (2010).
9. Poznansky MC, Evans RH, Foxall RB, et al. Efficient generation of human T cells from a tissue-engineered thymic organoid. Nat. Biotechnol. 18(7), 729-734 (2000). (Pubitemid 30460687)
10. Suematsu S, Watanabe T. Generation of a synthetic lymphoid tissue-like organoid in mice. Nat. Biotechnol. 22(12), 1539-1545 (2004). (Pubitemid 40039456)
11. Clark RA, Yamanaka K, Bai M, et al. Human skin cells support thymus-independent T cell development. J. Clin. Invest. 115(11), 3239-3249 (2005). (Pubitemid 41567588)
12. Marshall D, Bagley J, Le P, et al. T cell generation including positive and negative selection ex vivo in a three-dimensional matrix. J. Hematother. Stem Cell Res. 12(5), 565-574 (2003). (Pubitemid 37305568)
13. Vianello F, Poznansky MC. Generation of a tissue-engineered thymic organoid. Methods Mol. Biol. 380, 163-170 (2007). (Pubitemid 350183327)
14. Orlando G, Wood KJ, Stratta RJ, et al. Regenerative medicine and organ transplantation: past, present, and future. Transplantation 91(12), 1310-1317 (2011).
15. Orlando G, Baptista P, Birchall M, et al. Regenerative medicine as applied to solid organ transplantation: current status and future challenges. Transpl. Int. 24(3), 223-232 (2010).
16. Orlando G, Wood KJ, De Coppi P, et al. Regenerative medicine as applied to general surgery. Ann. Surg. (2012) (In Press).
17. Shinoka T, Imai Y, Ikada Y. Transplantation of a tissue-engineered pulmonary artery. N. Engl. J. Med. 344(7), 532-533 (2001).
18. Shinoka T, Matsumura G, Hibino N, et al. Midterm clinical result of tissue-engineered vascular autografts seeded with autologous bone marrow cells. J. Thorac. Cardiovasc. Surg. 129(6), 1330-1338 (2005).
19. Hibino N, McGillicuddy E, Matsumura G, et al. Late-term results of tissue-engineered vascular grafts in humans. J. Thorac. Cardiovasc. Surg. 139(2), 431-436 (2010).
20. Naito Y, Shinoka T, Duncan D, et al. Vascular tissue engineering: towards the next generation vascular grafts. Adv. Drug Deliv. Rev. 63(4-5), 312-323 (2011).
21. McAllister TN, Maruszewski M, Garrido SA, et al. Effectiveness of haemodialysis access with an autologous tissue-engineered vascular graft: a multicentre cohort study. Lancet 373(9673), 1440-1446 (2009).
22. L'Heureux N, McAllister TN, de la Fuente LM. Tissue-engineered blood vessel for adult arterial revascularization. N. Engl. J. Med. 357(14), 1451-1453 (2007). (Pubitemid 47535609)
23. L'Heureux N, Dusserre N, Konig G, et al. Human tissue-engineered blood vessels for adult arterial revascularization. Nat. Med. 12(3), 361-365 (2006). (Pubitemid 43355087)
24. Dahl SL, Kypson AP, Lawson JH, et al. Readily available tissue-engineered vascular grafts. Sci. Transl. Med. 3(68), 68ra9 (2011).
25. Atala A, Bauer SB, Soker S, et al. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet 367(9518), 1241-1246 (2006).
26. Folkman J, Hochberg M. Self-regulation of growth in three dimensions. J. Exp. Med. 138(4), 745-753 (1973).
27. Macchiarini P, Jungebluth P, Go T, et al. Clinical transplantation of a tissue-engineered airway. Lancet 372(9655), 2023-2030 (2008).
28. Baiguera S, Birchall MA, Macchiarini P. Tissue-engineered tracheal transplantation. Transplantation 89(5), 485-491 (2010).
