Microvesicles as novel biomarkers and therapeutic targets in transplantation medicine

American Journal of Transplantation

Volumn 12, Issue 2, 2012, Pages 289-297

  Fleissner, F ^a   Goerzig, Y ^a   Haverich, A ^a   Thum, T ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

Exosomes; gene transfer; microvesicles; solid organ transplantation

Indexed keywords

BETA SECRETASE 1; BIOLOGICAL MARKER; CISPLATIN; DEATH RECEPTOR 4; DRUG CARRIER; FAS LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; MICRORNA; PROTEIN P53; SONIC HEDGEHOG PROTEIN; TRICHOSANTHIN; TUMOR NECROSIS FACTOR;

ACUTE CORONARY SYNDROME; ALZHEIMER DISEASE; ATHEROSCLEROSIS; BONE MARROW TRANSPLANTATION; CARDIOVASCULAR SYSTEM; CD8+ T LYMPHOCYTE; DENDRITIC CELL; DRUG METABOLISM; DRUG RESISTANCE; EXOSOME; GRAFT REJECTION; HEPATITIS C VIRUS; HUMAN; IMMUNE DEFICIENCY; IMMUNOLOGICAL TOLERANCE; INFLAMMATION; KIDNEY GRAFT; LYMPHOCYTIC INFILTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; ORGAN TRANSPLANTATION; OVARY CANCER; PATHOPHYSIOLOGY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PLACENTA; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; STROKE; T LYMPHOCYTE; THROMBOCYTE; TROPHOBLAST;

BIOLOGICAL MARKERS; CELL COMMUNICATION; EXOSOMES; GRAFT SURVIVAL; HUMANS; ORGAN TRANSPLANTATION;

EID: 84856468503     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2011.03790.x     Document Type: Review

References (65)

