메뉴 건너뛰기




Volumn 51, Issue 2-3, 2011, Pages 257-266

Human immune system mice: Current potential and limitations for translational research on human antibody responses

Author keywords

Antibody responses; B lymphocytes; Chimeric mice; Human immune system; Secondary lymphoid organs

Indexed keywords

ANTIBODY; B LYMPHOCYTE ANTIGEN; INTERLEUKIN 7; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; POLYSACCHARIDE; PURIFIED POLYSACCHARIDE ANTIGEN; RECOMBINANT INTERLEUKIN 7; T LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG;

EID: 84856545139     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-011-8243-9     Document Type: Article
Times cited : (30)

References (68)
  • 1
    • 0020663062 scopus 로고
    • A severe combined immunodeficiency mutation in the mouse
    • DOI 10.1038/301527a0
    • Bosma GC, Custer RP, Bosma MJ. A severe combined immunodeficiency mutation in the mouse. Nature. 1983;301(5900): 527-30. (Pubitemid 13160576)
    • (1983) Nature , vol.301 , Issue.5900 , pp. 527-530
    • Bosma, G.C.1    Custer, R.P.2    Bosma, M.J.3
  • 3
    • 0026357869 scopus 로고
    • Hu-PBL-SCID mice: A model for human immune function AIDS and lymphomagenesis
    • Torbett BE, Picchio G, Mosier DE. hu-PBL-SCID mice: A model for human immune function, AIDS, and lymphomagenesis. Immunol Rev. 1991;124:139-64.
    • (1991) Immunol Rev. , vol.124 , pp. 139-164
    • Torbett, B.E.1    Picchio, G.2    Mosier, D.E.3
  • 4
    • 0027292942 scopus 로고
    • Differentiation of CD3-4-8- human fetal thymocytes in vivo: Characterization of a CD3-4 ? 8- intermediate
    • Kraft DL, Weissman IL, Waller EK. Differentiation of CD3-4-8- human fetal thymocytes in vivo: Characterization of a CD3-4 ? 8- intermediate. J Exp Med. 1993;178(1):265-77.
    • (1993) J Exp Med , vol.178 , Issue.1 , pp. 265-277
    • Kraft, D.L.1    Weissman, I.L.2    Waller, E.K.3
  • 5
    • 55749107812 scopus 로고    scopus 로고
    • The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases
    • Weissman IL, Shizuru JA. The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases. Blood. 2008;112(9):3543-53.
    • (2008) Blood , vol.112 , Issue.9 , pp. 3543-3553
    • Weissman, I.L.1    Shizuru, J.A.2
  • 6
    • 0031805237 scopus 로고    scopus 로고
    • SCID mouse models of human stem cell engraftment
    • Greiner DL, Hesselton RA, Shultz LD. SCID mouse models of human stem cell engraftment. Stem Cells. 1998;16(3):166-77. (Pubitemid 28235161)
    • (1998) Stem Cells , vol.16 , Issue.3 , pp. 166-177
    • Greiner, D.L.1    Hesselton, R.A.2    Shultz, L.D.3
  • 7
    • 0026581239 scopus 로고
    • Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice
    • Lapidot T, Pflumio F, Doedens M, Murdoch B, Williams DE, Dick JE. Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice. Science. 1992;255(5048):1137-41.
    • (1992) Science , vol.255 , Issue.5048 , pp. 1137-1141
    • Lapidot, T.1    Pflumio, F.2    Doedens, M.3    Murdoch, B.4    Williams, D.E.5    Dick, J.E.6
  • 8
    • 0030685762 scopus 로고    scopus 로고
    • Assay of human stem cells by repopulation of NOD/SCID mice
    • discussion 4-7
    • Dick JE, Bhatia M, Gan O, Kapp U, Wang JC. Assay of human stem cells by repopulation of NOD/SCID mice. Stem Cells. 1997;15(Suppl 1):199-203. discussion 4-7.
