Thrombotic thrombocytopenic purpura associated with ticlopidine: A review of 60 cases

Annals of Internal Medicine

Volumn 128, Issue 7, 1998, Pages 541-544

  Bennett, Charles L ^a,b   Weinberg, Peter D ^a,b   Rozenberg Ben Dror, Karine ^a,c   Yarnold, Paul R ^a,b   Kwaan, Hau C ^a,c   Green, David ^a,d  

^a NORTHWESTERN UNIVERSITY   (United States)

^b #205 ^*  (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d REHABILITATION INSTITUTE OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; DILTIAZEM; GLYCERYL TRINITRATE; HYDROCHLOROTHIAZIDE; METOPROLOL; TICLOPIDINE;

ADULT; AGED; ANEMIA; CHOLESTASIS; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEUTROPENIA; PRIORITY JOURNAL; REVIEW; THROMBOCYTE AGGREGATION; THROMBOCYTOPENIC PURPURA; THROMBOSIS;

EID: 0032055447     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-128-7-199804010-00004     Document Type: Review

References (20)

1. Bell WR, Braine HG, Ness PM, Kickler TS. Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Clinical experience in 108 patients. N Engl J Med. 1991;325:398-403.
2. Rose M, Rowe JM, Eldor A. The changing course of thrombotic thrombocytopenic purpura. Blood Rev. 1993;7:94-103.
3. Rock GA, Shumak KH, Buskard NA, Blanchette VS, Kelton JG, Nair RC, et al. Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group. N Engl J Med. 1991;325:393-7.
4. Torok TJ, Holman RC, Chorba TL. Increasing mortality from thrombotic thrombocytopenic purpura in the United States - analysis of national mortality data, 1968-1991. Am J Hematol. 1995;50:84-90.
5. Rose M, Eldor A. High incidence of relapse in thrombotic thrombocytopenic purpura. Clinical study of 38 patients. Am J Med. 1987;83:437-44.
6. Gordon LI, Kwaan HC. Cancer- and drug-associated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Semin Hematol. 1997;34:140-7.
7. Wysowski DK, Bacsanyi J. Blood dyscrasias and hematologic reactions in ticlopidine users [Letter]. JAMA. 1996;276:952.
8. Kovacs MJ, Soong PY, Chin-Hee IH. Thrombotic thrombocytopenic purpura associated with ticlopidine. Ann Pharmacother. 1993;27:1060-1.
9. Page Y, Tardy B, Zeni F, Comtet C, Terrana R, Bertrand JC. Thrombotic thrombocytopenic purpura related to ticlopidine. Lancet. 1991;337:774-6.
10. Capra R, Marciano N, Fieni F, Capucci M, Ferremi P, Orlandini A. Cerebral hemorrhage and thrombotic thrombocytopenic purpura during ticlopidine treatment: case report. Acta Neurol Belg. 1992;92:83-7.
11. Kodama K, Nomura T, Yasui K, Matsuo T. [Thrombotic thrombocytopenia purpura after administration of ticlopidine.] Rinsho Ketsueki. 1996;37:1334-6.
12. Ariyoshi K, Shinohara K, Ruirong X. Thrombotic thrombocytopenic purpura caused by ticlopidine, successfully treated by plasmapheresis [Letter]. Am J Hematol. 1997;54:175-6.
13. Kupfer Y, Tessler S. Ticlopidine and thrombotic thrombocytopenic purpura [Letter]. N Engl J Med. 1997;337:1245.
14. Ellie E, Durrieu C, Besse P, Julien J, Gbipki-Benissan G. Thrombotic thrombocytopenic purpura associated with ticlopidine [Letter]. Stroke. 1992; 23:922-3.
15. Gachet C, Stierle A, Cazenave JP, Ohlmann P, Lanza F, Bouloux C, et al. The thienopyridine PCR 4099 selectively inhibits ADP-induced platelet aggregation and fibrinogen binding without modifying the membrane glycoprotein IIb-IIIa complex in rat and in man. Biochem Pharmacol. 1990;40:229-38.
16. 3H]-2-methylthio ADP to rat platelets - effect of clopidogrel and ticlopidine. J Pharmacol Exp Ther. 1994;269:772-7.
17. de Maat MP, Arnold AE, van Buuren S, Wilson JH, Kluft C. Modulation of plasma fibrinogen levels by ticlopidine in healthy volunteers and patients with stable angina pectoris. Thromb Haemost. 1996;76:166-70.
18. Piovella F, Ricetti MM, Samaden A, Custodi P, Montecchio GP. Ticlopidine normalized abnormally high platelet fibronectin levels in retinopathic diabetics. Blood. 1985;66:311.
19. Defreyn G, Bernat A, Delebassee D, Maffrand JP. Pharmacology of ticlopidine: review. Semin Thromb Hemost. 1989;15:159-66.
20. Hass WK, Easton JD, Adams HP Jr, Pryse-Phillips W, Molony BA, Anderson S, et al. A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. Ticlopidine Aspirin Stroke Study Group. N Engl J Med. 1989;321:501-7.