1. Heijnen HF, Schiel AE, Fijnheer R, Geuze HJ, Sixma JJ,. Activated platelets release two types of membrane vesicles: Microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Blood 1999; 94: 3791-3799.
2. Muralidharan-Chari V, Clancy JW, Sedgwick A, D'Souza-Schorey C,. Microvesicles: Mediators of extracellular communication during cancer progression. J Cell Sci 2010; 123: 1603-1611.
3. Yu X, Harris SL, Levine AJ,. The regulation of exosome secretion: A novel function of the p53 protein. Cancer Res 2006; 66: 4795-4801.
4. Amzallag N, Passer BJ, Allanic D, et al,. TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. J Biol Chem 2004; 279: 46104-46112. (Pubitemid 39491604)
5. Yu X, Riley T, Levine AJ,. The regulation of the endosomal compartment by p53 the tumor suppressor gene. FEBS J 2009; 276: 2201-2212.
6. Cocucci E, Racchetti G, Meldolesi J,. Shedding microvesicles: Artefacts no more. Trends Cell Biol 2009; 19: 43-51.
7. Liepins A,. Possible role of microtubules in tumor cell surface membrane shedding, permeability, and lympholysis. Cell Immunol 1983; 76: 120-128. (Pubitemid 13118773)
8. Almqvist N, Lonnqvist A, Hultkrantz S, Rask C, Telemo E,. Serum-derived exosomes from antigen-fed mice prevent allergic sensitization in a model of allergic asthma. Immunology 2008; 125: 21-27.
9. Al-Nedawi K, Meehan B, Micallef J, et al,. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol 2008; 10: 619-624. (Pubitemid 351627382)
10. Caby MP, Lankar D, Vincendeau-Scherrer C, Raposo G, Bonnerot C,. Exosomal-like vesicles are present in human blood plasma. Int Immunol 2005; 17: 879-887. (Pubitemid 41417955)
11. Shet AS,. Characterizing blood microparticles: Technical aspects and challenges. Vasc Health Risk Manag 2008; 4: 769-774.
12. Scholz T, Temmler U, Krause S, Heptinstall S, Losche W,. Transfer of tissue factor from platelets to monocytes: Role of platelet-derived microvesicles and CD62P. Thromb Haemost 2002; 88: 1033-1038. (Pubitemid 36018792)
13. Morel O, Toti F, Freyssinet JM,. Markers of thrombotic disease: Procoagulant microparticles. Ann Pharm Fr 2007; 65: 75-84. (Pubitemid 46457335)
14. Janowska-Wieczorek A, Majka M, Kijowski J, et al,. Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment. Blood 2001; 98: 3143-3149.
15. Kim JW, Wieckowski E, Taylor DD, Reichert TE, Watkins S, Whiteside TL,. Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes. Clin Cancer Res 2005; 11: 1010-1020. (Pubitemid 40175748)
16. Barry OP, Pratico D, Savani RC, FitzGerald GA,. Modulation of monocyte-endothelial cell interactions by platelet microparticles. J Clin Invest 1998; 102: 136-144. (Pubitemid 28323840)
17. Sarkar A, Mitra S, Mehta S, Raices R, Wewers MD,. Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1. PLoS One 2009; 4: e7140.
18. Wolf P,. The nature and significance of platelet products in human plasma. Br J Haematol 1967; 13: 269-288.
19. Ratajczak J, Miekus K, Kucia M, et al,. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: Evidence for horizontal transfer of mRNA and protein delivery. Leukemia 2006; 20: 847-856.
20. Deregibus MC, Cantaluppi V, Calogero R, et al,. Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. Blood 2007; 110: 2440-2448. (Pubitemid 47523165)
21. Bruno S, Grange C, Deregibus MC, et al,. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 2009; 20: 1053-1067.
22. Teo BH, Wong SH,. MHC class II-associated invariant chain (Ii) modulates dendritic cells-derived microvesicles (DCMV)-mediated activation of microglia. Biochem Biophys Res Commun 2010; 400: 673-678.
23. Monleon I, Martinez-Lorenzo MJ, Monteagudo L, et al,. Differential secretion of Fas ligand- or APO2 ligand/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cells. J Immunol 2001; 167: 6736-6744. (Pubitemid 33144163)
24. Andreola G, Rivoltini L, Castelli C, et al,. Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J Exp Med 2002; 195: 1303-1316. (Pubitemid 34564332)
25. Szajnik M, Czystowska M, Szczepanski MJ, Mandapathil M, Whiteside TL,. Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg). PLoS One 2010; 5: e11469.
26. Wieckowski EU, Visus C, Szajnik M, Szczepanski MJ, Storkus WJ, Whiteside TL,. Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8+ T lymphocytes. J Immunol 2009; 183: 3720-3730.
27. Baj-Krzyworzeka M, Baran J, Weglarczyk K, et al,. Tumour-derived microvesicles (TMV) mimic the effect of tumour cells on monocyte subpopulations. Anticancer Res 2010; 30: 3515-3519.
28. Baj-Krzyworzeka M, Szatanek R, Weglarczyk K, Baran J, Zembala M,. Tumour-derived microvesicles modulate biological activity of human monocytes. Immunol Lett 2007; 113: 76-82. (Pubitemid 47562121)
29. Napoletano C, Rughetti A, Landi R, et al,. Immunogenicity of allo-vesicle carrying ERBB2 tumor antigen for dendritic cell-based anti-tumor immunotherapy. Int J Immunopathol Pharmacol 2009; 22: 647-658.
30. Pizzirani C, Ferrari D, Chiozzi P, et al,. Stimulation of P2 receptors causes release of IL-1beta-loaded microvesicles from human dendritic cells. Blood 2007; 109: 3856-3864. (Pubitemid 46641737)
31. Huber V, Fais S, Iero M, et al,. Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: Role in immune escape. Gastroenterology 2005; 128: 1796-1804. (Pubitemid 40824690)
32. Hedlund M, Stenqvist AC, Nagaeva O, et al,. Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: Evidence for immunosuppressive function. J Immunol 2009; 183: 340-351.
33. Pap E, Pallinger E, Falus A, et al,. T lymphocytes are targets for platelet- and trophoblast-derived microvesicles during pregnancy. Placenta 2008; 29: 826-832.