    • (1997) Stem Cells , vol.15 , Issue.SUPPL. 1 , pp. 199-203
    • Dick, J.E.1    Bhatia, M.2    Gan, O.3    Kapp, U.4    Wang, J.C.5
  • 10
    • 0030219809 scopus 로고    scopus 로고
    • Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice
    • DOI 10.1006/cimm.1996.0193
    • Christianson SW, Greiner DL, Schweitzer IB, Gott B, Beamer GL, Schweitzer PA, Hesselton RM, Shultz LD. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/ 6 J-scid mice and in C57BL/6 J-scid bg mice. Cell Immunol. 1996;171(2):186-99. (Pubitemid 26268474)
    • (1996) Cellular Immunology , vol.171 , Issue.2 , pp. 186-199
    • Christianson, S.W.1    Greiner, D.L.2    Schweitzer, I.B.3    Gott, B.4    Beamer, G.L.5    Schweitzer, P.A.6    Hesselton, R.M.7    Shultz, L.D.8
  • 11
    • 0028878330 scopus 로고
    • Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain
    • DiSanto JP, Muller W, Guy-Grand D, Fischer A, Rajewsky K. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci USA. 1995;92(2):377-81.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.2 , pp. 377-381
    • DiSanto, J.P.1    Muller, W.2    Guy-Grand, D.3    Fischer, A.4    Rajewsky, K.5
  • 13
    • 34248547056 scopus 로고    scopus 로고
    • Human-hemato-lymphoid-system mice: Opportunities and challenges
    • DOI 10.1016/j.immuni.2007.05.001, PII S1074761307002518
    • Manz MG. Human-hemato-lymphoid-system mice: Opportunities and challenges. Immunity. 2007;26(5):537-41. (Pubitemid 46756351)
    • (2007) Immunity , vol.26 , Issue.5 , pp. 537-541
    • Manz, M.G.1
  • 14
    • 33846630040 scopus 로고    scopus 로고
    • Humanized mice in translational biomedical research
    • DOI 10.1038/nri2017, PII NRI2017
    • Shultz LD, Ishikawa F, Greiner DL. Humanized mice in translational biomedical research. Nat Rev Immunol. 2007;7(2): 118-30. (Pubitemid 46174859)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.2 , pp. 118-130
    • Shultz, L.D.1    Ishikawa, F.2    Greiner, D.L.3
  • 15
    • 32044454701 scopus 로고    scopus 로고
    • Experimental models to study development and function of the human immune system in vivo
    • Legrand N, Weijer K, Spits H. Experimental models to study development and function of the human immune system in vivo. J Immunol. 2006;176(4):2053-8. (Pubitemid 43201649)
    • (2006) Journal of Immunology , vol.176 , Issue.4 , pp. 2053-2058
    • Legrand, N.1    Weijer, K.2    Spits, H.3
  • 16
    • 1842670944 scopus 로고    scopus 로고
    • The dynamic life of natural killer cells
    • DOI 10.1146/annurev.immunol.22.012703.104711
    • Yokoyama WM, Kim S, French AR. The dynamic life of natural killer cells. Annu Rev Immunol. 2004;22:405-29. (Pubitemid 38680428)
    • (2004) Annual Review of Immunology , vol.22 , pp. 405-429
    • Yokoyama, W.M.1    Kim, S.2    French, A.R.3
  • 19
    • 1842588698 scopus 로고    scopus 로고
    • Development of a Human Adaptive Immune System in Cord Blood Cell-Transplanted Mice
    • DOI 10.1126/science.1093933
    • Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti JC, Lanzavecchia A, Manz MG. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science. 2004;304(5667):104-7. (Pubitemid 38451466)
    • (2004) Science , vol.304 , Issue.5667 , pp. 104-107
    • Traggiai, E.1    Chicha, L.2    Mazzucchelli, L.3    Bronz, L.4    Piffaretti, J.-C.5    Lanzavecchia, A.6    Manz, M.G.7
  • 20
    • 33947596455 scopus 로고    scopus 로고
    • HIV-1 infection and pathogenesis in a novel humanized mouse model
    • DOI 10.1182/blood-2006-07-033159
    • Zhang L, Kovalev GI, Su L. HIV-1 infection and pathogenesis in a novel humanized mouse model. Blood. 2007;109(7):2978-81. (Pubitemid 46482096)
    • (2007) Blood , vol.109 , Issue.7 , pp. 2978-2981
    • Zhang, L.1    Kovalev, G.I.2    Su, L.3
  • 27
    • 76049092600 scopus 로고    scopus 로고
    • Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice
    • Chen Q, Khoury M, Chen J. Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice. Proc Natl Acad Sci USA. 2009;106(51):21783-8.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.51 , pp. 21783-21788
    • Chen, Q.1    Khoury, M.2    Chen, J.3
  • 28
  • 30
    • 77957773125 scopus 로고    scopus 로고
    • Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations
    • O'Connell RM, Balazs AB, Rao DS, Kivork C, Yang L, Baltimore D. Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations. PLoS One. 2010;5(8):e12009.
    • (2010) PLoS One , vol.5 , Issue.8
    • O'Connell, R.M.1    Balazs, A.B.2    Rao, D.S.3    Kivork, C.4    Yang, L.5    Baltimore, D.6
  • 31
    • 78651509914 scopus 로고    scopus 로고
    • Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20 ? CD27 ? CD43 ? CD70
    • Griffin DO, Holodick NE, Rothstein TL. Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20 ? CD27 ? CD43 ? CD70. J Exp Med. 2011; 208(1):67-80.
    • (2011) J Exp Med , vol.208 , Issue.1 , pp. 67-80
    • Griffin, D.O.1    Holodick, N.E.2    Rothstein, T.L.3
  • 32
    • 0035056376 scopus 로고    scopus 로고
    • B cell development pathways
    • DOI 10.1146/annurev.immunol.19.1.595
    • Hardy RR, Hayakawa K. B cell development pathways. Annu Rev Immunol. 2001;19:595-621. (Pubitemid 32368047)
    • (2001) Annual Review of Immunology , vol.19 , pp. 595-621
    • Hardy, R.R.1    Hayakawa, K.2
  • 33
    • 0029034242 scopus 로고
    • B-1a B-1b and B-2 B cells display uniqueVHDJHrepertoires formed atdifferent stages of ontogeny and under different selection pressures
    • Tornberg UC, Holmberg D. B-1a, B-1b and B-2 B cells display uniqueVHDJHrepertoires formed atdifferent stages of ontogeny and under different selection pressures. EMBO J. 1995;14(8):1680-9.
    • (1995) EMBO J , vol.14 , Issue.8 , pp. 1680-1689
    • Tornberg, U.C.1    Holmberg, D.2
  • 35
    • 0023722178 scopus 로고
    • Comparison of the fetal and adult functional B cell repertoires by analysis of VH gene family expression
    • Jeong HD, Teale JM. Comparison of the fetal and adult functional B cell repertoires by analysis of VH gene family expression. J Exp Med. 1988;168(2):589-603.
