S100A8/A9 aggravates post-ischemic heart failure through activation of RAGE-dependent NF-κB signaling

Basic Research in Cardiology

Volumn 107, Issue 2, 2012, Pages

  Volz, H Christian ^a   Laohachewin, Danai ^a   Seidel, Cathrin ^a   Lasitschka, Felix ^a   Keilbach, Kirsten ^a   Wienbrandt, Alexandra R ^a   Andrassy, Joachim ^b   Bierhaus, Angelika ^a   Kaya, Ziya ^a   Katus, Hugo A ^a   Andrassy, Martin ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Heart failure; Inflammation; Myocardial remodeling; RAGE; S100A8 A9

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; BETA ACTIN; CALGRANULIN A; CALGRANULIN B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; ADVANCED GLYCOSYLATION END PRODUCT RECEPTOR; ADVANCED GLYCOSYLATION END-PRODUCT RECEPTOR; IMMUNOGLOBULIN RECEPTOR; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; DISEASE MODEL; FIBROBLAST; GENE SILENCING; HEART FAILURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PERFORMANCE; HYPOXIA; IMMUNOCOMPETENT CELL; MACROPHAGE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; C57BL MOUSE; ECHOCARDIOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSFECTION; HISTOCOMPATIBILITY; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE MUTANT; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CALGRANULIN A; CALGRANULIN B; ECHOCARDIOGRAPHY; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEART FAILURE; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, IMMUNOLOGIC; REPERFUSION INJURY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION; TRANSPLANTATION CHIMERA;

EID: 84856573048     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-012-0250-z     Document Type: Article

References (64)

1. Aleshin A, Ananthakrishnan R, Li Q, Rosario R, Lu Y, Qu W, Song F, Bakr S, Szabolcs M, D'Agati V, Liu R, Homma S, Schmidt AM, Yan SF, Ramasamy R (2008) RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model. Am J Physiol Heart Circ Physiol 294:H1823-H1832. doi:10.1152/ajpheart.01210. 2007 (Pubitemid 351490612)
2. Altwegg LA, Neidhart M, Hersberger M, Muller S, Eberli FR, Corti R, Roffi M, Sutsch G, Gay S, von Eckardstein A, Wischnewsky MB, Luscher TF, Maier W (2007) Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes. Eur Heart J 28:941-948. doi:10.1093/ eurheartj/ehm078 (Pubitemid 47343918)
3. Andrassy M, Igwe J, Autschbach F, Volz C, Remppis A, Neurath MF, Schleicher E, Humpert PM, Wendt T, Liliensiek B, Morcos M, Schiekofer S, Thiele K, Chen J, Kientsch-Engel R, Schmidt AM, Stremmel W, Stern DM, Katus HA, Nawroth PP, Bierhaus A (2006) Posttranslationally modified proteins as mediators of sustained intestinal inflammation. Am J Pathol 169:1223-1237. doi:10.2353/ajpath.2006.050713 (Pubitemid 351194359)
4. Andrassy M, Volz HC, Igwe JC, Funke B, Eichberger SN, Kaya Z, Buss S, Autschbach F, Pleger ST, Lukic IK, Bea F, Hardt SE Humpert PM, Bianchi ME, Mairbaurl H, Nawroth PP, Remppis A, Katus HA, Bierhaus A (2008) High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation 117:3216-3226. doi:10.1161/CIRCULATIONAHA.108.769331
5. Bierhaus A, Haslbeck KM, Humpert PM, Liliensiek B, Dehmer T, Morcos M, Sayed AA, Andrassy M, Schiekofer S, Schneider JG, Schulz JB, Heuss D, Neundorfer B, Dierl S, Huber J, Tritschler H, Schmidt AM, Schwaninger M, Haering HU, Schleicher E, Kasper M, Stern DM, Arnold B, Nawroth PP (2004) Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily. J Clin Invest 114:1741-1751. doi: 10.1172/JCI18058 (Pubitemid 40385530)
