Anaemia in pregnancy

Best Practice and Research: Clinical Obstetrics and Gynaecology

Volumn 26, Issue 1, 2012, Pages 3-24

  Goonewardene, Malik ^a   Shehata, Mishkat ^b   Hamad, Asma ^c  

^a UNIVERSITY OF RUHUNA   (Sri Lanka)

^b UNIVERSITY OF MEDICAL SCIENCES AND TECHNOLOGY   (Sudan)

^c JAMES COOK UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

anaemia; B12; delayed cord clamping; haemolytic; haemolytic uraemic syndrome; nutritional iron deficiency; oral iron and folate; paroxysmal nocturnal haemoglobionuria; pregnancy; supplementation; thrombotic thrombocytopaenic purpura

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; CYANOCOBALAMIN; FERROUS SULFATE; FOLIC ACID; HEMOGLOBIN; METHEMOGLOBIN; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

ANEMIA; AUTOIMMUNE HEMOLYTIC ANEMIA; BLEEDING; BLOOD CELL COUNT; BLOOD TRANSFUSION; CHRONIC DISEASE; COUNSELING; DIET SUPPLEMENTATION; DIFFERENTIAL DIAGNOSIS; DISSEMINATED INTRAVASCULAR CLOTTING; ERYTHROCYTE TRANSFUSION; FOLIC ACID DEFICIENCY; HELLP SYNDROME; HEMATOCRIT; HEMOGLOBIN SYNTHESIS; HEMOLYSIS; HEMOLYTIC UREMIC SYNDROME; HEREDITARY HEMOLYTIC ANEMIA; HUMAN; INTELLECT; IRON ABSORPTION; IRON DEFICIENCY ANEMIA; IRON METABOLISM; IRON THERAPY; MATERNAL MORTALITY; MEAN CORPUSCULAR VOLUME; MEGALOBLASTIC ANEMIA; MENSTRUATION; NUTRITIONAL DEFICIENCY; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PERNICIOUS ANEMIA; PLASMAPHERESIS; PREGNANCY; PREGNANT WOMAN; PRIORITY JOURNAL; PROGNOSIS; PUERPERIUM; REVIEW; SMOKING CESSATION; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; THROMBOTIC THROMBOCYTOPENIC PURPURA; WORK CAPACITY;

ANEMIA; ANEMIA, HEMOLYTIC; ANEMIA, IRON-DEFICIENCY; ANEMIA, PERNICIOUS; FEMALE; FOLIC ACID DEFICIENCY; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; VITAMIN B 12 DEFICIENCY;

EID: 84856418384     PISSN: 15216934     EISSN: 15321932     Source Type: Journal    
DOI: 10.1016/j.bpobgyn.2011.10.010     Document Type: Review

References (191)

1. World Health Organization B. de Benoist, E. Mclean, I. Egli, and M. Cogswell Worldwide prevalence of anaemia 1993 - 2005. WHO Global Database on Anaemia 2008 World Health Organization Geneva (NLM: WH 155)
2. T.O. Scholl Iron status during pregnancy: setting the stage for mother and infant Am J Clin Nutr 81 5 2005 1218 S 1222 S
3. World Health Organization Iron deficiency anaemia assessment prevention and control: a guide for programme managers 2001 World Health Organization Geneva 132 (WHO/ NHD/01.3)
4. Vitamin and Mineral Nutrition Information System Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity 2011 World Health Organization Geneva (WHO/ NMH/NHD/MNM/11.1)
5. O. Koller The clinical significance of haemodilution during pregnancy Obstet Gynaecol Surv 37 11 1982 649 652
6. N. Milman, K.E. Byg, and A.O. Agger Haemoglobin and erythrocyte indices during normal pregnancy and postpartum in 206 women with and without iron supplementation Acta Obstet Gynaecol Scand 79 2 2000 89 98 (Pubitemid 30098789)
7. J.R. Smith, and S.A. Landaw Smokers polycythemia N Engl J Med 298 1 1978 6 10
8. E. Van Tiel, P.H. Peeters, and H.A. Smit Quitting smoking may restore haematological characteristics within five years Ann Epidemiol 12 6 2002 378 388 (Pubitemid 34823636)
9. G.F. Cope, P. Nayyar, and R. Holder Measurement of nicotine intake in pregnant women - associations to changes in blood cell count Nicotine Tob Res 3 2 2001 119 122 (Pubitemid 32621772)
10. S.C. Chang, K.O. O'Brien, and M.S. Nathanson Haemoglobin concentrations influence birth outcomes in pregnant African- American adolescents J Nutr 133 7 2003 2348 2355 (Pubitemid 36841564)
11. T. Strinc, D. Bukovic, and L. Sumilin Socio - demographic characteristics and life style habits of pregnant women smokers Coll Antropol 29 2 2005 611 614 (Pubitemid 43111105)
