Exploration of the pharmacophore of 3-alkyl-5-arylimidazolidinediones as new CB1 cannabinoid receptor ligands and potential antagonists: Synthesis, lipophilicity, affinity, and molecular modeling

Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2002, Pages 1748-1756

  Ooms, Frédéric ^a   Wouters, Johan ^b,d   Oscari, Olivier ^c   Happaerts, Thierry ^c   Bouchard, Géraldine ^a   Carrupt, Pierre Alain ^a   Testa, Bernard ^a   Lambert, Didier M ^c  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF NAMUR   (Belgium)

^c UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

^d Institut de Recherches Microbiologiques J M Wiame   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID 1 RECEPTOR; DEXANABINOL; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HYDANTOIN DERIVATIVE; LIGAND; RIMONABANT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CHO CELL; CONFORMATION; DRUG MECHANISM; DRUG SYNTHESIS; LIPOPHILICITY; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; X RAY ANALYSIS;

ANIMALS; BINDING, COMPETITIVE; CANNABINOIDS; CEREBELLUM; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDANTOINS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RADIOLIGAND ASSAY; RATS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037171832     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010896y     Document Type: Article

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