Monoclonal antibody interactions with micro- and nanoparticles: Adsorption, aggregation, and accelerated stress studies

Journal of Pharmaceutical Sciences

Volumn 98, Issue 9, 2009, Pages 3218-3238

  Bee, Jared S ^a   Chiu, David ^a   Sawicki, Suzanne ^a   Stevenson, Jennifer L ^b   Chatterjee, Koustuv ^b   Freund, Erwin ^b   Carpenter, John F ^c   Randolph, Theodore W ^a  

^a UCB 450   (United States)

^b AMGEN INC   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Adsorption; Biotechnology; Fluorescence spectroscopy; Microparticles; Monoclonal antibody; Monolayer; Processing; Protein aggregation; Stability; Surface chemistry

Indexed keywords

CELLULOSE; GLASS; IRON OXIDE; MONOCLONAL ANTIBODY; NANOPARTICLE; SILICON DIOXIDE; STAINLESS STEEL;

ADSORPTION; ARTICLE; DRUG STORAGE; FLUORESCENCE; PARTICLE SIZE; PREFORMULATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SURFACE PROPERTY;

EID: 68949119488     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21768     Document Type: Article

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