Measurement of serum levels of des-γ-carboxy prothrombin in patients with hepatocellular carcinoma by a revised enzyme immunoassay kit with increased sensitivity

Cancer

Volumn 85, Issue 4, 1999, Pages 812-818

  Okuda, Hiroaki ^a   Nakanishi, Toshimi ^a   Takatsu, Kazuko ^a   Saito, Akiko ^a   Hayashi, Naoaki ^a   Watanabe, Keisuke ^b   Magario, Naoki ^b   Yokoo, Takeshi ^b   Naraki, Toru ^b  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b EISAI CO LTD   (Japan)

Author keywords

fetoprotein; Conventional enzyme immunoassay kit; Des carboxy prothrombin; Hepatocellular carcinoma; Revised enzyme immuneassay kit

Indexed keywords

ALPHA FETOPROTEIN; DECARBOXYPROTHROMBIN;

ADULT; AGED; ARTICLE; CHRONIC HEPATITIS; DIAGNOSTIC ACCURACY; ENZYME IMMUNOASSAY; FEMALE; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CARCINOMA, HEPATOCELLULAR; FEMALE; HEPATITIS, CHRONIC; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROTEIN PRECURSORS; PROTHROMBIN; REAGENT KITS, DIAGNOSTIC; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 0033557988     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19990215)85:4<812::AID-CNCR8>3.0.CO;2-O     Document Type: Article

References (26)

1. Okuda K, Okuda H. Primary liver cell carcinoma. In: McIntyre N, Benhamou J-P, Bircher J, Rizzetto M, Rodes J, editors. Oxford textbook of clinical hepatology. Volume 2. New York/Tokyo: Oxford University Press, 1991:1019-53.
2. Okuda K and the Liver Cancer Study Group of Japan. Primary liver cancer in Japan. Cancer 1980;45:2663-9.
3. Abelev GI. Production of embryonal serum alpha-globulin by hepatomas: review of experimental and clinical data. Cancer Res 1968;28:1344-50.
4. O'Conor GI, Tatarinov YS, Abelev GI, Uriel J. A collaborative study for the evaluation of a serologic test for primary liver cancer. Cancer 1970;25:1091-8.
5. Nishi S, Hirai H. Radioimmunoassay of alpha-fetoprotein in hepatoma, other liver diseases and pregnancy. Gann Monogr 1973;14:79-87.
6. Nomura F, Ohnishi K, Tanabe Y. Clinical features and prognosis of hepatocellular carcinoma with reference to serum alpha-fetoprotein levels. Cancer 1989;64:1700-7.
7. Liebman H, Furie BC, Tong MJ, Blanchard RA, Lo K-J, Lee S-D, et al. Des-γ-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma. N Engl J Med 1984;310:1427-31.
8. Motohara K, Kuroki Y, Kan H, Endo F, Matsuda I. Detection of vitamin K deficiency by use of an enzyme-linked immunosorbent assay for circulating abnormal prothrombin. Pediatr Res 1985;19:354-7.
9. Okuda H, Obata H, Nakanishi T, Furukawa R, Hashimoto E. Production of abnormal prothrombin (des-γ-carboxy prothrombin) by hepatocellular carcinoma: a clinical and experimental study. J Hepatol 1987;4:357-63.
10. Fujiyama S, Morishita T, Hashiguchi O, Sato T. Plasma abnormal prothrombin (des-γ-carboxy prothrombin) as a marker of hepatocellular carcinoma. Cancer 1988;61: 1621-8.
11. Hattori N, Ohmizo R, Unoura M, Tanaka N, Kobayashi K, and the PIWA-II collaborative working group. Abnormal prothrombin measurements in hepatocellular carcinoma. J Tumor Marker Oncol 1988;3:207-16.
12. Soulier IP, Gozin D, Lefrere JJ. A new method to assay des-γ-carboxy prothrombin: results obtained in 75 cases of hepatocellular carcinoma. Gastroenterology 1986;91:1258-62.
13. King MA, Kew MC, Kuyl JM, Atkinson PM. A comparison between des-γ-carboxy prothrombin and α-fetoprotein as markers of hepatocellular carcinoma in southern African blacks. J Gastroenterol Hepatol 1989;4:17-24.
14. Furukawa M, Nakanishi T, Okuda H, Ishida S, Obata H. Changes of plasma des-γ-carboxy prothrombin levels in patients with hepatocellular carcinoma in response to vitamin K. Cancer 1992;69:31-8.
15. Weitz IC, Liebman HA. Des-γ-carboxy (abnormal) prothrombin and hepatocellular carcinoma: a critical review. Hepatology 1993;18:990-7.
16. Taketa K, Sekiya C, Namiki M, Akamatsu K, Ohta Y, Endo Y, et al. Lectin-reactive profiles of alpha-fetoprotein characterizing hepatocellular carcinoma and related conditions. Gastroentemlogy 1990;99:506-18.
17. Yamashita F, Tanaka M, Satomura S, Tanikawa K. Monitoring of lectin-reactive α-fetoprotein in patients with hepatocellular carcinoma treated using transcatheter arterial embolization. Eur J Gastroenterol Hepatol 1995;7: 627-33.
18. Suehiro T, Sugimachi K, Matsumata T, Itasaka H, Taketomi A, Maeda T. Protein induced by vitamin K absence or antagonist II as a prognostic marker in hepatocellular carcinoma: comparison with alpha-fetoprotein. Cancer 1994;73: 2464-71.
19. Aoyagi Y, Oguro M, Yanagi M, Mita Y, Suda T, Suzuki Y, et al. Clinical significance of simultaneous determinations of alpha-fetoprotein and des-gamma-carboxy prothrombin in monitoring recurrence in patients with hepatocellular carcinoma. Cancer 1996;77:1781-6.
20. Tsai SL, Huang GT, Yang PM, Sheu JC, Sung JL, Chen DS. Plasma des-γ-carboxy prothrombin in the early stage of hepatocellular carcinoma. Hepatology 1990;11:481-8.
21. Okuda H, Nakanishi T, Furukawa M, Obata H. Vitamin K-dependent proteins and hepatocellular carcinoma. J Gastroenterol Hepatol 1991;6:392-9.
22. Fujiyama S, Izuno K, Gohshi K, Shibata I, Sato T. Clinical usefulness of des-γ-carboxy prothrombin assay in early diagnosis of hepatocellular carcinoma. Dig Dis Sci 1992;36: 1787-92.
23. Saitoh S, Ikeda K, Koida I, Tsubota A, Arase Y, Chayama K, et al. Serum des-gamma-carboxyprothrombin concentration determined by the avidin-biotin complex method in small hepatocellular carcinomas. Cancer 1994;74:2918-23.
24. Kuromatsu R, Tanaka M, Shimauchi Y, Shimada M, Tanikawa K, Watanabe K, et al. Usefulness of ED036 kit for measuring serum PIVKA-II levels in small hepatocellular carcinoma. J Gastroenterol 1997;32:507-12.
25. Mita Y, Aoyagi Y, Yanagi M, Suda T, Suzuki Y, Asakura H. The usefulness of determining des-γ-carboxy prothrombin by sensitive enzyme immunoassay in the early diagnosis of patients with hepatocellular carcinoma. Cancer 1998;82: 1643-8.
26. Yamagata H, Nakanishi T, Furukawa M, Okuda H, Obata H. Levels of vitamin K, immunoreactive prothrombin, des-γ-carboxy prothrombin and γ-glutamyl carboxylase activity in hepatocellular carcinoma tissue. J Gastroenterol Hepatol 1995;10:8-13.