29. Baiguera S, Gonfiotti A, Jaus M, et al. Development of bioengineered human larynx. Biomaterials 32(19), 4433-4442 (2011).
30. Raya-Rivera A, Esquiliano DR, Yoo JJ, et al. Tissue-engineered autologous urethras for patients who need reconstruction: an observational study. Lancet 377(9772), 1175-1182 (2011).
31. Song JJ, Kim SS, Liu Z, et al. Enhanced in vivo function of bioartificial lungs in rats. Ann. Thorac. Surg. 92(3), 998-1006 (2011).
32. Wang Y, Cui CB, Yamauchi M, et al. Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds. Hepatology 53(1), 293-305 (2011).
33. Mertsching H, Schanz J, Steger V, et al. Generation and transplantation of an autologous vascularized bioartificial human tissue. Transplantation 88(2), 203-210 (2009).
34. Orlando G, Stratta RJ, Light J. Pancreas transplantation for type 2 diabetes mellitus. Curr. Opin. Organ. Transplant. doi: 10.1097/MOT. 0b013e3283424d1f (2010) (Epub ahead of print).
35. Cravedi P, van der Meer IM, Cattaneo S, et al. Successes and disappointments with clinical islet transplantation. Adv. Exp. Med. Biol. 654, 749-769 (2010).
36. Vaithilingam V, Tuch BE. Islet transplantation and encapsulation: an update on recent developments. Rev. Diabet. Stud. 8(1), 63-79 (2011).
37. Bach JF, Chatenoud L. Organ transplantation and autoimmunity: common mechanisms common therapies. Semin. Immunol. 23(3), 155-156 (2011).
38. Teramura Y, Iwata H. Bioartificial pancreas. Microencapsulation and conformal coating of islet of Langerhans. Adv. Drug Del. Rev. 62(2010), 827-840 (2010).
39. Lechler RI, Sykes M, Thomson AW, et al. Organ transplantation - how much of the promise has been realized? Nat. Med. 11(6), 605-613 (2005). (Pubitemid 40868300)
40. Giraldo JA, Weaver JD, Stabler CL. Tissue engineering approaches to enhancing clinical islet transplantation through tissue engineering strategies. J. Diabetes. Sci. Technol. 4(5), 1238-1247 (2010).
41. De Carlo E, Baiguera S, Conconi MT, et al. Pancreatic acellular matrix supports islet survival and function in a synthetic tubular device: in vitro and in vivo studies. Int. J. Mol. Med. 25(2), 195-202 (2010).
42. Brasile L, Glowacki P, Castracane J, Stubenitsky BM. Pretransplant kidney-specific treatment to eliminate the need for systemic immunosuppression. Transplantation 90(12), 1294-1298 (2010).
43. Stubenitsky BM, Brasile L, Rebellato LM, et al. Delayed skin allograft rejection following matrix membrane pretreatment. J. Plast. Reconstr. Aesthet. Surg. 62(4), 520-525 (2009).
44. Scott MD, Murad KL, Koumpouras F, et al. Chemical camouflage of antigenic determinants: stealth erythrocytes. Proc. Natl Acad. Sci. USA 94(14), 7566-7571 (1997). (Pubitemid 27345356)
45. Scott MD, Murad KL. Cellular camouflage: fooling the immune system with polymers. Curr. Pharm. Des. 4(6), 423-438 (1998). (Pubitemid 28536750)
46. Murad KL, Mahany KL, Brugnara C, et al. Structural and functional consequences of antigenic modulation of red blood cells with methoxypoly(ethylene glycol). Blood 93(6), 2121-2127 (1999). (Pubitemid 29128517)
47. Chen AM, Scott MD. Current and future applications of immunological attenuation via pegylation of cells and tissue. BioDrugs 5(12), 833-847 (2001). (Pubitemid 33759681)
48. Chen AM, Scott MD. Immunocamouflage: prevention of transfusion-induced graft-versus-host disease via polymer grafting of donor cells. J. Biomed. Mater. Res. A. 67(2), 626-636 (2003). (Pubitemid 37522470)
49. Rossi NA, Constantinescu I, Kainthan RK, et al. Red blood cell membrane grafting of multi-functional hyperbranched polyglycerols. Biomaterials 31(14), 4167-4178 (2010).
