α-lipoic acid prevents neointimal hyperplasia via induction of p38 mitogen-activated protein kinase/Nur77-mediated apoptosis of vascular smooth muscle cells and accelerates postinjury reendothelialization

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 30, Issue 11, 2010, Pages 2164-2172

  Kim, Han Jong ^a   Kim, Joon Young ^a   Lee, Sun Joo ^a   Kim, Hye Jin ^a,g   Oh, Chang Joo ^a   Choi, Young Keun ^b   Lee, Hyo Jeong ^a   Do, Ji Yeon ^a   Kim, Sun Yee ^a   Kwon, Taeg Kyu ^b   Choi, Hueng Sik ^c   Lee, Mi Ock ^d   Park, In Sun ^e   Park, Keun Gyu ^b   Lee, Ki Up ^f   Lee, In Kyu ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b Keimyung University School of Medicine   (South Korea)

^c Chonnam National University   (South Korea)

^d Seoul National University   (South Korea)

^e Inha University School of Medicine   (South Korea)

^f University of Ulsan College of Medicine   (South Korea)

^g GUNMA UNIVERSITY   (Japan)

Author keywords

lipoic acid; apoptosis; neointimal hyperplasia; Nur77; VSMC

Indexed keywords

ARACHIDONIC ACID; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NUCLEAR RECEPTOR NUR77; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE C; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; APOPTOSIS; ARTICLE; CARDIOVASCULAR DISEASE; CAROTID ARTERY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INTIMA; MALE; NEOINTIMA HYPERPLASIA; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; REENDOTHELIALIZATION; RESTENOSIS; SMOOTH MUSCLE FIBER; STENT THROMBOSIS; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; VASCULARIZATION;

ANIMALS; APOPTOSIS; CARDIOVASCULAR AGENTS; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HYPERPLASIA; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PLATELET AGGREGATION; RATS; THIOCTIC ACID; WOUND HEALING;

EID: 78149282847     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.212308     Document Type: Article

References (31)

