Should we lower the dose of iron when treating anaemia in pregnancy? A randomized dose-response trial

European Journal of Clinical Nutrition

Volumn 63, Issue 2, 2009, Pages 183-190

  Zhou, S J ^a,b   Gibson, R A ^a,c   Crowther, C A ^b   Makrides, M ^a,b  

^a WOMEN S AND CHILDREN S HOSPITAL   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; IRON;

ADULT; ANEMIA; ARTICLE; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEFECATION HABIT; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; DRUG RESPONSE; FECES COMPOSITION; FEMALE; GASTROINTESTINAL SYMPTOM; HEARTBURN; HEMOGLOBIN BLOOD LEVEL; HUMAN; INCIDENCE; IRON THERAPY; LOW DRUG DOSE; MAJOR CLINICAL STUDY; NAUSEA; OUTCOME ASSESSMENT; PREGNANCY; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; STOMACH PAIN; VOMITING;

ADULT; ANEMIA, IRON-DEFICIENCY; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEMOGLOBINS; HUMANS; INFANT, NEWBORN; IRON; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; TRACE ELEMENTS; YOUNG ADULT;

EID: 59849120858     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1602926     Document Type: Article

References (26)

1. Cuervo LG, Mahomed K (2003). Treatments for iron deficiency anaemia in pregnancy. Cochrane Database Syst Rev Issue 2, CD 003094.
2. Department of Health and Aging (DHA) & National Health and Medical Research Council (NHMRC) (2006). Nutrient Reference Values for Australia and New Zealand Including Recommended Dietary Intakes. Commonwealth of Australia: Canberra.
3. Ekstrom EC, Hyder SM, Chowdhury AM, Chowdhury SA, Lonnerdal B, Habicht JP et al. (2002). Efficacy and trial effectiveness of weekly and daily iron supplementation among pregnant women in rural Bangladesh: disentangling the issues. Am J Clin Nutr 76, 1392-1400.
4. Enkin M, Keirse M, Halmers I (1995). A Guide to Effective Care in Pregnancy and Childbirth, 2nd edn. Oxford University Press: New York.
5. Eskeland B, Malterud K, Ulvik RJ, Hunskaar S (1997). Iron supplementation in pregnancy: Is less enough? A randomized, placebo controlled trial of low dose iron supplementation with and without heme iron. Acta Obstet Gynecol Scand 76, 822-828.
6. Garn SM, Ridella SA, Petzold AS, Falkner F (1981). Maternal hematologic levels and pregnancy outcomes. Semin Perinatol 5, 155-162.
7. 59*. Am J Obstet Gynecol 61, 477-486.
8. Hallberg L, Ryttinger L, Solvell L (1966). Side-effects of oral iron therapy. a double-blind study of different iron compounds in tablet form. Acta Med Scand Suppl 459, 3-10.
9. Lee JI, Lee JA, Lim HS (2005). Effect of time of initiation and dose of prenatal iron and folic acid supplementation on iron and folate nutriture of Korean women during pregnancy. Am J Clin Nutr 82 843-849.
10. Letsky E (1991). The Haematological system. In: Hytten F, Chamberlain G (eds). Clinical Physiology in Obstetrics. Blackwell Scientific Publications: Oxford, UK. pp 39-82.
11. Mahomed K (2000). Iron supplementation in pregnancy. Cochrane Database Syst Rev Issue 2, CD 000117.
12. Makrides M, Crowther CA, Gibson RA, Gibson RS, Skeaff CM (2003). Efficacy and tolerability of low-dose iron supplements during pregnancy: a randomized controlled trial. Am J Clin Nutr 78, 145-153.
13. Milman N, Bergholt T, Eriksen L, Byg KE, Graudal N, Pedersen P et al. (2005). Iron prophylaxis during pregnancy - how much iron is needed? A randomized dose-response study of 20-80mg ferrous iron daily in pregnant women. Acta Obstet Gynecol Scand 84, 238-247.
14. Murphy JF, O'Riordan J, Newcombe RG, Coles EC, Pearson JF (1986). Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy. Lancet 1, 992-995.
15. Pena-Rosas J, Viteri F (2006). Effects of routine oral iron supplementation with or without folic acid for women during pregnancy. Cochrane Database Syst Rev Issue 3, CD004736.
16. Pena-Rosas JP, Nesheim MC, Garcia-Casal MN, Crompton DW, Sanjur D, Viteri FE et al. (2004). Intermittent iron supplementation regimens are able to maintain safe maternal hemoglobin concentrations during pregnancy in Venezuela. J Nutr 134, 1099-1104.
17. Reddaiah VP, Raj PP, Ramachandran K, Nath LM, Sood SK, Madan N et al. (1989). Supplementary iron dose in pregnancy anemia prophylaxis. Indian J Pediatr 56, 109-114.
18. Solomons NW (1986). Competitive interaction of iron and zinc in the diet: Consequences for human nutrition. J Nutr 116, 927-935.
19. Sood SK, Ramachandran K, Mathur M, Gupta K, Ramalingaswamy V, Swarnabai C et al. (1975). W.H.O. sponsored collaborative studies on nutritional anaemia in India. 1. The effects of supplemental oral iron administration to pregnant women. Q J Med 44, 241-258.
20. Steer P, Alam MA, Wadsworth J, Welch A (1995). Relation between maternal haemoglobin concentration and birth weight in different ethnic groups. BMJ 310, 489-491.
21. The British Nutrition Foundation (1995). Iron absorption. In: Iron Nutritional and Physiological Significance, the Report of the British Nutrition Foundation's Task Force. Chapman & Hall: London. pp 3-12.
22. WHO (2001). Iron Deficiency Anaemia: Assessment, Prevention and Control - a Guide for Programme Managers. WHO: Geneva.
23. Zhou LM, Yang WW, Hua JZ, Deng CQ, Tao X, Stoltzfus RJ (1998). Relation of hemoglobin measured at different times in pregnancy to preterm birth and low birth weight in Shanghai, China. Am J Epidemiol 148, 998-1006.
24. Zhou SJ, Gibson RA, Crowther CA, Baghurst P, Makrides M (2006). Effect of iron supplementation during pregnancy on the intelligence quotient and behavior of children at 4 y of age: Long-term follow-up of a randomized controlled trial. Am J Clin Nutr 83, 1112-1117.
25. Zhou SJ, Schilling MJ, Makrides M (2005). Evaluation of an iron specific checklist for the assessment of dietary iron intake in pregnant and postpartum women. Nutrition 21, 908-913.
26. Ziaei S, Norrozi M, Faghihzadeh S, Jafarbegloo E (2007). A randomised placebo-controlled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin ≥13.2 g/dl. BJOG 114, 684-688.