6. Bierhaus A, Schiekofer S, Schwaninger M, Andrassy M, Humpert PM, Chen J, Hong M, Luther T, Henle T, Kloting I, Morcos M, Hofmann M, Tritschler H, Weigle B, Kasper M, Smith M, Perry G, Schmidt AM, Stern DM, Haring HU, Schleicher E, Nawroth PP (2001) Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes 50:2792-2808. doi:10.2337/diabetes.50.12. 2792 (Pubitemid 33733131)
7. Boengler K, Hilfiker-Kleiner D, Drexler H, Heusch G, Schulz R (2008) The myocardial JAK/STAT pathway: from protection to failure. Pharmacol Ther 120:172-185. doi:10.1016/j.pharmthera. 2008.08.002
8. Boyd JH, Kan B, Roberts H, Wang Y, Walley KR (2008) S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products. Circ Res 102:1239-1246. doi:10.1161/CIRCRESAHA. 107. 167544
9. Bucciarelli LG, Ananthakrishnan R, Hwang YC, Kaneko M, Song F, Sell DR, Strauch C, Monnier VM, Yan SF, Schmidt AM, Ramasamy R (2008) RAGE and modulation of ischemic injury in the diabetic myocardium. Diabetes 57:1941-1951. doi:10.2337/db07-0326
10. Cohn JN, Ferrari R, Sharpe N (2000) Cardiac remodeling- concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol 35:569-582 S0735109799006300[pii] (Pubitemid 30167013)
11. Constien R, Forde A, Liliensiek B, Grone HJ, Nawroth P, Hammerling G, Arnold B (2001) Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line. Genesis 30:36-44. doi:10.1002/gene. 1030
12. Croce K, Gao H, Wang Y, Mooroka T, Sakuma M, Shi C, Sukhova GK, Packard RR, Hogg N, Libby P, Simon DI (2009) Myeloid-related protein-8/14 is critical for the biological response to vascular injury. Circulation 120:427-436. doi: 10.1161/CIRCULATIONAHA.108.814582
13. Dayan V, Yannarelli G, Billia F, Filomeno P, Wang XH, Davies JE, Keating A (2011) Mesenchymal stromal cells mediate a switch to alternatively activated monocytes/macrophages after acute myocardial infarction. Basic Res Cardiol 106:1299-1310. doi:10.1007/s00395-011-0221-9
14. Ehlermann P, Eggers K, Bierhaus A, Most P, Weichenhan D, Greten J, Nawroth PP, Katus HA, Remppis A (2006) Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products. Cardiovasc Diabetol 5:6. doi:10.1186/1475-2840-5-6 (Pubitemid 43880425)
15. Eue I, Pietz B, Storck J, Klempt M, Sorg C (2000) Transendothelial migration of 27E10? human monocytes. Int Immunol 12:1593-1604. doi:10.1093/intimm/12.11.1593
16. Frosch M, Strey A, Vogl T, Wulffraat NM, Kuis W, Sunderkotter C, Harms E, Sorg C, Roth J (2000) Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis. Arthr Rheum 43:628-637. doi:10.1002/1529-0131 (200003)43:3\628:AID-ANR20[3.0.CO;2-X (Pubitemid 30394955)
17. Frosch M, Vogl T, Seeliger S, Wulffraat N, Kuis W, Viemann D, Foell D, Sorg C, Sunderkotter C, Roth J (2003) Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritis. Arthr Rheum 48:2622-2626. doi:10.1002/ art.11177 (Pubitemid 37129439)
18. Fuster V, Badimon L, Badimon JJ, Chesebro JH (1992) The pathogenesis of coronary artery disease and the acute coronary syndromes (1). N Engl J Med 326:242-250. doi:10.1056/ NEJM199201233260406
19. Fuster V, Badimon L, Badimon JJ, Chesebro JH (1992) The pathogenesis of coronary artery disease and the acute coronary syndromes (2). N Engl J Med 326:310-318. doi:10.1056/NEJM 199201303260506
20. Gharaee-Kermani M, Denholm EM, Phan SH (1996) Costimulation of fibroblast collagen and transforming growth factor beta1 gene expression by monocyte chemoattractant protein-1 via specific receptors. J Biol Chem 271:17779-17784. doi:10.1074/ jbc.271.30.17779 (Pubitemid 26250752)
21. Goser S, Andrassy M, Buss SJ, Leuschner F, Volz CH, Ottl R, Zittrich S, Blaudeck N, Hardt SE, Pfitzer G, Rose NR, Katus HA, KayaZ (2006) Cardiac troponin I but not cardiac troponin T induces severe autoimmune inflammation in the myocardium. Circulation 114:1693-1702. doi:10.1161/CIRCULATIONAHA.106.635664 (Pubitemid 44607117)