12. S. Subramoney, and P.C. Gupta Anaemia in pregnant women who use smokeless tobacco Nicotine Tob Res 10 5 2008 917 920 (Pubitemid 351974073)
13. M.A. Johnson-Spear, and R. Yip Haemoglobin difference between black and white women with comparable iron status: justification for race -specific anaemia criteria Am J Clin Nutr 60 1 1994 117 121 (Pubitemid 24215764)
14. S.M.P.J. James, D.O.A. Daemen, and R. de Vos Are pregnant women of non northern European descent more anaemic than women of Northern European descent? A study in to the prevalence of anaemia in pregnant women in Amsterdam Midwifery 25 2009 766 773
15. M. Goonewardene, J. Seekkuge, and C. Liyanage Iron stores and its correlation to haemoglobin levels in pregnant women attending an antenatal clinic Ceylon Med J 40 1995 67 69
16. R. Yip Iron deficiency: contemporary scientific issues and international programmatic approaches J Nutr 124 1994 1479 S 1490 S
17. T.H. Bothwell Iron requirements in pregnancy and strategies to meet them Am J Clin Nutr 72 1 Suppl. 2000 257 S 264 S
18. A.G. Ronnenberg, R.J. Wood, and X. Wang Preconception Hb & Ferritin concentrations are associated with pregnancy outcome in a prospective cohort of Chinese women J Nutr 134 10 2004 2586 2591 (Pubitemid 39315259)
19. J. Fernandez-Ballart Iron metabolism during pregnancy Clin Drug Inves 19 Suppl. 1 2000 9 19 (Pubitemid 30198034)
20. L. Hallberg Perspectives of nutritional iron deficiency Annu Rev of Nutr 21 2001 1 21 Review
21. F.E. Viteri, and J. Berger Importance of pregnancy and pregnancy iron status: can long term weekly preventive iron and folic acid supplementation achieve desirable and safe status? Nutr Rev 63 12 pt 2 2005 S 65 S 76
22. B. Luke Nutrition and multiple gestations Semin Perinatol 29 5 2005 349 354
23. I.M.R. Goonewardene, and R.P.K. Deeyagaha Waduge Adverse effects of teenage pregnancy Ceylon Med J 50 3 2005 116 120
24. Y.M.S. Al-Farsi, D.R. Brooks, and M.M. Werler Effect of high parity on occurrence of anaemia in pregnancy: a cohort study BMC Pregnancy Childbirth 11 2011 7
25. K.G. Dewey, and R.J. Cohen Does birth spacing affect maternal or child nutritional status? A systematic literature review Matern Child Nutr 3 3 2007 151 173 (Pubitemid 46864280)
26. K.M. Sullivan, Z. Mei, and L. Grummer- Strawn Haemoglobin adjustment to define anaemia Trop Med Int Health 13 10 2008 1267 1271
27. F. Gustavo, G.F. Gonzales, and K. Steemland Maternal haemoglobin level and fetal outcome at low & high altitudes Am J Phys Regul Integr Comp Physiol 297 5 2009 R1477 R1485
28. K. Haram, S.T. Nilsen, and R.J. Ulwik Iron supplementation in pregnancy - evidence and controversies Acta Obstet Gynaecol Scand 80 8 2001 683 688 (Pubitemid 32802542)
29. J.F. Murphy, J. O'Riordan, and R.G. Newcombe Relation of haemoglobin level in first and second trimester to outcome Lancet 3 1 1986 992 995
30. J.D. Cook, C.H. Flowers, and B.S. Skikne The quantitative assessment of body iron Blood 101 9 2003 3359 3364 Re pub 2003 Jan 9 (Pubitemid 36857914)
31. B. Svanberg Absorption of iron in pregnancy Acta Obstet Gynaecol Scand Suppl 48 1975 1 108
32. J. Puolokka, O. Janne, and A. Pakarinen Serum ferritin as a measure of iron status during and after normal pregnancy with and without iron supplements Acta Obstet Gynaecol Scand Suppl 95 1980 43 51
33. K. Punnonen, K. Irjala, and A. Rajamaki Serum Transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency Blood 89 3 1997 1052 1057 (Pubitemid 27121300)
34. N.R. van den Broek, E.A. Letsky, and S.A. White Iron status in pregnant women: which measurements are valid? Br J Haematol 103 3 1998 817 824 (Pubitemid 28545323)
