Promoter methylation of MGMT, MLH1 and RASSF1A tumor suppressor genes in head and neck squamous cell carcinoma: Pharmacological genome demethylation reduces proliferation of head and neck squamous carcinoma cells

Oncology Reports

Volumn 27, Issue 4, 2012, Pages 1135-1141

  Koutsimpelas, Dimitrios ^a   Pongsapich, Warut ^a   Heinrich, Ulf ^a   Mann, Sylvia ^a   Mann, Wolf J ^a   Brieger, Jürgen ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

5 Azacytidine; Head and neck squamous cell carcinoma; mutL homolog 1; O 6 methylguanine DNA methyltransferase; Ras association domain family member 1; Tumor suppressor gene

Indexed keywords

ADULT; AGED; ARTICLE; CANCER CELL; CELL CYCLE REGULATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DNA SEQUENCE; EPIGENETICS; FEMALE; GENE EXPRESSION; HEAD AND NECK CARCINOMA; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MGMT GENE; MLH1 GENE; NUCLEOTIDE SEQUENCE; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION; RASSF1A GENE; SEQUENCE HOMOLOGY; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; AGED, 80 AND OVER; AZACITIDINE; BASE SEQUENCE; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CELL LINE, TUMOR; CELL PROLIFERATION; CPG ISLANDS; DEALKYLATION; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME INHIBITORS; FEMALE; GENES, TUMOR SUPPRESSOR; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; SEQUENCE ANALYSIS, DNA; TUMOR SUPPRESSOR PROTEINS;

EID: 84856568428     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1624     Document Type: Article

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