    • (1988) J Exp Med , vol.168 , Issue.2 , pp. 589-603
    • Jeong, H.D.1    Teale, J.M.2
  • 36
    • 0025193019 scopus 로고
    • Biased expression of J(H)-proximal V(H) genes occurs in the newly generated repertoire of neonatal and adult mice
    • Malynn BA, Yancopoulos GD, Barth JE, Bona CA, Alt FW. Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice. J Exp Med. 1990;171(3):843-59. (Pubitemid 20088986)
    • (1990) Journal of Experimental Medicine , vol.171 , Issue.3 , pp. 843-859
    • Malynn, B.A.1    Yancopoulos, G.D.2    Barth, J.E.3    Bona, C.A.4    Alt, F.W.5
  • 37
    • 0141790757 scopus 로고    scopus 로고
    • Lymphoid organ development and cell migration
    • DOI 10.1034/j.1600-065X.2003.00075.x
    • Cyster JG. Lymphoid organ development and cell migration. Immunol Rev. 2003;195:5-14. (Pubitemid 37153449)
    • (2003) Immunological Reviews , vol.195 , pp. 5-14
    • Cyster, J.G.1
  • 38
    • 0035854450 scopus 로고    scopus 로고
    • The art of the probable: System control in the adaptive immune system
    • DOI 10.1126/science.1062946
    • Germain RN. The art of the probable: System control in the adaptive immune system. Science. 2001;293(5528):240-5. (Pubitemid 32694729)
    • (2001) Science , vol.293 , Issue.5528 , pp. 240-245
    • Germain, R.N.1
  • 39
    • 23444437972 scopus 로고    scopus 로고
    • Structure and function of the spleen
    • DOI 10.1038/nri1669
    • Mebius RE, Kraal G. Structure and function of the spleen. Nat Rev Immunol. 2005;5(8):606-16. (Pubitemid 41113192)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.8 , pp. 606-616
    • Mebius, R.E.1    Kraal, G.2
  • 41
    • 70149100934 scopus 로고    scopus 로고
    • Secondary lymphoid organs: Responding to genetic and environmental cues in ontogeny and the immune response
    • Ruddle NH, Akirav EM. Secondary lymphoid organs: Responding to genetic and environmental cues in ontogeny and the immune response. J Immunol. 2009;183(4):2205-12.
    • (2009) J Immunol , vol.183 , Issue.4 , pp. 2205-2212
    • Ruddle, N.H.1    Akirav, E.M.2
  • 42
  • 43
    • 0030917003 scopus 로고    scopus 로고
    • Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice
    • Koni PA, Sacca R, Lawton P, Browning JL, Ruddle NH, Flavell RA. Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity. 1997;6(4):491-500. (Pubitemid 27208204)
    • (1997) Immunity , vol.6 , Issue.4 , pp. 491-500
    • Koni, P.A.1    Sacca, R.2    Lawton, P.3    Browning, J.L.4    Ruddle, N.H.5    Flavell, R.A.6
  • 45
    • 0030582773 scopus 로고    scopus 로고
    • A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    • DOI 10.1016/S0092-8674(00)81798-5
    • Forster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell. 1996;87(6):1037-47. (Pubitemid 26427987)
    • (1996) Cell , vol.87 , Issue.6 , pp. 1037-1047
    • Forster, R.1    Mattis, A.E.2    Kremmer, E.3    Wolf, E.4    Brem, G.5    Lipp, M.6
  • 49
    • 77956550041 scopus 로고    scopus 로고
    • The anergic B cell
    • Andrews SF, Wilson PC. The anergic B cell. Blood. 2010;115(24):4976-8.
    • (2010) Blood , vol.115 , Issue.24 , pp. 4976-4978
    • Andrews, S.F.1    Wilson, P.C.2
  • 50
    • 79956073079 scopus 로고    scopus 로고
    • Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells
    • Danner R, Chaudhari SN, Rosenberger J, Surls J, Richie TL, Brumeanu TD, Casares S. Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells. PLoS One. 2011;6(5):e19826.