35. A. Prual, P. Galan, and I. De Bernis Evaluation of iron status in Chadian pregnant women: consequence of maternal iron deficiency on the haematopoietic status of the newborns Trop Geogr Med 40 1 1988 1 6
36. M. Abbassi - Ghanavati, L.G. Greer, and F.G. Cunningham Pregnancy and laboratory studies: A reference table for clinicians Obstet Gynaecol 114 6 2009 1326 1331
37. I. Chanarin, I.R. McFadyen, and R. Kyle The physiological macrocytois of pregnancy Br J Obstet Gynaecol 84 7 1977 504 508
38. 12 and folate deficiency 2007 www.bcguidelines.ca/pdf/B12.pdf [accessed 21.04.11]
39. A.V. Hoffbrand Megaloblastic anaemia A.V. Hoffbrand, S.M. Lewis, Postgraduate haematology 3rd ed. 1989 Butterworth - Heinemann Oxford 56 82
40. M. Munoz, A. Romero, and F. Gomes Utility of point -of -care haemoglobin measurement in the HaemoCue-B haemoglobin for the initial diagnosis of anaemia Clin Lab Haematol 27 2005 99 104 (Pubitemid 40520502)
41. J. Critchley, and I. Bates Haemoglobin colour scale for anaemia diagnosis where there is no laboratory: a systematic review Int J Epidemiol 34 6 2005 1425 1434 Epub 2005 Sep 30 (Pubitemid 41819555)
42. P. Bergsjo, B. Evjen-Olsen, and S.G. Hindereker Validity of non invasive assessment of anaemia in pregnancy Trop Med Int Health 13 2008 272 277 (Pubitemid 351316980)
43. J.M. Hunt Reversing productivity losses from iron deficiency: the economic case J Nutr 132 4 Suppl. 2002 794 S 801 S
44. K. Prema, B.A. Ramalakshmi, and R. Madharapeddi Immune status of anaemic pregnant women Br J Obstet Gynaecol 89 3 1982 222 225 (Pubitemid 12192926)
45. A. Kandoi, B.D. Bhatia, and L.K. Pandey Cellular immunity status in anaemia in pregnancy Ind J Med Res 94 1991 11 15
46. B.J. Brabin, M. Hakimi, and D. Palletier An analysis of anaemia and pregnancy - related maternal mortality J Nutr 131 25-2 2001 604 S 615 S discussion 614 S - 615 S
47. K.S. Khan, D. Wojdyla, and L. Say WHO analysis of causes of maternal deaths: a systematic review Lancet 367 9516 2006 1066 1074
48. K.M. Rasmussen Is there a causal relationship between iron deficiency or iron deficiency anaemia and weight at birth, length of gestation, and perinatal mortality? J Nutr 131 2001 590 S 601 S
49. P.N. Singla, M. Tyagi, and R. Shankar Fetal iron status in maternal anaemia Acta Paediatr 85 1996 1327 1330 (Pubitemid 26382380)
50. B. Lozoff, J. Beard, and J. Connor Long -lasting neural and behavioral effects of iron deficiency in infancy Nutr Rev 64 5 Pt 2 2006 S 34 S 43
51. A.F. Lukowski, M. Koss, and M.J. Burden Iron deficiency in infancy and neurocognitive functioning at 19 years: evidence of long - term deficits in executive function and recognition memory Nutr Neurosci 13 2 2010 54 70
52. P.C. Gupta, and S. Subramoney Smokeless tobacco use and risk of still birth: a cohort study in Mumbai, India Epidemiology 17 1 2006 47 51
53. N.R. de Silva, J.L. Sirisena, and D.P. Gunasekera Effect of Mebandazole therapy during pregnancy on birth outcome Lancet 353 1999 1145 1149 (Pubitemid 29155208)
54. G.J. Casey, D. Jolley, and T.Q. Phuc Long -term weekly iron -folic acid and de-worming is associated with stabilized haemoglobin and increasing iron stores in non pregnant women in Vietnam PLoS ONE 5 12 2010 e 15691 doi:1371/journal.pone.0015691
55. O.O. Asa, A.A. Onayade, and A.O. Fatusi Efficacy of intermittent preventive treatment of malaria with sulphadioxide - pyrimethamine in preventing anaemia in pregnancy among Nigerian women Matern Child Health J 12 2008 692 698
56. M.S. Kramer, and R. Kakuma Energy and protein intake in pregnancy Cochrane Database Syst Rev 2003 issue 4. Art. No: CD 000032, DOI: 10.1002/14651858
57. Lindmarke G. Energy and protein intake in pregnancy, RHL Commentary (last revised 31 Dec, 2003) The WHO Reproductive Health Library 2011, Geneva, World Health Organization.
