Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 21, 2006, Pages 5605-5609

  Bachelier, Anke ^a   Mayer, Ralf ^b   Klein, Christian D ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Antibiotic; MurA; Peptidoglycan biosynthesis; Sesquiterpene lactones; Structure activity relationships

Indexed keywords

ALANTOLACTONE; ALPHA CYCLOCOSTUNOLIDE; ANTIINFECTIVE AGENT; CNICIN; COSTUNOLIDE; CYNAROPICRIN; CYSTEINE; DEHYDROCOSTUS LACTONE; EUPATORIOPICRIN; FOSFOMYCIN; MELAMPOLIDE; PARTHENOLIDE; SESQUITERPENE LACTONE; THIOL GROUP; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; COVALENT BOND; DRUG IDENTIFICATION; DRUG INHIBITION; STATISTICAL SIGNIFICANCE; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; ENZYME INHIBITORS; ESCHERICHIA COLI; LACTONES; PEPTIDOGLYCAN; PSEUDOMONAS AERUGINOSA; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS);

EID: 33748764203     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.021     Document Type: Article

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