34. Abrahams VM, Straszewski-Chavez SL, Guller S, Mor G,. First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis. Mol Hum Reprod 2004; 10: 55-63. (Pubitemid 38195966)
35. Nomura S, Uehata S, Saito S, Osumi K, Ozeki Y, Kimura Y,. Enzyme immunoassay detection of platelet-derived microparticles and RANTES in acute coronary syndrome. Thromb Haemost 2003; 89: 506-512. (Pubitemid 36329242)
36. Lee YJ, Jy W, Horstman LL, et al,. Elevated platelet microparticles in transient ischemic attacks, lacunar infarcts, and multiinfarct dementias. Thromb Res 1993; 72: 295-304. (Pubitemid 23329372)
37. Zeiger F, Stephan S, Hoheisel G, Pfeiffer D, Ruehlmann C, Koksch M,. P-Selectin expression, platelet aggregates, and platelet-derived microparticle formation are increased in peripheral arterial disease. Blood Coagul Fibrinolysis 2000; 11: 723-728. (Pubitemid 32010206)
38. Dasgupta SK, Abdel-Monem H, Niravath P, et al,. Lactadherin and clearance of platelet-derived microvesicles. Blood 2009; 113: 1332-1339.
39. Aharon A, Tamari T, Brenner B,. Monocyte-derived microparticles and exosomes induce procoagulant and apoptotic effects on endothelial cells. Thromb Haemost 2008; 100: 878-885.
40. Zernecke A, Bidzhekov K, Noels H, et al,. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal 2009; 2: ra81.
41. Gupta SK, Bang C, Thum T,. Circulating microRNAs as biomarkers and potential paracrine mediators of cardiovascular disease. Circ Cardiovasc Genet 2010; 3: 484-488.
42. Widera C, Gupta SK, Lorenzen JM, et al,. Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome. J Mol Cell Cardiol 2011; 51: 872-875.
43. Lorenzen JM, Kielstein JT, Hafer C, et al,. Circulating miR-210 predicts survival in critically ill patients with acute kidney injury. Clin J Am Soc Nephrol 2011; 6: 1540-1546.
44. Lorenzen JM, Volkmann I, Fiedler J, et al,. Urinary miR-210 as a mediator of acute T-cell mediated rejection in renal allograft recipients. Am J Transplant 2011; 11: 2221-2227.
45. Schuerholz T, Weissig A, Juettner B, Becker T, Scheinichen D,. Ex vivo microvesicle formation after prolonged ischemia in renal transplantation. Thromb Res 2007; 120: 231-236. (Pubitemid 46754421)
46. Peche H, Heslan M, Usal C, Amigorena S, Cuturi MC,. Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection. Transplantation 2003; 76: 1503-1510. (Pubitemid 37467702)
47. Peche H, Renaudin K, Beriou G, Merieau E, Amigorena S, Cuturi MC,. Induction of tolerance by exosomes and short-term immunosuppression in a fully MHC-mismatched rat cardiac allograft model. Am J Transplant 2006; 6: 1541-1550. (Pubitemid 43945794)
48. Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO,. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007; 9: 654-659. (Pubitemid 47214727)
49. Pegtel DM, Cosmopoulos K, Thorley-Lawson DA, et al,. Functional delivery of viral miRNAs via exosomes. Proc Natl Acad Sci U S A 2010; 107: 6328-6333.
50. Hunter MP, Ismail N, Zhang X, et al,. Detection of microRNA expression in human peripheral blood microvesicles. PLoS One 2008; 3: e3694.
51. Taylor DD, Gercel-Taylor C,. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol 2008; 110: 13-21. (Pubitemid 351853251)
52. Skog J, Wurdinger T, van Rijn S, et al,. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008; 10: 1470-1476.
53. Gourzones C, Gelin A, Bombik I, et al,. Extra-cellular release and blood diffusion of BART viral micro-RNAs produced by EBV-infected nasopharyngeal carcinoma cells. Virol J 2010; 7: 271.
54. Ohshima K, Inoue K, Fujiwara A, et al,. Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line. PLoS One 2010; 5: e13247.
55. Masciopinto F, Giovani C, Campagnoli S, et al,. Association of hepatitis C virus envelope proteins with exosomes. Eur J Immunol 2004; 34: 2834-2842. (Pubitemid 39430159)
56. Witek RP, Yang L, Liu R, et al,. Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. Gastroenterology 2009; 136: 320-330.e2.
57. Conde-Vancells J, Gonzalez E, Lu SC, Mato JM, Falcon-Perez JM,. Overview of extracellular microvesicles in drug metabolism. Expert Opin Drug Metab Toxicol 2010; 6: 543-554.
58. Bebawy M, Combes V, Lee E, et al,. Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells. Leukemia 2009; 23: 1643-1649.
59. Safaei R, Larson BJ, Cheng TC, et al,. Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells. Mol Cancer Ther 2005; 4: 1595-1604. (Pubitemid 41556443)
60. Shedden K, Xie XT, Chandaroy P, Chang YT, Rosania GR,. Expulsion of small molecules in vesicles shed by cancer cells: Association with gene expression and chemosensitivity profiles. Cancer Res 2003; 63: 4331-4337. (Pubitemid 36950999)
61. Conde-Vancells J, Rodriguez-Suarez E, Embade N, et al,. Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. J Proteome Res 2008; 7: 5157-5166.
62. De La Pena H, Madrigal JA, Rusakiewicz S, et al,. Artificial exosomes as tools for basic and clinical immunology. J Immunol Methods 2009; 344: 121-132.
63. Martinez-Lostao L, Garcia-Alvarez F, Basanez G, et al,. Liposome-bound APO2L/TRAIL is an effective treatment in a rabbit model of rheumatoid arthritis. Arthritis Rheum 2010; 62: 2272-2282.
64. Zhang F, Sun S, Feng D, Zhao WL, Sui SF,. A novel strategy for the invasive toxin: Hijacking exosome-mediated intercellular trafficking. Traffic 2009; 10: 411-424.
65. Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ,. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol 2011; 29: 341-345.