Gene-expression signature of vascular invasion in hepatocellular carcinoma

Journal of Hepatology

Volumn 55, Issue 6, 2011, Pages 1325-1331

  Mínguez, Beatriz ^a   Hoshida, Yujin ^b   Villanueva, Augusto ^c   Toffanin, Sara ^a,d   Cabellos, Laia ^a   Thung, Swan ^a   Mandeli, John ^a   Sia, Daniela ^c,d   April, Craig ^e   Fan, Jian Bing ^e   Lachenmayer, Anja ^a   Savic, Radoslav ^a   Roayaie, Sasan ^a   Mazzaferro, Vincenzo ^d   Bruix, Jordi ^c   Schwartz, Myron ^a   Friedman, Scott L ^a   Llovet, Josep M ^a,c,f  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^d NATIONAL CANCER INSTITUTE   (Italy)

^e ILLUMINA INC   (United States)

^f INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

Diagnosis; Gene expression signature; Hepatocellular carcinoma; Liver transplantation; Prediction; Surgical resection; Vascular invasion

Indexed keywords

FORMALDEHYDE; PARAFFIN;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER MORTALITY; CANCER PATIENT; CANCER RECURRENCE; CANCER SIZE; CANCER SURGERY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; EMBEDDING; FEMALE; GENE EXPRESSION; HEPATITIS C; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PREDICTION; PREDICTIVE VALUE; PRIORITY JOURNAL; VASCULAR INVASION;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; FEMALE; GENE EXPRESSION PROFILING; HUMANS; LIVER NEOPLASMS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; RISK FACTORS;

EID: 80054717602     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2011.02.034     Document Type: Article

References (40)