58. World Health Organization S.C. Vir, and T. Cavalli-Sforza Weekly iron folic acid supplementation (WIFS) program for women of reproductive age (WRA): an analysis of best program practices 2011 World Health Organization Geneva
59. J. Berger, H.T. Thanh, and T. Cavelli-Sforza Community mobilization and social marketing to promote Weekly Iron folic acid supplement in women of reproductive age in Vietnam: impact on anaemia and iron status Nutr Rev 63 12 pt 2 2005 S 95 S 108
60. I. Angeles - Agadeppa, L.S. Paulino, and A.C. Ramos Government industry partnership in weekly iron folic acid supplement for women of reproductive age in Philippines: impact on iron status Nutr Rev 63 12 pt 2 2005 S 116 S 125
61. B.L. Crape, E. Kenefick, and T. Cavelli- Sforza Positive impact of weekly iron folic acid supplement delivered with social marketing to Cambodian women. Compliance, participation and haemoglobin level increase with higher socio economic status: impact on iron status Nutr Rev 63 12 2005 S134 S 138
62. S.J. Openheimer Iron and its relation to immunity and infectious disease J Nutr 131 2001 616 S 635 S
63. A.M. Prentis, H. Ghattas, and C. Doherty Iron metabolism and malaria Food Nutr Bull 28 4 Suppl. 2007 S 524 S 539 (Pubitemid 351149503)
64. World Health Organization Malaria in pregnancy. Guidelines for measuring key monitoring and evaluation indicators 2007 World Health Organization Geneva (WC 750 2007 MA)
65. World Health Organization Global Malaria Report 2010. Global Malaria Program 2010 World Health Organization Geneva NLM: WC 765
66. J.P. Pena- Rosas, and F.E. Viteri Effects and safety of preventive oral iron or iron + folic acid supplementation for women during pregnancy Cochrane Database Syst Rev 2009 Issue 4. Art.No: CD004736. DOI: 10.1002/ 14651858. CD004736 pub 3
67. N.O. O'Brien, N. Zavaleta, and L.E. Canfield Prenatal iron supplements impair zinc absorption in pregnant Persian women J Nutr 130 9 2000 2251 2255
68. M. Merialdi, L.E. Canfield, and N. Zavaleta Randomized controlled trial of prenatal zinc supplementation and fetal bone growth Am J Clin Nutr 79 5 2004 826 830 (Pubitemid 41103883)
69. M.W. Bloem, M. Wedel, and E.J. van Agtmaal Vitamin A intervention: short term effects of a single, oral, massive dose on iron metabolism Am J Clin Nutr 51 1 1990 76 79
70. D. Suharno, C.E. West, and Muhilal Supplementation with vitamin A and iron for nutritional anaemia in pregnant women in West Java, Indonesia Lancet 342 1993 1325 1328 (Pubitemid 23345180)
71. N.R. van den Broek, R. Kulier, and A.M. Gulmezoglu Vitamin A supplementation during pregnancy (Cochrane Review) The Cochrane Library Issue 5 2003 Update Software Oxford
72. Lumbriganon P. Multiple micronutrient supplementation for women during pregnancy: RHL commentary (last revised 23 August 2007). The WHO Reproductive Health Library Geneva, World Health Organization.
73. F. Habib, E.H.Z. Albadin, and M. Alenazy Compliance to iron supplementation during pregnancy J Obstet Gynaecol 29 6 2009 487 492
74. I.M.R. Goonewardene, and C. Liyanage Efficacy of the current antenatal oral iron supplementation programme Sri Lanka J Obstet Gynaecol 18 1996 14 17
75. M. Gillooly, T.H. Bothwell, and J.D. Torrance The effects of organic acids, phytates and polyphenols on the absorption of iron from vegetables Brit J Nutr 49 1983 331 342 (Pubitemid 13028053)
76. Zhou, R.A. Gibson, and C.A. Crowther Should we lower the dose of iron when treating anaemia in pregnancy? A randomized dose - response trial Eur J Clin Nutr 63 2 2009 183 190 E pub 2007 Oct. 10
77. J.K. Thomsen, J.C. Prien-Larsen, and A. Devantier Low dose iron supplementation does not cover the need for iron during pregnancy Acta Obstet Gynaecol Scand 72 2 1993 93 98 (Pubitemid 23113163)
78. D. Sathish, Y.S. Kumar, and Y.M. Rao Floating drug delivery systems for prolonging gastric residence time A Review Curr Drug Del 2011 Apr 1 Epub ahead of print
79. O.J. Kikouama, and L. Balde From edible clay to clay containing formulation for optimization of oral delivery of some trace elements: a review Int J Food Sci Nutr 61 8 2010 803 822 Epub 2010 Jun 9
80. L. Saha, P. Pandhi, and S. Gopalan Comparison of efficacy, tolerability, and cost of iron polymaltose complex with ferrous sulphate in the treatment of iron deficiency anaemia in pregnant women Med Gen Med 9 1 2007 1
81. G.J. Ruiz-Arguelles, A. Diaz - Hernandez, and C. Manzano Ineffectiveness of oral iron hydroxide polymaltose in iron-deficiency anemia Hematology 12 3 2007 255 256 (Pubitemid 46930254)
82. L. Hallberg, M. Brune, and L. Rosander Calcium: effects of different amount on non haem absorption in man Am J Clin Nutr 68 1991 213 217