22. Gwechenberger M, Mendoza LH, Youker KA, Frangogiannis NG, Smith CW, Michael LH, Entman ML (1999) Cardiac myocytes produce interleukin-6 in culture and in viable border zone of reperfused infarctions. Circulation 99:546-551. doi:10.1161/ 01.CIR.99.4.546 (Pubitemid 29061871)
23. Hardt SE, Geng YJ, Montagne O, Asai K, Hong C, Yang GP, Bishop SP, Kim SJ, Vatner DE, Seidman CE, Seidman JG, Homcy CJ, Vatner SF (2002) Accelerated cardiomyopathy in mice with overexpression of cardiac G(s)alpha and a missense mutation in the alpha-myosin heavy chain. Circulation 105:614-620. doi:10.1161/hc0502.103012 (Pubitemid 34123437)
24. Healy AM, Pickard MD, Pradhan AD, Wang Y, Chen Z, Croce K, Sakuma M, Shi C, Zago AC, Garasic J, Damokosh AI, Dowie TL, Poisson L, Lillie J, Libby P, Ridker PM, Simon DI (2006) Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events. Circulation 113:2278-2284. doi:10.1161/CIRCULATIONAHA.105. 607333 (Pubitemid 43947973)
25. Hermani A, De Servi B, Medunjanin S, Tessier PA, Mayer D (2006) S100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cells. Exp Cell Res 312:184-197. doi: 10.1016/j.yexcr.2005.10.013 (Pubitemid 41721180)
26. Hermani A, Hess J, De Servi B, Medunjanin S, Grobholz R, Trojan L, Angel P, Mayer D (2005) Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancer. Clin Cancer Res 11:5146-5152. doi:10.1158/ 1078-0432.CCR-05-0352 (Pubitemid 41003699)
27. Heymans S, Hirsch E, Anker SD, Aukrust P, Balligand JL, Cohen-Tervaert JW, Drexler H, Filippatos G, Felix SB, Gullestad L, Hilfiker-Kleiner D, Janssens S, Latini R, Neubauer G, Paulus WJ, Pieske B, Ponikowski P, Schroen B, Schultheiss HP, Tschope C, Van Bilsen M, Zannad F, McMurray J, Shah AM (2009) Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 11:119-129. doi:10.1093/eurjhf/hfn043
28. Hiratsuka S, Watanabe A, Aburatani H, Maru Y (2006) Tumourmediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol 8:1369-1375. doi:10.1038/ncb1507 (Pubitemid 44835111)
29. Hofmann MA, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, Kambham N, Bierhaus A, Nawroth P, Neurath MF, Slattery T, Beach D, McClary J, Nagashima M, Morser J, Stern D, Schmidt AM (1999) RAGE mediates a novel proinflammatory axis: acentral cell surface receptor for S100/calgranulin polypeptides. Cell 97:889-901 S0092-8674(00)80801-6[pii] (Pubitemid 29375048)
30. Hu Y, Zhang H, Lu Y, Bai H, Xu Y, Zhu X, Zhou R, Ben J, Chen Q (2011) Class A scavenger receptor attenuates myocardial infarction-induced cardiomyocyte necrosis through suppressing M1 macrophage subset polarization. Basic Res Cardiol 106:1311-1328. doi:10.1007/s00395-011-0204-x
31. Huttunen HJ, Kuja-Panula J, Sorci G, Agneletti AL, Donato R, Rauvala H (2000) Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation. J Biol Chem 275:40096-40105. doi:10.1074/jbc.M006993200M006993200 (Pubitemid 32064635)
32. Ihm SH, Chang K, Kim HY, Baek SH, Youn HJ, Seung KB, Kim JH (2010) Peroxisome proliferator-activated receptor-gamma activation attenuates cardiac fibrosis in type 2 diabetic rats: the effect of rosiglitazone on myocardial expression of receptor for advanced glycation end products and of connective tissue growth factor. Basic Res Cardiol 105:399-407. doi:10.1007/s00395-009- 0071-x
33. Ikemoto M, Tanaka T, Takai Y, Murayama H, Tanaka K, Fujita M (2003) New ELISA system for myeloid-related protein complex (MRP8/14) and its clinical significance as a sensitive marker for inflammatory responses associated with transplant rejection. Clin Chem 49:594-600. doi:10.1373/49.4.594 (Pubitemid 36379525)