50. Le Y, Scott MD. Immunocamouflage: the biophysical basis of immunoprotection by grafted methoxypoly(ethylene glycol) (mPEG). Acta Biomater. 6(7), 2631-2641 (2010).
51. Wang D, Kyluik DL, Murad KL, et al. Polymer-mediated immunocamouflage of red blood cells: effects of polymer size on antigenic and immunogenic recognition of allogeneic donor blood cells. Sci. China Life Sci. 54(7), 589-598 (2011).
52. Wang D, Toyofuku WM, Chen AM, et al. Induction of immunotolerance via mPEG grafting to allogeneic leukocytes. Biomaterials 32(35), 9494-9503 (2011).
53. Sutton TC, Scott MD. The effect of grafted methoxypoly(ethylene glycol) chain length on the inhibition of respiratory syncytial virus (RSV) infection and proliferation. Biomaterials 31(14), 4223-4230 (2010).
54. Seach N, Layton D, Lim J, et al. Thymic generation and regeneration: a new paradigm for establishing clinical tolerance of stem cell-based therapies. Curr. Opin. Biotechnol. 18(5), 441-447 (2007). (Pubitemid 350119857)
55. Yamada K, Gianello PR, Ierino FL, et al. Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts. J. Exp. Med. 186(3), 497-506 (1997). (Pubitemid 27360794)
56. Nobori S, Samelson-Jones E, Shimizu A, et al. Long-term acceptance of fully allogeneic cardiac grafts by cotransplantation of vascularized thymus in miniature swine. Transplantation 81(1), 26-35 (2006). (Pubitemid 43122145)
57. Nobori S, Shimizu A, Okumi M, et al. Thymic rejuvenation and the induction of tolerance by adult thymic grafts. Proc. Natl Acad. Sci. USA 103(50), 19081-19086 (2006). (Pubitemid 350002831)
58. Yamada K, Shimizu A, Ierino FL, et al. Thymic transplantation in miniature swine. I. Development and function of the 'thymokidney'. Transplantation 68(11), 1684-1692 (1999). (Pubitemid 30004799)
59. Yamada K, Shimizu A, Utsugi R, et al. Thymic transplantation in miniature swine. II. Induction of tolerance by transplantation of composite thymokidneys to thymectomized recipients. J. Immunol. 164(6), 3079-3086 (2000). (Pubitemid 30148968)
60. Yamada K, Vagefi PA, Utsugi R, et al. Thymic transplantation in miniature swine: III. Induction of tolerance by transplantation of composite thymokidneys across fully major histocompatibility complex-mismatched barriers. Transplantation 76(3), 530-536 (2003). (Pubitemid 37013258)
61. Vagefi PA, Ierino FL, Gianello PR, et al. Role of the thymus in transplantation tolerance in miniature swine: IV. The thymus is required during the induction phase, but not the maintenance phase, of renal allograft tolerance. Transplantation 77(7), 979-985 (2004). (Pubitemid 38508909)
62. Suematsu S, Watanabe T. Generation of a synthetic lymphoid tissue-like organoid in mice. Nat. Biotechnol. 22(12), 1539-1545 (2004). (Pubitemid 40039456)
63. BBC news. Windpipe transplant success in UK child. http://news.bbc.co.uk/ 2/hi/8576493.stm
64. USA today. Patient gets world's first artificial trachea. http://yourlife.usatoday.com/health/story/2011/07/Patient-gets-worlds-first- artificial-trachea/49176868/1
65. Breonics, Inc. Immunocloaking. http://breonics.com/ems. html#immunocloaking