1. Dzau VJ, Braun-Dullaeus RC, Sedding DG. Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat Med. 2002;8:1249-1256.
2. Schwartz SM, de Blois D, O'Brien ER. The intima: soil for atherosclerosis and restenosis. Circ Res. 1995;77:445-465.
3. Costa MA, Simon DI. Molecular basis of restenosis and drug-eluting stents. Circulation. 2005;111:2257-2273.
4. Ruiz E, Gordillo-Moscoso A, Padilla E, Redondo S, Rodriguez E, Reguillo F, Briones AM, van Breemen C, Okon E, Tejerina T. Human vascular smooth muscle cells from diabetic patients are resistant to induced apoptosis due to high Bcl-2 expression. Diabetes. 2006;55:1243-1251.
5. Suzuki J, Isobe M, Morishita R, Nishikawa T, Amano J, Kaneda Y. Antisense Bcl-x oligonucleotide induces apoptosis and prevents arterial neointimal formation in murine cardiac allografts. Cardiovasc Res. 2000;45:783-787.
6. Pollman MJ, Hall JL, Mann MJ, Zhang L, Gibbons GH. Inhibition of neointimal cell bcl-x expression induces apoptosis and regression of vascular disease. Nat Med. 1998;4:222-227.
7. Joner M, Finn AV, Farb A, Mont EK, Kolodgie FD, Ladich E, Kutys R, Skorija K, Gold HK, Virmani R. Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol. 2006;48:193-202.
8. Hutter R, Sauter BV, Reis ED, Roque M, Vorchheimer D, Carrick FE, Fallon JT, Fuster V, Badimon JJ. Decreased reendothelialization and increased neointima formation with endostatin overexpression in a mouse model of arterial injury. Circulation. 2003;107:1658-1663.
9. Asahara T, Bauters C, Pastore CJ, Kearney M, Rossow S, Bunting S, Ferrara N, Symes JF, Isner JM. Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery. Circulation. 1995;91:2793-2801.
10. Martínez-González J, Badimon L. The NR4A subfamily of nuclear receptors: new early genes regulated by growth factors in vascular cells. Cardiovasc Res. 2005;65:609-618.
11. Williams GT, Lau LF. Activation of the inducible orphan receptor gene Nur77 by serum growth factors: dissociation of immediate early and delayed-early responses. Mol Cell Biol. 1993;13:6124-6136.
12. Fahrner TJ, Carroll SL, Milbrandt J. The NGFI-B protein, an inducible member of the thyroid/steroid receptor family, is rapidly modified posttranslationally. Mol Cell Biol. 1990;10:6454-6459.
13. Liu ZG, Smith SW, McLaughlin KA, Schwartz LM, Osborne BA. Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77. Nature. 1994;367:281-284.
14. Woronicz JD, Calnan B, Ngo V, Winoto A. Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas. Nature. 1994;367:277-281.
15. Andrew JW, Diego A, John MM, Barbara GH, Leonard HA. TR3/Nur77 in colon cancer cell apoptosis. Cancer Res. 2003;63:5401-5407.
16. Li H, Kolluri SK, Gu J, Dawson MI, Cao X, Hobbs PD, Lin B, Chen G, Lu J, Lin F, Xie Z, Fontana JA, Reed JC, Zhang XK. Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science. 2000;289:1159-1164.
17. Lin B, Kolluri SK, Lin F, Liu W, Han YH, Cao X, Dawson MI, Reed JC, Zhang XK. Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell. 2004;116:527-540.
18. Arkenbout EK, de Waard V, van Bragt M, van Achterberg TA, Grimbergen JM, Pichon B, Pannekoek H, de Vries CJ. Protective function of transcription factor TR3 orphan receptor in atherogenesis: decreased lesion formation in carotid artery ligation model in TR3 transgenic mice. Circulation. 2002;106:1530-1535.
19. Pires NM, Pols TW, de Vries MR, van Tiel CM, Bonta PI, Vos M, Arkenbout EK, Pannekoek H, Jukema JW, Quax PH, de Vries CJ. Activation of nuclear receptor Nur77 by 6-mercaptopurine protects against neointima formation. Circulation. 2007;115:493-500.
20. Novotny L, Rauko P, Cojocel C. alpha-Lipoic acid: the potential for use in cancer therapy. Neoplasma. 2008;55:81-86.
21. Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta. 2009;1790:1149-1160.
22. Van de Mark K, Chen JS, Steliou K, Perrine SP, Faller DV. a-Lipoic acid induces p27Kip-dependent cell cycle arrest in non-transformed cell lines and apoptosis in tumor cell lines. J Cell Physiol. 2004;194:325-340.
23. Yi X, Maeda N. Alpha-lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/ lowcholesterol diet. Diabetes. 2006;55:2238-2244.
24. Lee WJ, Lee IK, Kim HS, Kim YM, Koh EH, Won JC, Han SM, Kim MS, Jo IH, Oh GT, Par IS, Youn JH, Park SW, Lee KU, Park JY. Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler Thromb Vasc Biol. 2005;25:2488-2494.
25. Lee KM, Park KG, Kim YD, Lee HJ, Kim HT, Cho WH, Kim HS, Han SW, Koh GY, Park JY, Lee KU, Kim JG, Lee IK. Alpha-lipoic acid inhibits fractalkine expression and prevents neointimal hyperplasia after balloon injury in rat carotid artery. Atherosclerosis. 2006;189:106-114.
26. Kim HS, Kim HJ, Park KG, Kim YN, Kwon TK, Park JY, Lee KU, Park JG, Lee IK. a-Lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-κB transcriptional activity. Exp Mol Med. 2007;39:106-113.
27. Artwohl M, Muth K, Kosulin K, de Martin R, Holzenbein T, Rainer G, Freudenthaler A, Huttary N, Schmetterer L, Waldhausl WK, Baumgartner-Parzer SM. R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1. Am J Physiol Endocrinol Metab. 2007;293:E681-E689.
28. Pols TW, Bonta PI, de Vries CJ. NR4A nuclear orphan receptors: protective in vascular disease? Curr Opin Lipidol. 2007;18:515-520.
29. You B, Jiang YY, Chen S, Yan G, Sun J. The orphan nuclear receptor Nur77 suppresses endothelial cell activation through induction of IkappaBalpha expression. Circ Res. 2009;104:742-749.
30. Evans PC. Nur77: orphaned at birth but adopted by the nuclear factor kappaB signaling pathway. Circ Res. 2009;104:707-709.
31. Austin D, Pell JP, Oldroyd KG. Drug-eluting stents: a review of current evidence on clinical effectiveness and late complications. Scott Med J. 2008;53:16-24.