83. C. Menendez, J. Todd, and P.L. Alonso The effects of iron supplementation during pregnancy, given by traditional birth attendants, on the prevalence of anaemia and malaria Trans R Soc Trop Med Hyg 88 5 1994 590 593 (Pubitemid 24325220)
84. J.D. Cook, and M.B. Reddy Efficacy of weekly versus daily iron supplementation Am J Clin Nutr 62 1995 117 120
85. A.A. Mamun, S.S. Padmadas, and M. Khatun Maternal health during pregnancy and perinatal mortality in Bangladesh: evidence from a large-scale community-based clinical trial Paediatr Perinat Epidemiol 20 6 2006 482 490 (Pubitemid 44581546)
86. O. Stephansson, P.W. Dickman, and A. Johansson Maternal hemoglobin concentration during pregnancy and risk of stillbirth JAMA 284 2000 2611 2617
87. L. Hallberg Combating iron deficiency: daily administration of iron is far superior to weekly administration Am J Clin Nutr 68 1998 213 217 (Pubitemid 28355632)
88. M. Goonewardene, C. Liyanage, and R.J. Fernando Intermittent oral iron supplementation during pregnancy Ceylon Med J 46 4 2001 132 135
89. Z. Mumtas, S. Shahab, and N. Butt Daily iron Supplementation in pregnant women in Pakistan in a randomised double blind clinical trial Nutrition 130 11 2000 2697 2702
90. A.R. Zamani, Z. Farajadegan, and A.A. Ghahiri Effectiveness of twice weekly iron supplementation compared with daily regimen in reducing anaemia and iron deficiency during pregnancy: a Randomised trial in Iran J Res Med Sc 13 5 2008 230 239
91. W.J. Prendiville, D. Elbuorne, and S. Mc Donald Active versus expectant management in the third stage of labour Cochrane Database Syst Rev 2000 Issue 3. Art. No.: CD 000007. DOI:10.1002/14651858
92. P. van Rheenen, and B.J. Brabin Late umbilical cord - clamping as an intervention of reducing iron deficiency anaemia in term infants in developing and industrialized countries: a systematic review Ann Trop Paediatr 24 1 2004 3 16 (Pubitemid 38379730)
93. C.E. Shulman, E.K. Dorman, and J.N. Bulmer Malaria as a cause of severe anaemia in pregnancy Lancet 360 9391 2002 494 (Pubitemid 34880161)
94. M. Rohilla, A. Raveenran, and K.L. Dhaliwal Severe anaemia in pregnancy: a tertiary hospital experience from northern India J Obstet Gynaecol 30 7 2010 694 696
95. P.B. Dislor, S.R. Lynchi, and R.W. Charlton The effect of tea on iron absorption Gut 16 1975 193 200
96. L. Reveiz, G.M.L. Gyte, and L.G. Cuervo Treatment for iron -deficiency in pregnancy Cochrane Data Base of Systematic Reviews 2007 Issue 4. Art. No: CD003094. DOI:10.1002/14651859. CD003094. Pub 2
97. Walraven G. Treatments for iron deficiency anaemia in pregnancy: RHL Commentary (last revised 20 June 2007) The WHO Reproductive Health Library Geneva, World Health Organization.
98. A. Khalafallah, A. Dennis, and J. Bates A prospective randomized, controlled trial of intravenous versus oral iron for moderate iron deficiency anaemia of pregnancy J Int Med 268 2010 286 295
99. C. Breymann, E. Visca, and R. Huch Efficacy and safety of intravenously administered iron sucrose with and without adjuvant recombinant human erythropoietin for the treatment of resistant iron deficiency anaemia during pregnancy Am J Obstet Gynaecol 184 2000 662 667 (Pubitemid 32234981)
100. J. Metz, K. McGrath, and M. Bennett Biochemical indices of vitamin B12 nutrition in pregnant patients with subnormal serum vitamin B12 levels Am J Hematol 48 1995 251 255
101. Food and Agriculture Organization of the United Nations, World Health Organization Requirements of vitamin A, thiamin, riboflavin, and niacin. Report of a joint FAO/WHO Expert Group 1985 FAO Rome
102. D. Savage, O. Gangaidz, and J. Lindenbaum Vitamin B12 deficiency in the primary cause of megaloblastic anaemia in Zimbabwe Br J Haematol 86 1994 844 850 (Pubitemid 24194446)
103. S.J. Baker, E. Jacob, and K.T. Rajan Vitamin B12 deficiency in pregnancy and puerperium Br Med J 1 1962 1658 1661
104. V. Herbert Vitamin B12 Present Knowledge in Nutrition 17th ed. 1996 International Life Sciences Institute Press Washington, DC
105. Elizabeth A. Letsky. Clinics in haematology. Haematological disorders in pregnancy. October 1985. Volume 14/Number 3
106. J. MacDonald Holmes Cerebral manifestations of vitamin-B12 deficiency British Medical Journal Dec 15, 1956
107. I. Chanarin Megaloblastic anaemia associated with pregnancy. The Megaloblastic Anaemias 1979 Blackwell Scientific Publications Oxford 466
108. E. Nexo, and M.D. Hollenberg Characterization of the particulate and soluble acceptor for transcobalamin II from human placenta and rabbit liver Biochim Biophys Acta 628 1980 190 200 (Pubitemid 10097243)
