Computational fluid dynamics (CFD) insights into agitation stress methods in biopharmaceutical development

International Journal of Pharmaceutics

Volumn 423, Issue 2, 2012, Pages 264-280

  Bai, Ge ^a   Bee, Jared S ^a   Biddlecombe, James G ^a   Chen, Quanmin ^a   Leach, W Thomas ^a  

^a MEDIMMUNE   (United States)

Author keywords

Agitation stress; Computational fluid dynamics (CFD); Protein aggregation; Shear

Indexed keywords

ARTICLE; BIOCHEMICAL EQUIPMENT; COMPUTATIONAL FLUID DYNAMICS; HYDRODYNAMICS; HYDROPHOBICITY; MAGNETIC STIRRER; ORBITAL SHAKER; PRIORITY JOURNAL; PROTEIN DEGRADATION; ROTATOR; SHEAR RATE; SHEAR STRESS; SURFACE STRESS; TURBULENT FLOW; VORTEX MIXER; VORTEX MOTION;

BIOPHARMACEUTICS; COMPUTER SIMULATION; DRUG STABILITY; EQUIPMENT DESIGN; HYDRODYNAMICS; MODELS, CHEMICAL; MOTION; NUMERICAL ANALYSIS, COMPUTER-ASSISTED; PRESSURE; PROTEIN STABILITY; PROTEINS; REPRODUCIBILITY OF RESULTS; STRESS, MECHANICAL; SURFACE PROPERTIES; TIME FACTORS; VISCOSITY;

EID: 84856524794     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.11.044     Document Type: Article

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