Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway

Journal of Clinical Investigation

Volumn 110, Issue 9, 2002, Pages 1359-1369

  Gommerman, Jennifer L ^a   Mackay, Fabienne ^a,b   Donskoy, Elina ^a   Meier, Werner ^a   Martin, Pauline ^a   Browning, Jeffrey L ^a  

^a BIOGEN   (United States)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; INHIBITOR PROTEIN; KEYHOLE LIMPET HEMOCYANIN; LYMPHOTOXIN;

ADOLESCENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; GERMINAL CENTER; IMMUNE COMPLEX DEPOSITION; IMMUNOMODULATION; LYMPHOID ORGAN; MACACA; MALE; MICROENVIRONMENT; NONHUMAN; PRIMATE; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM; SIGNAL TRANSDUCTION; SPLEEN;

EID: 0036840139     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0215975     Document Type: Article

References (51)

1. Lu, T.T., and Cyster, J.G. 2002. Integrin-mediated long-term B cell retention in the splenic marginal zone. Science. 297:409-412.
2. Ansel, K.M., et al. 2000. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature. 406:309-314.
3. Ware, C.F., VanArsdale, T.L., Crowe, P.D., and Browning, J.L. 1995. The ligands and receptors of the lymphotoxin system. Curr. Top. Microbiol. Immunol. 198:175-218.
4. Mackay, F., et al. 1997. Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice. Eur. J. Immunol. 27:2033-2042.
5. Ngo, V.N., et al. 1999. Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J. Exp. Med. 189:403-412.
6. Mackay, F., and Browning, J.L. 1998. Turning off follicular dendritic cells. Nature. 395:26-27.
7. Grimaldi, C.M., Michael, D.J., and Diamond, B. 2001. Cutting edge: expansion and activation of a population of autoreactive marginal zone B cells in a model of estrogen-induced lupus. J. Immunol. 167:1886-1890.
8. Groom, J., et al. 2002. Association of Baff/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. J. Clin. Invest. 109:59-68. doi: 10.1172/JCI200214121.
9. Imai, Y., and Yamakawa, M. 1996. Morphology, function and pathology of follicular dendritic cells. Pathol. Int. 46:807-833.
10. Luther, S.A., et al. 2000. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity. 12:471-481.
11. Ruddle, N.H. 1999. Lymphoid neo-organogenesis: lymphotoxin's role in inflammation and development. Immunol. Res. 19:119-125.
12. Van-den-Berg, T.K., Yoshida, K., and Dijkstra, C.D. 1995. Mechanism of immune complex trapping by follicular dendritic cells. Curr. Top. Microbiol. Immunol. 201:49-67.
13. Terashima, K., Dobashi, M., Maeda, K., and Imai, Y. 1992. Follicular dendritic cell and ICCOSOMES in germinal center reactions. Sem. Immunol. 4:267-274.
14. Tew, J.G., and Mandel, T.E. 1979. Prolonged antigen half-life in the lymphoid follicles of specifically immunized mice. Immunology. 37:69-76.
15. Endres, R., et al. 1999. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J. Exp. Med. 189:159-168.
16. Fu, Y.X., and Chaplin, D.D. 1999. Development and maturation of secondary lymphoid tissues. Annu. Rev. Immunol. 17:399-433.
17. Kapasi, Z.F., et al. 1998. Follicular dendritic cell (FDC) precursors in primary lymphoid tissues. J. Immunol. 160:1078-1084.
18. Kagami, Y., et al 2001. Establishment of a follicular lymphoma cell line (FLK-1) dependent on follicular dendritic cell-like cell line HK. Leukemia. 15:148-156.
19. Spiegel, H., et al. 1992. Follicular dendritic cells are a major reservoir for human immunodeficiency virus type 1 in lymphoid tissues facilitating infection of CD4+ T-helper cells. Am. J. Pathol. 140:15-22.
20. Tenner-Racz, K., and Racz, P. 1995. Follicular dendritic cells initiate and maintain infection of the germinal centers by human immunodeficiency virus. Curr. Top Microbiol. Immunol. 201:141-159.
21. Smith, B.A., et al. 2001. Persistence of infectious HIV on follicular dendritic cells. J. Immunol. 166:690-696.
22. Brown, K.L., et al. 1999. Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells. Nat. Med. 5:1308-1312.
23. Mabbott, N.A., Mackay, F., Minns, F., and Bruce, M.E. 2000. Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie. Nat. Med. 6:719-720.
24. Lindhout, E., et al. 1999. Fibroblast-like synoviocytes from rheumatoid arthritis patients have intrinsic properties of follicular dendritic cells. J. Immunol. 162:5949-5956.