109. 12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic acid fortification Pediatrics 123 No. 3 March 1, 2009 917 923
110. E.D. Shinwell, and R. Gorodisher Totally vegetarian diets and infant nutrition Pediatrics 70 4 1982 Oct 582 586 (Pubitemid 12028375)
111. E. Andres, B. Goichot, and J.L. Schlienger Food cobalamin malabsorption: a usual cause of vitamin B12 deficiency Arch Intern Med 160 2000 2061 2062 (Pubitemid 30437591)
112. M. Elia Oral or parenteral therapy for B12 deficiency Lancet 352 1998 1721 1722
113. B.M. Hibbard The role of folic acid in pregnancy; with particular reference to anaemia, abruption and abortion J Obstet Gynaecol Br Commonw 71 1964 529 542
114. E.D. Hibbard, and R.W. Smithells Folic acid metabolism and human embryopathy Lancet i 1965 1254
115. L.D. Botto, C.A. Moore, and M.J. Khoury Neural-tube defects N Engl J Med 341 1999 1509 1519 (Pubitemid 29526355)
116. N.M. van der Put, H.W. van Straaten, and F.J. Trijbels Folate, homocysteine and neural tube defects: an overview Exp Biol Med (Maywood) 226 2001 243 270 (Pubitemid 32520289)
117. L.D. Botto, J. Mulinare, and J.D. Erickson Occurrence of congenital heart defects in relation to maternal multivitamin use Am J Epidemiol 151 2000 878 884 (Pubitemid 30461128)
118. T.O. Scholl, and W.G. Johnson Folic acid: influence on the outcome of pregnancy Am J Clin Nutr 71 Suppl. 2000 1295S 1303S (Pubitemid 30230532)
119. S. Hernández-Díaz, M.M. Werler, and C. Louik Risk of gestational hypertension in relation to folic acid supplementation during pregnancy Am J Epidemiol 156 2002 806 812 (Pubitemid 35215761)
120. L.M. Bodnar, G. Tang, and R.B. Ness Periconceptional multivitamin use reduces the risk of preeclampsia Am J Epidemiol 164 2006 470 477 (Pubitemid 44576614)
121. W.W. Fawzi, G.I. Msamanga, and W. Urassa Vitamins and perinatal outcomes among HIV-negative women in Tanzania N Engl J Med 356 2007 1423 1431 (Pubitemid 46556327)
122. A.J. Wilcox, R.T. Lie, and K. Solvoll Folic acid supplements and risk of facial clefts: national population based case-control study BMJ 334 2007 464 467 (Pubitemid 46586604)
123. Megaloblastic anemia and other causes of macrocytosis Clin Med Res 4 2006 23
124. Macrocytic anaemias BMJ 314 1997 1552
125. Postgraduate Haematology, 6th ed. A. Victor Hoffbrand, Daniel Catovsky, Edward G.D. Tuddenham and Anthony R. Green.
126. G. Varela-Moreiras, M.M. Murphy, and J.M. Scott Cobalamin, folic acid, and homocysteine Nutr Rev 67 Suppl. 1 May 2009 S69 S72
127. G. Wang, J.M. Mao, and X. Wang Effect of homocysteine on plaque formation and oxidative stress in patients with acute coronary syndromes Chin Med J (Engl) 117 11 Nov 2004 1650 1654 (Pubitemid 39619240)
128. J.J. Genest Jr., J.R. McNamara, and D.N. Salem Plasma homocyst(e)ine levels in men with premature coronary artery disease J Am Coll Cardiol 16 5 Nov 1990 1114 1119 (Pubitemid 20378460)
129. B.M. Coull, M.R. Malinow, and N. Beamer Elevated plasma homocyst(e)ine concentration as a possible independent risk factor for stroke Stroke 21 4 Apr 1990 572 576 (Pubitemid 20141879)
130. S.W. Bokhari, Z.W. Bokhari, and J.A. Zell Plasma homocysteine levels and the left ventricular systolic function in coronary artery disease patients Coron Artery Dis 16 3 May 2005 153 161 (Pubitemid 40586197)
131. N. Colman, M. Barker, and R. Green Prevention of folate deficiency in pregnancy by food fortification Am J Clin Nutr 27 1974 339 344
132. Roy M. Nilsen, Stein E. Vollset, and Svein A. Rasmussen Folic acid and multivitamin supplement use and risk of placental abruption: a population-based registry study Am J Epidemiol 167 7 2008 867 874 (Pubitemid 351451743)
133. Willianne L.D.M. Nelen, Henk J. Blom, and Eric A.P. Steegers Homocysteine and folate levels as risk factors for recurrent early pregnancy loss Obstetrics & Gynecology 95 Issue 4 April 2000 519 524 (Pubitemid 30139570)
134. James N. George Thrombotic thrombocytopenic purpura N Engl J Med 354 2006 1927 1935 (Pubitemid 43872694)
135. Johnny R. McMinn, and James N. George Evaluation of women with clinically suspected thrombotic thrombocytopenic purpura-hemolytic uremic syndrome during pregnancy J Clin Apher 16 4 2001 202 209 (Pubitemid 34037610)
136. N. James, and M.D. George The association of pregnancy with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome Curr Opin Hematol 10 5 September 2003 339 344
137. J. Evan Sadler, Joel L. Moake, and Toshiyuki Miyata Recent advances in thrombotic thrombocytopenic purpura Hematology 2004
138. Charles L. Bennett, Jean M. Connors, and John M. Carwile Thrombotic thrombocytopenic purpura associated with clopidogrel N Engl J Med 2000 342 June 15, 2000 1773 1777 (Pubitemid 30390236)