    • (2011) PLoS One , vol.6 , Issue.5
    • Danner, R.1    Chaudhari, S.N.2    Rosenberger, J.3    Surls, J.4    Richie, T.L.5    Brumeanu, T.D.6    Casares, S.7
  • 52
    • 0036840139 scopus 로고    scopus 로고
    • Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway
    • DOI 10.1172/JCI200215975
    • Gommerman JL, Mackay F, Donskoy E, Meier W, Martin P, Browning JL. Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway. J Clin Invest. 2002;110(9):1359-69. (Pubitemid 35285762)
    • (2002) Journal of Clinical Investigation , vol.110 , Issue.9 , pp. 1359-1369
    • Gommerman, J.L.1    Mackay, F.2    Donskoy, E.3    Meier, W.4    Martin, P.5    Browning, J.L.6
  • 53
    • 0032480316 scopus 로고    scopus 로고
    • Turning off follicular dendritic cells
    • Mackay F, Browning JL. Turning off follicular dendritic cells. Nature. 1998;395(6697):26-7.
    • (1998) Nature , vol.395 , Issue.6697 , pp. 26-27
    • Mackay, F.1    Browning, J.L.2
  • 54
  • 55
    • 0141889318 scopus 로고    scopus 로고
    • Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis
    • DOI 10.1182/blood-2003-02-0426
    • Alugupalli KR, Michelson AD, Joris I, Schwan TG, Hodivala- Dilke K, Hynes RO, Leong JM. Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis. Blood. 2003;102(8):2843-50. (Pubitemid 37248855)
    • (2003) Blood , vol.102 , Issue.8 , pp. 2843-2850
    • Alugupalli, K.R.1    Michelson, A.D.2    Joris, I.3    Schwan, T.G.4    Hodivala-Dilke, K.5    Hynes, R.O.6    Leong, J.M.7
  • 56
    • 0025001618 scopus 로고
    • Antigenic variation of a relapsing fever Borrelia species
    • Barbour AG. Antigenic variation of a relapsing fever Borrelia species. Annu Rev Microbiol. 1990;44:155-71.
    • (1990) Annu Rev Microbiol , vol.44 , pp. 155-171
    • Barbour, A.G.1
  • 57
    • 0035140048 scopus 로고    scopus 로고
    • In vitro and in vivo neutralization of the relapsing fever agent Borrelia hermsii with serotype-specific immunoglobulin M antibodies
    • Barbour AG, Bundoc V. In vitro and in vivo neutralization of the relapsing fever agent Borrelia hermsii with serotype-specific immunoglobulin M antibodies. Infect Immun. 2001;69(2): 1009-15.
    • (2001) Infect Immun , vol.69 , Issue.2 , pp. 1009-10015
    • Barbour, A.G.1    Bundoc, V.2
  • 58
    • 0035140048 scopus 로고    scopus 로고
    • In vitro and in vivo neutralization of the relapsing fever agent Borrelia hermsii with serotype-specific immunoglobulin M antibodies
    • DOI 10.1128/IAI.69.2.1009-1015.2001
    • Barbour AG, Bundoc V. In vitro and in vivo neutralization of the relapsing fever agent Borrelia hermsii with serotype-specific immunoglobulin M antibodies. Infect Immun. 2001;69: 1009-15. (Pubitemid 32109568)
    • (2001) Infection and Immunity , vol.69 , Issue.2 , pp. 1009-1015
    • Barbour, A.G.1    Bundoc, V.2
  • 60
    • 4444335352 scopus 로고    scopus 로고
    • B1b lymphocytes confer T cell-independent long-lasting immunity
    • DOI 10.1016/j.immuni.2004.06.019, PII S1074761304002146
    • Alugupalli KR, Leong JM, Woodland RT, Muramatsu M, Honjo T, Gerstein RM. B1b Lymphocytes confer T cell-independent long-lasting immunity. Immunity. 2004;21:379-90. (Pubitemid 39208339)
    • (2004) Immunity , vol.21 , Issue.3 , pp. 379-390
    • Alugupalli, K.R.1    Leong, J.M.2    Woodland, R.T.3    Muramatsu, M.4    Honjo, T.5    Gerstein, R.M.6
  • 61
    • 17844363213 scopus 로고    scopus 로고
    • The versatile roles of antibodies in Borrelia infections
    • DOI 10.1038/nrmicro1149
    • Connolly SE, Benach JL. The versatile roles of antibodies in Borrelia infections. Nat Rev Microbiol. 2005;3(5):411-20. (Pubitemid 40590383)
    • (2005) Nature Reviews Microbiology , vol.3 , Issue.5 , pp. 411-420
    • Connolly, S.E.1    Benach, J.L.2
  • 62
    • 0035314006 scopus 로고    scopus 로고
    • B1 cells: Similarities and differences with other B cell subsets
    • DOI 10.1016/S0952-7915(00)00204-1
    • Martin F, Kearney JF. B1 cells: Similarities and differences with other B cell subsets. Curr Opin Immunol. 2001;13:195-201. (Pubitemid 32176039)
    • (2001) Current Opinion in Immunology , vol.13 , Issue.2 , pp. 195-201
    • Martin, F.1    Kearney, J.F.2
  • 63
    • 38449097469 scopus 로고    scopus 로고
    • A distinct role for B1b lymphocytes in T cellindependent immunity
    • Alugupalli KR. A distinct role for B1b lymphocytes in T cellindependent immunity. Curr Top Microbiol Immunol. 2008; 319:105-30.