1. J.M. Llovet, A. Burroughs, and J. Bruix Hepatocellular carcinoma Lancet 362 2003 1907 1917
2. J.M. Llovet, A.M. Di Bisceglie, J. Bruix, B.S. Kramer, R. Lencioni, and A.X. Zhu Design and endpoints of clinical trials in hepatocellular carcinoma J Natl Cancer Inst 100 2008 698 711
3. J.M. Llovet, M. Schwartz, and V. Mazzaferro Resection and liver transplantation for hepatocellular carcinoma Semin Liver Dis 25 2005 181 200
4. V. Mazzaferro, J.M. Llovet, R. Miceli, S. Bhoori, M. Schiavo, and L. Mariani Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis Lancet Oncol 10 2009 35 43
5. H. Imamura, Y. Matsuyama, E. Tanaka, T. Ohkubo, K. Hasegawa, and S. Miyagawa Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy J Hepatol 38 2003 200 207
6. S. Jonas, W.O. Bechstein, T. Steinmüller, M. Herrmann, C. Radke, and T. Berg Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis Hepatology 33 2001 1080 1086
7. S. Roayaie, I.N. Blume, S.N. Thung, M. Guido, M.I. Fiel, and S. Hiotis A system of classifying microvascular invasion to predict outcome after resection in patients with hepatocellular carcinoma Gastroenterology 137 2009 850 855
8. V. Mazzaferro, E. Regalia, R. Doci, S. Andreola, A. Pulvirenti, and F. Bozzetti Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis N Engl J Med 334 1996 693 699
9. S. Roayaie, J.S. Frischer, S.H. Emre, T.M. Fishbein, P.A. Sheiner, and M. Sung Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 centimeters Ann Surg 235 2002 533 539
10. F.Y. Yao, L. Ferrell, N.M. Bass, P. Bacchetti, N.L. Ascher, and J.P. Roberts Liver transplantation for hepatocellular carcinoma: comparison of the proposed UCSF criteria with the Milan criteria and the Pittsburgh modified TNM criteria Liver Transpl 8 2002 765 774
11. T.M. Pawlik, K.A. Delman, J.N. Vauthey, D.M. Nagorney, I.O. Ng, and I. Ikai Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma Liver Transpl 11 2005 1086 1092
12. J.R. Parfitt, P. Marotta, M. Alghamdi, W. Wall, A. Khakhar, and N.G. Suskin Recurrent hepatocellular carcinoma after transplantation: use of a pathological score on explanted livers to predict recurrence Liver Transpl 13 2007 543 551
13. M.C. Ho, J.J. Lin, C.N. Chen, C.C. Chen, H. Lee, and C.Y. Yang A gene expression profile for vascular invasion can predict the recurrence after resection of hepatocellular carcinoma: a microarray approach Ann Surg Oncol 13 2006 1474 1484
14. Q.H. Ye, L.X. Qin, M. Forgues, P. He, J.W. Kim, and A.C. Peng Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning Nat Med 9 2003 416 423
15. D.Y. Chiang, A. Villanueva, Y. Hoshida, J. Peix, P. Newell, and B. Minguez Focal gains of VEGFA and molecular classification of hepatocellular carcinoma Cancer Res 68 2008 6779 6788
16. S. Roayaie, I.N. Blume, S.N. Thung, M. Guido, and M.I. Fiel A system of classifying microvascular invasion to predict outcome after resection in patients with hepatocellular carcinoma Gastroenterology 137 3 2009 Sep 850 855
17. J.M. Llovet, Y. Chen, E. Wurmbach, S. Roayaie, M.I. Fiel, and M. Schwartz A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis Gastroenterology 131 2006 1758 1767
18. Y. Hoshida, A. Villanueva, M. Kobayashi, J. Peix, D.Y. Chiang, and A. Camargo Gene expression in fixed tissues and outcome in hepatocellular carcinoma N Engl J Med 359 2008 1995 2004
19. J.B. Fan, J.M. Yeakley, M. Bibikova, E. Chudin, E. Wickham, and J. Chen A versatile assay for high-throughput gene expression profiling on universal array matrices Genome Res 14 2004 878 885
20. C. April, B. Klotzle, T. Royce, E. Wickham-Garcia, T. Boyaniwsky, and J. Izzo Whole-genome gene expression profiling of formalin-fixed, paraffin-embedded tissue samples PLoS One 4 2009 e8162
21. M. Reich, T. Liefeld, J. Gould, J. Lerner, P. Tamayo, and J.P. Mesirov GenePattern 2.0 Nat Genet 38 2006 May 500 501
22. L. Xu, S.S. Shen, Y. Hoshida, A. Subramanian, K. Ross, and J.P. Brunet Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases Mol Cancer Res 6 2008 760 769
23. E.R. DeLong, D.M. DeLong, and D.L. Clarke-Pearson Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach Biometrics 44 1988 837 845
24. S.C. Lim CD24 and human carcinoma: tumor biological aspects Biomed Pharmacother 59 2005 S351 S354
25. E. Sagiv, L. Memeo, A. Karin, D. Kazanov, J. Jacob-Hirsch, and M. Mansukhani CD24 is a new oncogene, early at the multistep process of colorectal cancer carcinogenesis Gastroenterology 131 2006 630 639
26. X.R. Yang, Y. Xu, B. Yu, J. Zhou, J.C. Li, and S.J. Qiu CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery Clin Cancer Res 15 2009 5518 5527
27. Z.X. Wang, H.Y. Wang, and M.C. Wu Identification and characterization of a novel human hepatocellular carcinoma-associated gene Br J Cancer 85 2001 1162 1167
28. J. Bruix, and J.M. Llovet Major achievements in hepatocellular carcinoma Lancet 373 2009 614 616
29. J.M. Llovet, and J. Bruix Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival Hepatology 37 2003 429 442
30. J.M. Llovet, S. Ricci, V. Mazzaferro, P. Hilgard, E. Gane, and J.F. Blanc Sorafenib in advanced hepatocellular carcinoma N Engl J Med 359 2008 378 390
31. J. Bruix, and M. Sherman Management of hepatocellular carcinoma Hepatology 42 2005 1208 1236
32. F.Y. Yao, L. Ferrell, N.M. Bass, J.J. Watson, P. Bacchetti, and A. Venook Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival Hepatology 33 2001 1394 1403
33. H.G. Woo, E.S. Park, J.H. Cheon, J.H. Kim, J.S. Lee, and B.J. Park Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma Clin Cancer Res 14 2008 2056 2064
34. A. Villanueva, B. Minguez, A. Forner, M. Reig, and J.M. Llovet Hepatocellular carcinoma: novel molecular approaches for diagnosis, prognosis, and therapy Ann Rev Med 61 2010 317 328
35. R. Simon The use of genomics in clinical trial design Clin Cancer Res 14 2008 5984 5993
36. N. Iizuka, M. Oka, H. Yamada-Okabe, M. Nishida, Y. Maeda, and N. Mori Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection Lancet 361 2003 923 929
37. Y. Kurokawa, R. Matoba, I. Takemasa, H. Nagano, K. Dono, and S. Nakamori Molecular-based prediction of early recurrence in hepatocellular carcinoma J Hepatol 41 2004 284 291
38. S.M. Wang, L.L. Ooi, and K.M. Hui Identification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma Clin Cancer Res 13 2007 6275 6283
39. M.A. Silva, B. Hegab, Hyde, B. Guo, J.A.C. Buckels, and D.F. Mirza Needle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis Gut 57 2008 1592 1596
40. K. Maturen, H. Nighiem, J. Marrero, H. Hussain, E. Higgins, and G. Fox Lack of tumor seeding of hepatocellular carcinoma after percutaneous needle biopsy using coaxial cutting needle technique AJR 187 2006 1184 1187