139. C.L. Bennett, P.D. Weinberg, and K. Rozenberg-Ben-Dror Thrombotic thrombocytopenic purpura associated with ticlopidine: a review of 60 cases Ann Intern Med 128 1998 541 544 (Pubitemid 28177661)
140. E.L. Amorosi, and J.E. Ultman Thrombotic thrombocytopenic purpura: Report of 16 cases and review of the literature Medicine (Baltimore) 45 1994 139 159
141. L.L. Brailey, M.E. Brecher, and N. Bandarenko Apheresis and the thrombotic thrombocytopenic purpura syndrome: current advances in diagnosis, pathophysiology, and management Ther Apher 3 1999 20 24 (Pubitemid 29133866)
142. J.L. Moake Thrombotic microangiopathies N Engl J Med 347 8 2000 589 600
143. Michael Permezel, Newton Lee, and June Corry Thrombotic thrombocytopenic purpura in pregnancy ANZJOG 32 3 August 1992 278 281
144. X.L. Zheng, R.M. Kaufman, and L.T. Goodnough Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura Blood 103 11 2004 4043 4049 (Pubitemid 38685342)
145. Gail A. Rock, Kenneth H. Shumak, and Noel A. Buskard Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura N Engl J Med 325 1991 393 397 August 8, 1991
146. J. Ellis, C. Theodossiou, and P. Schwarzenberger Treatment of thrombotic thrombocytopenic purpura with the cryosupernatant fraction of plasma: a case report and review of the literature Am J Med Sci 318 1999 190 193 (Pubitemid 30387251)
147. D. Sgarabotto, F. Vianello, and F. Scano Clinical and laboratoristic remission after cryosupernatant plasma exchange in thrombotic thrombocytopenic purpura Haematologica 83 1998 569 570 (Pubitemid 28331177)
148. E. Real, E. Pastor, and M. Perella Elective splenectomy in relapsing thrombotic thrombocytopenic purpura Haematologica 83 1998 959 960 (Pubitemid 28538459)
149. Mariea S, Richarda S, Richardb L, et-al. Successful management of pregnancy in women with a history of thrombotic thrombocytopaenic purpura. September 2006;17(6):459-463.
150. Han-Mou Tsai Current concepts in thrombotic thrombocytopenic purpura Annu Rev Med (Annu Rev) 57 February 2006 419 436 (Pubitemid 43261999)
151. R.L. Siegler Management of hemolytic-uremic syndrome J Pediatr 112 6 Jun 1988 1014 1020
152. R. Siegler, and R. Oakes Hemolytic uremic syndrome; pathogenesis, treatment, and outcome Curr Opin Pediatr 17 2 Apr 2005 200 204 (Pubitemid 40516100)
153. M. Furlan, R. Robles, and M. Galbusera von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome N Engl J Med 339 22 Nov 26 1998 1578 1584 (Pubitemid 28536132)
154. H.M. Tsai, and E.C. Lian Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura N Engl J Med 339 22 Nov 26 1998 1585 1594 (Pubitemid 28536133)
155. J.N. George ADAMTS13, thrombotic thrombocytopenic purpura, and hemolytic uremic syndrome Curr Hematol Rep 4 3 May 2005 167 169
156. R.L. Haspel, and P. Jarolím The "cutting" edge: von Willebrand factor-cleaving protease activity in thrombotic microangiopathies Transfus Apher Sci 32 2 Apr 2005 177 184 (Pubitemid 40387371)
157. D.P. Blackall, and M.B. Marques Hemolytic uremic syndrome revisited: shiga toxin, factor H, and fibrin generation Am J Clin Pathol 121 Suppl. Jun 2004 S81 S88
158. P.I. Tarr, C.A. Gordon, and W.L. Chandler Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome Lancet 365 9464 Mar 19-25 2005 1073 1086
159. J. Caprioli, P. Bettinaglio, and P.F. Zipfel The molecular basis of familial hemolytic uremic syndrome: mutation analysis of factor H gene reveals a hot spot in short consensus repeat 20 J Am Soc Nephrol 12 2 Feb 2001 297 307 (Pubitemid 32116371)
160. V. Fremeaux-Bacchi, E.J. Kemp, and J.A. Goodship The development of atypical haemolytic-uraemic syndrome is influenced by susceptibility factors in factor H and membrane cofactor protein: evidence from two independent cohorts J Med Genet 42 11 Nov 2005 852 856 (Pubitemid 41598193)
161. M.M. Edey, P.A. Mead, and R.E. Saunders Association of a factor H mutation with hemolytic uremic syndrome following a diarrheal illness Am J Kidney Dis 51 3 Mar 2008 487 490 (Pubitemid 351273479)
162. A.L. Lapeyraque, E. Wagner, and V. Phan Efficacy of plasma therapy in atypical hemolytic uremic syndrome with complement factor H mutations Pediatr Nephrol 23 8 Aug 2008 1363 1366
163. N. James George How I treat patients with thrombotic thrombocytopenic purpura Blood 116 2010 4060 4069
164. H.J. Timothy, Goodship, and David Kavanagh Pulling the trigger in atypical hemolytic uremic syndrome: the role of pregnancy J Am Soc Nephrol 21 May 1, 2010 731 732
165. F. Fakhouri, L. Roumenina, and F. Provot Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations J Am Soc Nephrol 21 2010 859 867