    • (2008) Curr Top Microbiol Immunol , vol.319 , pp. 105-130
    • Alugupalli, K.R.1
  • 64
    • 0035013708 scopus 로고    scopus 로고
    • Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens
    • DOI 10.1016/S1074-7613(01)00129-7
    • Martin F, Oliver AM, Kearney JF. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity. 2001;14(5):617-29. (Pubitemid 32520872)
    • (2001) Immunity , vol.14 , Issue.5 , pp. 617-629
    • Martin, F.1    Oliver, A.M.2    Kearney, J.F.3
  • 65
    • 0033822039 scopus 로고    scopus 로고
    • B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms
    • Vos Q, Lees A, Wu ZQ, Snapper CM, Mond JJ. B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms. Immunol Rev. 2000;176:154-70.
    • (2000) Immunol Rev , vol.176 , pp. 154-170
    • Vos, Q.1    Lees, A.2    Wu, Z.Q.3    Snapper, C.M.4    Mond, J.J.5
  • 66
    • 37649011029 scopus 로고    scopus 로고
    • Immune responses to polysaccharides: Lessons from humans and mice
    • Gonzalez-Fernandez A, Faro J, Fernandez C. Immune responses to polysaccharides: Lessons from humans and mice. Vaccine. 2008;26(3):292-300.
    • (2008) Vaccine , vol.26 , Issue.3 , pp. 292-300
    • Gonzalez-Fernandez, A.1    Faro, J.2    Fernandez, C.3
  • 67
    • 11244309062 scopus 로고    scopus 로고
    • The role of B cells and accessory cells in the neonatal response to TI-2 antigens
    • DOI 10.1385/IR:31:1:25
    • Landers CD, Chelvarajan RL, Bondada S. The role of B cells and accessory cells in the neonatal response to TI-2 antigens. Immunol Res. 2005;31(1):25-36. (Pubitemid 40065422)
    • (2005) Immunologic Research , vol.31 , Issue.1 , pp. 25-36
    • Landers, C.D.1    Chelvarajan, R.L.2    Bondada, S.3
  • 68
    • 78049448242 scopus 로고    scopus 로고
    • Toll-like receptor 2 deficiency results in impaired antibody responses and septic shock during Borrelia hermsii infection
    • Dickinson GS, Piccone H, Sun G, Lien E, Gatto L, Alugupalli KR. Toll-like receptor 2 deficiency results in impaired antibody responses and septic shock during Borrelia hermsii infection. Infect Immun. 2010;78(11):4579-88.
    • (2010) Infect Immun , vol.78 , Issue.11 , pp. 4579-4588
    • Dickinson, G.S.1    Piccone, H.2    Sun, G.3    Lien, E.4    Gatto, L.5    Alugupalli, K.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.