25. Browning, J.L., et al. 1995. Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors. J. Immunol. 154:33-46.
26. Cornacoff, J.B., et al. 1983. Primate erythrocyte-immune complex-clearing mechanism. J. Clin. Invest. 71:236-247.
27. Davies, K.A., et al. 1990. A study of in vivo immune complex formation and clearance in man. J. Immunol. 144:4613-4620.
28. Zannini, C., et al. 2000. A video densitometric analysis of viral burden and follicular dendritic cell damage in lymph nodes in the latency phase of HIV infection. Cytometry. 40:209-213.
29. Zhang, Z.Q., et al. 1999. Reversibility of the pathological changes in the follicular dendritic cell network with treatment of HIV-1 infection. Proc. Natl. Acad. Sci. USA. 96:5169-5172.
30. Liu, Y.J., et al. 1997. Follicular dendritic cells specifically express the long CR2/CD21 isoform. J. Exp. Med. 185:165-170.
31. i-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J. Pathol. 168:357-363.
32. Fu, Y.X., et al. 1997. Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node. Proc. Natl. Acad. Sci. USA. 94:5739-5743.
33. Gonzalez, M., et al. 1998. The sequential role of lymphotoxin and B cells in the development of splenic follicles. J. Exp. Med. 187:997-1007.
34. Steiniger, B., and Barth, P. 1999. Microanatomy and function of the spleen. Springer-Verlag. Berlin, Germany. 101 pp.
35. Koopman, G., et al. 1991. Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways. Exp. Med. 173:1297-1304.
36. Freedman, A.S., et al. 1990. Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110. Science. 249:1030-1033.
37. Maeda, K., et al. 1995. In vitro immune complex binding assay to examine the mechanism of immune complex trapping by human follicular dendritic cells (FDC). Dendritic Cells in Fundamental and Clinical Immunology. 2:317-319.
38. Yoshida, K., van den Berg, T.K., and Dijkstra, C.D. 1993. Two different mechanisms of immune complex trapping in the mouse spleen during immune responses. Dendritic cells in Fundamental and Clinical Immunology. Plenum Press. New York, New York, USA. 377-381.
39. Fang, Y., et al. 1998. Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of strong antigenspecific IgG response. Immunol. 160:S273-5279.
40. Van den Berg, T.K., et al. 1992. Selective inhibition of immune complex trapping by follicular dendritic cells with monoclonal antibodies against rat C3. Eur. J. Immunol. 22:957-962.
41. Vora, K.A., Ravetch, J.V., and Manser, T. 1997. Amplified follicular immune complex deposition in mice lacking the Fc receptor gammachain does not alter maturation of the B cell response. J. Immunol. 159:2116-2124.
42. Szakal, A.K., Holmes, K.L., and Tew, J.G. 1983. Transport of immune complexes from the subcapsular sinus to lymph node follicles on the surface of nonphagocytic cells, including cells with dendritic morphology. J. Immunol. 131:1714-1727.
43. Koni, P.A., et al. 1997. Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity. 6:491-500.
44. Futterer, A., et al. 1998. The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity. 9:59-70.
45. Matsumoto, M., et al. 1996. Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice. Nature. 382:462-466.
46. Koni, P.A., and Flavell, R.A. 1999. Lymph node germinal centers form in the absence of follicular dendritic cell networks. J. Exp. Med. 189:855-864.
47. Berney, C., et al. 1999. A member of the dendritic cell family that enters B cell follicles and stimulates primary antibody responses identified by a mannose receptor fusion protein. J. Exp. Med. 190:851-860.
48. Szakal, A.K., Kosco, M.H., and Tew, J.G. 1988. A novel in vivo follicular dendritic cell-dependent iccosome-mediated mechanism for delivery of antigen to antigen-processing cells. Immunol. 140:341-353.
49. Martinez-Pomares, L., et al. 1996. Fc chimeric protein containing the cysteine-rich domain of the murine mannose receptor binds to macrophages from splenic marginal zone and lymph node subcapsular sinus and to germinal centers. J. Exp. Med. 184:1927-1937.
50. Rennert, P.D., et al. 2001. Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice. J. Exp. Med. 193:1227-1238.
51. Tangye, S.G., et al. 1998. Identification of functional human splenic memory B cells by expression of CD148 and CD27. J. Exp. Med. 188:1691-1703.