166. E. Bresin, E. Daina, and M. Noris Outcome of renal transplantation in patients with non-shiga toxin-associated hemolytic uremic syndrome: prognostic significance of genetic background Clin J Am Soc Nephrol 1 2006 88 99
167. J. Takeda, T. Miyata, and K. Kawagoe Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria Cell 73 1993 703 711 (Pubitemid 23159009)
168. M. Bessler, P.J. Mason, and P. Hillmen Paroxysmal nocturnal hemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene EMBO J 13 1994 110 117
169. P. Hillmen, S.M. Lewis, and M. Bessler Natural history of paroxysmal nocturnal hemoglobinuria N Engl J Med 333 1995 1253 1258
170. W.H. Crosby Paroxysmal nocturnal hemoglobinuria: a classic description by Paul Strübing in 1882, and a bibliography of the disease Blood 6 1951 270 284
171. W.F. Rosse Dr. Ham's test revisited Blood 78 1991 547 550
172. A. Tichelli, G. Socie, and J. Marsh Outcome of pregnancy and disease course among women with aplastic anemia treated with immunosuppression Ann Intern Med 137 2002 164 172 (Pubitemid 34827512)
173. J.G. Ray, R.F. Burows, and J.S. Ginsberg Paroxysmal nocturnal hemoglobinuria and the risk of venous thrombosis: review and recommendations for management of the pregnant and nonpregnant patient Haemostasis 30 2000 103 117
174. M.H. Holguin, L.R. Fredrick, and N.J. Bernshaw Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria J Clin Invest 84 1989 7 17 (Pubitemid 19170089)
175. S.A. Rollins, and P.J. Sims The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9 J Immunol 144 1990 3478 3483 (Pubitemid 20146382)
176. B.P. Morgan Isolation and characterization of the complement-inhibiting protein CD59 antigen from platelet membranes Biochem J 282 1992 409 413
177. T. Fujita, T. Inoue, and K. Ogawa The mechanism of action of decay-accelerating factor (DAF): DAF inhibits the assembly of C3 convertases by dissociating C2a and Bb J Exp Med 166 1987 1221 1228 (Pubitemid 18051418)
178. A.H. Merry, V.I. Rawlinson, and M. Uchikawa Studies on the sensitivity to complement-mediated lysis of erythrocytes (Inab phenotype) with a deficiency of DAF (decay accelerating factor) Br J Haematol 73 1989 248 253 (Pubitemid 19256120)
179. M.J. Telen, and A.M. Green The Inab phenotype: characterization of the membrane protein and complement regulatory defect Blood 74 1989 437 441 (Pubitemid 19187462)
180. M. Yamashina, E. Ueda, and T. Kinoshita Inherited complete deficiency of 20-kilodalton homologous restriction factor (CD59) as a cause of paroxysmal nocturnal hemoglobinuria N Engl J Med 323 1990 1184 1189 (Pubitemid 20347405)
181. N. Motoyama, N. Okada, and M. Yamashina Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene Eur J Immunol 22 1992 2669 2673
182. M.H. Holguin, C.B. Martin, and N.J. Bernshaw Analysis of the effects of activation of the alternative pathway of complement on erythrocytes with an isolated deficiency of decay accelerating factor J Immunol 148 1992 498 502
183. N. Okada, R. Harada, and H. Okada Erythrocytes of patients with paroxysmal nocturnal haemoglobinuria acquire resistance to complement attack by purified 20-kD homologous restriction factor Clin Exp Immunol 80 1990 109 113 (Pubitemid 20113413)
184. J. Schubert, M. Alvarado, and P. Uciechowski Diagnosis of paroxysmal nocturnal haemoglobinuria using immunophenotyping of peripheral blood cells Br J Haematol 79 1991 487 492
185. S.J. Richards, A.C. Rawstron, and P. Hillmen Application of flow cytometry to the diagnosis of paroxysmal nocturnal hemoglobinuria Cytometry 42 2000 223 233 (Pubitemid 30660538)
186. S.E. Hall, and W.F. Rosse The use of monoclonal antibodies and flow cytometry in the diagnosis of paroxysmal nocturnal hemoglobinuria Blood 87 1996 5332 5534
187. Charles Parker, Mitsuhiro Omine, and Stephen Richards Diagnosis and management of paroxysmal nocturnal hemoglobinuria Blood 106 no. 12 December 1, 2005 3699 3700
188. P. Hillmen, C. Hall, and J.C. Marsh Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria N Engl J Med 350 2004 552 559 (Pubitemid 38160785)
189. J.G. Lange, G.E. Griever, and A. Brand Paroxysmal nocturnal hemoglobinuria in pregnancy Ned Tijdschr Geneeskd 142 42 1998 Oct 17 2308 2311
190. Stefania Fieni, Laura Bonfanti, and Dandolo Gramellini Clinical Management of paroxysmal nocturnal hemoglobinuria in pregnancy: a case report and updated review Obstet Gynecol Surv 61 9 September 2006 593 601 (Pubitemid 44325469)
191. Line Bjørge, Peter Ernst, and Kjell O. Haram Paroxysmal nocturnal hemoglobinuria in pregnancy Acta Obstetricia et Gynecol Scand 82 12 December 2003 1067 1071 (Pubitemid 37449370)