34. Katashima T, Naruko T, Terasaki F, Fujita M, Otsuka K, Murakami S, Sato A, Hiroe M, Ikura Y, Ueda M, Ikemoto M, Kitaura Y (2010) Enhanced expression of the S100A8/A9 complex in acute myocardial infarction patients. Circ J 74:741-748 JST.JSTAGE/circj/CJ-09-0564[pii]
35. Kleinbongard P, Heusch G, Schulz R (2010) TNFalpha in atherosclerosis, myocardial ischemia/reperfusion and heart failure. Pharmacol Ther 127:295-314. doi:10.1016/j.pharmthera.2010.05.002
36. Kubota T, Bounoutas GS, Miyagishima M, Kadokami T, Sanders VJ, Bruton C, Robbins PD, McTiernan CF, Feldman AM (2000) Soluble tumor necrosis factor receptor abrogates myocardial inflammation but not hypertrophy in cytokine-induced cardiomyopathy. Circulation 101:2518-2525. doi:10.1161/01.CIR. 101.21. 2518 (Pubitemid 30366257)
37. Liliensiek B, Weigand MA, Bierhaus A, Nicklas W, Kasper M, Hofer S, Plachky J, Grone HJ, Kurschus FC, Schmidt AM, Yan SD, Martin E, Schleicher E, Stern DM, Hammerling GG, Nawroth PP, Arnold B (2004) Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response. J Clin Invest 113:1641-1650. doi:10.1172/JCI18704 (Pubitemid 39071688)
38. Loser K, Vogl T, Voskort M, Lueken A, Kupas V, Nacken W, Klenner L, Kuhn A, Foell D, Sorokin L, Luger TA, Roth J, Beissert S (2010) The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells. Nat Med 16:713-717. doi:10.1038/nm.2150
39. Lugering N, Stoll R, Schmid KW, Kucharzik T, Stein H, Burmeister G, Sorg C, Domschke W (1995) The myeloic related protein MRP8/14 (27E10 antigen)-usefulness as a potential marker for disease activity in ulcerative colitis and putative biological function. Eur J Clin Invest 25:659-664. doi: 10.1111/j.1365-2362.1995.tb01982.x
40. Mann DL (2002) Inflammatory mediators and the failing heart: past, present, and the foreseeable future. Circ Res 91:988-998. doi:10.1161/01.RES. 0000043825.01705.1B (Pubitemid 35416635)
41. McCormick MM, Rahimi F, Bobryshev YV, Gaus K, Zreiqat H, Cai H, Lord RS, Geczy CL (2005) S100A8 and S100A9 in human arterial wall. Implications for atherogenesis. J Biol Chem 280:41521-41529. doi:10.1074/jbc.M509442200 (Pubitemid 41832213)
42. McKay RG, Pfeffer MA, Pasternak RC, Markis JE, Come PC, Nakao S, Alderman JD, Ferguson JJ, Safian RD, Grossman W (1986) Left ventricular remodeling after myocardial infarction: a corollary to infarct expansion. Circulation 74:693-702. doi: 10.1161/01.CIR.74.4.693 (Pubitemid 16007186)
43. Michel MC, Li Y, Heusch G (2001) Mitogen-activated protein kinases in the heart. Naunyn Schmiedebergs Arch Pharmacol 363:245-266 (Pubitemid 32186523)
44. Nacken W, Roth J, Sorg C, Kerkhoff C (2003) S100A9/S100A8: myeloid representatives of the S100 protein family as prominent players in innate immunity. Microsc Res Tech 60:569-580. doi: 10.1002/jemt.10299
45. Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ (2007) The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 204:3037-3047. doi:10.1084/jem.20070885 (Pubitemid 350179569)
46. Newton RA, Hogg N (1998) The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophils. J Immunol 160:1427-1435 (Pubitemid 28093444)
47. NianM, Lee P, Khaper N, Liu P (2004) Inflammatory cytokines and postmyocardial infarction remodeling. Circ Res 94:1543-1553. doi: 10.1161/01.RES.0000130526.20854.fa94/12/1543 (Pubitemid 38856961)
48. Orlova VV, Choi EY, Xie C, Chavakis E, Bierhaus A, Ihanus E, Ballantyne CM, Gahmberg CG, Bianchi ME, Nawroth PP, Chavakis T (2007) A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin. EMBO J 26:1129-1139. doi:10.1038/sj.emboj.7601552
49. Rahimi F, Hsu K, Endoh Y, Geczy CL (2005) FGF-2, IL-1beta and TGF-beta regulate fibroblast expression of S100A8. FEBS J 272:2811-2827. doi:10.1111/j.1742-4658.2005.04703.x (Pubitemid 40825427)
50. Riad A, Jager S, Sobirey M, Escher F, Yaulema-Riss A, Westermann D, Karatas A, Heimesaat MM, Bereswill S, Dragun D, Pauschinger M, Schultheiss HP, Tschope C (2008) Toll-like receptor-4 modulates survival by induction of left ventricular remodeling after myocardial infarction in mice. J Immunol 180:6954-6961 180/10/6954[pii]
51. Ryckman C, Vandal K, Rouleau P, Talbot M, Tessier PA (2003) Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion. J Immunol 170:3233-3242 (Pubitemid 36302201)
52. Schmidt AM, Yan SD, Yan SF, Stern DM (2001) The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest 108:949-955. doi: 10.1172/JCI14002 (Pubitemid 32946067)
53. Schnekenburger J, Schick V, Kruger B, Manitz MP, Sorg C, Nacken W, Kerkhoff C, Kahlert A, Mayerle J, Domschke W, Lerch MM (2008) The calcium binding protein S100A9 is essential for pancreatic leukocyte infiltration and induces disruption of cell-cell contacts. J Cell Physiol 216:558-567. doi: 10.1002/jcp.21433 (Pubitemid 351898485)
54. Shishido T, Nozaki N, Yamaguchi S, Shibata Y, Nitobe J, Miyamoto T, Takahashi H, Arimoto T, Maeda K, Yamakawa M, Takeuchi O, Akira S, Takeishi Y, Kubota I (2003) Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction. Circulation 108:2905-2910. doi:10.1161/01.CIR. 0000101921.93016.1C01.CIR.0000101921.93016.1C (Pubitemid 37517819)
55. Sun C, Liang C, Ren Y, Zhen Y, He Z, Wang H, Tan H, Pan X, Wu Z (2009) Advanced glycation end products depress function of endothelial progenitor cells via p38 and ERK 1/2 mitogenactivated protein kinase pathways. Basic Res Cardiol 104:42-49. doi:10.1007/s00395-008-0738-8
56. Valeur HS, Valen G (2009) Innate immunity and myocardial adaptation to ischemia. Basic Res Cardiol 104:22-32. doi: 10.1007/s00395-008-0756-6
57. Vandal K, Rouleau P, Boivin A, Ryckman C, Talbot M, Tessier PA (2003) Blockade of S100A8 and S100A9 suppresses neutrophil migration in response to lipopolysaccharide. J Immunol 171:2602-2609 (Pubitemid 37025572)
58. Viemann D, Strey A, Janning A, Jurk K, Klimmek K, Vogl T, Hirono K, Ichida F, Foell D, Kehrel B, Gerke V, Sorg C, Roth J (2005) Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells. Blood 105:2955-2962. doi:10.1182/blood-2004-07-2520 (Pubitemid 40446292)
59. Vogl T, Ludwig S, Goebeler M, Strey A, Thorey IS, Reichelt R, Foell D, Gerke V, Manitz MP, Nacken W, Werner S, Sorg C, Roth J (2004) MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes. Blood 104:4260-4268. doi:10.1182/blood-2004-02-04462004-02-0446 (Pubitemid 39620181)
60. Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen MA, Nacken W, Foell D, van der Poll T, Sorg C, Roth J (2007) Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 13:1042-1049. doi:10.1038/nm1638 (Pubitemid 47517513)
61. Volz HC, Seidel C, Laohachewin D, Kaya Z, Muller OJ, Pleger ST, Lasitschka F, Bianchi ME, Remppis A, Bierhaus A, Katus HA, Andrassy M (2010) HMGB1: the missing link between diabetes mellitus and heart failure. Basic Res Cardiol 105:805-820. doi:10.1007/s00395-010-0114-3
62. Weisman HF, Bush DE, Mannisi JA, Weisfeldt ML, Healy B (1988) Cellular mechanisms of myocardial infarct expansion. Circulation 78:186-201. doi:10.1161/01.CIR.78.1.186
63. Wu J, Li J, Zhang N, Zhang C (2011) Stem cell-based therapies in ischemic heart diseases: a focus on aspects of microcirculation and inflammation. Basic Res Cardiol 106:317-324. doi: 10.1007/s00395-011-0168-x
64. Yan SF, Ramasamy R, Naka Y, Schmidt AM (2003) Glycation, inflammation, and RAGE: a scaffold for the macrovascular complications of diabetes and beyond. Circ Res 93:1159-1169. doi:10.1161/01.RES.0000103862.26506.3D93/12/1159 (Pubitemid 37543056)